ライフサイエンスコーパス: molecule

1 only micro- or nanogram amounts of the guest molecule.

2 nanosensor has high sensitivity for the CPX molecule.

3 affinity improvement compared to the parent molecule.

4 acy and also reverse-engineer the smell of a molecule.

5 the majority contain only zero or one target molecule.

6 class II alleles encoding for the HLA DQ2.5 molecule.

7 ) and activation of its downstream signaling molecules.

8 d through the configuration of the plasmonic molecules.

9 mplified by secondary and tertiary messenger molecules.

10 ion, and pairing between double-stranded DNA molecules.

11 ing to cytoplasmic signaling and scaffolding molecules.

12 to establish the key stereocentres of these molecules.

13 is the base chemistry of the associated RNA molecules.

14 presented on the cell surface by MHC class I molecules.

15 teractions, are difficult to target by small molecules.

16 ctions susceptible to perturbations by other molecules.

17 upregulation of inhibitory immune checkpoint molecules.

18 lation of dienes with electron-rich aromatic molecules.

19 l-GEF Trio, and other adaptors and signaling molecules.

20 nding interaction with the first-shell water molecules.

21 irst time as late-stage gametocyte-targeting molecules.

22 relevant to the biological function of these molecules.

23 ng and the sequence-mandated topology of the molecules.

24 rom both alpha and gamma phosphates of donor molecules.

25 erfacial cavities on mass transport of guest molecules.

26 d detection limit for free PEG and PEGylated molecules.

27 corporation of alkynyl moieties into organic molecules.

28 everal novel candidate retinotectal guidance molecules.

29 ethod for quantifying free PEG and PEGylated molecules.

30 ational methods for enantiosensing of chiral molecules.

31 focusing on the role of stromal interaction molecule 1 (STIM1), an endo/sarcoplasmic reticulum Ca(2+

32 and immobilized intercellular cell adhesion molecule 1.

33 former studies of similar silicon compounds, molecules 1 and 4 prefer to adopt the Pheq conformation.

34 inery that mediate SOCE: stromal interaction molecule-1 (STIM1), which functions as the SR Ca(2+) sen

35 asis-related proteins intercellular adhesion molecule-1 and urokinase-type plasminogen activator.

36 ectin, apolipoprotein C-I, and kidney injury molecule-1).

37 droplet consists of approximately 2400 water molecules, 22 hydronium ions, and 10 chloride and contai

38 Here we disclose an efficacious hybrid molecule 4-(5-Amino-1,2,3-oxadiazol-3-yl)-2,2,6,6-tetram

39 the small molecule crystal structure of lead molecule 7 and hypothesized that disruption of the cryst

40 very low detection limit to the level of few molecules, a realistic possibility.

41 We identified a small molecule, AC1903, that specifically blocks TRPC5 channel

42 ls and propagation of this variation between molecules across cells.

43 Anaesthetic molecules act on synaptic transmission via the allosteri

44 advancement toward the development of small molecule activators of tumor suppressor proteins.

45 s-strand RNA viruses that binds to the small molecule ADP-ribose.

46 led high-throughput screen to identify small-molecule agonists of TFEB and discover three novel compo

47 ator, WHSC1, and key intracellular signaling molecules, AKT, RICTOR, and Rac1, to drive PCa metastasi

48 Using the telomere-specific single-molecule analysis of replicated DNA technique, we found

49 is a Siglec that may function as an adhesion molecule and a facilitator of the recognition and intern

50 f DT through PEGylation, which polarizes the molecule and increases its size.

51 ition that are orthogonal to classical small molecule and protein-based approaches.

52 unds and efforts toward development of small molecules and biologics that could be of therapeutic use

53 nnate immune receptors for sensing microbial molecules and damage-associated molecular patterns relea

54 on modes of many but not all of the membrane molecules and highlight a powerful experimental approach

55 R) recognizes mannose 6-phosphate-containing molecules and IGF2 and plays an important role in many p

56 of the IgE sensitization to Phleum pratense molecules and investigating the diagnostic relevance of

57 Synthetic supramolecular molecules and materials are creating new opportunities f

58 establish potent Sirt6 activation with small molecules and provide a structural basis for further dev

59 l structure allows the insertion of reporter molecules and surface-binding agents in specific locatio

60 riginates from the interaction between water molecules and the ionic substituents and shows a concent

61 the coordinated discovery of bioactive small molecules and their molecular targets.

