ライフサイエンスコーパス: molecular probe

1 ondrial specific dye used was rhodamine 800 (Molecular Probes).

2 ntravitreal injection of an oxygen-sensitive molecular probe.

3 n intravenously injected palladium porphyrin molecular probe.

4 and induced RONS detected by a general RONS molecular probe.

5 pool sizes using the photoacid pyranine as a molecular probe.

6 floxacin (CIPRO), were chosen as nonresonant molecular probes.

7 te-specific incorporation of any one of many molecular probes.

8 y preventing brain delivery of most targeted molecular probes.

9 proteins that are useful as therapeutics or molecular probes.

10 hampered by the lack of chromosome-specific molecular probes.

11 ncreasingly sensitive, selective, and robust molecular probes.

12 distinguishing between bound verses unbound molecular probes.

13 avital catheter-based imaging of fluorescent molecular probes.

14 l in vivo applications using NIR polymethine molecular probes.

15 target cells for the generation of effective molecular probes.

16 d characterization of phosphonium cations as molecular probes.

17 imaged by use of specific activity-dependent molecular probes.

18 e and eliminates any requirement for dyes or molecular probes.

19 alidating their use as therapeutic agents or molecular probes.

20 ursor protein (APP) and Notch by using small molecular probes.

21 signed to encourage the development of small molecular probes.

22 ures as customizable substitutes for organic molecular probes.

23 ude a more complete set of immunological and molecular probes.

24 by X-linked clonal analysis with the use of molecular probes.

25 th computer-assisted microscopy and specific molecular probes.

26 te for developing robust and informative new molecular probes.

27 ized by (19)F NMR and evaluated as (19)F NMR molecular probes.

28 H was not detected when using *OH scavenging molecular probes.

29 al nanoplatform for developing photoacoustic molecular probes.

30 , due to low availability of target-specific molecular probes.

31 and synthesized fluorinated bromopyronins as molecular probes.

32 by many researchers for developing reactive molecular probes.

33 The structurally optimized molecular probe 3 responds exclusively to microM-level c

34 A molecular probe, 3-amino-2,2,5,5,-tetramethy-1-pyrrolydi

35 A fluorescent molecular probe, 6-carboxy fluorescein, was used in conj

36 as measured using a profluorescent nitroxide molecular probe 9-(1,1,3,3-tetramethylisoindolin-2-yloxy

37 By using an oxidation-dependent fluorescent molecular probe a 2- to 3-fold increase in fluorescence

38 n cleaved site-specifically by using a small molecular probe, a bulky metallointercalator, Rhchrysi o

39 Here we report the synthesis of fluorescent molecular probes able to unambiguously detect ozone in b

40 sment, insensitive to nonspecific sources of molecular probe accumulation and contrast, is presented

41 We used a molecular probe activated by protease cleavage to image

42 ombined with fluorescence imaging of various molecular probes, activity-dependent cellular processes

43 owever, unspecific antigen recognition, poor molecular probe adsorption and the need for sample dilut

44 the cross-linked interactions we observed as molecular probes, allowing quantification of conformatio

45 ections of replication-defective viruses and molecular probes allows the genetic analysis of essentia

46 Using intrinsic tryptophan as a molecular probe and from mutation studies, we ascertaine

47 stant to deiodination in vivo, both as small molecular probes and as antibody conjugates.

48 which have proven their potential as useful molecular probes and as next-generation therapeutics.

49 lanized humic materialas can be seen as both molecular probes and as potent candidate materials for s

50 d complexes allow a rational design of novel molecular probes and drugs.

51 recognition in muro, and that the access of molecular probes and enzymes to xylan epitopes/ligands a

52 Prompted by the urgent need for new molecular probes and inhibitors to understand LSD1/CoRES

53 This assay consumes only attomoles of molecular probes and is able to quantitatively detect su

54 s-sectional multimodal imaging incorporating molecular probes and other novel noninvasive techniques

55 by the relatively small number of pertinent molecular probes and the limited physicochemical propert

56 lung preparations incorporating fluorescent molecular probes and transgenic reporter mice.

