ライフサイエンスコーパス: molecularly

1 h diverse phenotypes yet to be characterized molecularly.

2 ion of N-Myc, to generate phenotypically and molecularly accurate tumors that closely model human MYC

3 ctroscopy experiments, we found that methane molecularly adsorbed as a strongly bound sigma complex o

4 l activity promotes the growth of a range of molecularly and clinically distinct HGG types, including

5 Prostate cancer is a highly heritable molecularly and clinically heterogeneous disease.

6 indings lend order to chaos by revealing how molecularly and functionally defined cellular subsets ar

7 mycin (mTOR) protein operates as part of two molecularly and functionally distinct complexes.

8 Early embryonic piwi-1+ cells are molecularly and functionally distinct from neoblasts: th

9 LRCs are molecularly and functionally distinct from reporter-mark

10 We thus conclude that hair cells express two molecularly and functionally distinct mechanotransductio

11 Although they are often molecularly and functionally symmetric, recent work has

12 s closely resemble primary neural stem cells molecularly and functionally.

13 ignaling through GP130 and pSTAT3Y705 and is molecularly and mechanistically distinct from the suppre

14 ngly beta-hemolytic spirochete that has been molecularly and phenotypically characterized and provisi

15 Four representative but molecularly and phenotypically diverse strains were used

16 e memory formation following PTC through two molecularly and temporally distinct signaling mechanisms

17 ughput drug screening in approximately 1,000 molecularly annotated cancer cell lines.

18 nd gene expression) can be mapped onto 1,001 molecularly annotated human cancer cell lines and correl

19 Understanding the interaction of molecularly assembled nanoparticles with physiological f

20 bute different GJ-forming proteins, creating molecularly asymmetric channels that are correlated with

21 treatment to distinguish the two strands of molecularly barcoded DNA; its specificity arises from th

22 There is a need for a more refined, molecularly based classification model for glioblastoma

23 in gliomas and provide suggestions for a new molecularly based classification.

24 Standard molecularly based strategies to predict and/or prevent o

25 rotonation barriers of 0.36 eV and find that molecularly bound water is preferred over the surface-bo

26 Collectively, we decrypt molecularly, cell biologically, and genetically the impo

27 ion cyclotron resonance mass spectrometry to molecularly characterize the iron-coagulating fractions

28 ex determination systems and pave the way to molecularly characterize these systems.

29 Here we molecularly characterize this therapy-resistant high-mes

30 with a poor response to chemotherapy and are molecularly characterized by RAS pathway activation.

31 We evaluate the performance of our method on molecularly characterized collections of cell lines prof

32 itative RT-PCR, and immunohistochemistry, we molecularly characterized DNs and analyzed the differenc

33 SC-derived neuronal and glial cells and have molecularly characterized subpopulations of these cells

34 All CPNFs were molecularly characterized to identify beta-lactamase gen

35 While some non-apoptotic programs have been molecularly characterized, none appear to control develo

36 es we found 26 cases, only 54% of which were molecularly characterized, the remainder being syndromic

37 V), a putative herpesvirus that has not been molecularly characterized.

38 ile greatly used, very few of them have been molecularly characterized.

39 ferentiation genes, our atlas identifies and molecularly characterizes 605 bilateral pairs of neurons

40 onse to RAFi, highlighting the importance of molecularly classifying PLGG patients for targeted thera

41 splicing along isoforms, including 683 intra-molecularly co-associated intron pairs.

42 With a broader view, we envision that a molecularly complete membrane-scaffold could be useful f

43 A total of 199 patients and 326 eyes with molecularly confirmed (ABCA4) STGD1 underwent testing wi

44 a multinational cohort of 834 patients with molecularly confirmed autosomal recessive cerebellar ata

45 Provision of a molecularly confirmed diagnosis in a timely manner for c

46 if any, of the total newly proliferated and molecularly confirmed scar-forming astrocytes.