62 conjugates, where Ub is attached to other Ub molecules and to protein substrates in various forms, im

63 was optimized using CCS values of 205 small molecules and validated using a set of 131 pesticides.

64 e' for) the magnetic quantum number m of the molecules, and a previously unrecognized type of quantum

65 s on individual atoms, residues, domains and molecules, and generates an output that can be visualize

66 sed to screen for structural elements, small molecules, and host factors that alter these relatively

67 drainage of the brain ISF, CSF, CNS-derived molecules, and immune cells from the CNS and meninges to

68 epertoire of potential bacterial RNA capping molecules, and provide mechanistic insights into their i

69 rate that the secondary structure of the RNA molecule-and its absence-plays an essential role in dete

70 oil (EVOO) or nuts] and 1-y changes in these molecules; and 3) 1-y changes in lipid species and subse

71 and IGF-1R phosphorylated the prometastatic molecule Annexin A2 (AnxA2) at Y23 and Y333 in response

72 clonal antibodies were generated against OTC molecule (anti-OTC), purified and the quality was assess

73 Thus, small molecules applied locally to the skin can be used to mod

74 We also discuss how single-molecule approaches have increased our understanding of

75 de lead to steering and reorientation of the molecules approaching the surface, activating the O-H bo

76 Biological functions of RNA molecules are dependent upon sustained specific three-di

77 Thiolated PNA molecules are firstly self-assembled onto gold electrode

78 23 (IL23) and T-helper (Th) 17 cell pathway molecules are increased in inflamed intestinal tissues o

79 plex formation by showing that bait and prey molecules are simultaneously trafficked and actively con

80 ic compounds, particularly iodinated organic molecules, are absent from inland natural systems and th

81 zed distinct IGRP peptides, implicating this molecule as a trigger for CD4(+) T cell expansion.

82 Using clustered syntaxin molecules as an example, we study the influence of a cyt

83 ons indicate that the self-assembly of small molecules, as multifaceted entities and processes to int

84 This powerful single-molecule assay can be highly useful in diagnostic applic

85 nce energy transfer (FRET) to resolve single-molecule association dynamics at up to millimolar concen

86 ation of nanocapsules with multiple pyridine molecules at the capsule surface prevents them from asse

87 cause an explicit inclusion of several water molecules at the density-functional theory level is a re

88 to account for both the lateral diffusion of molecules at the membrane and the continuous release of

89 owered by using adsorbents that discriminate molecules based on adsorption entropy rather than enthal

90 Single-molecule-based super-resolution microscopy offers resear

91 ty to exchange phosphatidylinositol (PtdIns) molecules between membranes, and this property is centra

92 otes and eukaryotes, and recognized as small-molecule binding proteins.

93 in pancreatic cancer cells by means of small molecules binding to RG4s in the 5'-UTR of mRNA.

94 ration of (-)3TC-MP, with a second (-)3TC-TP molecule bound to the active site in the absence of PPi,

95 ports based on >1000 measurements for single molecule break junctions.

96 eliminates surface expression of all class I molecules, but leaves the cells vulnerable to lysis by n

97 The up-regulation of cell surface adhesion molecules by BMP9/10 in the presence of TNFalpha was inh

98 ll class II major histocompatibility complex molecules by small interfering RNA targeting of class II

99 apsulated allergen extracts: The protein/DNA molecule can be protected from degradation, higher local

100 mally activated delayed-fluorescence-emitter molecules can be manipulated in the solid state by explo

101 is review, we illustrate how photoswitchable molecules can be used to escape the global thermodynamic

102 In this approach, single RNA molecules captured by the nanopore can freely fold from

103 RNA molecules cause the proteins involved in the formation o

104 cells (NKT cells) and the antigen-presenting molecule CD1d is distinct from interactions between the

105 bosome-nascent chain libraries enable single-molecule co-localization of genotypes with phenotypes, a

106 The initial screen of small molecule compound libraries identified more than thirty

107 d evolution of proteins with designer single-molecule conformational phenotypes of interest.

