ライフサイエンスコーパス: monocyclic

1 enzyme somewhat more slowly than that of the monocyclic.

2 The monocyclic 1,2,3-thiadiazoles do not inactivate any of t

3 5-fused bicyclic and three 4,5-disubstituted monocyclic 1,2,3-thiadiazoles have been examined for the

4 N2 elimination from monocyclic 1,2,3-triazoles can generate iminocarbenes, 1

5 irst general late-stage functionalization of monocyclic 1,2-azaborines at the C(6) position is descri

6 azaborine (2) to furnish new 2,3-substituted monocyclic 1,2-azaborines.

7 is a tribute to Dewar's first synthesis of a monocyclic 1,2-dihydro-1,2-azaborine 50 years ago and di

8 ular aldol reaction of two differently sized monocyclic 1,3-diketones bearing a chiral, oxygenated si

9 method for the synthesis of a wide range of monocyclic 1,4-azaborines, including the first examples

10 o-2,6-dioxaphosphorinanone(3)-1-oxide] and a monocyclic [1-hydroxy-4-phenyl-2,6-dioxaphosphorinanone(

11 Monocyclic [11]annulenium cations, which are experimenta

12 These include monocyclics 3, bicyclics 4, tricyclics 5, and tetracycli

13 The monocyclic 5-thiapyrimidinones were synthesized by coupl

14 Specifically, monocyclic, 6, 5-bicyclic, and 6,7-bicyclic structures p

15 ters, and four tertiary stereocenters from a monocyclic, achiral precursor.

16 ) appear to differ significantly from the OH-monocyclic adduct + O(2) reactions.

17 shifted to Ser14-Asp17 in the weakly potent monocyclic agonist II.

18 opening metathesis polymerization of several monocyclic alkenes as well as norbornene and oxanorborne

19 ulted in their reductive cyclization to form monocyclic alkenes in moderate yields, in addition to th

20 ting and pi-accepting properties compared to monocyclic (alkyl)(amino)carbenes (CAACs).

21 However, 6-methylsalicylic acid, a monocyclic analog of the reactive ring, is not recognize

22 The helical content in water of both monocyclic analogs I and II is approximately 22%; that o

23 r of galactopyranose derivatives relative to monocyclic analogs.

24 stem was found to be more selective than its monocyclic analogue beta-proline 5b.

25 The most potent monocyclic analogues were cyclo(4-10)[Ac-DNal(1), DFpa(2

26 The monocyclic analogues with a C-4 chloro group did show so

27 itude for the bicyclic phospholanes over the monocyclic analogues.

28 Both monocyclic and benzofused ketone derived beta-keto sulfo

29 and coupled cluster calculations on numerous monocyclic and bicyclic (CH)12(*-) isomers.

30 A series of substituted monocyclic and bicyclic azepinones were incorporated as

31 Monocyclic and bicyclic cyclobutylanilines successfully

32 zation under physiologic conditions to yield monocyclic and bicyclic peptides.

33 tes are slow and reversible, and mixtures of monocyclic and bicyclic products are formed.

34 method can be used to construct an array of monocyclic and bicyclic scaffolds, many of which are fou

35 ineering that unlocked the path to alternate monocyclic and bicyclic synthons representing the basis

36 A variety of monocyclic and bicyclic vinylidene cyclopropanes can be

37 ation for conversion of structurally diverse monocyclic and fused aromatics to the corresponding prim

38 thod provides a straightforward synthesis of monocyclic and spiro beta- or gamma-lactams with good to

39 cubane, prismane, tetrahedrane, and expanded monocyclics and bicyclics were optimized at the HF/6-31G

40 piperazinyl group with a variety of linear, monocyclic, and bicyclic diamines.

41 is group of catalysts that generate acyclic, monocyclic, and bicyclic olefin products.

42 induces ring opening to afford predominantly monocyclic anti-1,2-hydroxamic acids 12.

43 induces ring opening to afford predominantly monocyclic anti-1,4-hydroxamic acids 3.

44 -PAH)Mn(CO)(3)(+) complexes in comparison to monocyclic arene analogues.

