ライフサイエンスコーパス: monopolar

1 UNC-6 or SLT-1 causes the neurons to become monopolar.

2 bition of aurora B or Eg5 kinesin, underwent monopolar anaphase on time and without additional interv

3 om cultured cells also leads to formation of monopolar and abnormal spindles and centrosome loss.

4 reas klp-18(-) and mei-1(-) mutants assemble monopolar and apolar spindles, respectively.

5 creased levels of nuclear envelope proteins, monopolar and asymmetric spindles, and chromosomes that

6 se the effects of NuSAP and Kid depletion in monopolar and bipolar cells with or without kinetochore

7 - termed 'new-end take-off' (NETO) - between monopolar and bipolar growth mid-way through the cell cy

8 icrotubules during cytokinesis in cells with monopolar and bipolar spindles shows that a subpopulatio

9 coding gene merry-go-round (mgr), leading to monopolar and disorganized mitotic spindles containing f

10 rmal spindle development, as we observe both monopolar and multipolar spindles in Eg5 transgenic mice

11 It also induced the formation of monopolar and multipolar spindles in mitotic cells.

12 forced-choice adaptive procedure under both monopolar and quadrupolar stimulation.

13 efects and aberrant MT structures, including monopolar and small spindles.

14 ytes that do divide are either diminutive or monopolar, and do not make contact with the fusome.

15 der ultrasound guidance using a novel LeVeen monopolar array needle electrode and an RF 2000 generato

16 pole body (SPB) assembles a long and stable monopolar array of nuclear microtubules that spans the e

17 t depletion of Pak1/2 allows cells to escape monopolar arrest by Eg5 inhibition, highlighting the pot

18 Monopolar attached sister centromeres are resolved to bi

19 osed on sister kinetochores that facilitates monopolar attachment to the MI spindle.

20 es at MI, and univalents constrained to form monopolar attachments should be inherently unstable and

21 er mechanosensitive mechanism to correct the monopolar attachments.

22 copy reveals that intercalating cells extend monopolar, basolateral protrusions in their direction of

23 OBJECTIVE(S): The monopolar "Bovie" is used in virtually every laparoscopi

24 oduce one daughter cell that develops into a monopolar cell and one daughter that develops into a bip

25 tes, and the Deltapom1 mutation brings about monopolar cell growth.

26 Large type 2 monopolar cells (L2) and type 1 amacrine cells, which in

27 arrying out spatial summation are the lamina monopolar cells (LMCs) of the first visual processing ar

28 L2 monopolar cells ending in the medulla are accompanied by

29 with cells of various types, including large monopolar cells, but close apposition to photoreceptor t

30 Locust lamina monopolar cells, L1 and L2, were the main targets of the

31 dly, cytokinesis occurs at high frequency in monopolar cells.

32 nal net, is predicted to support states with monopolar charge order at entropies below that of the pr

33 ltiple functions, including the promotion of monopolar chromosome attachment in the first division.

34 kinetochore functions that are essential for monopolar chromosomes to establish bipolar connections a

35 Four ablations, two bipolar and two monopolar (control probe), were made in each of five liv

36 icrotubules promote symmetry breaking during monopolar cytokinesis and regional specialization of the

37 We employed monopolar cytokinesis to reveal that midzone plus ends a

38 ail to form a cleavage furrow [3] and during monopolar cytokinesis when myosin contractility is block

39 ed to the distal ends of microtubules during monopolar cytokinesis, depletion of PRC1 and KIF4A displ

40 e array, we sought to clarify their roles in monopolar cytokinesis.

41 n in HeLa cells undergoing drug-synchronized monopolar cytokinesis.

42 The monopolar Deltapom1 mutant fails to eliminate Rga4 from

43 The monopolar device demonstrated the expected inverse assoc

44 a-phosphatidylcholine (DPPC), a conventional monopolar diester lipid.

45 e main phase transitions of saturated diacyl monopolar diester lipids.