47 hundred fifty-nine patients (489 eyes) with molecularly confirmed STGD1 enrolled at 9 centers in the

48 Compared to the case of diluted or molecularly crowded buffer solutions, the G-quadruplex i

49 spontaneous assembly of chemically encoded, molecularly crowded, water-rich micro-droplets into peri

50 We sought to characterize molecularly cutaneous inflammation and its correlation w

51 The capacity to simultaneously map and molecularly define the components of this complex multis

52 the past decade, for both reactions, several molecularly defined and nanostructured catalysts have be

53 -cell lymphoma with BL gene signature (adult-molecularly defined BL [mBL]) revealed the MYC-ARF-p53 a

54 r and clinical datasets enables discovery of molecularly defined categories of highly similar patient

55 To study molecularly defined cell functions, biologically inspire

56 These findings reveal a molecularly defined cell type that coordinates the diver

57 thods promise to fill this gap by localizing molecularly defined cell types in tissues, with simultan

58 The activity of multiple molecularly defined cell types was found to reflect this

59 We then identify molecularly defined cell types within the OVLT and MnPO

60 that enables the efficient identification of molecularly defined cells that participate in a specific

61 evaluation of a targeted treatment within a molecularly defined cohort of patients.

62 an ASO-dependent method for treating certain molecularly defined diseases associated with alterations

63 To test whether molecularly defined features of the rostral nTS correlat

64 Altogether, our approach identifies eight molecularly defined glioma groups with distinct sequence

65 ated analysis classified PCCs/PGLs into four molecularly defined groups: a kinase signaling subtype,

66 We found 25 molecularly defined human cell types, including five sub

67 innocuous stimuli are processed by distinct molecularly defined interneuron cell types.

68 We identify specific anatomically and molecularly defined LHA elements that integrate diverse

69 the critical role of oxytocin signaling in a molecularly defined neuronal population in order to modu

70 ification can be broadly applied to identify molecularly defined neurons comprising complex, multisyn

71 Generation of molecularly defined null mutants revealed that loss of 8

72 With the molecularly defined parvafox nucleus as a centerpiece, t

73 nd such unprecedented sensitivity to broader molecularly defined patient populations.

74 ohort Study) is a large, ongoing registry of molecularly defined patients with heterozygous FH treate

75 rincipal cell excitability and declines in a molecularly defined population of interneurons that regu

76 ide, long-term prospective cohort study of a molecularly defined population with FH with or without p

77 By fiberoptic recordings from molecularly defined populations of LH neurons in awake f

78 HDAC1/HDAC2 and MYC may present a novel and molecularly defined strategy to target mutant p53 in pan

79 era of targeted agents for the treatment of molecularly defined subtypes of AML.

80 Genetic access to molecularly defined subtypes of inhibitory neurons has a

81 reliable, and effective, and can be used on molecularly defined subtypes to determine connectivity i

82 erum profile of autoantibodies reactive with molecularly defined synaptic plasma membrane proteins of

83 1) was the first tumor suppressor gene to be molecularly defined.

84 Their repetitive molecularly-defined architecture is attractive for engin

85 Despite the ability to regenerate specific, molecularly-defined neuronal subtypes, we also uncovered

86 Exploratory analyses in 318 molecularly-defined patients confirmed the significantly

87 the caudal nTS shows clear morphological and molecularly delimited subdivisions, the rostral part doe

88 ate the power of transcriptome sequencing to molecularly diagnose 10% (5 of 48) of mitochondriopathy

89 years of age); 2,752 of those enrolled were molecularly diagnosed FH cases.

90 sed infants (n = 81), genetic disorders were molecularly diagnosed in 39 (48.1%) by exome sequencing,

91 The phenotypic similarity between molecularly diagnosed pairs of diseases was calculated w

92 cally in enabling quantitative drug loading, molecularly discrete delivery devices, and a priori know

93 We molecularly dissected leptomeningeal metastasis, or spre

94 as solid-state Merrifield-type approaches or molecularly dissolved solution-phase systems.

95 her, our study identifies a functionally and molecularly distinct acinar subpopulation and thus trans

96 s in the pretectum of Xenopus revealed three molecularly distinct anteroposterior subdivisions, ident

97 energy balance, fertility and growth through molecularly distinct cell types, many of which remain un

98 Cells contain numerous, molecularly distinct cellular compartments that are not

99 of histologically similar but clinically and molecularly distinct entities that have been grouped und

100 ing demonstrated that Krt15+ basal cells are molecularly distinct from Krt15- basal cells.