57 liant green and crystal violet dyes were the molecular probes, and the experiments were carried out o

58 ma system by facilitating development of new molecular probes, and the linkage map will allow compara

59 ovides a mechanistic understanding of drugs, molecular probes, and their biologic targets.

60 Molecular probes are currently being developed not only

61 ted with these ecological manipulations, and molecular probes are powerful tools for monitoring bioco

62 s review, recent examples of lesion-specific molecular probes are surveyed; their specificities of in

63 These molecular probes are validated via multi-scale imaging,

64 idine orange and Lysotracker Red [Invitrogen-Molecular Probes]), autophagic vacuole content (MDC), SA

65 Molecular probes available for infection imaging have un

66 will dramatically increase the repertoire of molecular probes available to determine the developmenta

67 This is followed by a survey on (a) molecular probes, (b) nanomaterials, and (c) bulk materi

68 We have applied a fluorophore-labeled molecular probe based on a high-affinity platelet-derive

69 we report a new, to our knowledge, class of molecular probes based on dye-conjugated dendrimers for

70 Fluorescent molecular probes based on phosphonate-functionalized por

71 We chose to design new molecular probes based on the structure of 2-(1-(6-((2-[

72 drorhodamine 6G (DHR-6G) was selected as the molecular probe because it is sensitive to typical smoke

73 of(18)F-FDG, as well as the addition of new molecular probes beyond(18)F-FDG, the future holds signi

74 retion and reduced lumenal flux of different molecular probes (bovine serum albumin, alexa350, and de

75 We used a new class of molecular probes called molecular beacons to genotype th

76 lf-assembly of polyelectrolytes to which the molecular probes can be bound covalently.

77 ndicate that such small technetium-99m-based molecular probes can be developed as in vivo diagnostic

78 oxide, making this system the first discrete molecular probe capable of detecting HNO over NO under p

79 ogression and poor survival, suggesting that molecular probes capable of assaying TSPO levels may hav

80 Molecular probes capable of detecting colorectal cancer

81 erein we report the synthesis of a series of molecular probes capable of detection of tau protein dep

82 rs, we report the discovery of peptide-based molecular probes capable of selectively discriminating F

83 ,6-diaminido-2-phenylindole dihydrochloride (Molecular Probes, Carlsband, CA) revealed a relative uni

84 that a dualsteric design principle, that is, molecular probes, carrying two pharmacophores to simulta

85 HER2-specific molecular probes, combined with modern imaging technique

86 upon binding of the antibody on the grafted molecular probe; conversely, when diclofenac is present

87 ide GRDSPK with a near-infrared carbocyanine molecular probe (Cypate) yielded a previously undescribe

88 A novel aptamer-based molecular probe design employing intramolecular signal t

89 covalently labeled with a hydroxamate-based molecular probe designated AspR1, which was developed fo

90 t of the luciferase construct as a sensitive molecular probe, detecting a specific DNA target sequenc

91 Three main strategies used in molecular probe development for H2S detection include az

92 to explore novel techniques for accelerating molecular probe development.

93 The first one is a molecular probe, diclofenac, coupled with an arylamine o

94 Molecular probes directed to structural elements of thes

95 n be fully realized only when novel types of molecular probes distinguishable in the Raman spectrosco

96 ly encoded sequences may find application as molecular probes, drug leads, and biosensors to monitor

97 488, Oregon Green 488, and Oregon Green 514 (Molecular Probes (Eugene, OR)) are compared when conjuga

98 as assessed by using Sytox Green (Invitrogen-Molecular Probes, Eugene, OR) a nucleic acid dye uptake

99 intracellular injection with Lucifer yellow (Molecular Probes, Eugene, OR) and neurobiotin at E15.5,

100 eal permeability to AlexaFluor dextran (AFD; Molecular Probes, Eugene, OR) was measured by a fluorome

101 led with aminostilbamidine methanesulfonate (Molecular Probes, Eugene, OR), and loss of fluorescently

102 ondrial content (Mitotracker Red; Invitrogen-Molecular Probes, Eugene, OR), lysosomal content (acridi

103 amber and the proliferation assays (CyQUANT; Molecular Probes, Eugene, OR), respectively.