46 o observed in bilayers composed of saturated monopolar diester phosphatidylcholines at their main pha

47 result opposite that previously obtained on monopolar diester phospholipids.

48 4 from the nongrowing cell end, resulting in monopolar distribution of GTP-Cdc42 to the growing cell

49 on achieves better frequency resolution than monopolar electrical stimulation.

50 te, which is traditionally performed using a monopolar electrocautery system resulting in the possibi

51 e performance of acquiring EHG signals using monopolar electrode and three types of Laplacian concent

52 the present study, we tested the effects of monopolar electrode stimulation and low-duty cycle AC st

53 The suppression generated by the monopolar electrode was localized to a region surroundin

54 sign of the experiment involved placement of monopolar electrodes into the medial hypothalamus from w

55 either intracochlear bipolar or round window monopolar electrodes.

56 ed if an operative event includes the use of monopolar electrosurgery ('Bovie') or significant fluid

57 Unlike more common monopolar, ester-linked phospholipids, C20BAS-PC exhibit

58 r results suggest that, in contrast to other monopolar-growing mutants, the monopolar phenotype of th

59 is a critical regulator to ensure persistent monopolar growth during S phase.

60 nt polarity factor tea1p, which prepares for monopolar growth initiation and later switching to bipol

61 yeast and their unusual localization in the monopolar growth mutant orb2-34, which carries a non-let

62 orb2-34 allele of shk1 exhibit a pattern of monopolar growth similar to that observed in tea1 Delta

63 The deltawsh3 mutant shows monopolar growth with abnormal Tea1 aggregate at the non

64 regulates the mitotic exit network (MEN) and monopolar homolog orientation in meiosis I.

65 or input, whereas amacrine cells are usually monopolar inhibitory interneurons with synapses almost e

66 ver, as spindles assemble through a perilous monopolar intermediate.

67 We identified a monopolar interneuron in the mouse retina that resembles

68 These glutamatergic monopolar interneurons (GluMIs) do not receive direct ph

69 a new treatment modality which replaces the monopolar IRE pulses with a burst of bipolar pulses, has

70 etraploids have a high incidence of syntelic/monopolar kinetochore attachments to the spindle pole.

71 Moreover, reducing KLP-7 function in monopolar klp-18(-) mutants often restored spindle bipol

72 into 11 major subgroups representing lamina monopolar (L), medulla intrinsic (Mi, Mt), bushy T (T),

73 pends on the hydrocarbon chain length of the monopolar lipid and the bolalipid concentration.

74 mismatch between hydrophobic regions of the monopolar lipid hydrocarbon chains and the membrane-span

75 phobic thicknesses of the pure bolalipid and monopolar lipid layers.

76 In the monopolar lipid-rich phase, bolalipids are the minor com

77 riving force for the phase separation in the monopolar lipid/bolalipid mixture is the packing mismatc

78 ipid layer that is a mixture of conventional monopolar lipids and C20 bipolar bolalipids was studied

79 s the length of the hydrocarbon chain of the monopolar lipids, was probed.

80 h: after cell division, they grow first in a monopolar manner at the old end, and in G2 phase, initia

81 elta and bud6Delta cells generally grow in a monopolar manner but exhibit different growth patterns.

82 esoderm explants, neural plate cells express monopolar medially directed motility and notoplate cells

83 absence of the notochord, the characteristic monopolar, medially directed behavior occurred, but only

84 nd determine whether it alone can induce the monopolar, medially directed cell behavior.

85 overlying notoplate were found to induce the monopolar, medially directed protrusive activity of deep

86 mesoderm, lateral neural plate cells show a monopolar, medially directed protrusive activity.

87 r3p, meiotic cells are blocked with prophase monopolar microtubule arrays and incomplete synaptonemal

88 Inhibition of Eg5 resulted in monopolar microtubule arrays emanating from chromatin be

89 Furthermore, we show that the formation of monopolar microtubule arrays in human cell extracts does

90 calizes to actin cables in a gap between the monopolar midzone and the furrow-like cortex, suggesting

91 -dense material and resemble similar foci in monopolar midzones in cells.

