ライフサイエンスコーパス: molecular motor

1 using a transiently assembled phage-encoded molecular motor.

2 involved in the intrinsic operation of this molecular motor.

3 TolA, which is part of the conserved Tol-Pal molecular motor.

4 et instead of a singlet excited state of the molecular motor.

5 e of TEM requires microtubules and a kinesin molecular motor.

6 these cargoes with microtubules mediated by molecular motors.

7 n by processive microtubule- and actin-based molecular motors.

8 rocesses are directional movements driven by molecular motors.

9 disruption of microtubules and inhibition of molecular motors.

10 and are mostly driven by different forms of molecular motors.

11 ey still function properly as unidirectional molecular motors.

12 provides the tracks for transport driven by molecular motors.

13 will be essential in designing future rotary molecular motors.

14 nsport of cargo is accomplished by groups of molecular motors.

15 e structural support and serve as tracks for molecular motors.

16 e of motile cells without the implication of molecular motors.

17 ight and heat, thus providing a new class of molecular motors.

18 ly worked our way up to megadalton-sized RNA molecular motors.

19 standing of the general mechanisms of rotary molecular motors.

20 omponents and internal force generation from molecular motors.

21 key to understanding the mechanochemistry of molecular motors.

22 reach 340%, and estimate the velocity of the molecular motors.

23 highly regulated interactions of actomyosin molecular motors.

24 nfolding, making it consistent with those of molecular motors.

25 eleton, a system of filamentous proteins and molecular motors.

26 mulations of a variety of nucleic-acid-based molecular motors.

27 PP is transported through axons on kinesin-1 molecular motors.

28 is powered by kinesin and cytoplasmic dynein molecular motors.

29 logous to the behavior of well-characterized molecular motors.

30 he investigation of synthetic and biological molecular motors.

31 ormed viral procapsids is driven by powerful molecular motors.

32 ssembly of bipolar spindle in the absence of molecular motors.

33 of a series of third-generation light-driven molecular motors.

34 ensure mRNA silencing and provide a link to molecular motors.

35 cation, but also preserve the bioactivity of molecular motors.

36 cturing of dynamic nanodevices using protein molecular motors.

37 for optical-trapping-based investigations of molecular motors.

38 on of the rotational position for the A-type molecular motor A3B3DF, from the Methanosarcina mazei Go

39 ort and may reveal common mechanisms for how molecular motors accurately deposit cargoes at the corre

40 that there are general rules for functional molecular motors across the different families.

41 Molecular motors actively step along microtubules to shu

42 anical forces on the nuclear surface through molecular motor activity, we conclude that the intermedi

43 Here, we show that a stand-alone molecular motor adsorbed on a gold surface can be made t

44 , filament assembly, and force generation by molecular motors, all of which occur much faster [1-4].

45 Forces produced by molecular motors also contribute to chromosome alignment

46 Drosophila nonmuscle myosin-2 is a bona fide molecular motor and establish an important link between

47 cell-cycle-regulated membrane receptor for a molecular motor and suggest a mechanistic basis for achi

48 ion requires cyclic interactions between the molecular motor and the adhesion proteins of the outer m

49 active zone (AZ) proteins are transported by molecular motors and accumulate at discrete presynaptic

50 ives many essential processes in vivo, using molecular motors and actin assembly as force generators.

51 be shifted by altering the number of active molecular motors and clutches.

52 We designed molecular motors and complementary experimental protocol

53 stems built around self-propelled biological molecular motors and cytoskeletal filaments hold signifi

54 es a properly regulated transport network of molecular motors and cytoskeletal tracks.

55 IFT relies on molecular motors and IFT complexes that mediate the cont

56 rized in the context of the myosin family of molecular motors and is emerging as a versatile structur

57 Roop Mallik studies how molecular motors and lipids interact to drive intracellu

58 The collective activity of several molecular motors and other active processes generate lar

59 New evidence reveals roles for molecular motors and potential impacts on genomic organi

60 critical for many applications ranging from molecular motors and responsive materials to sensors.

