ライフサイエンスコーパス: monofunctional

1 al, whereas moDC-generated cells were mostly monofunctional.

2 ys after both vaccinations and was primarily monofunctional.

3 contain a single carboxyl group, making them monofunctional.

4 er time, with CD8(+) responses becoming more monofunctional.

5 The Mthfd1l gene encodes a mitochondrial monofunctional 10-formyl-tetrahydrofolate synthetase, te

6 A monofunctional 10-formyl-THF synthetase (MTHFD1L gene pr

7 Monofunctional 2-hydroxypentadienoic acid hydratase from

8 is N-acetylated, supporting the concept that monofunctional acetylation is an activation, rather than

9 ntly enhanced copolymer molecular weights vs monofunctional acrylate monomers.

10 ducts of bifunctional activation to those of monofunctional activation was 6-20-fold higher at the ac

11 tion has been overproduced as an independent monofunctional activity in Escherichia coli.

12 ow a site-specific phenanthriplatin-DNA d(G) monofunctional adduct affects the Pol II elongation and

13 The rate constant for monofunctional adduct formation, k(MF), for 1 (0.87 M(-1

14 of the chloride ligands, forms highly potent monofunctional adducts on DNA having a structure and spe

15 nor groove of DNA, are the first examples of monofunctional adenine adducts of divalent platinum form

16 ally differentiated T cells, the presence of monofunctional Ag-specific T cells, and increased expres

17 between isocyanides, alpha-amino acids, and monofunctional aldehydes.

18 sed on the type of mediated transformations: monofunctional (alkene and alkyne metathesis), bifunctio

19 apn2Delta strain enhances sensitivity to the monofunctional alkylating agent methyl methanesulfonate

20 Cellular sensitivity to two monofunctional alkylating agents (methyl methane sulfona

21 he DNA ligase I mutant cell line 46BR.1G1 to monofunctional alkylating agents, indicating that a cyto

22 and crosslinking agents but not sensitive to monofunctional alkylating agents, UV, or ionizing radiat

23 N-nitrosoguanidine (MNNG) is a direct-acting monofunctional alkylator.

24 resistance of tumor cells to treatment with monofunctional alkylators, implicating inhibition of APE

25 h N,N'-p-phenylenedimaleimide (pPDM) and its monofunctional analog phenylmaleimide (PM) were measured

26 e originating from the fusion of prokaryotic monofunctional ancestor genes.

27 nd subsequently during formation of both the monofunctional and bifunctional adducts.

28 Monofunctional and bifunctional cisplatin adducts were g

29 c site and nicked intermediates generated by monofunctional and bifunctional glycosylases.

30 enzoylglycine as a substrate at pH 6.0 using monofunctional and bifunctional monooxygenase activities

31 -SH2 helix in scallop S1 were examined using monofunctional and bifunctional thiol reagents.

32 is characterized by elevated frequencies of monofunctional and dual-functional CD4(+) Th1 cells foll

33 n the spontaneous and Ag-specific Fo of both monofunctional and dual-functional Th1 cells compared wi

34 zed by a parasite Ag-dependent regulation of monofunctional and dual-functional Th1, Th2, and Th17 ce

35 also exhibited significantly decreased Fo of monofunctional and dual-functional Th17 cells upon Ag st

36 oth the spontaneous and the Ag-induced Fo of monofunctional and dual-functional Th2 cells was signifi

37 f Mycobacterium tuberculosis H37Rv encodes a monofunctional and secreted chorismate mutase (*MtCM) wi

38 +) T cells from SYMP individuals were mostly monofunctional and were directed mainly against nonoverl

39 on are available, but similar studies of the monofunctional archaeal enzyme that catalyzes only GTP-d

40 mosome 2 is coincident with genes encoding a monofunctional Asp kinase 2 and a bifunctional Asp kinas

41 t), threonine (Thr), and isoleucine involves monofunctional Asp kinases (AKs) and dual-functional Asp

42 ional isozyme, with an artificially produced monofunctional aspartokinase I, or with a fusion constru

43 l enzyme was also created between the native monofunctional aspartokinase III, an allosteric enzyme r

44 bifunctional ATP sulfurylase/APS kinase and monofunctional ATP sulfurylases shows a limited number o

45 The expressed monofunctional ATP-sulfurylase, which was initially full

46 The thermodynamics and kinetics for the monofunctional binding of nitrogen mustard class of anti

47 The thermodynamics and kinetics for the monofunctional binding of the antitumor drug cisplatin,

48 movement of the linker group is seen at the monofunctional binding step from changes of chemical shi

49 Monofunctional binding to the guanine N7 of the duplex o

50 2 then undergoes monofunctional binding to the guanine N7 of the duplex t

51 The differences in redox behavior of the monofunctional bis(imino)acenaphthene (BIAN) and bifunct

52 ting in Negishi cross-couplings between four monofunctional branch (dendritic) modules and the tetraf

53 ifunctional catalase-peroxidases and to lack monofunctional catalase and peroxidase.

