ライフサイエンスコーパス: monomethylate

1 ture of species with either Lys-40 or Lys-55 monomethylated.

2 tes 1j-l showed similar mode selectivity, as monomethylated 1j exhibited exclusively [4 + 2] reactivi

3 The three most potent analogues were the monomethylated (3R)-7-hydroxy-N-[(1S,2S)-1-{[(3R,4R)-4-(

4 The first synthesis of all five possible monomethylated [4]dendralenes has been achieved via two

5 A levels at the same site despite its unique monomethylating activity and the lack of any evidence fo

6 In contrast, signals from monomethylated adenines decay monoexponentially.

7 The pattern of lifetimes measured for the monomethylated adenines suggests a special role for the

8 The DNA base adenine and four monomethylated adenines were studied in solution at room

9 A series of N,N-dimethylated and N-monomethylated analogues of N,N-dimethyl-2-(2'-amino-4'-

10 hemagglutinin-PRMT5 complex was also able to monomethylate and symmetrically dimethylate bovine histo

11 e-existing "old" histones continue to be K79-monomethylated and -dimethylated at a rate equal to the

12 re methylated and show that cellular Fmrp is monomethylated and asymmetrically dimethylated.

13 tivity, catalyzing the formation of omega-NG-monomethylated and asymmetrically omega-NG,NG-dimethylat

14 e demethylase that specifically demethylates monomethylated and dimethylated histone H3 at K4.

15 e malignant brain tumor (MBT) repeats, binds monomethylated and dimethylated lysines, but not trimeth

16 ternal urinary concentrations of iAs and its monomethylated and dimethylated metabolites (MMAs and DM

17 erentiated keratinocytes, where it was found monomethylated and dimethylated on Lys104 and interacted

18 is a potent substrate for Prmt5-Mep50 and is monomethylated and symmetrically dimethylated at Arg-187

19 ining H3 peptides, and discriminates against monomethylated and unmodified counterparts.

20 roM) and potentiated the cytotoxicity of the monomethylating antitumor agent Temozolomide by approxim

21 , including those with trimethylated Lys-20, monomethylated Arg-3, and the novel dimethylated Arg-3 (

22 MT9 at arginine 508, which takes the form of monomethylated arginine (MMA) and symmetrically dimethyl

23 initially found to generate only omega-N(G)-monomethylated arginine residues in small peptides, sugg

24 , inorganic arsenate (</= 20 muM), trivalent monomethylated arsenic (MMA3+, </= 1 muM), and trivalent

25 senite are consistent with a scheme in which monomethylated arsenical produced from arsenite is the s

26 s and/or iAs metabolites, measured as %iAs, %monomethylated arsenicals (MMAs), and %dimethylated arse

27 residue, trimethylated at Lys-3 by Rkm2, and monomethylated at Arg-66.

28 wild-type strains, it was found that 78% was monomethylated at both Lys-40 and Lys-55 and that 22% wa

29 l product of the RPL42A and RPL42B genes) is monomethylated at Lys-40 and Lys-55.

30 ts of G9a-like protein (GLP) recognizes RelA monomethylated at Lys310.

31 omains defined by the presence of histone H3 monomethylated at lysine 4.

32 at they preferentially bind histone peptides monomethylated at lysine residues with no apparent seque

33 haromyces cerevisiae), is stoichiometrically monomethylated at position 243, producing a 3-methylhist

34 We provide evidence that O-8-monomethylated benzo[a]pyrene-7,8-catechol is formed in

35 n at the 4'-position of the dimethylated and monomethylated benzylamines differently influenced SERT

36 s spectrometric analyses reveal that RelA is monomethylated by Set9 at lysine residues 314 and 315 in

37 Monomethylated catechol from 4-OH-tam was formed at a 3-

38 er of benzo[a]pyrene-7,8-catechol as the O-8-monomethylated catechol.

39 identified SETD6 as a methyltransferase that monomethylated chromatin-associated transcription factor

40 An unsymmetrical monomethylated cyclic unsaturated acetal leads to hypero

41 d significant quantities of precorrin-1, the monomethylated derivative of uroporphyrinogen III.