92 lso compromised, mps1-1 cells proceed with a monopolar mitosis and rapidly lose viability.

93 early in SPB duplication and proceed through monopolar mitosis with lethal consequences.

94 ter forced mitotic exit, the cytoskeleton of monopolar mitotic cells is initially radially symmetric

95 at of paclitaxel and caused the formation of monopolar mitotic figures identical to those produced in

96 cut12.1 mutants form a monopolar mitotic spindle, chromosome segregation fails,

97 First, monopolar mitotic spindles form.

98 o the skin, either non- or invasively, via a monopolar mode that utilizes an active electrode and a g

99 es as well as, in some instances, the normal monopolar morphology of the P cell becoming multipolar.

100 triggered (RT) bipolar (BP) sequence, (b) RT monopolar (MP) sequence, (c) free-breathing (FB) BP sequ

101 el partial tripolar (pTP) and (b) 14-channel monopolar (MP), and four variable-channel programs, deri

102 becomes fragmented at meiosis I, leading to monopolar, multiple, and mislocalized spindles.

103 dy (SPB), which becomes enlarged as in other monopolar mutants.

104 al circuits that includes the cholinergic L2 monopolar neurons from the lamina.

105 Parvalbumin neurons were mainly round monopolar neurons, especially common in the superficial

106 as control cells had long, radially oriented monopolar or bipolar neurites.

107 We found that Eg5 inhibition led to either monopolar or bipolar spindle formation, depending on whe

108 Kif2b-deficient cells assemble monopolar or disorganized spindles.

109 ing the relative stability of bipolar versus monopolar organization.

110 the orb2-34 allele of shk1, Rga8 exhibits a monopolar pattern of localization, providing evidence th

111 We show that the cut12.1 monopolar phenotype arises from a failure to activate an

112 rast to other monopolar-growing mutants, the monopolar phenotype of the orb2-34 mutant might not be d

113 4 in the Deltapom1 mutant contributes to its monopolar phenotype.

114 expansion coefficients are within 20% of the monopolar phospholipid, DLPC.

115 d the dorsal midline using medially directed monopolar protrusions.

116 dodermal cells within these explants display monopolar protrusive activity and radially intercalate d

117 lateral edge of these explants restores the monopolar protrusive activity over the entire extent of

118 RE uses ultra-short duration, high-intensity monopolar pulsed electric fields to permanently disrupt

119 s which uses short (50-100 mus) high voltage monopolar pulses to disrupt the membranes of cells withi

120 ritic structures, four types of SCN neurons (monopolar, radial, simple bipolar and curly bipolar) wer

121 Monopolar radiofrequency energy was delivered to a lapar

122 discharge pattern (less than 1 ms apart) in monopolar recordings from electrodes placed in the corte

123 Each animal was implanted with three monopolar/referential electrodes chosen among the follow

124 , tumors were treated with (a) conventional, monopolar RF (250 mA +/- 25 [SD] at 70 degrees C +/- 1 f

125 o four experimental groups: (a) conventional monopolar RF (70 degrees C for 5 minutes) alone, (b) lip

126 ors each were treated with (a) conventional, monopolar RF (96 mA +/- 28; 70 degrees C for 5 minutes);

127 , tumors were treated with (a) conventional, monopolar RF (mean, 250 mA +/- 25 [SD] at 70 degrees C +

128 Conclusion Unlike monopolar RF ablation, change in portal vein flow rates

129 o four experimental groups: (a) conventional monopolar RF alone (70 degrees C for 5 min), (b) IV lipo

130 A 17-gauge monopolar RF probe was inserted into the pancreas with M

131 to a thin bolalipid-rich layer and a thicker monopolar-rich layer.