54 enzymes for this detoxification include the monofunctional catalases KatB and KatE and the bifunctio

55 despite their structural dissimilarity with monofunctional catalases.

56 a role similar to that of the distal His in monofunctional catalases.

57 C-O bond activation on monofunctional catalysts (metals, carbides, and oxides)

58 The monofunctional catalysts Lambda- and Delta-[Co(en)3 ](3+

59 her species, however, these enzymes occur as monofunctional catalytic activities on separate enzymes.

60 A competitive monofunctional catechol slows COF-5 formation but does n

61 contrast, symptomatic individuals have more monofunctional CD44(high)CD62L(high)CD8(+) central memor

62 A monofunctional CD8(+) T cell response was observed in pa

63 Moreover, proportions of HIV-specific monofunctional CD8(+) T cells positively associated with

64 Unlike monofunctional CD8(+) T cells secreting IFN-gamma, which

65 gene expression but generated low-frequency, monofunctional CD8(+) T lymphocytes with restricted anat

66 tions (p < 0.001), and a lower proportion of monofunctional cells (p < 0.001) compared with terminall

67 there were frequent less-differentiated and monofunctional central memory CD8(+) T cells (TCM cells)

68 ontrol was achieved through the inclusion of monofunctional chain transfer agents during the polymeri

69 Mutation of Gln88 to glutamate in the monofunctional chorismate mutase from Escherichia coli r

70 , providing genetic evidence for the role of monofunctional chromium-DNA adducts in the toxic effects

71 agreement with the calculated values for the monofunctional cinnamic acid, as well as the multifuncti

72 e revealed a large TPS family, including the monofunctional class I diTPS PxaTPS8, which converts ger

73 The monofunctional class I diTPSs of DRA biosynthesis form a

74 ts of orthologous PbdiTPSs and PcdiTPSs were monofunctional class I enzymes that lacked functional cl

75 produced by the consecutive activity of two monofunctional class II and class I diTPSs.

76 s an additional function to the portfolio of monofunctional class II diTPSs, which catalytically most

77 ifunctional nanoparticles in the presence of monofunctional colloidal chain stoppers.

78 ocess DNA modified by pyriplatin and related monofunctional complexes is not at all understood.

79 nd decrease in stoichiometry relative to the monofunctional compound, supporting the overall design s

80 Protonated oxygen-containing monofunctional compounds react with selected methoxybora

81 ing cisplatin as well as other, less active, monofunctional compounds such as [Pt(NH3)3Cl](+) and cis

82 ffluent from the first flow reactor contains monofunctional compounds, such as alcohols, ketones, car

83 characterize CB[5], CB[6], CB[7], and CB[8] monofunctional compounds.

84 (II) complexes with trans geometry or with a monofunctional coordination mode, polynuclear platinum(I

85 This inhibitor, however, is unique in being monofunctional, cyclic and far shorter (14 amino acid re

86 Peptidoglycan is polymerized by monofunctional d,d-transpeptidases belonging to class B

87 The potential roles for this monofunctional Delta(3),Delta(2)-enoyl-CoA isomerase in

88 Leishmania major is compared to that of the monofunctional DHFR purified from Escherichia coli.

89 their covalent structure in the presence of monofunctional diols that competed for bonding with the

90 The domain organization resembles that of monofunctional diterpene synthases and is consistent wit

91 The presence of separate monofunctional diterpene synthases for ent-copalyl dipho

92 correlated with increased resistance to the monofunctional DNA alkylating agent methyl methanesulfon

93 Recent evidence indicates that the monofunctional DNA alkylating agent N-methyl-N'-nitro-N-

94 The 1.8 A crystal structure of the monofunctional DNA glycosylase AlkA (E. coli 3-methylade

95 We have recently shown that AlkA, a monofunctional DNA glycosylase that acts on alkylated ba

96 ble for processing spontaneous, chemical, or monofunctional DNA glycosylase-initiated AP sites via it

97 n DNA polymerase beta, are hypersensitive to monofunctional DNA methylating agents such as methyl met

98 Finally, in the model, monofunctional DNA polymer beads representing the tips o

99 though they exhibit increased sensitivity to monofunctional DNA-alkylating agents, but not to other D

100 ships that may apply to the entire family of monofunctional DNA-damaging agents and pave the way for

101 platinum anticancer drug candidates using a monofunctional DNA-damaging strategy.