101 cells are morphologically, functionally, and molecularly distinct from those found in veins and lymph

102 les revealed gastric-type IPMN to comprise 2 molecularly distinct layers: a basal crypt segment that

103 rt here that auditory hair cells contain two molecularly distinct mechanotransduction channels.

104 in leiomyomas, suggesting the involvement of molecularly distinct pathways.

105 ed transcriptional network produces multiple molecularly distinct progenitor domains, each generating

106 he EP and reveal the existence of cascading, molecularly distinct projections through striatum and gl

107 harmacological autophagy inhibition overcame molecularly distinct resistance mechanisms, inhibited tu

108 ion and clustering algorithms, we identified molecularly distinct subpopulations of cells during repr

109 We found that PL contains anatomically and molecularly distinct subpopulations that target three do

110 Here, we show induction of a molecularly distinct subset of activated lung ILC2, term

111 Assuming two molecularly distinct subtypes, we have examined 27 commo

112 nanoparticle delivery to a diverse array of molecularly distinct target cells.

113 Several molecularly distinct types of LH neurons have been ident

114 s of 80 uveal melanomas (UM) identifies four molecularly distinct, clinically relevant subtypes: two

115 These results thus identify a molecularly distinct, orexin-activated LH submodule that

116 5 reveals that endocrine-committed cells are molecularly distinct, whereas multipotent and bipotent p

117 rent regions of the colon are clinically and molecularly distinct.

118 rent regions of the colon are clinically and molecularly distinct.

119 he outstanding controversies and suggest how molecularly divergent NPCs in different species can perf

120 sential node for social behaviors, comprises molecularly diverse neurons with widespread projections.

121 Pancreatic cancer is molecularly diverse, with few effective therapies.

122 Molecularly, E-cadherin localizes and tunes EGFR activit

123 Critically, using a molecularly encoded calcium sensor, we found that the ca

124 of a strategy that uses region-specific and molecularly engineered astrocytes to turn an unfavorable

125 We report a molecularly engineered reporter fragment complementation

126 ansferred large numbers of T cells that were molecularly engineered with anti-simian immunodeficiency

127 Molecularly, excess RA signaling negatively regulates fi

128 class of amphiphilic dendrimers has not been molecularly explored using molecular simulation methods.

129 nce, most biogeochemical studies that aim at molecularly fingerprinting the source of natural DOM cou

130 mor heterogeneity may reduce the efficacy of molecularly guided systemic therapy for cancers that hav

131 to identify actionable targets for informing molecularly guided therapies, especially for patients fo

132 oncogene; therefore, TNBC lacks targets for molecularly-guided therapies.

133 l molecules tend to aggregate into racemate (molecularly heterochiral) crystals much more frequently

134 The tumors were molecularly heterogeneous by gene expression analysis us

135 Triple-negative breast cancer (TNBC) is a molecularly heterogeneous cancer that is difficult to tr

136 to targeted therapy; however, melanoma is a molecularly heterogeneous cancer, and which mutations ar

137 he need to advance gene fusion detection for molecularly heterogeneous cancers.

138 monary arterial hypertension form a rare but molecularly heterogeneous disease group.

139 Follicular lymphoma (FL) is a clinically and molecularly heterogeneous disease.

140 eogenesis imperfecta is a phenotypically and molecularly heterogeneous group of inherited connective

141 iple-negative breast cancer (TNBC) and other molecularly heterogeneous malignancies present a signifi

142 WDSM represents a rare clinically and molecularly heterogeneous variant of SM that requires un

143 Follicular lymphoma (FL) is a clinically and molecularly highly heterogeneous disease, yet prognostic

144 Follicular lymphoma (FL) is a clinically and molecularly highly heterogeneous disease.

145 tals much more frequently than conglomerate (molecularly homochiral) crystals.

146 Although V0v interneurons are molecularly homogenous, their activity pattern during lo

147 Molecularly, iHPs transcriptionally resemble native Kit(

148 Binding study of molecularly imprinted and non-imprinted polymer (MIP and

149 on the colloidal crystal allows formation of molecularly imprinted cavities exclusively on the intern

150 A molecularly imprinted electrochemical sensor for neuron

151 ys to produce active sites for anchoring the molecularly imprinted film.

