ライフサイエンスコーパス: molecular switch

1 n of keratinocyte migration via a dual-state molecular switch.

2 ecule 1 to function as a mechanically driven molecular switch.

3 ction of a working prototype of a biomimetic molecular switch.

4 o convert an ordinary binding protein into a molecular switch.

5 ith 1,4-diazabicyclo[2.2.2]octane resets the molecular switch.

6 nd is thought to involve the activation of a molecular switch.

7 apping through a simple interaction model: a molecular switch.

8 The most appealing example is the molecular switch.

9 erions, a practical limitation in the use of molecular switches.

10 acceptor oligorotaxane foldamers, a class of molecular switches.

11 multiple post-translational modifications as molecular switches.

12 sterically controllable, metal-ion-triggered molecular switches.

13 uch as light or an added chemical can act as molecular switches.

14 mRNA-mRNA interactions rather than as on-off molecular switches.

15 ticles, nanoscale phase-change materials and molecular switches.

16 n principle for enhancing the performance of molecular switches.

17 be used in biosensors or assays that exploit molecular switching.

18 photochemical behavior of five photochromic molecular switches 7a-e with attached molecular wires ba

19 Biased modulation, probe dependence, and molecular switches all contribute to the complex molecul

20 Therefore, PRAS40 phosphorylation acts as a molecular switch allowing mTORC1 activation during physi

21 This molecular switch also regulates the closely related fami

22 Ras GTPases act as "molecular switches", alternating between inactive GDP-bo

23 he role of electron transfer in triggering a molecular switch and in altering water-mediated interfac

24 ptor phytochrome A acts as a light-dependent molecular switch and regulates responses initiated by ve

25 Here, the new light-driven chiral molecular switch and upconversion nanoparticles, doped i

26 Members of this family act as molecular switches and are required for coordinated cyto

27 tures diversified producing cofactor-binding molecular switches and barrel structures.

28 ults will lead to designing highly sensitive molecular switches and electrochemical sensors based on

29 ic and kinetic characterization of cis-trans molecular switches and isomer-specific interactions invo

30 Molecular switches and machines that are powered by acid

31 h for the design and creation of solid-state molecular switches and machines.

32 mic behavior of a series of novel tetrapodal molecular switches and motors containing common function

33 V/vis absorption spectroscopy shows that the molecular switches and motors retain their ability to un

34 in the design of single-atropisomer drugs or molecular switches and motors.

35 for facilitating the extraction of work from molecular switches and motors.

36 Ras-like small GTPases function as molecular switches and regulate diverse cellular events.

37 e used for sensing analytes other than pH or molecular switching and signaling.

38 application of single-molecule junctions as molecular switches, and general physical phenomena in si

39 de exchange factors, the activators of these molecular switches, and their upstream signaling partner

40 ificant extension of their lifetimes, facile molecular switching, and extremely large stabilization e

41 Two molecular switches are considered to play a role in this

42 erstanding the working of the protein kinase-molecular switch as an allosteric network of "communitie

43 MTA1's lysine 532 methylation represents a molecular switch as methylated and demethylated MTA1 nuc

44 dow carrying immobilized aptamer/quantum dot molecular switches as a part of a portable fluorescent s

45 parameters relevant for photocontrolled WLA molecular switches, as well as offer new ways of tuning

46 The doublesex (dsx) gene functions as a molecular switch at the base of the insect sex determina

47 propose that pUL135 and pUL138 constitute a molecular switch balancing states of latency and reactiv

48 A six level molecular switch based on terpyridine(Ni-salphen)2 tweez

49 proach for the construction of protein-based molecular switches based on artficially autoinhibited pr

50 ar interest as electrochemically addressable molecular switches because, in contrast with more conven

51 bers of which are Cdc42, Rac1, and RhoA, are molecular switches best known for regulating the actin c

52 Rho family GTPases are molecular switches best known for their pivotal role in

53 nd remove a single modification can act as a molecular switch between "on" and "off" and has been wid

54 nt for the transition from life to death.The molecular switch between how tumour necrosis factor (TNF

55 ription processivity and thereby serves as a molecular switch between replication and transcription,

56 , Akt3-mediated phosphorylation of Ago2 is a molecular switch between target mRNA cleavage and transl

57 al stimulus have been used to activate these molecular switches between bistable or even multiple sta

58 We propose that MARCKS acts as a "molecular switch," binding to and regulating PIP2 signal

59 that hGBP1F acts as a nucleotide-controlled molecular switch by modulating the accessibility of its

60 on of GIT1 on serine 46 by PKD3 represents a molecular switch by which GIT1 localization, paxillin tr

61 penetrance as a mechanism through which new molecular switches can gradually and adaptively evolve.