104 uorescent dyes (SYTOX Orange and SYTO Green; Molecular Probes, Eugene, OR), which differentiate betwe

105 rescent dye, LysoSensor Yellow-Blue DND 160 (Molecular Probes, Eugene, OR), which localizes to highly

106 with the nuclear dye SYTOX Green (Invitrogen-Molecular Probes, Eugene, OR).

107 acidotropic probe, (Lysotracker Red DND-99; Molecular Probes, Eugene, OR).

108 Quenching of molecular probe fluorescence is achieved through unique

109 and interactions without any disturbances by molecular probes, fluorescent labels, or immobilization

110 (18)F-FB-NAPamide is a promising molecular probe for alpha-MSH receptor-positive melanoma

111 Using lumogallion as a direct-fluorescent molecular probe for aluminium, complemented with transmi

112 ell line, using lumogallion as a fluorescent molecular probe for aluminium.

113 make SL-H2DADS-maleimide an extremely useful molecular probe for characterization of the physical pro

114 While the (5F)LOH acts as a molecular probe for CN(-), (2F)LOH, (1F)LOH, and (0F)LOH

115 results suggest that PatA will be a valuable molecular probe for future studies of eukaryotic transla

116 s, behaves as a highly selective chromogenic molecular probe for hydrogenpyrophosphate anion in a com

117 ings, acts as a highly selective fluorescent molecular probe for hydrogenpyrophosphate anion in eithe

118 Thus, the mpo gene should provide a useful molecular probe for identifying zebrafish mutants with d

119 synthesis and evaluation of (18)F-FTPP as a molecular probe for imaging mitochondrial dysfunction.

120 elop and evaluate 99mTc-duramycin as a novel molecular probe for imaging PtdE.

121 Our study identifies SPI as a novel molecular probe for interrogating Stat3 signaling and th

122 ld therefore be considered as an appropriate molecular probe for NTS1 imaging by PET.

123 etallopeptide (18)F-FB-RMSH-1 is a promising molecular probe for PET of MC1R-positive tumors.

124 It is a strong candidate as a molecular probe for PtdE imaging and warrants further de

125 olecule was further evaluated as a potential molecular probe for small-animal PET HER2 imaging in a S

126 ng radiopeptide was evaluated as a potential molecular probe for small-animal PET of melanoma and MC1

127 sembles native TPN, it will be a very useful molecular probe for studying the inward-rectifier K+ cha

128 A molecular probe for the luminescent detection of adenosi

129 antibody and have the potential to serve as molecular probes for a variety of biomedical application

130 Conversely, there are a plethora of molecular probes for alternative in vivo vascular imagin

131 sis of liver neoplasia, as well as providing molecular probes for both diagnosis and monitoring treat

132 using EETI 2.5F and EETI 2.5-Fc as targeted molecular probes for brain tumor imaging.

133 holds a great promise in developing specific molecular probes for cancer diagnosis and cancer biomark

134 ncer-specific aptamers hold great promise as molecular probes for cancer early diagnosis and basic me

135 on vary considerably, requiring a variety of molecular probes for detection.

136 le-imidazole polyamides as sequence-specific molecular probes for DNA accessibility in nucleosomes.

137 fective anti-Toxoplasma trioxanes as well as molecular probes for elucidating the mechanism of action

138 tagonists of LRH-1 could be used as specific molecular probes for elucidating the roles of the recept

139 n of 19 of the genes and identified a set of molecular probes for genes that are up-regulated in the

140 cess to this growing chemical toolbox of new molecular probes for H2S and related RSS sets the stage

141 ecessary confirmation for the development of molecular probes for Hg-methylation in nature.