102 Because of the current interest in monofunctional, DNA-damaging metallodrugs, these results

103 limiting step in the kinetic pathway for the monofunctional E. coli enzyme is the release of product,

104 yl-CoA isomerases revealed the presence of a monofunctional enoyl-CoA isomerase (ECI) in addition to

105 belongs to the aroQ class of CMs, encodes a monofunctional enzyme (AroQf) able to complement the CM

106 identical assays were performed with a known monofunctional enzyme (uracil DNA glycosylase) and a kno

107 odynamic signatures of ligand binding to the monofunctional enzyme differ significantly from those me

108 evolved from bifunctional diTPS rather than monofunctional enzymes (TPS-c and TPS-e) of gibberellin

109 An equimolar mixture of the two monofunctional enzymes catalyzed the overall reaction (s

110 They are distinct monofunctional enzymes in all eukaryotes and some bacter

111 e functionally divided into two classes: the monofunctional enzymes that catalyze only biotin additio

112 hown for bifunctional PutAs, but whether the monofunctional enzymes utilize an analogous channeling m

113 dissociated FASII system, which consists of monofunctional enzymes, and acyl carrier protein (ACP) a

114 dation, which can be catalyzed by individual monofunctional enzymes, multifunctional enzymes comprisi

115 One of these monofunctional enzymes, SimC7, was proposed to supply a

116 olyketide synthase working in trans with two monofunctional enzymes.

117 tional PAM protein they produce into soluble monofunctional enzymes.

118 ms PRODH and P5CDH are expressed as separate monofunctional enzymes.

119 kinase strongly indicated the presence of a monofunctional FAD synthetase.

120 Monofunctional FAD synthetases are known to exist in mam

121 Monofunctional FAD synthetases exist in eukaryotes, whil

122 d detailed biochemical characterization of a monofunctional feedback-insensitive HSD from any plant.

123 the C-H bond cleavage were measured for the monofunctional form of the enzyme using a double-label t

124 ing differences between the bifunctional and monofunctional forms of the dihydrofolate reductase enzy

125 tions observed in the molecular model of the monofunctional (G/Cl) adduct.

126 physiologically important regulation seen in monofunctional gamma-GCS enzymes.

127 trifunctional protein of 110 kDa, but also a monofunctional GARS protein of 50 kDa.

128 ths after ART, IRIS patients were strikingly monofunctional (generally interferon gamma alone), even

129 Although adenine removal proceeds via monofunctional glycosylase activity, MutY is able to for

130 ufficient, in the case of MutY, to convert a monofunctional glycosylase to a bifunctional glycosylase

131 , we observed tissue-specific alterations in monofunctional glycosylase-initiated BER activity, e.g.

132 ase release suggest MutY behaves as a simple monofunctional glycosylase.

133 Monofunctional glycosylases such as MutY are thought to

134 o the DNA glycosylase MutY: both enzymes are monofunctional glycosylases, which are trappable to thei

135 A gene (mgt) encoding a monofunctional glycosyltransferase (MGT) from Staphyloco

136 ed by mutagenesis study and the structure of monofunctional glycosyltransferase in complex with moeno

137 ccus aureus membrane-bound transglycosylase, monofunctional glycosyltransferase, in complex with a li

138 ass B penicillin-binding proteins (PBPs) and monofunctional glycosyltransferases and by bifunctional

139 n contrast, fungi and Chlorella virus encode monofunctional guanylyltransferase polypeptides that lac

140 h type of reference sensor (bifunctional and monofunctional) has a distinctive structural feature, wh

141 e have cloned the cDNA and gene encoding the monofunctional HSD (GmHSD) from soybean.

142 terized, but the molecular properties of the monofunctional HSD remain unexamined.

143 and the protonated amines are the strongest monofunctional hydrogen bond acids that we have studied.

144 The carboxylate anions are the strongest monofunctional hydrogen bond bases, and the protonated a

145 GDP leaving group in the ground state and a monofunctional hydrogen bond donor in the transition sta

146 -65 mutants, suggesting this residue to be a monofunctional hydrogen bond donor to the GDP leaving gr

147 potential enzyme forms (bifunctional versus monofunctional) in the plant biotin pathway are unknown.