62 ates the death-domain (DD) protein PIDD as a molecular switch capable of signaling cell survival or d

63 They function as molecular switches capable of altering gene expression;

64 We propose that sFRPs can act as a molecular switch, channeling the signal input for differ

65 e metabolic state was punctuated by an early molecular switch, characterized by a transient burst in

66 ummary, the 2'OH group seems to be a primary molecular switch contributing to specific protein-RNA re

67 Ras GTPase is a molecular switch controlling a number of cellular pathwa

68 hese results suggest that miR-146a acts as a molecular switch controlling hyper-inflammation in clini

69 -mediated dephosphorylation of DAXX is a key molecular switch controlling its function upon neuronal

70 covered microRNA-21 (miR-21) as a downstream molecular switch controlling macrophage activation and i

71 t two neighboring G-quadruplexes behave as a molecular switch controlling the expression of HRAS.

72 our results implicate calpain cleavage as a molecular switch converting Src from a promoter of cell

73 nsic curvature of the FtsZ filaments and the molecular switch coupled to the high-affinity end-wise a

74 The results indicate that the properties of molecular switches depend heavily on their immediate che

75 chemistry; sensors; host-guest complexes for molecular switching devices, such as catenanes and rotax

76 alance of Pax3, Nkx3.2 and Sox9 may act as a molecular switch during the chondrogenic differentiation

77 These versatile materials consist of molecular switches embedded in liquid-crystalline polyme

78 Finally, molecular switches embedded in self-assembled monolayers

79 addressable, multistate, and multifunctional molecular switches exhibiting contrasts of both linear a

80 ional change of the MPD putatively acts as a molecular switch, facilitating a global reorientation of

81 11-cis-retinal that functions not only as a molecular switch for activating cone and rod visual pigm

82 modification of histone H3K27 acts as a key molecular switch for activation or suppression of many c

83 oto/thermoswitch has attracted interest as a molecular switch for advanced materials and molecular el

84 single divergent amino acid, highlighting a molecular switch for chloride insensitivity that is tran

85 ontributes to a tension-sensitive Sgo1-based molecular switch for chromosome segregation.

86 throcyte phagocytosis, with CD47 acting as a molecular switch for controlling erythrocyte phagocytosi

87 NTera2 cells, showing the importance of this molecular switch for differentiation state-dependent reg

88 e propose that Drd3 palmitoylation acts as a molecular switch for Drd3-biased signaling via a GIPC1-d

89 Alternatively, a molecular switch for fusion offers a route to mixing dro

90 monstrate that DNA can behave as a promising molecular switch for molecular electronics applications

91 oswitch has recently attracted interest as a molecular switch for molecular electronics.

92 cription factors and show that AHR acts as a molecular switch for monocyte fate specification in resp

93 ion gene Olig2 expression and functions as a molecular switch for oligodendrocyte and astrocyte linea

94 r, these results indicate that TOR acts as a molecular switch for the activation of cell proliferatio

95 f this agent using the salicylate as a novel molecular switch for the chemoselective construction of

96 xchange factor that serves as a prototypical molecular switch for the regulation of essential cellula

97 show that cellular ATP level might act as a molecular switch for Thr55 phosphorylation on the p21 pr

98 , we identify a single residue (A/P205) as a molecular switch for TraA recognition.

99 nd extrinsic influences by acting as a rapid molecular switch for transcription of poised RNA pol II.

100 formation of the heteromeric complex is the molecular switch for transmembrane signaling.

101 Overall, we propose that HPSE acts as a molecular switch for turning a virus-permissive 'attachm

102 LARP1 serves as a phosphorylation-sensitive molecular switch for turning off or on RP mRNA translati

103 s endogenous opsin-mediated, light-activated molecular switch for vasorelaxation might be harnessed f

104 otide exchange factors (GEFs), are conserved molecular switches for signal transductions that regulat

105 lts indicate that distinct MMPs might act as molecular switches for specific types of LTP.