152 This paper describes the synthesis of novel molecularly imprinted hydrogels (MIHs) for the natural a

153 phosphoserine and phosphotyrosine to prepare molecularly imprinted monoliths with surface layers sele

154 Several fluorescent molecularly imprinted nanogels for the detection of the

155 Molecularly imprinted nanoparticles (MINPs) were prepare

156 Highly selective molecularly imprinted poly[acrylamide-co-(ethylene glyco

157 d biological testing of a new type of linear molecularly imprinted polymer (LMIP) designed to act as

158 e main objective of this study is to develop molecularly imprinted polymer (MIP) based micromechanica

159 ing removal of PSA, it was proposed that the molecularly imprinted polymer (MIP) cavity would act syn

160 ltaneous structural control of the deposited molecularly imprinted polymer (MIP) film on three length

161 nsistor (EG-FET) transducers integrated with molecularly imprinted polymer (MIP) film recognition uni

162 The molecularly imprinted polymer (MIP) film showed an appre

163 A molecularly imprinted polymer (MIP) for sulfamethizole (

164 ew approach on the use of stimuli-responsive molecularly imprinted polymer (MIP) for trace level sens

165 sensing film of the biosensor consisted of a molecularly imprinted polymer (MIP) layer for 8-OHdG ass

166 nvenient behavior was exploited to prepare a molecularly imprinted polymer (MIP) layer on the surface

167 Binding of template molecule with molecularly imprinted polymer (MIP) layer results in the

168 n-doped ZnS quantum dots (QDs) coated with a molecularly imprinted polymer (MIP) material selective t

169 Molecularly imprinted polymer (MIP) nanoparticles includ

170 We applied fluorescently-labeled molecularly imprinted polymer (MIP) particles for bioima

171 Electrosynthesis of molecularly imprinted polymer (MIP) templated with myogl

172 n template, and then its extracting from the molecularly imprinted polymer (MIP) was confirmed by the

173 A new molecularly imprinted polymer (MIP)-based fluorescent ar

174 Herein, a hybrid material based on molecularly imprinted polymer (MIP)-decorated magnetite

175 A novel magnetic molecularly imprinted polymer (MMIP) for the preconcentr

176 new analytical method that combines magnetic molecularly imprinted polymer (MMIP)-based sample prepar

177 A nano-molecularly imprinted polymer (N-MIP) assembled on a scr

178 uel cell anode catalysts are modified with a molecularly imprinted polymer (plastic antibody) capable

179 led carbon nanotubes (MWCNT) and then with a molecularly imprinted polymer film (MIP), viz., myoglobi

180 Molecularly imprinted polymer microspheres were synthesi

181 metric sensor for cocaine detection based on molecularly imprinted polymer nanoparticles (nanoMIPs) p

182 Here we show that molecularly imprinted polymer nanoparticles, prepared in

183 Fluorescent sensory MIP (molecularly imprinted polymer) particles were combined w

184 tion of magnetic nanoparticles modified with molecularly imprinted polymers (Mag-MIP) through core-sh

185 We synthesized novel molecularly imprinted polymers (MIP) as biomimetic speci

186 Molecularly imprinted polymers (MIPs) are biomimetics wh

187 Molecularly imprinted polymers (MIPs) are synthetic mate

188 Molecularly imprinted polymers (MIPs) are tailor made re

189 A series of molecularly imprinted polymers (MIPs) comprising reactio

190 ork describes a sensing element comprised of molecularly imprinted polymers (MIPs) for the specific r

191 Molecularly imprinted polymers (MIPs) have been successf

192 ip biosensors are based on the conduction of molecularly imprinted polymers (MIPs) that employ label-

193 eration and use of "smart materials", namely molecularly imprinted polymers (MIPs) to facilitate the

194 The aim of this study was to prepare molecularly imprinted polymers (MIPs) with ampicillin (A

195 We combine a molecularly imprinted polymers (MIPs) with surface enhan

196 ts (QDs) with polymer shells, in particular, molecularly imprinted polymers (MIPs), by using the visi

197 amples by combining the superior features of molecularly imprinted polymers and cryogels.