108 anometallic zigzag structures, consisting of molecules connected by coordination bonds to Ag adatoms.

109 ssays revealed that the arthropod HSP70-like molecule contributes to differential fibrinogenolysis du

110 ergic events and suggest that targeting this molecule could be a novel approach to treat allergic ast

111 ome based screening of key HPVOPC associated molecules could be beneficial for early cancer diagnosis

112 We investigated the small molecule crystal structure of lead molecule 7 and hypoth

113 th protonated and deuterated 4,4'-bipyridine molecules demonstrates the single molecule response of p

114 y gaps between SWNT and the LUMO of acceptor molecules dictate the ET process.

115 ss spectrometry, we generated a map of small molecules differentially expressed in the Drosophila win

116 ment errors in bacterial cells is to analyze molecule displacements only along the long axis of the c

117 However, as single-molecule drugs or synergistic mixtures, these remedies h

118 Here we identified a range of small organic molecules, drugs, drug metabolites and drug-like molecul

119 particles broadly used to investigate single molecule dynamics in vitro.

120 Barcoding of DNA template molecules early in next-generation sequencing (NGS) libr

121 opy, enabling the localization of individual molecules even in densely labeled samples and in cellula

122 only along the long axis of the cell, where molecules experience the least confinement, and hence tu

123 ral integrity is necessary to observe single-molecule fluorescence of GFP.

124 Here, using single-molecule fluorescence resonance energy transfer imaging,

125 ch C kinase substrate) as a potential target molecule for kidney cancer.

126 rous silica nanoshells filled with porphyrin molecules, for effective cancer imaging and therapy.

127 tors' Pick by Echelman et al. applied single-molecule force spectroscopy to show that an adhesin prot

128 ain protein, Luciferase, by combining single-molecule force-spectroscopy experiments and coarse-grain

129 In low-frequency AC fields, long DNA molecules form macro-ion clusters.

130 , infrared evanescent scattering, and single-molecule FRET imaging, providing real-time multiparamete

131 structure of the structurally unknown guest molecule from only micro- or nanogram amounts of the gue

132 we expressed multiple complementary reporter molecules from the murine Hmox1 locus, including firefly

133 o exclude water along with other interfering molecules from the surface of the internal reflection el

134 brosis, we sought to identify improved small molecule functional mimetics of H2-RLX with selective, f

135 Here, we explore this family of molecules further, and we demonstrate that flavonoids sp

136 and support the further development of small molecule Gas6-TAM interaction inhibitors as a novel clas

137 ) targeting the T-cell receptor coregulatory molecule GITR exert potent therapeutic activities in pre

138 riments were performed to understand the ion-molecule growth mechanism of small acetylene clusters (u

139 their application to the detection of small molecules (haptens).

140 and its interaction with a natural receptor molecule has tremendous importance in cell signaling, me

141 Dithienylethene-containing molecules have been examined due to their photoswitching

142 This group of molecules, having diverse pharmacological activities, ma

143 T cells that express the Tr1-cell-associated molecules IL-10, inducible T-Cell costimulator (ICOS), l

144 Our real-time single-molecule imaging data demonstrate that TFIID alone binds

145 By secreting proinflammatory molecules, immune cells may induce myocyte inflammation,

146 between miR-17-92 and as-of-yet unidentified molecules important for the control of palatogenesis.

147 f how many reads need to support a short RNA molecule in a given dataset before it can be considered

148 RGS4 each likely interact with one neurabin molecule in a neurabin homo-oligomer to form a ternary c

149 ndings identify Sema3E as a novel regulatory molecule in allergic asthma that acts upstream of proall

150 , selective and sensitive monitoring of this molecule in food samples is of great importance.

151 the computed ro-vibrational line list of the molecule in question.

152 label-free approach to chemically map small molecules in aggregated and single Escherichia coli cell

153 rived from cellulose are perceived as signal molecules in Arabidopsis (Arabidopsis thaliana), trigger

154 vestigating the diagnostic relevance of such molecules in childhood.

155 l from 200 random iterations with 25% of the molecules in each case yielded the following figures of

156 ly in the gut, and at least 20% of the small molecules in human blood are products of the microbiota.