106 obilize nearby amino acid residues to act as molecular switches for the formation of a continuous wat

107 he band 3-deoxyHb interaction constitutes a "molecular switch" for regulating erythrocyte biology, we

108 t PKR activation is an essential part of the molecular switch from adaptation to inflammation in resp

109 Furthermore, we describe the molecular switch from cytokine receptor to pre-BCR signa

110 hypothesis whereby IL-13Ralpha2 serves as a molecular switch from invasion to proliferation, and sug

111 y poised as therapeutic targets due to their molecular switch function in turning gene expression on

112 he free energy of nucleotide hydrolysis into molecular switching (G-proteins) or force generation (ki

113 Molecular switches gate many fundamental processes in na

114 ese opposing signaling cascades serve as the molecular switch gauging Ag dose.

115 transcriptional network, where it acts as a molecular switch governing the balance between TSC proli

116 Molecular switches have great potential to convert diffe

117 ctivity relationships, species differences, "molecular switches"), have been identified.

118 We conclude that necdin functions as a molecular switch in adult hematopoiesis, acting in a p53

119 Here, we reveal a defective molecular switch in head and neck squamous cell carcinom

120 The ability of this pathway to function as a molecular switch in lens differentiation depends on the

121 Ras is a small monomeric GTPase acting as molecular switch in multiple cellular processes.

122 cure, although MYC was described as a potent molecular switch in OSM signaling.

123 mperature coaction in the circuitry drives a molecular switch in PIF activity and control of cell exp

124 ical mitochondrial death pathway to act as a molecular switch in signaling lens cell differentiation.

125 main of Pin1 (WW domain) and a key cis-trans molecular switch in the amyloid precursor protein cytopl

126 oduce Thp5, which plays a critical role as a molecular switch in the differentiation of Th cells, bia

127 ts suggest that the MED26-NTD functions as a molecular switch in the exchange of TBP-associated facto

128 ctive and inhibited receptor states reveal a molecular switch in the modulatory binding site that med

129 esults revealed that RhoA represents a major molecular switch in the regulation of HO and muscle rege

130 eudorotaxane that acts as a thermally driven molecular switch in the single-crystal state.

131 Mechanistically, TAK1 functions as a molecular switch in tumor necrosis factor receptor-1 sig

132 We identified an AP-1 molecular switch in which c-FOS and FRA1 are preferentia

133 Small GTPases act as master regulators and molecular switches in a GTP-dependent manner, initiating

134 Galpha subunits are central molecular switches in cells.

135 s have great potential to be incorporated as molecular switches in highly demanding and multivalent p

136 tertiary structure, might serve as rotameric molecular switches in other biological processes as well

137 Here we review the roles of these molecular switches in regulating immune cell homeostasis

138 essing the mechanically purposeful motion of molecular switches in supramolecular tubules.

139 , and we confirm that Phe-126 is indeed the "molecular switch" in endotoxic signaling.

140 , which is subject to regulation by multiple molecular switches, including mTOR and hypoxia-inducible

141 s highly selective and controlled by a novel molecular switch induced by EBI3 or IL-6R, respectively.

142 a judiciously chosen thermoresponsive chiral molecular switch into an achiral liquid crystalline medi

143 Previous attempts to incorporate molecular switches into thermally stable photoisomers we

144 ily of small GTPases are membrane-associated molecular switches involved in the control of a wide ran

145 dynamics simulations, which revealed a novel molecular switch involving the strictly conserved residu

146 ts, we propose a mode of action for possible molecular switches involving the HCV RNA.

147 L1 ligase (L1L) molecular switch is an in vitro optimized synthetic allo

148 Thus, a unique molecular switch is generated that regulates both AR and

149 Thiol-aromatic molecular switch is responsible for NO-related modificat

150 erstanding of the translational movements in molecular switches is essential for designing machine-li

151 The isomerization behavior of photochromic molecular switches is strongly influenced by adsorption

152 Substantial chiral-achiral molecular switching is observed in di(haloacetyl) bispid

153 /far-red-dependent fashion and regulates, as molecular switch, many aspects of light-dependent develo

154 mong IE1 proteins further suggests that this molecular switch may be a common mechanism by which the

155 ta cell physiology, and manipulation of this molecular switch may serve as a therapy in T2DM.