198 report here for the first time on the use of Molecularly Imprinted Polymers as modifiers in bulk opto

199 Researches on protein molecularly imprinted polymers have been challenged by t

200 Herein, molecularly imprinted polymers were grown on Fe3O4 nanoz

201 th fluorescence detection, after clean up on molecularly imprinted polymers, is herein described.

202 nanoparticles, graphene@carbon nanotubes and molecularly imprinted polymers.

203 Molecularly imprinted porous polymer microspheres select

204 A dual-emission mesoporous structured molecularly imprinted sensor was designed for specific r

205 After removing NSE templates, a molecularly imprinted sensor was successfully fabricated

206 Molecularly imprinted silica layers appended to quantum

207 nique was applied for the synthesis of dummy molecularly imprinted silica nanoparticles (DMISNPs).

208 Herein we describe the preparation of molecularly imprinted silica nanoparticles by Ostwald ri

209 A molecularly imprinted solid phase extraction (MISPE) met

210 The validated method of molecularly imprinted solid-phase extraction (MISPE) car

211 atform is presented which provides automated molecularly imprinted solid-phase extraction (MISPE) fol

212 The variables affecting the molecularly imprinted solid-phase extraction (MISPE) pro

213 In this work, a novel hybrid molecularly-imprinted polymer with magnetic properties i

214 e the profuse amount of recent literature on molecularly-imprinted polymers (MIPs) and some limited c

215 Subsequently, molecularly-imprinted polymers and Peptide nucleic acid

216 Recently, the nanostructured modified molecularly imprinting polymer has created a great atten

217 s analysis demonstrated a high proportion of molecularly inactive pAMR1(I+), and there was significan

218 ogramming result in stem cell lines that are molecularly indistinguishable, full differentiation comp

219 Molecularly, inhibition of CK2 leads to reduced STAT3 ph

220 The AuNPs that were molecularly interfaced with the electrode exhibited near

221 The opportunities afforded to delve molecularly into scarce material and to model human embr

222 Molecularly, ITSN1 associates with the VLDLR and its dow

223 We further reveal the existence of molecularly layered structures of the confined electroly

224 deletion of mouse uterine Trp53 (p53(d/d)), molecularly linked to mTORC1 activation and causally lin

225 ure, although it is unclear whether they are molecularly linked.

226 o phases of STAT1 activation, which we argue molecularly links the biological changes that occur foll

227 ial adaptive value of leaf shape, and how to molecularly manipulate it, will prove to be invaluable i

228 ogical perturbations of the cytoskeleton and molecularly modulated integrin catch-slip bonds biased t

229 Molecularly, mSH3BGRL specifically bound the inactive fo

230 pluripotency states have been characterized molecularly, our understanding of events regulating stat

231 matode, they have not yet been characterized molecularly outside vertebrates.

232 research has explored genomic techniques to molecularly phenotype patients with interstitial lung di

233 Molecularly, Pml(-/-) animals fail to properly activate

234 To molecularly profile mesolimbic dopamine neurons and thei

235 human V2a interneurons limits the ability to molecularly profile these cells and examine their therap

236 sequently, few pretreatment tumors have been molecularly profiled, and there are no validated prognos

237 actions in a model size growth reaction from molecularly pure Au25 to Au44 nanoparticles.

238 s molecules or materials, we anticipate that molecularly regulated reversible DNA polymerization hold

239 sects, involves the combined activity of two molecularly related but neuronally distinct hygrosensing

240 nclude that tPTP openings (MitoWinks) may be molecularly related to pathological mPTP, but are likely

241 homogenate was used to generate a viable and molecularly relevant control matrix for spiked drug stan

242 Molecularly, ROCK inhibition induced glycogen synthase k

243 d cetuximab plus irinotecan in patients with molecularly selected (G13D mutation) chemotherapy-refrac

244 erentiated, invasive prostate cancer that is molecularly similar to human NEPC.

245 t also aimed to assess if this epithelium is molecularly similar to sporadic Barrett esophagus, there

246 Molecularly sized pores significantly enhance the associ

247 of next generation sequencing to recruit for molecularly stratified clinical trials is discussed in t

248 patients with advanced colorectal cancer in molecularly stratified cohorts.