45 In contrast to degradation pathways of monocyclic aromatic compounds where ring-cleavage is ach

46 In anaerobic microorganisms, most monocyclic aromatic growth substrates are converted to t

47 mixtures (mineral oil or crude oil), but not monocyclic aromatic hydrocarbons (MAHs) or polycyclic ar

48 ta for the OH radical-initiated reactions of monocyclic aromatic hydrocarbons, the reactions of OH-na

49 and conclusions from BN isosteres of simple monocyclic aromatic systems such as benzene and toluene

50 Monocyclic as well as fused bicyclic systems with a nitr

51 In contrast to the photochemistry of monocyclic aza-cyclohexenones, their counterparts with a

52 Two of the most potent compounds, monocyclic azepinone 2n and bicyclic azepinone 3q, demon

53 alosporins (ceftobiprole and ceftaroline), a monocyclic beta-lactam (BAL30072), the beta-lactamase in

54 nd G, a late step of the biosynthesis of the monocyclic beta-lactam antibiotic nocardicin A.

55 The nocardicins are a family of monocyclic beta-lactam antibiotics produced by the actin

56 cardicin A is the most potent of a series of monocyclic beta-lactam antibiotics produced by this orga

57 eart of nocardicin biosynthesis, a family of monocyclic beta-lactam antibiotics.

58 N(2)-(carboxyethyl)-L-arginine (CEA) to the monocyclic beta-lactam deoxyguanidinoproclavaminic acid

59 Nocardicin A is a monocyclic beta-lactam isolated from the actinomycete No

60 Nocardicin A is a monocyclic beta-lactam isolated from the actinomycete No

61 an enzyme that catalyzes the formation of a monocyclic beta-lactam ring in a similar ATP/Mg2+-depend

62 ase, an enzyme that catalyzes formation of a monocyclic beta-lactam ring with concomitant ATP hydroly

63 provide an attractive entry to a variety of monocyclic beta-lactam structures related to monobactams

64 This class of monocyclic beta-lactams are stable to metallo-beta-lacta

65 bition of LDL-associated phospholipase A2 by monocyclic beta-lactams has shown that LDL phospholipase

66 mples illustrate the direct incorporation of monocyclic beta-lactams into a variety of molecular arch

67 l acetohydroxamates facilitated syntheses of monocyclic beta-lactams suitable for incorporation of a

68 ld CsF-induced N1 benzylation of alpha-azido monocyclic beta-lactams, the preparation of alpha-keto-b

69 L phospholipase A2 is capable of hydrolyzing monocyclic-beta-lactams by a mechanism which shares many

70 A series of monocyclic, bicyclic, and tricyclic aromatic compounds w

71 versible covalent drugs, we have synthesized monocyclic, bicyclic, and tricyclic compounds containing

72 1065 and the duocarmycins containing dimeric monocyclic, bicyclic, and tricyclic heteroaromatic repla

73 diverse sesquiterpenes, including humulene (monocyclic); caryophyllene (bicyclic); and protoilludene

74 ch the most commonly occurring types are the monocyclic chlorobactene and the dicyclic isorenieratene

75 PTDI) units: linear foldamers lin2 and lin4, monocyclic complement cyc2, and concatenated foldable ri

76 A monocyclic compound 3 (3-ethynyl-3-methyl-6-oxocyclohexa

77 Among them, a monocyclic compound 5 is the most potent in these assays

78 he phosphoryl-enzyme complex formed from the monocyclic compound is significantly less mobile than th

79 Models of the noncovalent complexes of the monocyclic compound with the R61 DD-peptidase and a stru

80 the carbohydrates was a determinant for the monocyclic compounds of global activity patterns.

81 Oxidation of the monocyclic compounds results in extrusion of the three h

82 aluation of a series of isoxazoles and other monocyclic compounds.

83 nzo[e][1,4]diazepin-3-yl]succin amic acid, a monocyclic conformationally constrained form of the tetr

84 Novel monocyclic cyanoenones examined to date display unique f

85 Among monocyclic cyanoenones, 1 is a highly reactive Michael a

86 of 26 was at least 10-fold less than that of monocyclic cyclo(1-3)[Ac-DAsp(1),DCpa(2),DLys(3),DNal(6)

87 experimental measurements of the energy of a monocyclic cyclobutadiene.

88 Ten acyclic and monocyclic delta,epsilon-unsaturated ketones, with and w

89 ilon cyclase adds only one ring, forming the monocyclic delta-carotene (epsilon, psi-carotene), where

90 d-catalyzed condensation of tripyrranes with monocyclic dialdehydes, followed by an oxidation step.