156 the phosphorylation of CY, and, acting as a molecular switch, may both serve as a negative feedback

157 We report a molecular switch mechanism controlling polarity orientat

158 lex and i-motif, providing a rationale for a molecular switch mechanism driven by SP1-induced negativ

159 However, the molecular switch mechanism from autoinhibited to the act

160 We propose a molecular switch mechanism involving multistate conforma

161 l and functional studies elucidate a dynamic molecular switch mechanism that governs the repression a

162 This molecular switching mechanism can couple AP2's membrane

163 esults implicate vinculin translocation in a molecular switching mechanism that senses substrate visc

164 phatase domains, leading to a change in SHP2 molecular switching mechanism.

165 imotor gliding assays and sheds light on the molecular switching mechanism.

166 hree supramolecular chemistry related areas: molecular switches, metallo-assemblies and sensors.

167 Rab GTPases are molecular switches mobilizing intracellular vesicles, an

168 tion of T406 can be regarded as an important molecular switch modulating TRPV1-related behavior and p

169 eraction site for inhibitors, is a sensitive molecular switch, modulating receptor activity.

170 We propose that a unique molecular switch occurs during lamprey metamorphosis res

171 ding membrane-proximal domain, which acts as molecular switch of ADAM17 activity operated by a protei

172 glucosylceramide equilibrium as a downstream molecular switch of BCR signaling, also providing novel

173 phogenic9 (COP9) signalosome (CSN) acts as a molecular switch of CRLs activity by reverting their ned

174 tudies of microRNAs (miRNAs), which act as a molecular switch of gene expression, have shown promise

175 Troponin I (TnI) is the molecular switch of the sarcomere.

176 Cardiac troponin I (cTnI) functions as the molecular switch of the thin filament.

177 Su(H) operates as molecular switch on Notch target genes: within activator

178 Over the past decade, molecular switches on surfaces have been intensely inves

179 Tyr-80(2.61) and Trp-99(3.28) act either as molecular switches or as gatekeeper residues that introd

180 on different classes of light-driven chiral molecular switches or motors in liquid crystal media for

181 Light-driven chiral molecular switches or motors in liquid crystals that are

182 gs") was coupled to maleimide-functionalized molecular switches or motors under ambient conditions.

183 crystals enabled by photoisomerizable chiral molecular switches or motors.

184 nanosciences, chemosensing, liquid crystals, molecular switches, polymers, foldamers, supramolecular

185 wo novel light-driven dithienylethene chiral molecular switches possessing remarkable changes in heli

186 ZFP36L2 therefore functions as part of a molecular switch promoting BFU-E self-renewal and a subs

187 m and the strategies to exploit photochromic molecular switches' properties for sensing application.

188 Hence insulin signaling to the molecular switch Rab8A connects with the motor protein M

189 ctivated RhoA/ROCK signalling functions as a molecular switch regarding the fate of MSCs in arterial

190 We propose that minor introns are embedded molecular switches regulated by U6atac abundance, provid

191 Rab-GTPases are important molecular switches regulating intracellular vesicle traf

192 Thus, DNMT3A functions as a molecular switch, repressing neural to favor neural cres

193 Proteins that function like molecular switches respond to fluctuations in the enviro

194 ious work on the o-hydroxychalcone/flavanone molecular switching scaffold showed that simple substitu

195 nd 7 (mGlu1-5,7) highlighting key concepts ("molecular switches", signal bias, heterodimers) and prac

196 potential in various applications including molecular switch, spin memory device, molecular battery,

197 has been much activity of late in the use of molecular switches such as photochromes in the construct

198 These results provide the first details of a molecular switch that allows parasites take advantage of

199 of CORVET/HOPS, we find that VPS11 acts as a molecular switch that binds either CORVET-specific TGFBR

200 esidues, Leu-222 and Asn-251, form a two-way molecular switch that controls channel modulation by cho

201 t time we propose that the i-motif acts as a molecular switch that controls gene expression and that

202 Thus, PAI-1 is a molecular switch that controls the cardiac TGF-beta axis

203 tein (CREB) is an essential component of the molecular switch that controls the conversion of short-t