61 More recently, molecular motors and switches that can change their conf

62 onal rotation of [2]- and [3]catenane rotary molecular motors and the transport of substrates away fr

63 given of the principal designs of artificial molecular motors and their modes of operation.

64 These organelles can also recruit molecular motors and transport their cargo virions along

65 amentous network under stresses generated by molecular motors, and deeply couples mechanics and chemi

66 f systems such as photoresponsive materials, molecular motors, and photoactivated drugs.

67 that contains APP, the secretase machinery, molecular motors, and previously proposed and new reside

68 h defined functionality, such as organelles, molecular motors, and transmembrane pumps.

69 Network dynamics is driven by molecular motors applying force onto the networks and th

70 Molecular motors are cellular trucks that help regulate

71 Teams of processive molecular motors are critical for intracellular transpor

72 The linear and rotary molecular motors are driven by aliquots of a chemical fu

73 be generally applicable to studies in which molecular motors are labeled with cargos that are artifi

74 In this design the functionalized molecular motors are not interfering and preserve their

75 However, although biological molecular motors are powered by chemical gradients or th

76 Molecular motors are responsible for numerous cellular p

77 dimension typically being less than 100 nm, molecular motors are significantly below the optical-res

78 We focus here on molecular motors as a paradigm.

79 phage T4 DNA packaging machine consists of a molecular motor assembled at the portal vertex of an ico

80 The mechanisms by which molecular motors associate with specific cargo is a cent

81 The strategic placement of a molecular motor at the center of the particle further su

82 sotropic fluid, composed of microtubules and molecular motors, autonomously flows through meter-long

83 Unidirectional rotary molecular motors based on chiral overcrowded alkenes ope

84 ed in various fields including the design of molecular motors based on nanostructure complexation wit

85 The enantiomeric homogeneity of light-driven molecular motors based on overcrowded alkenes is crucial

86 Symmetric molecular motors based on two overcrowded alkenes with a

87 mpact microtubule-based processes, including molecular motor-based intracellular transport.

88 hese interactions critical to the success of molecular motor-based nanodevices.

89 ules exist, but whether these defects impact molecular motor-based transport remains unknown.

90 Recently, a molecular-motor-based mechanism for axonal length sensin

91 enes are among the most promising artificial molecular motors because of their ability to undergo rep

92 used in biology and nanotechnology to study molecular motors, biopolymers and nanostructures, its ap

93 ynein and kinesin are both microtubule-based molecular motors but are structurally and evolutionarily

94 ted along microtubules by kinesin and dynein molecular motors, but how transport is regulated is not

95 nsequently, the rotational behavior of these molecular motors can be dynamically controlled with chem

96 duction components, epigenetic machinery and molecular motors can be engineered and introduced into p

97 Synthetic molecular motors can be fuelled by the hydrolysis or hyb

98 These results demonstrate that molecular motors can reproducibly drive proteins through

99 that Saccharomyces cerevisiae condensin is a molecular motor capable of adenosine triphosphate hydrol

100 upon by the mitochondrial m-AAA protease, a molecular motor capable of dislocating proteins from the

101 Synthetic molecular motors continue to attract great interest due

102 le location, net directional rotation of the molecular motor continues for as long as unreacted fuel

103 anization of filamentous actin and myosin II molecular motor contractility is known to modify the mec

104 d, we examined the group function of a major molecular motor, conventional kinesin, when transporting

105 Light-driven molecular motors convert light into mechanical energy th

106 Rab6, with Kif5B and dynein as two opposite molecular motors coordinating the traffic of vesicles al

107 tramuscular temperature gradients may enable molecular motors (cross-bridges) to store elastic strain

108 The molecular motor cytoplasmic dynein is responsible for mo

109 ures differs substantially in T. gondii, the molecular motor dependence of DG trafficking is far from

110 Members of the kinesin superfamily of molecular motors differ in several key structural domain

111 articular interest are unidirectional rotary molecular motors driven by chemical fuel or light.