132 ard current showed four types of morphology: monopolar, simple bipolar, curly bipolar and radial shap

133 py and computational alignment, we find that monopolar sperm asters do not show evidence for flux, pa

134 We found that the checkpoint protein kinase monopolar spindle 1 (Mps1) directly bound to Ndc80C thro

135 The dual-specificity protein kinase monopolar spindle 1 (Mps1) is a central component of the

136 Monopolar spindle 1 (Mps1) is a dual-specificity protein

137 Monopolar spindle 1 (Mps1) is essential for the spindle

138 e checkpoint as a consequence of stabilizing monopolar spindle 1 (Mps1) levels in human melanoma cell

139 Monopolar spindle 1 (MPS1) plays a central role in the t

140 nked by Lox mutation was introduced into the monopolar spindle 1 (Mps1) spindle-assembly checkpoint g

141 Monopolar spindle 1 (Mps1/TTK) is a protein kinase essen

142 Monopolar spindle 1 (Mps1; also known as TTK protein kin

143 Thr/Tyr kinase (TTK)/monopolar spindle 1 kinase (Mps-1) is a kinase of the sp

144 the proper localization of the kinase Mps1 (monopolar spindle 1) is critical to both these processes

145 spd1 (heat shock 60-kDa protein 1) and mps1 (monopolar spindle 1), were up-regulated.

146 t arrest with an intact Golgi clustered at a monopolar spindle and an active spindle assembly checkpo

147 vation results in force imbalance leading to monopolar spindle and chromosome segregation failure.

148 and microtubule severing--both contribute to monopolar spindle assembly in klp-18(-) mutants.

149 ntrast, sequester centrosomal NEK2 and mimic monopolar spindle defects induced by a dominant negative

150 bsequent gamma-tubulin sorting, resulting in monopolar spindle formation and cell cycle arrest in mei

151 Here, we use controlled monopolar spindle formation to systematically define the

152 gives partial rescue of tubulin instability, monopolar spindle formation, and loss of centrosomes, le

153 e of human KSP, can cause mitotic arrest and monopolar spindle formation.

154 on and growth of microtubules and results in monopolar spindle formation.

155 l proliferation failure, mitotic arrest, and monopolar spindle formation.

156 ntrosome separation is reduced, resulting in monopolar spindle formation.

157 ng as well as to investigate the role of the monopolar spindle in cytokinesis.

158 Both mutants exhibit defective monopolar spindle microtubules that emanate from the mot

159 cells and elevated Cdc25 levels suppress the monopolar spindle phenotype of cut12.1 loss of function

160 Yeast MPS1 (monopolar spindle) is required for spindle pole duplicat

161 ed open reading frame that we call MPS3 (for monopolar spindle).

162 The monopolar spindle-one-binder (Mob) family of kinase-inte

163 uplicate but do not separate, resulting in a monopolar spindle.

164 28 kinase activity despite the presence of a monopolar spindle.

165 PA-1 inhibits cell proliferation and induces monopolar-spindle formation in tumor cells.

166 r spindles (most ESCRT-III/VPS4 proteins) or monopolar spindles (CHMP2A or CHMP5) and causing defects

167 Mos, requires the spindle-checkpoint kinase monopolar spindles 1 (Mps1), a cyclin E-Cdk2 target that

168 Monopolar spindles accumulated as a result of defective

169 Cells overexpressing NDC1 arrest with monopolar spindles and exhibit increase-in-ploidy phenot

170 investigated the cause for the formation of monopolar spindles and found that only one of the two sp

171 spindle assembly; its suppression results in monopolar spindles and mitotic arrest.

172 haracterized by the formation of tripolar or monopolar spindles and nondisjunction of homologous chro

173 S to activate Kif2a are injected into cells, monopolar spindles are generated.

174 aneuploid cells and, in the case of aurora, monopolar spindles arising from a failure in centrosome

175 In vivo, centrosomes fail to separate and monopolar spindles assemble without Eg5 activity.

176 mps3-1 mutants arrest in mitosis with monopolar spindles at the nonpermissive temperature, sug

177 crotubules in Xenopus egg extracts remain as monopolar spindles attached to condensed chromosomes aft

178 egradable CKAP2 led to a mitotic arrest with monopolar spindles containing highly bundled microtubule

179 y experiments in vitro also showed that only monopolar spindles formed in Xenopus egg extracts supple

180 some increase in the formation of cells with monopolar spindles in HeLa cells but not in human diploi

181 nd complete loss of BimC function results in monopolar spindles that have two spindle poles that are

182 ly 0.5 microm/min, the same rate measured in monopolar spindles that lack antiparallel MTs.