204 Thus, As(III) binding to Yap8 acts as a molecular switch that converts inactive Yap8 into an act

205 Thus, ATP hydrolysis is a molecular switch that converts MRE11 from an endonucleas

206 ether, our findings identify DNA-PKcs as the molecular switch that coordinates end-processing and end

207 olytic enzyme hexokinase II (HKII) acts as a molecular switch that determines cellular fate by regula

208 However, the enzymatic component of the molecular switch that determines lineage specification o

209 The aim of this study was to identify the molecular switch that determines whether the AhR acts as

210 R of Med13 plays a key role in controlling a molecular switch that dictates cell fate following expos

211 ese results indicate that Ser776 acts as the molecular switch that discriminates between normal and a

212 n E. coli GlnK is to effect a 2-OG-dependent molecular switch that drives a conformational change in

213 rated by isomerization of a light-responsive molecular switch that drives the twisting of strips of l

214 that PINK1-Parkin constitutes a damage-gated molecular switch that governs cellular-context-specific

215 Our data implicate AC DNA methylation as the molecular switch that imprints their regulatory properti

216 An auto-inhibitory segment of Apc1 acts as a molecular switch that in apo unphosphorylated APC/C inte

217 d in the epithelial cell layer and acts as a molecular switch that initiates epithelial stratificatio

218 The small GTPase RhoA is an intracellular molecular switch that integrates cytokine, chemokine, an

219 of JAM-A may thus act as a barrier-inducing molecular switch that is activated when cells become con

220 alcium binding affinities to create a robust molecular switch that is responsive to calcium concentra

221 TAT1 transcriptional activity) as a critical molecular switch that is secreted by intracellular paras

222 heroidene/spheroidenone transition acts as a molecular switch that is suggested to twist spheroidenon

223 echanism of melanoma formation: miR-211 is a molecular switch that is turned off in melanoma cells, r

224 Thus, in this case, IL-13 acts as a molecular switch that leads to resolution of inflammatio

225 activities of Aurora B and CENP-I generate a molecular switch that maintains a robust spindle checkpo

226 s displacement of RIAM by vinculin acts as a molecular switch that mediates the transition of integri

227 -activated cancer and identify mortalin as a molecular switch that mediates the tumor-suppressive ver

228 or the recruitment of CAK and as a potential molecular switch that might control TFIIH composition an

229 C3 botulinum toxin substrate (Rac), a master molecular switch that positively regulates many immune c

230 can epigenetically silence BIM expression, a molecular switch that prevents apoptosis.

231 n which the heterotypic segment is part of a molecular switch that promotes release of BicD autoinhib

232 findings suggest a new role for MCPIP1 as a molecular switch that regulates fibroblast migration in

233 r282 phosphorylation may serve as a critical molecular switch that regulates the phosphorylation of n

234 ation-mediated control of mRNA turnover is a molecular switch that regulates the stress response tran

235 ncRNA by environmental signals operates as a molecular switch that regulates the structure and functi

236 The troponin complex is a molecular switch that ties shifting intracellular calciu

237 nd provide evidence that the coreceptor is a molecular switch that undergoes ligand-induced conformat

238 he Glu(3) --> Ala substitution resulted in a molecular switch that was transmitted to adjacent residu

239 GTP-binding proteins are membrane-associated molecular switches that are commonly activated by ligand

240 nd StkP protein kinase have been proposed as molecular switches that balance septal and peripheral (s

241 extend and improve these methods to predict molecular switches that characterize conformational chan

242 We have created molecular switches that consist of nucleic-acid cleaving

243 RAS and Rho small GTPases are key molecular switches that control cell dynamics, cell grow

244 A better understanding of the molecular switches that control the apoptosis sensitivit

245 The cell cycle is composed of bistable molecular switches that govern the transitions between g

246 y an array of equilibrium and nonequilibrium molecular switches that harmonize to promote functional

247 ure coupling energies between side chains in molecular switches that mediate shear during domain moti

248 Rho GTPases are molecular switches that modulate a variety of cellular p

249 T cells in tumor-bearing mice by introducing molecular switches that regulate cell fate decisions via

250 Heterotrimeric G proteins are molecular switches that relay intracellular signaling in

251 Voltage-gated K(+) (Kv) channels are molecular switches that sense membrane potential and in

252 Rho GTPases are molecular "switches" that cycle between "on" (GTP-bound)

253 Thus, these data implicate CD39 as a key "molecular switch" that allows macrophages to self-limit

254 d form a Schiff base with MR1, triggering a 'molecular switch' that allows MR1-VitB antigen complexes

255 ection of tetracycline based on triple-helix molecular switch (THMS) and gold nanoparticles (AuNPs).