112 ntracellular stiffness and power output from molecular motor-driven fluctuations in cells overexpress

113 SecA is thought to act as a molecular motor driving translocation of the preprotein

114 The molecular motor dynein concentrates at the kinetochore r

115 We show that the molecular motor dynein is required for perinuclear local

116 Mutations in components of the molecular motor dynein/dynactin lead to neurodegenerativ

117 Molecular motors embedded within collections of actin an

118 cellular cargo transport relies on myosin Va molecular motor ensembles to travel along the cell's thr

119 osin Va (myoVa) is a processive, actin-based molecular motor essential for intracellular cargo transp

120 In dsDNA viruses, powerful molecular motors essentially pump the viral DNA into a p

121 Unconventional myosin 15 is a molecular motor expressed in inner ear hair cells that t

122 Cytoskeletal filaments and molecular motors facilitate the micron-scale force gener

123 ses are governed by two different species of molecular motors, fast and slow ones, that both move in

124 s, viral capsids depend on microtubule-based molecular motors for efficient and fast transport.

125 y ATP hydrolysis, this hexameric ring-shaped molecular motor formed by three alphabeta-dimers creates

126 uantitative mechanistic understanding of DBP molecular motor function.

127 lagellar transport (IFT) employing kinesin-2 molecular motors has been implicated in trafficking of p

128 Although synthetic molecular motors have also found widespread application

129 Although molecular motors have been implicated in this process, t

130 Although several spindle-associated molecular motors have been shown to be essential for cel

131 ctions with the cytoskeleton exists, but the molecular motors have received no attention as anestheti

132 es that explore the behavior of ensembles of molecular motors have used nonphysiological cargoes such

133 the recognition of TPs by the major stromal molecular motor Hsp70 are specific for the physicochemic

134 During mitosis, molecular motors hydrolyze ATP to generate sliding force

135 HC) possess voltage-dependent membrane bound molecular motors, identified as the solute carrier prote

136 myosin-18A does not operate as a traditional molecular motor in cells.

137 Molecular motors in cells typically produce highly direc

138 e well-defined energy landscapes in studying molecular motors in general and myosin in particular.

139 pen new vistas to the transport phenomena by molecular motors in general.

140 ging ATPase, and are among the most powerful molecular motors in nature.

141 ese results emphasize the different roles of molecular motors in particular mechanisms.

142 and assessing the utility of novel synthetic molecular motors in the future.

143 measurements of individual cargoes hauled by molecular motors in their native environment.

144 The role of molecular motors in this process is unclear.

145 generates much smaller forces than canonical molecular motors, including those driving eukaryotic chr

146 Nonmuscle myosin IIs (NM IIs) are a group of molecular motors involved in a wide variety of cellular

147 Dyneins are important molecular motors involved in many essential biological p

148 ledge on the key RNA-binding protein and the molecular motors involved, it is unclear how mRNAs are c

149 nching of the porphyrin excited state by the molecular motor is diffusion-controlled.

150 n an active nematic film of microtubules and molecular motors is encapsulated within a shape-changing

151 The myosin-V family of molecular motors is known to be under sophisticated regu

152 e now find that the budding yeast kinesin-14 molecular motor Kar3-Cik1 can efficiently align spindle

153 These results reveal that HIV-1 requires the molecular motor KIF3 to complete its cycle in primary ma

154 ndent association of MMP-9 vesicles with the molecular motor kinesin, whose association with the MT n

155 c domain that were essential for binding the molecular motor kinesin-1.

156 hondria is mediated by the microtubule-based molecular motor kinesin-1.