157 outinely considered when studying polyatomic molecules in intense laser fields.

158 rast and real-time imaging of endogenous RNA molecules in living mammalian cells.

159 he unfolding of individual bacteriorhodopsin molecules in native lipid bilayers.

160 Poisson statistics to estimate the number of molecules in such two channel ddPCR data.

161 nsion and impaired upregulation of cytotoxic molecules in TEFF cells.

162 sensory neurons that physically contact odor molecules in the nose and provide the initial sensory in

163 Moreover, we show that the two actin molecules in the unit cell are related to each other by

164 ring fluorescent signal patterns of long DNA molecules (in the range of 0.1-1 Mbp).

165 cules, drugs, drug metabolites and drug-like molecules, including salicylates and diclofenac, as MR1-

166 elf-assembly and cohesion of many biological molecules, including the adhesion proteins of several ma

167 rts also determined that many of these small molecules inhibit the protein-protein interactions throu

168 Intraperitoneal injection of the HuR small-molecule inhibitor MS-444 in AOM/DSS mice, a model of IB

169 the drebrin/EB3 pathway using BTP2, a small molecule inhibitor of drebrin binding to actin filaments

170 ecular effects of a recently developed small-molecule inhibitor of the KDM5 family of proteins (KDM5i

171 arizes the current status of exogenous small-molecule inhibitors of RAGE and concludes by identifying

172 We discuss how small-molecule inhibitors of the tryptophan (Trp) catabolic en

173 en GAS6 and AXL and the promiscuity of small molecule inhibitors represent important challenges faced

174 iscovery of nonnucleoside, reversible, small-molecule inhibitors with greater specificity against hRR

175 lectrokinetically driven introduction of DNA molecules into a nanochannel is facilitated by incorpora

176 disruption (BBB) and release of toxic blood molecules into the brain contributes to neuronal injury

177 nase and mammalian target of rapamycin (both molecules involved in sensing amino acid levels) was ass

178 e mechanism of its introduction into organic molecules is important.

179 of electron-deficient and strained aliphatic molecules is rare.

180 t genome that is composed only of linear DNA molecules is unprecedented among eukaryotes, and highlig

181 iverse TCRs interact with a multitude of MHC molecules is unresolved.

182 We calculate single-molecule junction transmission and the complex band stru

183 The sweetest tasting molecule known is the protein thaumatin, first isolated

184 nces in the synthesis and screening of small-molecule libraries have accelerated the discovery of che

185 erformed phenotypic screens on a NINDS small molecule library of 1040 drugs.

186 show that this can be used to perform single-molecule localization microscopy (SMLM) on cells express

187 CAF1 binds preferentially to DNA molecules longer than 40 bp, and two CAF1-H3-H4 complexe

188 ch in the spirit of recent works with single-molecule magnets.

189 The mitochondrial adaptor molecule MAVS plays critical roles in coordinating both

190 s the possibility that HMBA or related small molecules may be explored as therapeutic adjuvants to im

191 To automatically extract arrival times for molecules measured by DTIMS at multiple electric fields

192 hat extracellular matrix organization, small molecule metabolic process, cell adhesion (GO IDs: 00301

193 gical and pharmacological diversity of small molecule metabolites.

194 Major histocompatibility complex class I molecules (MHC I) help protect jawed vertebrates by bind

195 Because the number of molecules modulating RGGT is limited, we combined molecu

196 Existing small-molecule modulators of V-ATPase either are restricted to

197 or protein carrier, the neural cell adhesion molecule NCAM, play important roles in many nervous syst

198 we hypothesized that selective exclusion of molecules needed for growth may contribute to regenerati

199 e receptor 4 (TLR4) is a pattern recognition molecule of the innate immune system, and evidence sugge

200 Here, we identify a presynaptic effector molecule of the Wingless/Wnt signal, Cortactin.

201 ormed via covalent binding of 3-QCA with DOM molecules of above-average O/C and H/C ratios.