256 dependent change, this region could act as a molecular switch to activate HIV-1 Gag for VLP assembly.

257 , indicate that the Rab1b increase acts as a molecular switch to control the expression of these gene

258 show that Ser-322 phosphorylation acts as a molecular switch to control the subcellular distribution

259 omeostasis, YAP/TAZ function as the critical molecular switch to coordinate growth and patterning in

260 direct target of the insulin receptor, as a molecular switch to coordinate this process.

261 PINK1-Parkin operates as a molecular switch to dictate cell fate decisions in respo

262 , suggests that this sequence functions as a molecular switch to facilitate stress adaptation.

263 is suggested in which this is employed as a molecular switch to fine tune the relative expression of

264 ation of the activation loop in MLKL trips a molecular switch to induce necroptotic cell death.

265 ly small GTP-binding protein that works as a molecular switch to regulate cytoskeleton remodeling and

266 actor-like 4C (Arl4C) small GTPase acts as a molecular switch to regulate morphological changes and c

267 e region, and that this event functions as a molecular switch to regulate subsequent glycosaminoglyca

268 phosphorylation of S421 of JIP1 serves as a molecular switch to regulate the direction of APP transp

269 Thus, MglA acts as a nucleotide-dependent molecular switch to regulate the motility machinery spat

270 phonium targeting group and a boronate-based molecular switch to selectively respond to H(2)O(2) over

271 poles, suggesting phosphorylation acts as a molecular switch to specifically activate cortical Mud f

272 of kinases and phosphatases that act as key molecular switches to fine tune cellular events.

273 ectronics applications from designing robust molecular switches to nanoelectronic DNA sequencing.

274 Rab GTPases serve as molecular switches to regulate eukaryotic membrane traff

275 s mechanism allows the photoisomerization of molecular switches to stimulate rapid shape changes at t

276 The aptamer complexes were designed as molecular switches to undergo conformational change and

277 herapy, the use of light as a photochemical "molecular switch" to promote differentiation should expa

278 Rational molecular designs of chiral molecular switches toward endowing handedness inversion

279 ntire hormone receptor system is driven by a molecular switch triggered by the binding of small lipop

280 We begin by presenting the molecular switches triggered by various external stimuli

281 is review is to highlight recent advances in molecular switches triggered by various external stimuli

282 onolayers of switchable MIMs employed in the molecular switch tunnel junctions (MSTJs) associated wit

283 nt on HD1, we propose that GDAP1 undergoes a molecular switch, turning from a pro-fission active to a

284 This unique molecular switch undergoes structural isomerisation in r

285 of the full cycle of motion in this class of molecular switch using cyclic voltammetry.

286 We propose a model by which, via this molecular switch, W-acidic cargo binding regulates the a

287 The function of Ras as molecular switch was demonstrated by a beryllium trifluo

288 ata indicate that UL135 and UL138 comprise a molecular switch whereby UL135 is required to overcome U

289 Ser-379 phosphorylation is a molecular switch which initiates p47(phox) conformationa

290 all-important distinction between artificial molecular switches which are now ten a penny-or a dime a

291 Similarly, molecular switches which respond to reactivation are imp

292 erformances allow the execution of an 8-step molecular switch, which renders this molecular system th

293 proceed through the programmed operation of molecular switches, which trigger both local and global

294 These findings identify SIKs as a key molecular switch whose inhibition reprograms macrophages

295 ins, comprising Ga, Gb, and Gg subunits, are molecular switches whose function tightly depends on Ga

296 tal (CLC) containing a photosensitive chiral molecular switch with high helical twisting power.

297 Two enantiomeric light-driven azo molecular switches with axial chirality and extended con

298 perties of the AAPs could be tuned to obtain molecular switches with favorable photostationary states

299 These small GTPases function as molecular switches within cells, impacting nearly all ce

300 t-specific small G proteins that function as molecular switches within elementary signal transduction