157 s-end tracker EB1 and the minus-end-directed molecular motor Kinesin-14 is sufficient to promote para

158 zation of RNA transport complexes carried by molecular motor kinesin.

159 The molecular motors kinesin and dynein drive bidirectional

160 dria are transported on microtubules via the molecular motors kinesin-1 and dynein and recruited to e

161 and systematic proteomic characterization of molecular motor kinesins to identify the populations of

162 packaging motors are among the most powerful molecular motors known.

163 del is that fluctuations in the transport of molecular motors lead to a reduction in the reliability

164 s coordination with the activity of specific molecular motors like myosin.

165 erface; and of the structure and function of molecular motors, making the study of these interactions

166 ween Brownian diffusion in the cytoplasm and molecular motor-mediated active transport.

167 nt upon a large array of proteins, including molecular motors, membrane tethering, fusion and restruc

168 es are transported to the plasma membrane by molecular motors moving on their respective cytoskeletal

169 Mutations of the molecular motor myosin 15 stunt stereocilia growth and c

170 d by expression of the rare isoform A of the molecular motor myosin IC, however the function of this

171 this study, we have investigated whether the molecular motor myosin II represents such a target by ex

172 The molecular motor myosin teams up to drive muscle contract

173 The molecular motor myosin V (MyoV) exhibits a wide repertoi

174 delivery of SGs to the PM by recruiting the molecular motor myosin Va.

175 The actin-based molecular motor myosin VI functions in the endocytic upt

176 mponent the thick filament, comprised of the molecular motor myosin.

177 According to recent experiments, the molecular-motor myosin behaves like a strain sensor, exh

178 we focus on mutations in the cardiac muscle molecular motor, myosin, and its associated light chains

179 is issue, Lelli et al. reveal that a pair of molecular motors, myosin IIIa and myosin IIIb, is involv

180 We also find that LSP1 binds to the class I molecular motor myosin1e.

181 e conventional myosin-II or other processive molecular motors, Ncd requires two ATP turnovers rather

182 tated by contractile forces generated by the molecular motor, non-muscle myosin II (NMII).

183 hat they neither depend on microtubule-based molecular motors nor pressure generated by myosin-II.

184 The two opposed rotary molecular motors of the F0F1-ATP synthase work together

185 Molecular motors of the myosin superfamily share a gener

186 ts into uncovering how force is generated by molecular motors.Omecamtiv mecarbil (OM) is a cardiac my

187 For transport mediated by molecular motors on filament networks in vitro and in vi

188 ical pulling forces exerted in particular by molecular motors on MTs and controlled by external cues

189 Upon physical adsorption of the molecular motors onto lipid bilayers and subsequent acti

190 The speed at which a molecular motor operates is critically important for the

191 We observed unidirectional movements of the molecular motors over 3 microm with a translocation velo

192 a two-dimensional array of proton-fueled DNA molecular motors packed at the maximal density as a mode

193 for applications including light-harvesting molecular motors, photocontrolled drug delivery, gene re

194 Previously, rotary molecular motors powered by light and chemical energy ha

195 ion by a voltage-dependent activation of the molecular motor, prestin (SLC26a5), in the cell's latera

196 Molecular motors produce force when they interact with t

197 fashion using a large number of independent, molecular-motor-propelled agents then solves the mathema

198 ays allow for the direct characterization of molecular motor properties including stepping velocity a

199 e 5 (AdV5) capsid protein hexon recruits the molecular motor protein cytoplasmic dynein in a pH-depen

200 We find that the molecular motor protein myosin-1c (Myo1c) regulates the

201 rete molecular photodynamic steps, action of molecular motors, protein folding, diffusion, etc. down

202 affect microtubule-related proteins such as molecular motor proteins and microtubule severing enzyme

203 Both ATP-driven molecular motor proteins are able to translocate nucleos

204 Molecular motor proteins are responsible for long-range

205 g myosin heavy chain 7 (Myh7), which encodes molecular motor proteins for heart contraction.