142 The key requirements of suitable molecular probes for in situ monitoring of ROS are prese

143 easingly important in the development of new molecular probes for in vivo imaging, both experimentall

144 dings have implications on the design of LNA molecular probes for intracellular monitoring applicatio

145 These inhibitors represent novel molecular probes for modulating gene regulation mediated

146 Using recently developed molecular probes for mouse MIF, we have examined the rol

147 endocytic ligands, represent a new class of molecular probes for quantitative imaging of endocytic r

148 d molecules were then evaluated as potential molecular probes for small-animal HER2 PET by use of a S

149 his paper, we describe a new way to generate molecular probes for specific recognition of cancer cell

150 ial enrichment) method for the generation of molecular probes for specific recognition of liver cance

151 nyl)propyl-N,N-bis(4-fluorophenyl)amines, as molecular probes for the dopamine transporter (DAT).

152 The lack of molecular probes for the isolation of this protein has m

153 AMACR the ideal candidate for development of molecular probes for the noninvasive identification of p

154 en developed in order to provide a series of molecular probes for the quantification of intracellular

155 will assist in the development of selective molecular probes for the study of this and structurally

156 uation of two novel dimeric cyclic RGD-based molecular probes for the targeted imaging of alpha V bet

157 As molecular probes for this study, derivatives of isopropy

158 This research provides valuable, new molecular probes for use in exploring HDAC biology.

159 and INCh2 therefore represent important new molecular probes for Viridiplantae research.

160 and offers the potential to rapidly assemble molecular probes from an array of structurally diverse,

161 The generation of molecular probes from other families of CBMs will dramat

162 tachment of antibodies to yield gold nanorod molecular probes (GNrMPs).

163 n attached to the GNRs to yield gold nanorod molecular probes (GNrMPs).

164 The lack of molecular probes hampers the research in this area.

165 accessible new class of near infrared (NIR) molecular probes has been synthesized and evaluated.

166 Novel molecular probes have been developed for the analysis an

167 A variety of methods and molecular probes have been developed, but long term (fro

168 Hyperpolarized (13)C labeled molecular probes have been used to investigate metabolic

169 Lesion-specific molecular probes have been used to study polymerase-medi

170 Herein we report a superfluorinated molecular probe, herein called PERFECTA, possessing exce

171 f nuclear RNAs that cannot be seen with many molecular probes heretofore used.

172 vide a flexible system that utilizes CBMs as molecular probes in a range of applications.

173 d compounds for drug discovery and excellent molecular probes in biomedical research.

174 l building blocks for chemical synthesis, as molecular probes in chemical genomics and systems biolog

175 earch in molecular imaging shows promise for molecular probes in endoscopy, using fluorescently label

176 s an important target for the development of molecular probes in oncology because of its 10-fold high

177 Phenylenediamine derivatives are utilized as molecular probes in the solid state on a nanoporous memb

178 enable to click chemistry and can be used as molecular probes in vitro and in vivo.

179 Studies with small molecular probes indicate that these self-assembled arch

180 Self-assembly of molecular probes into supramolecular nanoprobes presents

181 systems to deliver BBB-impermeable targeted molecular probes into the brain for diagnostic neuroimag

182 ed using the sensitive DNA dye SYBR Green I (Molecular Probes-Invitrogen).

183 demonstrates that operating a robust single-molecular probe is not restricted to ultra-high vacuum a

184 Competitive adsorption among the three molecular probes is clearly resolved by in situ SFG meas

185 ome- or dendrimer-based cellular delivery of molecular probes is inefficient, slow, and often detrime

186 ization of protein molecules conjugated with molecular probes is performed by UV-vis spectroscopy.

187 et the poor cellular uptake of water-soluble molecular probes limits their use as protease sensors.

188 In conclusion, we have used a novel molecular probe (mAb C9BB) to demonstrate the existence

189 FK506, and rapamycin, and that its use as a molecular probe may lead to the discovery of a novel tar

190 The isolation in 1993 of the first molecular probe of acyl-coenzyme A: cholesterol acyltran

191 tide substrate represents a highly sensitive molecular probe of palmitoyl acyltransferase activity th

192 This work shows how catechol, a molecular probe of the oxygenated aromatic hydrocarbons

193 ADS) has been synthesized as a site-specific molecular probe of the stilbenedisulfonate binding site

194 ds were tested for their utility as (1)H NMR molecular probes of intracellular pH.