249 tal CR+ interneurons comprise at least three molecularly, structurally, and topographically distinct

250 This effect on cell adhesion was molecularly supported by the regulation of the focal adh

251 lso identified a signature that revealed the molecularly supported link between the MexT regulon and

252 o represent phenotypically and genotypically/molecularly susceptible or resistant strains.

253 r of viruses transmitted using SIVmac239X, a molecularly tagged viral stock containing 10 genotypic v

254 al profiles, making an important step toward molecularly tailored therapy.

255 Molecularly targeted agents (MTAs) have different toxici

256 For molecularly targeted agents, occasional exceptional resp

257 e of cancer stem cell (SC) subpopulations to molecularly targeted cancer therapies.

258 Finally, combining molecularly targeted drugs and novel photosensitizers ha

259 ill lacking to predict which combinations of molecularly targeted drugs may be most efficacious.

260 ious treatments, may nevertheless respond to molecularly targeted drugs.

261 group trial to evaluate this strategy using molecularly targeted oral combination therapy for the tr

262 Therefore, we sought to determine whether molecularly targeted PET, combined with diffusion-weight

263 al imaging technologies such as low-dose CT, molecularly targeted PET, MRI, and the functional-anatom

264 Imaging with PET and MRI using molecularly targeted probes is a promising precision med

265 Molecularly targeted therapeutic and imaging strategies

266 the identification of the NF1 and NF2 genes, molecularly targeted therapies are beginning to emerge,

267 ial to understanding the clinical utility of molecularly targeted therapies in oncology.

268 a has been shown to modulate the response to molecularly targeted therapies through proliferative and

269 py, for example (i) enabling combinations of molecularly targeted therapies with immunotherapies that

270 ypes, coupled with an expanding portfolio of molecularly targeted therapies, demands flexible and com

271 of response to cancer immunotherapy, unlike molecularly targeted therapies, have remained elusive, a

272 er a poor prognosis due in part to a lack of molecularly targeted therapies, which represents a criti

273 will guide the development and use of novel molecularly targeted therapies.

274 inical Development and Use of Biomarkers for Molecularly Targeted Therapies.

275 ropriate clinical use of biomarker tests for molecularly targeted therapies.This article presents an

276 Molecularly targeted therapy and immunotherapy have dram

277 r 2016, in the approval of the first precise molecularly targeted therapy for SMA (nusinersen), and a

278 clide therapy, biotherapy, chemotherapy, and molecularly targeted therapy, and the potential role of

279 xpressing tumor cells as well as for evading molecularly targeted therapy.

280 developing child, and highlight the need for molecularly targeted treatments with reduced toxicity.

281 omparison between (a) three-dimensional (3D) molecularly targeted ultrasonography (US) by using clini

282 Conclusion Three-dimensional molecularly targeted US and destruction-replenishment 3D

283 Three-dimensional molecularly targeted US signal correlated well with VEGF

284 Results Molecularly targeted US signal with VEGFR2-targeted micr

285 ducer by using the following techniques: (a) molecularly targeted US with VEGFR2-targeted microbubble

286 e proven to be refractory to most cytotoxic, molecularly targeted, or immunotherapeutic approaches.

287 Different regimens of chemotherapy and molecularly-targeted therapies, as adjuvants to surgery,

288 Interestingly, the molecularly tethered NPs also had significantly more ele

289 Molecularly, the failure to suppress gene expression cor

290 Molecularly, the role of XIAP mutations in the pathogene

291 Functionally and molecularly, these p53 mutants resemble the naturally oc

292 Molecularly, this phenotype is mediated by Nol3(-/-)-ind

293 we do not know where and how-physically and molecularly-this load distributes across the spindle.

294 o optically direct the synthetic creation of molecularly tunable fluorescent quantum defects in semic

295 of 727 additional unrelated individuals with molecularly uncharacterized RP were completely screened

296 ing in additional SBDS-negative SDS cases or molecularly undiagnosed IBMFS cases, we identified 3 ind

297 tinct genomic differences establish SBA as a molecularly unique intestinal cancer.

298 somal-dominant Robinow syndrome cases remain molecularly unsolved.

299 In this study, we took advantage of a molecularly validated mouse model of pSS to characterize

300 M transformations via elemental analysis and molecularly via ultrahigh-resolution mass spectrometry.