42 iochemical level and find that histone H3 is monomethylated, dimethylated, and trimethylated on lysin

43 PKMTs catalyze the formation of monomethylated, dimethylated, or trimethylated products,

44 itoleoylphosphatidylethanolamine (DPoPE), or monomethylated dioleoyl phosphatidylethanolamine (DOPE-M

45 to 31 amino acids, were incorporated into N-monomethylated dioleoylphosphatidylethanolamine (DOPE-Me

46 d processes in phosphatidylethanolamine or N-monomethylated dioleoylphosphatidylethanolamine systems.

47 requires the combined activities of a H3K27 monomethylating enzyme (PRC2 containing WT EZH2 or EZH1)

48 Methylseleninic acid (MSA) is a monomethylated form of selenium effective in inhibiting

49 ause it is stable in solution and provides a monomethylated form of selenium that can be reduced by c

50 d aberrantly elevated H3K27me3 and decreased monomethylated H3K27 (H3K27me1) and dimethylated H3K27 (

51 y demethylates di- and trimethylated but not monomethylated H3K27.

52 Histone H3K27 can be monomethylated (H3K27me1), dimethylated (H3K27me2), or t

53 reover, a Mut11 mutant showed global loss of monomethylated H3K4 (H3K4me1) and an increase in dimethy

54 s) and resulted in a substantial decrease in monomethylated H3K4 (H3K4me1) and chromatin interaction

55 n analyses, phosphorylated H3T3 (H3T3ph) and monomethylated H3K4 (H3K4me1) are inversely correlated w

56 Whereas monomethylated H3K4 (H3K4me1) is found throughout the ge

57 airway epithelial cells and is enriched for monomethylated H3K4 histones (H3K4me1).

58 le transcriptional enhancers are marked with monomethylated H3K4.

59 erminal PR/SET domain of Riz1 preferentially monomethylates H3K9.

60 Similarly, monomethylated H4 Lys-20 and H3 Lys-9 partitioned togeth

61 Consistent with this, detailed analysis of monomethylated H4 Lys-20 and H3 Lys-9 revealed that both

62 ne a novel trans-tail histone code involving monomethylated H4 Lys-20 and H3 Lys-9 that act cooperati

63 Monomethylated H4-K20 is detected on condensed chromosom

64 s unique properties, including enrichment of monomethylated H4K20 and H3K27, which correlate with the

65 Set8 and monomethylated H4K20 are virtually undetectable during G

66 The selective loss of monomethylated H4K20 at the RUNX1 promoter resulted in t

67 riptional regulatory pathway in vivo whereby monomethylated H4K20 binds the L3MBTL1 repressor protein

68 Importantly, the lack of monomethylated H4K20 in the human K562 multipotent cell

69 We therefore propose that monomethylated H4K20 is involved in the maintenance of p

70 The lack of PR-Set7 and monomethylated H4K20 resulted in a number of aberrant ph

71 By contrast, monomethylated H4K31 is enriched in the core body of T.

72 e methyltransferase SET8 is the sole PKMT to monomethylate histone 4 lysine 20 (H4K20) and its functi

73 Monomethylated histone H3 lysine 4 (H3K4me1), together w

74 ly discovered that normal cellular levels of monomethylated histone H3 lysine 9 (H3K9me1) were also d

75 ed a novel trans-tail histone code involving monomethylated histone H4 lysine 20 (H4K20) and H3 lysin

76 Monomethylated histone H4 lysine 20 (H4K20me1) is tightl

77 n of Prdm2, a histone methyltransferase that monomethylates histone 3 at the lysine 9 residue (H3K9me

78 re, we demonstrate that PR-SET7/SETD8, which monomethylates histone H4 lysine 20 (H4K20me1), controls

79 histone methyltransferase that specifically monomethylates histone H4 lysine 20 (K20) and is essenti

80 tone methyltransferase in mammals capable of monomethylating histone H4 lysine 20 (H4K20me1).

81 tenance of genomic stability, most likely by monomethylating histone H4K20.