206 iquitous in bacteria and play a dual role as molecular motor proteins responsible for branch migratio

207 nd protein kinase C isozymes and then on the molecular motor proteins that function downstream to dri

208 g most members of the kinesin superfamily of molecular motor proteins that is critical for kinesin's

209 in axons and dendrites primarily depends on molecular motor proteins that move along the cytoskeleto

210 DBPs are molecular motor proteins that utilize chemical energy in

211 Molecular motor proteins use the energy released from AT

212 osite orientation are spatially separated by molecular motor proteins.

213 atable forces imposed on the microtubules by molecular motor proteins.

214 SecA is an ATP-dependent molecular motor pumping secretory and outer membrane pro

215 Multimeric, ring-shaped molecular motors rely on the coordinated action of their

216 Ultimately, controlling the efficiency of molecular motors requires a detailed picture of the mole

217 Myosin is a molecular motor responsible for biological motions such

218 Kinesin-1 is a molecular motor responsible for cargo transport along mi

219 Cytoplasmic dynein is a molecular motor responsible for minus-end-directed cargo

220 Myosin Va is an actin-based molecular motor responsible for transport and positionin

221 Furthermore, the new molecular motor retains unidirectional rotation while sh

222 Synthetic light-driven rotary molecular motors show complicated structural dynamics du

223 Applications of this analysis include molecular-motor stepping, fluorophore bleaching, electro

224 Molecular motors such as kinesin and dynein use the ener

225 ich model the interaction between processive molecular motors, such as kinesin and dynein, and the bi

226 A new unidirectional light-driven molecular motor suitable for host-guest surface inclusio

227 Finally, we discuss how these molecular motors tailor their operation-often through re

228 The field of artificial molecular motors takes inspiration from these tiny but p

229 catalytic complex of the ATP synthase, is a molecular motor that can consume ATP to drive rotation o

230 F1-ATPase is a highly efficient molecular motor that can synthesize ATP driven by a mech

231 licase of Hepatitis C virus is an ATP-fueled molecular motor that can translocate along single-strand

232 e of F-actin polymerization and myosin II, a molecular motor that drives memory-promoting dendritic s

233 FtsK is a powerful molecular motor that functions in cell division, co-ordi

234 Gyrase is a molecular motor that harnesses the free energy of ATP hy

235 an acceleration of the rotation rate of the molecular motor that is larger than the acceleration obt

236 Myosin 10 is an actin-based molecular motor that localizes to the tips of filopodia

237 Myosin Va is a double-headed cargo-carrying molecular motor that moves processively along cellular a

238 Cytoplasmic dynein is a microtubule-based molecular motor that participates in a multitude of cell

239 Myosin-10 is an actin-based molecular motor that participates in essential intracell

240 Mutations in genes encoding myosin, the molecular motor that powers cardiac muscle contraction,

241 on-muscle myosin II holoenzyme (myosin) is a molecular motor that powers contraction of actin cytoske

242 Myosin Va (myoVa) is a molecular motor that processively transports cargo along

243 utic target, nonmuscle myosin IIB (NMIIB), a molecular motor that supports memory by directly driving

244 sviruses, this is accomplished by a powerful molecular motor that translocates the viral DNA into a p

245 Cytoplasmic dynein is a molecular motor that transports a large variety of cargo

246 Myosin 5a is a dual-headed molecular motor that transports cargo along actin filame

247 Myosin-5B is a ubiquitous molecular motor that transports cargo vesicles of the en

248 Myosin Va (myoV) is a processive molecular motor that transports intracellular cargo alon

249 FoF1 is a membrane-bound molecular motor that uses proton-motive force (PMF) to d

250 rs of the myosin superfamily are actin-based molecular motors that are indispensable for cellular hom

251 of passive diffusion and active transport by molecular motors that ballistically move along a network