195 their discriminative potential and value as molecular probes of the corresponding transcriptome.

196 ric dissolved organic matter (CDOM) by using molecular probes of varying hydrophobicity.

197 The combination of MR imaging and molecular probes offers exciting possibilities of direct

198 In conjunction with specific molecular probes, optical coherent tomography (OCT) is a

199 pounds are essential to their application as molecular probes or therapeutic agents.

200 elf-assembled monolayer for conjugation of a molecular probe reporter (ovalbumin or mouse IgG) to doc

201 ated in radiofluorogenic droplets containing molecular probes sensitive to byproducts of ionizing rad

202 on established using confocal microscopy and molecular probes showed that both photosensitizers were

203 t circumvents many of the limitations of the molecular probe Singlet Oxygen Sensor Green((R)) (SOSG).

204 ibitors on the basis of the highly selective molecular probe Skepinone-L is described.

205 ally, rather than experimentally, by placing molecular probes (small molecules or functional groups)

206 Solvent mapping moves molecular probes, small organic molecules containing var

207 Computational mapping places molecular probes--small molecules or functional groups--

208 The method moves molecular probes--small organic molecules containing var

209 Fluorescent molecular probe studies indicate that the O2 (-) species

210 Although many molecular probes such as aptamers and antibodies can rec

211 the decomposition rate of suitably selected molecular probes, such as 4-hydroxybenzoic acid and meth

212 acent to the active site by docking of small molecular probes suggest that it plays a crucial role by

213 -infrared pH-sensitive fluorescence lifetime molecular probe suitable for biological applications in

214 In combination with a molecular probe targeting angiogenesis, this approach ma

215 combination of optical windows with specific molecular probes targeting the tumour microenvironment w

216 A wide range of molecular probing technologies involving real-time polym

217 Here we report a new type of fluorescent molecular probe, termed a chameleon NanoCluster Beacon (

218 diabetes development, there is currently no molecular probe that allows measurement of hepatic gluco

219 The infrared RGD molecular probe that tracks integrin expression can be s

220 The development of molecular probes that allow in vivo imaging of neural si

221 echanisms of carcinogenesis and describe the molecular probes that are currently being developed.

222 Using molecular probes that bind to and neutralize specific cy

223 f this field relies on the identification of molecular probes that can effectively interrogate pathwa

224 iomedical sciences is to devise a palette of molecular probes that can enable simultaneous and quanti

225 Thus, molecular probes that can selectively target quadruplex-

226 ray scattering signatures from high-contrast molecular probes that correlate with the presence of bio

227 dy is to identify liver cancer cell-specific molecular probes that could be used for liver cancer rec

228 osis; however, its success is dependent upon molecular probes that demonstrate selective tissue targe

229 Furthermore, the use of selective molecular probes that enable histochemical differentiati

230 ation of the MAP-based scaffold by designing molecular probes that fluoresce only after enzymatic tre

231 Biosensors are molecular probes that have been developed to directly tr

232 Here we discuss some of the molecular probes that illustrate this shift from a "one

233 be low throughput or require preselection of molecular probes that limit the information obtained.

234 poly(A) and poly(dA) x poly(dT) can serve as molecular probes that report the pH and free salt concen

235 e development of highly selective and potent molecular probes that will prove useful in the elucidati

236 conjugation of proteins to amine-containing molecular probes through formation of a thiourea bridge.