148 This compound was shown to be a monofunctional inducer of NAD(P)H:quinone oxidoreductase

149 Michael acceptors and phenolic antioxidants (monofunctional inducers), and reactive oxygen species (R

150 operties of the hybrids, which form the same monofunctional-intercalative DNA adducts as the parent c

151 The frequency of monofunctional interferon-gamma-producing CD8(+) T cells

152 ple bonds, there is no evidence for a stable monofunctional intermediate-only starting material and t

153 AtICS1 acts as a monofunctional isochorismate synthase (ICS), catalyzing

154 ith aspartokinase III, a naturally occurring monofunctional isozyme, with an artificially produced mo

155 ue attached to lipid A, predicting in vivo a monofunctional Kdo transferase (WaaA).

156 donor sites of HIV-1 integrase, whereas the monofunctional L-708,906 derivative binds selectively to

157 single base change: the D297G mutant of the monofunctional l-Ala-d/l-Glu epimerase (AEE) from Escher

158 The rate of monofunctional labeling of scallop S1 was increased in t

159 ross-linking of SH1 and SH2 groups and their monofunctional labeling with NPM are ascribed to the inh

160 rther stabilization is realized by replacing monofunctional ligands with difunctional versions that c

161 in ligases, we have conducted studies of the monofunctional ligase from Pyrococcus horikoshii.

162 ority of TD HIV-specific CD8(+) T cells were monofunctional (median 69% [interquartile range: 57-83])

163 A source of the recombinant monofunctional Methanococcus vannielii PR-AMP cyclohydro

164 When compared with the behavior of a monofunctional model compound, the catalytic superiority

165 SH1-SH2 cross-linking and those due to their monofunctional modification, we used S1 with the SH1 and

166 ed homing endonuclease, was grafted into the monofunctional Mycobacterium xenopi GyrA intein at the p

167 he yeast Saccharomyces cerevisiae contains a monofunctional NAD(+)-dependent 5,10-methylenetetrahydro

168 metry can be controlled by the addition of a monofunctional oligomer.

169 We attached either monofunctional or bifunctional fluorescent probes to the

170 ional (p)ppGpp synthetase/hydrolase, and two monofunctional (p)ppGpp synthetases, YwaC and YjbM.

171 In addition, a monofunctional PDT domain (PDT20, residues 101-285) was

172 her demonstrate that, unlike the traditional monofunctional peroxidases, the oxyferrous state in DHP

173 and mouse PECI, a novel gene that encodes a monofunctional peroxisomal Delta(3),Delta(2)-enoyl-CoA i

174 rocesses the most abundant DNA lesion of the monofunctional phenanthriplatin anticancer drug candidat

175 PAM-1; although release of newly synthesized monofunctional PHM/H3A was increased, release of soluble

176 The monofunctional platination of adenine at its N7, N3, and

177 DeltaG++ = approximately 23 kcal/mol for the monofunctional platination of guanine, our model gives D

178 The monofunctional platinum agent pyriplatin displays antitu

179 r DNA adducts, further supporting a role for monofunctional platinum anticancer agents in human cance

180 and pave the way for rational improvement of monofunctional platinum anticancer drugs.

181 , where G* is a G platinated at N7 by di- or monofunctional platinum anticancer drugs.

182 The monofunctional platinum complex cis-[Pt(NH3)2Cl(Am)](+),

183 henanthridinechloroplatinum(II), is a potent monofunctional platinum complex that displays a spectrum

184 ))(6)NH(2)[cis-PtCl(2)(NH(3))]](+) contain a monofunctional platinum coordination sphere linked to a

185 The effect of the novel and potent monofunctional platinum(II) agent phenanthriplatin on Es

186 hloroplatinum(II), cDPCP or pyriplatin, is a monofunctional platinum(II) analogue of the widely used

187 ical and biological properties of a cationic monofunctional platinum(II) complex, cis-diammine(pyridi

188 Monofunctional platinum(II) complexes of general formula

189 of the complex, unlike DNA lesions of other monofunctional platinum(II) compounds like {Pt(dien)}(2+

190 To discover the most potent monofunctional platinum(II) compounds, the N-heterocycle

191 The second RP gene, AtRP2, encodes a monofunctional polypeptide that possesses in vitro RP-li

192 erococcus faecalis gene coaB encodes a novel monofunctional PPCS which has been cloned into pET23a an

193 of bifunctional PutA enzymes is conserved in monofunctional PRODH-P5CDH enzyme pairs.