202 t two molecules of Cas2/3 assemble with four molecules of Cas1 (Cas2/32:Cas14) into a four-lobed prop

203 ical and structural methods to show that two molecules of Cas2/3 assemble with four molecules of Cas1

204 These small molecules of the heterocyclic diamidine family disrupted

205 -H4 complexes concertedly associate with DNA molecules of this size, resulting in deposition of H3-H4

206 The role of these molecules on attachment, migration, and proinflammatory

207 rate quantifications of the effects of small molecules on specific microscopic steps in Abeta42 aggre

208 The potential impact of encapsulated molecules on the thermal properties of individual carbon

209 st that while most lamps can photolyze these molecules, only sunlight and fluorescent tubes will be i

210 Deposition of 4,4"-diiodo-m-terphenyl molecules onto either Ag(111) or Ag(110) surfaces leads

211 or rapid identification of synergistic small-molecule pairs, the overlap2 method (O2M).

212 High protein expression of coinhibitory molecules PD1, CTLA4, and LAG3, accompanied by low expre

213 g specific 14-3-3 protein complexes by small molecules, peptide mimetics, and natural products.

214 is enriched in the nervous system, affecting molecules pertinent for excitability and neuronal morpho

215 type of the tissue environment, making these molecules pivotal biomarkers in many disease processes.

216 e investigate here the properties of two C60 molecules placed in parallel and sandwiched between top

217 udied Rho GTPase TC10 as an immunomodulatory molecule playing a role in physiological B cell response

218 Since the Sema3 subfamily of signaling molecules plays diverse roles in the regulation of cell

219 of a TRBV9(+) TCR in complex with the HLA-E molecule presenting the two peptides.

220 y) of small molecules with the efficacy of a molecule process against cancer cells, this work provide

221 SRM to materials characterization and single-molecule reactions.

222 Compared with conventional methods, single-molecule real-time (SMRT) DNA sequencing exhibits longer

223 map of 6mA in Tetrahymena by applying single-molecule real-time (SMRT) sequencing.

224 We exploited the capacity of single-molecule real-time sequencing technology to determine th

225 Thus, the Soc molecules reinforce the structure where there is the gre

226 -inflammatory receptor GPR84 but so also can molecules related to 3,3'-diindolylmethane.

227 2Y2R) activated by extracellular ATP and UTP molecules released following injury/stress.

228 tools, locus-specific delivery of synthetic molecules remains limited by a lack of adequate technolo

229 cells demonstrates how critically important molecules required for T cell differentiation, such as J

230 Though biosynthesis of these complex molecules requires substrate flux from the isoprenoid pa

231 bipyridine molecules demonstrates the single molecule response of plasmon-driven electron transfer oc

232 However, the types of cells and molecules responsible for the engulfment of dead cells i

233 sults show that seroconversion to a salivary molecule, rLinB-13, is a marker of risk for CL developme

234 cient is sensitive to the number of parallel molecules sandwiched between the electrodes, whereas cla

235 ypes, are well suited for multiplexed single-molecule screening of protein libraries, and should enab

236 ction of "alarmins." Alarmins are endogenous molecules secreted from cells undergoing nonprogrammed c

237 Host-microbe communication via small molecule signals is important for both symbiotic and pat

238 ex with His and NAD(+) displays the cofactor molecule situated in a way that would allow for a hydrid

239 Small molecule splicing modifiers have been previously describ

240 ays of regulation of ILC2s by co-stimulatory molecules such as ICOS, regulatory T cells and by compou

241 docrine cells are a rich source of bioactive molecules such as peptides, hormones, and neurotransmitt

242 allows for label-free detection of explosive molecules such as trinitrotoluene (TNT) down to 10(-10)M

243 a common means for regulation in biological molecules suggests that it is a relatively easy property

244 , accompanied by low expression of cytolytic molecules suggests that the decidual microenvironment re

245 types of amphiphiles (both polymer and small-molecule surfactants) were guided to form hetero-vesicle

246 In this study, we evaluated HuR as a small-molecule target for preventing colorectal cancer in high

247 Fibronectin (Fn), a ubiquitous host molecule targeted by many pathogens, promotes vascular i

248 Here, we screened a panel of small molecules targeting epigenetic modulators against human

249 sandwich assays) are not suitable for small molecule targets.

250 finnis were assembled with long-read, single-molecule technology.