183 how, by inducing mammalian tissue cells with monopolar spindles to enter anaphase, that furrow format

184 ficient in HBXIP arrest in prometaphase with monopolar spindles whereas HBXIP overexpression causes t

185 e-depolymerizing kinesins initially produced monopolar spindles with abnormally long microtubules, bu

186 n of mitosis in Eg5 inhibitors, which induce monopolar spindles without disrupting MT dynamics, was t

187 le with large buds, a G2 content of DNA, and monopolar spindles, although this phenotype can vary dep

188 ryos caused cleavage arrest and formation of monopolar spindles, an effect previously seen in embryos

189 mitotic microtubules, high rate of transient monopolar spindles, and subsequent high rate of chromoso

190 ts from excess XKCM1 included monoastral and monopolar spindles, as well as small prometaphase-like s

191 or addition of inactive Aur-A, which lead to monopolar spindles, delays but does not block mitotic en

192 d bipolar spindles into pairs of independent monopolar spindles, demonstrating the role of sister chr

193 kinesin Eg5 in hTPX2-depleted cells leads to monopolar spindles, indicating that Eg5 function is nece

194 acking both TOGp and MCAK formed bipolar and monopolar spindles, indicating that TOGp and MCAK contri

195 abilizing drug paclitaxel (taxol), including monopolar spindles, or complete lack of a mitotic spindl

196 In two-cell-stage embryos harboring abnormal monopolar spindles, SPDL-1 is required to induce the SAC

197 Similarly, oocytes exhibiting monopolar spindles, via inhibition of aurora B or Eg5 ki

198 a SH-SY5Y cell lines is sufficient to induce monopolar spindles.

199 n through mitotic arrest and accumulation of monopolar spindles.

200 d works by arresting cells in mitosis due to monopolar spindles.

201 ll cycle progression because cells assembled monopolar spindles.

202 te when Kid is perturbed in cells containing monopolar spindles.

203 ol, arrested mammalian cells in mitosis with monopolar spindles.

204 arrest of cleavage that was associated with monopolar spindles.

205 d a concomitant increase in the frequency of monopolar spindles.

206 letion of Nup98 leads to formation of stable monopolar spindles.

207 sustained polarized growth; most cells have monopolar spindles.

208 For behavioral pharmacological experiments, monopolar stimulating electrodes were implanted in the m

209 Monopolar stimulating electrodes were implanted into lat

210 Monopolar stimulating electrodes were implanted into sit

211 Monopolar stimulating electrodes were implanted into the

212 In the first phase of the study, monopolar stimulating electrodes were implanted into the

213 Monopolar stimulating electrodes were placed in the midb

214 Finally, in a monopolar stimulation configuration, the differences bet

215 ll psychophysical testing was performed in a monopolar stimulation mode (MP 1 + 2).

216 l near the behavioral threshold, at least in monopolar stimulation.

217 B-INCENP, led to assembly of mono-astral and monopolar structures instead of bipolar spindles.

218 and the resecting loop are different to the monopolar system, the resection technique is very simila

219 nds of its cylindrical cells switches from a monopolar to a bipolar mode, before it ceases during mit

220 ltiple mechanisms underlying the switch from monopolar to bipolar chromosome attachment between the m

221 , a condition known to delay transition from monopolar to bipolar growth (termed NETO [new end takeof

222 Take-Off (NETO), the normal transition from monopolar to bipolar growth.

223 However, an ultrasensitive monopolar-to-bipolar transition in spindle architecture

224 rior hemostatic outcomes compared to classic monopolar transurethral resection of the prostate.