252 Intracellular transport is mediated by molecular motors that bind cargo to be transported along

253 process is mediated by kinesins and dyneins, molecular motors that bind to cargoes and translocate on

254 Helicases are molecular motors that couple the energy of ATP hydrolysi

255 Kinesins comprise a superfamily of molecular motors that drive a wide variety of cellular p

256 V-ATPases are rotary molecular motors that generally function as proton pumps

257 Myosins are molecular motors that generate force to power a wide arr

258 Many viruses use molecular motors that generate large forces to package D

259 Class I myosins are molecular motors that link cellular membranes to the act

260 emically-driven artificial rotary and linear molecular motors that operate through a fundamentally di

261 Myosins are molecular motors that power diverse cellular processes,

262 The novel concept of amphiphilic molecular motors that self-assemble into responsive supr

263 orce-induced changes in contractility of the molecular motor, the beta-cardiac myosin (betaCM).

264 rce spectroscopy of DNA, macromolecules, and molecular motors, this can lead to errors of up to 100%

265 phages and herpesviruses, utilize a powerful molecular motor to package their genomic DNA into a pref

266 essive exopeptidase digestion, or by using a molecular motor to pull proteins through a tunnel juncti

267 uctuations are rectified or ratcheted by the molecular motor to transport substrate proteins along a

268 Many DNA viruses use powerful molecular motors to cleave concatemeric viral DNA into g

269 Although several viral proteins engage molecular motors to facilitate transport, the initial st

270 By improving the attachment of molecular motors to microtubules, huntingtin dephosphory

271 Many viruses utilize molecular motors to package their genomes into preformed

272 uctural domains, which probably allows these molecular motors to serve the different physiologies req

273 s and herpes viruses use powerful ATP-driven molecular motors to translocate their viral genomes into

274 tified myosin-1E (MYO1E), an actin-dependent molecular motor, to interact directly with the FAK FERM-

275 Molecular motors translocate along cytoskeletal filament

276 elles of living cells are often regulated by molecular motor transport.

277 Within axons, molecular motors transport essential components required

278 Specific recognition of the cargo that molecular motors transport or tether to cytoskeleton tra

279 Molecular motors transport organelles to specific subcel

280 Molecular motors transport organelles to their proper de

281 cytokinesis precursor nodes that include the molecular motor type-II myosin Myo2 and the actin assemb

282 aptic vesicles throughout the axon driven by molecular motors ultimately yields this even distributio

283 uncover a surprising role of the anterograde molecular motor UNC-104/KIF1A as a key regulator of neur

284 The dynamic function of the molecular motor units inside the supramolecular assembli

285 Dynamin superfamily molecular motors use guanosine triphosphate (GTP) as a s

286 length of both axons and dendrites, and the molecular motors use these intracellular 'highways' to t

287 follow photon absorption by a unidirectional molecular motor using ultrafast fluorescence up-conversi

288 ransport is that organelles directly recruit molecular motors via cargo-specific adaptors.

289 To this end, a new molecular motor was designed, and the isomerization proc

290 id racemization, a new class of light-driven molecular motors was designed, synthesized, and studied.

291 Monolayers of fluorinated light-driven molecular motors were synthesized and immobilized on gol

292 astes are carried upstream (retrogradely) by molecular motors, which act as cargo porters.

293 ic scale, this stress is generated by myosin molecular motors, which bind to actin cytoskeletal filam

294 nticipate that autonomous chemically fuelled molecular motors will find application as engines in mol

295 Here the excited-state dynamics of a molecular motor with electron donor and acceptor substit

296 A third-generation molecular motor with the potential to be the fastest bas

297 on is controlled by interactions of cortical molecular motors with astral microtubules.

298 Engineering molecular motors with controllable properties will allow

299 A series of first-generation light-driven molecular motors with rigid substituents of varying leng

300 imizing the efficiency of operation of these molecular motors without modifying their overall rotatio