194 e first structure and biochemical data for a monofunctional PRODH.

195 mmonalities between eukaryotic and bacterial monofunctional PRODHs.

196 se enolase superfamily, we discovered that a monofunctional progenitor could acquire the ability to c

197 The monofunctional protein displayed a nucleotide specificit

198 ike spinach is apparently a consequence of a monofunctional protein methyltransferase incapable of me

199 , whereas, in most other organisms, FARs are monofunctional proteins of similar size and domain struc

200 nic transcript potentially encoding separate monofunctional proteins that can be produced following a

201 tional proteins and several ORFs that encode monofunctional proteins.

202 ins on the cDNA level and expressing them as monofunctional proteins.

203 the screening of the amido functionality in monofunctional protonated analytes.

204 PyrD (encoded by At4g20960) is known to be a monofunctional pyrimidine deaminase, but no pyrimidine r

205 Monofunctional pyriplatin reacted with plasmid DNA as ef

206 (pol II) complex stalled at a site-specific monofunctional pyriplatin-DNA adduct in the active site.

207 e of RNA polymerase II (Pol II) stalled at a monofunctional pyriplatin-DNA adduct.

208 Ligand and receptor were labeled with monofunctional quantum dots, thus allowing long-term tra

209 Modification of Cys707 with the fluorescent monofunctional reagents 7-diethylamino-3-(4'-maleimidylp

210 e, we also treat the same residue pairs with monofunctional reagents in separate experiments.

211 presentative bis-glutathione conjugate and a monofunctional reference compound indicates that the biv

212 For each series, a monofunctional reference compound was also prepared to d

213 ginal anti-SIV Gag + Env CD8(+) T cell total monofunctional responses.

214 bifunctional capping enzymes such as Mce1 or monofunctional RNA phosphatases such as BVP.

215 st CCR5, plus a marker epitope (AU1), or its monofunctional RNAi-carrying homologue, SV(RNAiR5).

216 that a bifunctional sensor is better than a monofunctional sensor both at amplifying changes in the

217 hereas in other cases it has no such effect (monofunctional sensor).

218 These principals are most effective in monofunctional settings, wherein individual functional g

219 ies of the reagents toward SH2, the rates of monofunctional SH2 modification on SH1-labeled S1 were a

220 s metallopolymer can be controlled by adding monofunctional subcomponents to end-cap the conjugated l

221 in can be further dissected into overlapping monofunctional subdomains, since purified peptides displ

222 odular PKSs along with physically separated, monofunctional TEs (TE IIs) has been reported for a numb

223 the presence of a photoinitiator and a free monofunctional thiol, photodegradation is achieved.

224 Furthermore, the incorporation of monofunctional thiol-terminated polymers into the polyme

225 The bases are recognized by the monofunctional thymine DNA glycosylase (Tdg), which clea

226 homolog may preferentially cooperate with a monofunctional transglycosylase as the alternative sourc

227 s engineered onto the homologous domain of a monofunctional transmembrane variant of the rPACAPR (rPA

228 molecular explanations for the existence of monofunctional transpeptidases and glycosidases (glycosi

229 TS reactivity in human and Escherichia coli monofunctional TS and in T. gondii and Leishmania major

230 tural and mechanical regulation of entangled monofunctional UPy-PEG fibrils by cross-linking bifuncti

231 Single-strand-selective monofunctional uracil DNA glycosylase (SMUG1) belongs to

232 cosylase (UNG) or by single-strand selective monofunctional uracil DNA glycosylase (SMUG1).

233 recently characterized human single-stranded monofunctional uracil DNA N-glycosylase (hSMUG1).

234 ase DNA glycosylase, single-strand-selective monofunctional uracil-DNA glycosylase (SMUG1), and local

235 hSMUG1 (human single-stranded selective monofunctional uracil-DNA glyscosylase) is one of three

236 Animals given either the bifunctional or the monofunctional vector were largely protected from KA-ind

237 Novel, highly fluorescent, monofunctional, water-soluble heptamethine cyanine dyes

238 ter suppressed if the transmitting sensor is monofunctional, which is the more appropriate design whe

239 The catalytically active form of monofunctional yeast orotidine-5'-phosphate decarboxylas

240 bifunctionality in the largest genomes, to a monofunctional, yet not necessarily specialized, ineffic