251 Tenascin-C is an extracellular matrix molecule that drives progression of many types of human

252 dative stress-responsive cytoplasmic adapter molecule that is an upstream regulator of both IkappaB k

253 ough TGF-beta, which may act as the bridging molecule that mediates IL-37 binding to the TGF-beta rec

254 We screened for all molecules that are expressed differentially along the an

255 her, these observations establish that small molecules that bind to the interface between TAM Ig1 dom

256 has been to develop genes encoding effector molecules that block parasite development within the vec

257 tate the identification of APOL1-interacting molecules that could serve as new drug targets to treat

258 le targets and identify a new class of small molecules that may be further optimized for the repair o

259 d vascular cell adhesion protein 1 (VCAM-1), molecules that mediate leukocyte infiltration and are as

260 mplement alternative pathway proteins or the molecules that regulate this pathway were detected in 71

261 Small molecules that target Bcl-2 are used in the clinic to tr

262 Bacteria of many species rely on a simple molecule, the intracellular secondary messenger c-di-GMP

263 xidative oligomerization of catecholic small molecules, the physical properties of melanins are influ

264 provide efficient access to many halogenated molecules, the use of typical protocols for the selectiv

265 hNHE1 is probably located on the apex of the molecule; the receptor-binding mode might be different f

266 uorochrome labelled probes allows the target molecules to be detected by measuring the fluorescence i

267 The development of exogenous molecules to control stem cell self-renewal or different

268 tion by active pathways, attachment of cargo molecules to CPPs invariably reduces their cellular upta

269 he diffusion and adsorption process of guest molecules to improve the performances of MOFs in adsorpt

270 n sequence recognition of DNA-targeted-small-molecules to include both A.T and G.C base pairs, we rec

271 s can be inhibited by administering specific molecules to prevent induction of capsid-specific CD8(+)

272 ell metabolism has been emerged as signaling molecules to regulate stem cell behaviors such as migrat

273 ith more protein ligands or one or two water molecules, to determine which structure fits two sets of

274 h can potentially be developed into a single-molecule toolbox to investigate the biophysical mechanis

275 F treatment and eventually for designing new molecules toward AD therapeutic drugs.

276 to develop and characterize a specific small-molecule tracer for PET imaging that binds with high aff

277 ly 40 gene families, including cell-adhesion molecules, transmitter-modulator receptors, ion channels

278 lation of endothelial selectins and adhesion molecules, ultimately resulting in increased monocyte re

279 and felt, changed the reactivity of the TCS molecule under hydrothermal conditions significantly.

280 each of the 3 parental allergens, the hybrid molecule was designed to cover relevant epitopes and eva

281 e structure of the conformationally flexible molecules was determined largely through J-based configu

282 an electrochemical (EC) gate voltage to the molecule, we switch the redox group between the oxidized

283 Biology emerges from interactions between molecules, which are challenging to elucidate with curre

284 scribed for these increasingly important NHC molecules, which are generally considered robust ancilla

285 processes is built upon studies of diatomic molecules, which typically have electronic states that a

286 neutralizing antibodies are the key effector molecules while a shift to Th1 or Treg cells mainly cont

287 (CIP, 1b), as well as a curved antiaromatic molecule with 48 pi-electrons, dibenzo[a,c]diindeno[7,1,

288 he aldehyde groups of ZIF-90 using a diamine molecule with a conversion efficiency of 70%.

289 Notably, in one structure, an ordered water molecule with a high GIST displacement penalty was obser

290 ct the perceptual qualities of virtually any molecule with high accuracy and also reverse-engineer th

291 Riboflavin was used as a biological molecule with inherent properties, for the first time, a

292 borately designing and choosing two flexible molecules with C3v molecular symmetry as building units,

293 A variety of small neutral guest molecules with complementary sizes and geometries may be

294 are useful enzymes for providing halogenated molecules with improved biological activity, or intermed

295 Small molecules with novel and defined mechanisms of inhibitio

296 ies (e.g., self-assembling ability) of small molecules with the efficacy of a molecule process agains

297 e developed zebrafish model for screening of molecules with therapeutic value against this toxic neur

298 puting will depend on the ability to produce molecules with weak but measurable interactions between

299 effects depend upon strength of the partner molecules with which it is confronted to.

300 sistent cleft palate phenotype to test small-molecule Wnt agonist therapies.