91 Molecular dynamic behaviors of both the monocyclic dimer and the concatenated dimer-dimer ring w

92 h shows distinct stacking activities for the monocyclic dimer and the concatenated tetramer.

93 corresponding derivatives 7-10 (based on the monocyclic DMAP core).

94 f customizable diastereomeric cis- and trans-monocyclic enol-phosphonate analogs to Cyclophostin and

95 ) lipases suggests that these seven-membered monocyclic enol-phosphonates should provide useful leads

96 Reactions of acyclic or monocyclic enolates generally lead to 1,2,3-triazoles bu

97 icular for the most challenging reactions of monocyclic, functionalized aryl bromides and triflates.

98 Construction of the critical monocyclic guanidine has been achieved through two chann

99 We have previously reported that a monocyclic hAGRP(103-122) peptide is an antagonist at th

100 Here we report the discovery of a simple monocyclic host that matches the earlier designs, but is

101 The monocyclic humulyl cation, the product of 11,1-cyclizati

102 Whereas monocyclic hydrocarbons evoked patterns similar to those

103 were exposed to sets of odorants, including monocyclic hydrocarbons, bicyclic compounds, and various

104 site double mutant fails to turn over, but a monocyclic hydroxyphenyl-thiazolinyl-cysteine (HPT-Cys)

105 centre, and proceeds through an enzyme-bound monocyclic intermediate.

106 (1H and 13C) NMR and found to be 14-membered monocyclic isocembrenyl diterpenes, indicating that the

107 een suggested to proceed through a series of monocyclic isocembrenyl- and bicyclic verticillyl-carboc

108 Monocyclic lactams are predicted to have amidicities at

109 The binding affinity of monocyclic [Lys13,Asp17]-(I) and bicyclic [Lys13,Asp17,L

110 Elongated monocyclic mimics show much longer residence time within

111 homology model for CYP2E1, the two sites for monocyclic molecules, pNP and 4MP, exist within a narrow

112 phenolic acid, were used in the synthesis of monocyclic mycophenolic acid analogues 2a-i.

113 However, this cyanobacterium also produces a monocyclic myxoxanthophyll, which was identified as myxo

114 o generate 11 conjugated double bonds in the monocyclic myxoxanthophyll.

115 ncreased reactivity was observed relative to monocyclic NA.

116 synthase transforms geranyl diphosphate to a monocyclic olefin and constitutes the simplest model for

117 -(crotonamido)quinoline-3-carbonitriles with monocyclic or bicyclic anilines.

118 The monocyclic peptides showed no activity in these assays.

119 Cyclic peroxides, such as monocyclic peroxides and serial-cyclic peroxides, give a

120 e of hydroperoxides, bicyclic endoperoxides, monocyclic peroxides, and serial cyclic peroxides.

121 rings may afford higher affinity relative to monocyclic phenyl-based systems.

122 al/mol higher than those of the six-membered monocyclic phosphoester, 2-ethoxy-1,3,2-dioxaphosphinane

123 of the bicyclic tropane ring system with the monocyclic piperidine ring system or an acyclic aminoalk

124 ine 1 and N-methyl- and N-benzyl-substituted monocyclic polyamines 2 and 3 was studied.

125 icyclic products (B) and their corresponding monocyclic precursors (M).

126 The monocyclic ring closure and the dimer-dimer ring concate

127 clusters of this size should exist as planar monocyclic rings.

128 y higher affinity compared to the [3.3.1] or monocyclic scaffolds, which could be attributed to bette

129 follows the order 11a > 11b > 15a > 1 in the monocyclic series, and 24a > 19a > 28ain the bicyclic se

130 l, the reaction cycle was interrupted at the monocyclic stage.

131 to intercept the cyclization cascade at the monocyclic stage.

132 d at very similar rates to the corresponding monocyclic substrate, that is, cyclopropylcarbinyl mesyl

133 Furthermore, the formation of a monocyclic sulphoxide product from ACmC is most simply e

134 vity that was comparable to an unconstrained monocyclic system.

135 ty, as introduced in 1965, usually refers to monocyclic systems with 4n pi electrons.

136 (NaX; X = anion) to make contact, and to be monocyclic to simplify analyses.

137 ctive monofluorination reaction to yield the monocyclic trans-substituted alpha-fluoro lactam product

138 or multiple amino acid modifications in this monocyclic truncated hAGRP sequence resulted in molecule