ライフサイエンスコーパス: monomethylation

1 -l-methionine (SAM) for SET8-catalyzed H4K20 monomethylation.

2 36 along with a reduced preference for H3K36 monomethylation.

3 one SET domain catalyzes at least weak H3K4 monomethylation.

4 In contrast, H3K27 monomethylation, a modification enriched at pericentrome

5 We identify H4K20 monomethylation, a modification previously linked with r

6 lian COMPASS-like proteins deficient in H3K4 monomethylation activity and point to a possible role fo

7 thermore, we observed that WDR5 inhibits the monomethylation activity of the MLL3 core complex, which

8 complexes, and its expression reduces G3BP1 monomethylation and asymmetric dimethylation at three Ar

9 These sites show high levels of histone H3K4 monomethylation and CBP/P300 binding characteristic of e

10 ied five putative enhancers marked with H3K4 monomethylation and depletion of H3.

11 genome-wide analysis of its substrates H3K4 monomethylation and dimethylation, and gene expression p

12 ancer elements marked by histone H3 lysine 4 monomethylation and histone H3 lysine 27 acetylation, de

13 cupied DNA segments have high levels of H3K4 monomethylation and low levels of H3K27me3 around the ca

14 Our studies identify the importance of H4K20 monomethylation and of PR-SET7 for L3MBTL1 function.

15 Monomethylation and trimethylation of histone H4-lysine

16 ges had increased histone 3, lysine 4 (H3K4) monomethylation, and H3K9 acetylation, accompanied by de

17 lysine 4 trimethylation, histone H3 lysine 4 monomethylation, and histone H3 lysine 27 acetylation (H

18 ites also correspond to high levels of H3K27 monomethylation, and mutation of the catalytic SET domai

19 with histone H4-Y72 phosphorylation, H4-K20 monomethylation, and the Ki-67 proliferation marker.

20 -translational modification, possibly lysine monomethylation, appears to be the single most important

21 Although levels of H3.3K79 monomethylation are higher than that of H3.2/H3.1, the r

22 methyl-lysine modifications, H4K20 and H3K27 monomethylation are versatile and dynamic with respect t

23 lation is reduced dramatically compared with monomethylation as the concentration of the substrate is

24 Most interestingly, monomethylation at Arg-17 in histone H4 not only raised

25 Rps3 is stoichiometrically modified by omega-monomethylation at arginine-146 by mass spectrometric an

26 e1 in these cells, with the greatest loss of monomethylation at enhancer regions.

27 We also observed enrichment of H3K79 monomethylation at intergenic regions occupied by DNA-bi

28 ates nucleosome remodeling, followed by H3K4 monomethylation at large numbers of genomic regions asso

29 In contrast, dimethylation at Lys-27 and monomethylation at Lys-36 were commonly found together.

30 proteomic analysis, this study revealed AF-1 monomethylation at Lys-464.

31 Furthermore, we show that RB monomethylation at lysine 860 provides a direct binding

32 we show that the enzyme primarily generates monomethylation at this position.

33 dentify a glutamate residue critical for its monomethylation behavior.

34 es of the BAF component BAF45C indicate that monomethylation, but not trimethylation, is accommodated

35 e H3 (H3K4), whereas enhancers are marked by monomethylation, but not trimethylation, of H3K4.

36 anism of NF-kappaB regulation through lysine monomethylation by SET9 methyltransferase.

37 Arginines were modified by monomethylation, dimethylation, or deimination.

38 t with its role in the maintenance of Lys-20 monomethylation during cell division.

39 irrors the progressive accumulation of H4K20 monomethylation during the cell cycle.

40 companied by a decrease in levels of histone monomethylation (H3-K4me1).

41 e modifications, including histone H3 Lys 27 monomethylation (H3K27me1), imparted by ATXR5 and ATXR6.