237 Molecular probing throughout a simulated estrous cycle r

238 In summary, this ligand provides a novel molecular probe to assess the specific role of P2X4 in i

239 as a potent MmpL3 inhibitor, and use it as a molecular probe to demonstrate the requirement for funct

240 -type glutaminase (GLS) that has served as a molecular probe to determine the therapeutic potential o

241 toinduced charge transfer between a QD and a molecular probe to even low-affinity binding events at t

242 5-fluoropentanoic acid (AFPA), was used as a molecular probe to examine the reactivity of PLP in both

243 intravenous injection of an oxygen-sensitive molecular probe to generate phosphorescence optical sect

244 al component of catecholamine agonists) as a molecular probe to identify mechanistic differences betw

245 specific synthetic antibody and used it as a molecular probe to map functional domains within nicastr

246 This new approach allows a new type of the molecular probes to be well manipulated to monitor impor

247 terface are new targets for the discovery of molecular probes to block association of LSD1/CoREST wit

248 changes at an interface functionalized with molecular probes to detect label-free biomolecular bindi

249 Next, using specific molecular probes to discriminate the rare black morph of

250 be a promising starting point for exploring molecular probes to elucidate biological functions and t

251 e nonspecific proteins (i.e., BSA) as innate molecular probes to explore FG domain conformational cha

252 Our results highlight a set of novel molecular probes to further elucidate druggable mechanis

253 ific advances in both functional imaging and molecular probes to improve our understanding of the mol

254 hen discuss applications of state-of-the-art molecular probes to interrogate important aspects of car

255 resent an important advance toward using NIR molecular probes to measure the polarity of complex biol

256 Surprisingly, molecular probes to monitor GalNAc-transferase activity

257 ork extends the application of conotoxins as molecular probes to non-excitatory cells, such as macrop

258 hod that samples atomic hotspots with simple molecular probes to produce fragment hotspot maps.

259 Currently, there are no effective molecular probes to recognize biomarkers that are specif

260 es for the treatment of HCV infection and as molecular probes to study HCV pathogenesis.

261 These findings are useful in developing molecular probes to study negative energy balance condit

262 vide potential therapeutic lead compounds or molecular probes to study p300/HIF-1alpha interactions a

263 disorders, and as such, there is a need for molecular probes to study this receptor.

264 actions by distributing different aspects of molecular probe trajectories into distinct locations and

265 struct that is able to accommodate the small molecular probes used for the mapping, but has a too nar

266 To answer this question, six molecular probes using available DNP isomers were develo

267 The molecular probe was a biocompatible autoquenched near-in

268 A molecular probe was developed to monitor caspase activit

269 A molecular probe was prepared that selectively responds t

270 Using a novel molecular probe, we characterized the activity pattern o

271 Utilizing biotinylated-epoxomicin as a molecular probe, we demonstrate that epoxomicin covalent

272 a metal ion chelator beta-thujaplicinol as a molecular probe, we observed a second mode of metal ion

273 NMR spectroscopy of tethered carbamates as a molecular probe, we systematically investigate the degre

274 types, both in cuticle preparations and with molecular probes, we have assessed the functional signif

275 ohydrate microarrays with the specificity of molecular probes, we have developed a sensitive, high th

276 Using human autoimmune sera as molecular probes, we previously described the associatio

277 nitrite, nitric oxide, and hydroxylamine as molecular probes, we show that the active site for the o

278 this DDS, three fluorescent and fluorogenic molecular probes were designed, synthesized, characteriz

279 AP domain flexibility, 2-aminopurine labeled molecular probes were employed in steady state fluoresce

280 Molecular probes were not necessary.

281 Molecular probes were used to measure the magnitude of m

282 which increase in the presence of a Gd-based molecular probe, were significantly higher within the li

283 me the single-molecule spectroscopy of a new molecular probe which uses an intramolecular electron tr

284 Here we introduce a molecular probe, which upon proteolytic processing is re

285 he interaction and speciation of Eu(3+) as a molecular probe with the mineral as a function of time.

286 There exists by now many molecular probes with absorption and fluorescence proper

287 ification, light-emitting new materials, and molecular probes with long-lasting light emission and im

288 otube tips should be possible, thus creating molecular probes with potential applications in many are

289 We demonstrate that a molecular probe, with a pro-fluorophore substrate and li

290 CA represents a novel class of Dnmt-targeted molecular probes, with biochemical properties that allow

291 nsporter and will be useful in the design of molecular probes within this class of dopamine uptake in