82 HDM1, which mediate demethylation of di- and monomethylated histones.

83 ing either the unmethylated substrate or the monomethylated intermediate.

84 methyl-H3K9 and decreases the release of the monomethylated intermediate.

85 known as Pr-Set7) was previously reported to monomethylate Lys(20) of histone H4.

86 re, we provide evidence to support that SET8 monomethylates Lys(20) of histone H4 during S phase by t

87 rectly interacts with DNMT1 and specifically monomethylates Lys-142 of DNMT1.

88 ain containing methyltransferase reported to monomethylate lysine residues on histone and nonhistone

89 brain tumor (MBT) domain of PHF20L1 binds to monomethylated lysine 142 on DNMT1 (DNMT1K142me1) and co

90 -1 promoter chromatin, which was enriched in monomethylated lysine 20 at histone H4 (H4K20me1), a mar

91 GATA-1 selectively induced H4 monomethylated lysine 20 at repressed, but not activated

92 reported to have the demethylase activity of monomethylated lysine 9 of histone 3 in vivo.

93 nium ions (126 for acetylated lysine, 98 for monomethylated lysine, and 84 for di-, tri-, and unmethy

94 7/Set8 is a cell-cycle-regulated enzyme that monomethylates lysine 20 of histone H4 (H4K20).

95 ic acid already serves as a preformed active monomethylated metabolite, and this could be an underlyi

96 - and trimethylated myricetins and increased monomethylated myricetin.

97 In addition to H4K20, SETD8 monomethylates non-histone substrates including prolifer

98 d transmembrane protein 3 (IFITM3) was found monomethylated on its lysine 88 residue (IFITM3-K88me1)

99 ent binding of HP1 to full length histone H3 monomethylated on K9 (H3K9me1).

100 ines exhibited higher SERT affinity than the monomethylated ones, (ii) alkyl, alkenyl, or hydroxymeth

101 PRMTs are a family of proteins that either monomethylate or dimethylate the guanidino nitrogen atom

102 , which demonstrated that HR can demethylate monomethylated or dimethylated histone H3 lysine 9 (H3K9

103 We find that SET8 specifically monomethylates p53 at lysine 382 (p53K382me1).

104 larged active site can favorably accommodate monomethylated peptide and provide sufficient space for

105 p mutant has markedly increased affinity for monomethylated peptide with respect to the WT, suggestin

106 l group transfer, S-adenosylhomocysteine and monomethylated polypeptide dissociate from monomethyltra

107 e, one of the most carcinogenic PAHs, has 12 monomethylated positional isomers (MBAPs).

108 The compounds were identified as monomethylated products by HPLC-MS and NMR.

109 that the beta-lyase-mediated production of a monomethylated selenium metabolite from Se-methylselenoc

110 in support of our earlier hypothesis that a monomethylated selenium metabolite is important for canc

111 A monomethylated selenium metabolite, called methylselenin

112 may have only a modest ability to generate a monomethylated selenium species from Se-methylselenocyst

113 the peptide substrate where turnover of the monomethylated species is negligible.

114 ion involves the transient accumulation of a monomethylated species, suggesting that the MLL1 core co

115 Although L. infantum CYP51 prefers C4-monomethylated sterol substrates such as C4-norlanostero

116 cei (TB), which like plant CYP51 requires C4-monomethylated sterol substrates, TCCYP51 prefers C4-dim

117 human PRMT1 using both an unmethylated and a monomethylated substrate peptide based on the N-terminus

118 tion provides necessary interactions with C4-monomethylated substrates, which Ile cannot.

119 SET domain containing 6 (SETD6) monomethylates the RelA subunit of nuclear factor kappa

120 ion; the former dimethylates, and the latter monomethylates, the target nucleotide.

121 predict that SET1 family enzymes should only monomethylate their substrates, mono-, di-, and trimethy

122 inine methyltransferase (PRMT) that strictly monomethylates various substrates, thus classifying it a

123 he AcH4-21 and R1 peptides, as well as their monomethylated versions, indicate, in contrast to a prev