42 lls showed a deficiency in histone H3 Lys 27 monomethylation (H3K27me1), while DeltaEZL2 cells, delet

43 SR1 and the epigenome of histone H3 lysine 4 monomethylation (H3K4me1) in a cancer- and cell type-spe

44 Histone H3 lysine 4 monomethylation (H3K4me1) is an evolutionarily conserved

45 ndreds of mouse-specific histone H3 lysine 4 monomethylation (H3K4me1)- and histone H3 lysine 27 acet

46 We now report the presence of H3K56 monomethylation (H3K56me1) in mammalian cells and find t

47 K79 dimethylation (H3K79me2) is converted to monomethylation (H3K79me1) at HOX loci as hematopoietic

48 e, prometaphase, and metaphase, whereas H3K9 monomethylation (H3K9me1) and dimethylation (H3K9me2), b

49 We found that H4K20 monomethylation (H4K20me1) is enriched at centromeres.

50 tion (H4K16ac) is underrepresented and H4K20 monomethylation (H4K20me1) is enriched on hermaphrodite

51 monomethyltransferase responsible for H4K20 monomethylation (H4K20me1) that is the substrate for fur

52 cetylation (H4K16ac) and enrichment of H4K20 monomethylation (H4K20me1)) in both wild type and develo

53 f BAP1 results in a marked decrease in H4K20 monomethylation (H4K20me1).

54 igenetic enhancer marks (histone H3 lysine 4 monomethylation, histone H3 lysine 27 acetylation, and t

55 Here, we find that SET7/9 monomethylation in a putative nucleolar localization reg

56 Our findings point to a unique role for H3K4 monomethylation in establishing boundaries that restrict

57 ur at weak/poised enhancers marked with H3K4 monomethylation in hematopoietic progenitor cells.

58 sults demonstrate the critical role of H4K20 monomethylation in mammals in a developmental context.

59 1) and Mll4 (GeneID 381022) in enhancer H3K4 monomethylation in mouse embryonic fibroblast (MEF) cell

60 Conversion of H3K79 monomethylation into di- and trimethylation correlated w

61 In this report, we demonstrate that H3K9 monomethylation is dependent upon the PR-Set7 H4K20 mono

62 motifs, KX(G/A/V/I)N and KT(I/L/F), whereas monomethylation is pervasive throughout OmpB.

63 We find that, in vitro, LSD1 removes both monomethylation (K370me1) and dimethylation (K370me2) at

64 ase activity results in reduced histone H3K4 monomethylation levels, followed by a global increase in

65 rase 7 (PRMT7) catalyzes the introduction of monomethylation marks at the arginine residues of substr

66 Monomethylation-mediated repression was not restricted t

67 coded by TMT1 catalyzes the AdoMet-dependent monomethylation of 3-isopropylmalate, an intermediate of

68 rylation on Tyr109 [p-Tyr109], p-Ser111, and monomethylation of Arg114 [me-Arg114]) within an N-termi

69 Monomethylation of dimethylmalonate followed by alkylati

70 biquitylation of H2B-K123 is dispensable for monomethylation of H3-K4 and H3-K79 but is required for

71 tment of these factors as well as diminished monomethylation of H3K4 (H3K4me1) and acetylation of H3K

72 Monomethylation of H4K20 (H4K20me1) is mediated by the c

73 Set8/KMT5a is the sole enzyme that catalyzes monomethylation of H4K20 (H4K20me1).

74 Monomethylation of H4K20 has been implicated in regulati

75 ila genome, suggesting that PR-Set7-mediated monomethylation of H4K20 is critical for maintaining the

76 tablishment of the epigenetic mark H4K20me1 (monomethylation of H4K20) by PR-Set7 during G2/M directl

77 n greater abundance, as well as a pattern of monomethylation of histone H3 at lysine 4 (H3K4) across

78 Monomethylation of histone H3 at lysine 4 (H3K4me1) and

79 ed tissue-specific enhancer marks, including monomethylation of histone H3 at lysine 4 (H3K4me1) and

80 e or primed enhancers are commonly marked by monomethylation of histone H3 at lysine 4 (H3K4me1) in a

81 sence of chromatin regulators p300 and BRG1, monomethylation of histone H3 at lysine 4 (H3K4me1), and

82 nd that the subset of enhancers enriched for monomethylation of histone H3 Lys4 (H3K4me1) and binding

83 Monomethylation of histone H3 lysine 27 (K27me1) is a po

84 Monomethylation of histone H3 on Lys 4 (H3K4me1) and ace

85 lated recruitment of Stat5b, as did lysine 4 monomethylation of histone H3, which was enriched in 6/7

86 Monomethylation of histone H3K4 (H3K4me1) is relatively

87 We present evidence that PRMT7-mediated monomethylation of histone H4 Arg-17 regulates PRMT5 act

88 -Set7/Set8 is the sole enzyme that catalyzes monomethylation of histone H4 at K20 (H4K20me1).

89 , a histone methyltransferase that catalyzes monomethylation of histone H4 at lysine 20 (H4K20me1), i

90 8/KMT5A is the sole enzyme known to catalyze monomethylation of histone H4 lysine 20 (H4K20) and is p

91 its corresponding histone modification, the monomethylation of histone H4 lysine 20 (H4K20), display

92 only known methyltransferase that catalyzes monomethylation of histone H4 lysine 20 (H4K20).

93 During G2 and mitosis, Set8 catalyzes monomethylation of histone H4 on lysine 20 (H4K20me1), w

94 dothelial cells, silencing of Set7 prevented monomethylation of lysine 4 of histone 3 and abolished N

95 Patients with T2DM showed Set7-dependent monomethylation of lysine 4 of histone 3 on NF-kB p65 pr

96 Monomethylation of lysine 4 on histone H3 (H3K4me1) is a

97 We previously found that monomethylation of p53 at lysine 382 (p53K382me1) by the

98 ls as measured by reduction of SMYD2-induced monomethylation of p53 Lys(370) at submicromolar concent

99 These results suggest that monomethylation of PR at Lys-464 probably has a repressi

100 Remarkably, we find that MLL3/4 provokes monomethylation of promoter regions and the conditional

101 ewhat surprisingly, AtMETTL20 also catalyzed monomethylation of RpL7/L12 on Lys-86, a common modifica

102 lysine methyltransferase that catalyzes the monomethylation of several protein substrates including

103 This unique feature, in combination with the monomethylation of the phosphonic acid, renders DHP a Tr

104 Monomethylation of the potentially ambident RNH[N(O)NO](

105 are the specific enzymes responsible for the monomethylation of the two sites in Rpl42ab.

106 Monomethylations of cytidine and adenosine are common po

107 The monomethylations of H3K27, H3K9, H4K20, H3K79, and H2BK5

108 egulation of di- and trimethylation, but not monomethylation, of H3-Lys-4 in vivo.

109 Our in vitro studies show that the onset of monomethylation on an unmethylated histone H3 by COMPASS

110 ng positional variables, the requirement for monomethylation (primary and dialkylated amides are inac

111 yl cyanide, complex 9 is regenerated and the monomethylation product 2-phenylpropanenitrile is releas

112 alytic efficiency (k(cat)/K) for the zero to monomethylation reaction of H3K27 and diminished efficie

113 f p300 recruitment, while MLL4-mediated H3K4 monomethylation, reciprocally, requires p300 function.

114 370, a previously identified Smyd2-dependent monomethylation site.

115 ver, the molecular mechanism linking p53K382 monomethylation to repression is not known.

116 -K79 but is required for the transition from monomethylation to subsequent methylation states.

117 ration and identification of tails involving monomethylation, trimethylation, acetylation, or phospho

118 At some locations, H3K27 monomethylation was also found to be associated with chr

119 read 3' into the bodies of genes, while H3K4 monomethylation was diminished.

120 and trimethylation, while histone 3 lysine 4 monomethylation was not affected.

121 ATXR6-dependent histone H3 lysine 27 (H3K27) monomethylation, we show that millions of base pairs of

122 Selective monoreduction and monomethylation were observed for 3.

123 The sequence is halted at monomethylation when the conformation of the Enz.Lys-N(M

124 PKMT1 catalyzes predominantly monomethylation, whereas PKMT2 catalyzes mainly trimethy

125 di-OH-tam) catechol, was demonstrated by its monomethylation with [3H]S-adenosyl-L-methionine ([3H]SA

126 s9 dimethylation and a significant amount of monomethylation within silent euchromatin.

127 that the WRAD subcomplex catalyzes weak H3K4 monomethylation within the context of the MLL3 core comp

128 ones display markedly reduced levels of H3K4 monomethylation without obvious changes in the levels of

129 und that CTK1 deletion nearly abolished H3K4 monomethylation yet caused a significant increase in H3K