ライフサイエンスコーパス: monoubiquitination

1 ubiquitin chain elongation and directs Rim8 monoubiquitination.

2 oting nucleosome reassembly coupled with H2B monoubiquitination.

3 , chromosome aberrations, and reduced FANCD2 monoubiquitination.

4 ntering endogenous lesions in the absence of monoubiquitination.

5 ed a significant reduction in H2A lysine 119 monoubiquitination.

6 ortant role in the regulation of H2A Lys-119 monoubiquitination.

7 gulated by Pirh2 E3 ubiquitin ligase through monoubiquitination.

8 protein Dam1 by Set1 similarly requires H2B monoubiquitination.

9 ed by DNA damage-induced phosphorylation and monoubiquitination.

10 action with Rad18 but is independent of PCNA monoubiquitination.

11 s well as the activity to down-regulate PCNA monoubiquitination.

12 r other alternative RFCs did not affect PCNA monoubiquitination.

13 in promoting DNA repair, independent of its monoubiquitination.

14 eir resistance to MMC re-establishing FANCD2 monoubiquitination.

15 BMs) of the polymerases and enhanced by PCNA monoubiquitination.

16 ear import of FANCD2, a prerequisite for its monoubiquitination.

17 ls via a mechanism that is dependent on PCNA monoubiquitination.

18 kes place following and independently of H2B monoubiquitination.

19 indin and its E2 enzyme but was defective in monoubiquitination.

20 f FANCL and FANCI in the catalysis of FANCD2 monoubiquitination.

21 that PTEN nuclear import is mediated by its monoubiquitination.

22 equired for a function independent of FANCD2 monoubiquitination.

23 ex is recruited before or after the critical monoubiquitination.

24 rt proliferation cell nuclear antigen (PCNA) monoubiquitination.

25 erminus of SMN(K0) and thereby mimicking SMN monoubiquitination.

26 hway, and localizes to ICLs dependent on its monoubiquitination.

27 in early FA genes with the absence of FANCD2 monoubiquitination.

28 tes, resulting in an efficient site-specific monoubiquitination.

29 ng activity compromise DNA-stimulated FANCD2 monoubiquitination.

30 lex and biochemical reconstitution of FANCD2 monoubiquitination.

31 measured by the Fanconi D2 protein (FANCD2) monoubiquitination.

32 en proposed to function downstream of FANCD2 monoubiquitination, a critical event in the FA pathway.

33 nds to both Rad18 and PCNA and promotes PCNA monoubiquitination, a function unique to Poleta among Y-

34 8 and FAAP20 are needed for efficient FANCD2 monoubiquitination, a key step of the FA network; RNF8 a

35 and is also inefficient in promoting FANCD2 monoubiquitination, a key step of the Fanconi anemia pat

36 While monoubiquitination activates mutagenic translesion synth

37 Residual FANCD2 monoubiquitination activity is retained in cells defecti

38 ctional interplay is disabled, switching its monoubiquitination activity toward a polyubiquitination

39 H2A monoubiquitination acts to prevent FACT recruitment at t

40 Monoubiquitination aids in the nuclear export and entran

41 crease of Taf1 results in a decrease in Pax3 monoubiquitination, an increase in the levels of Pax3 pr

42 t the ability for RNF168 to promote H2A/H2AX monoubiquitination and 53BP1 IRIF, but not RNF168 self-a

43 more, addition of the FANCI protein enhances monoubiquitination and also restricts it to the in vivo

44 2) targets the key enzyme, CCTalpha, for its monoubiquitination and degradation, thereby reducing syn

45 A critical step in this pathway is the monoubiquitination and deubiquitination of FANCD2.

46 Monoubiquitination and deubiquitination of FANCD2:FANCI

47 Exchange of histone H2A monoubiquitination and deubiquitination reflects the suc

48 d MHF2, (2) impairment of DNA damage-induced monoubiquitination and foci formation of FANCD2, (3) def

49 The misregulation of histone H2B monoubiquitination and H3K4 methylation result in the pa

50 PCNA monoubiquitination and TLS in a FANCD2 monoubiquitination and HR-independent manner in response

51 Finally, we find that Deltex2 causes Jmjd1c monoubiquitination and inhibits its demethylase activity

52 Monoubiquitination and nuclear foci formation of FANCD2

53 es S-phase and DNA damage-inducible FANCD2/I monoubiquitination and nuclear foci formation.

54 n remains competent for DNA damage-inducible monoubiquitination and phosphorylation.

55 nterstrand cross-links independently of PCNA monoubiquitination and Poleta, whereas RAD18 plus Poleta

56 ass spectrometry analysis revealed that both monoubiquitination and polyubiquitination (via both K48-

57 silencing caused suppression of beta-catenin monoubiquitination and polyubiquitination, and transcrip

58 TLS and TS depend on site-specific PCNA K164 monoubiquitination and polyubiquitination, respectively.

59 that levels of Pax3 protein are regulated by monoubiquitination and proteasomal degradation during po

60 of Pax7 rendered that protein susceptible to monoubiquitination and proteasomal degradation.

61 -catalytic role for Poleta in promoting PCNA monoubiquitination and provide a new potential mechanism

62 athway, an upstream FA core complex mediates monoubiquitination and recruitment of the central FANCD2

63 Following UV, HLTF enhances PCNA monoubiquitination and recruitment of TLS polymerase eta

64 the ~300 kilodalton ID complex reveals that monoubiquitination and regulatory phosphorylation sites

65 gs highlight an E3-independent mechanism for monoubiquitination and reveal mechanistic details of SET

66 The UBZ4 motif is required for PCNA monoubiquitination and survival after UV damage.

67 nal region of Pax3 reduced the extent of its monoubiquitination and susceptibility to proteasomal deg

68 Here, we show that H-Ras is activated by monoubiquitination and that ubiquitination at Lys-117 ac

69 in the FA pathway at both signaling through monoubiquitination and the ensuing DNA repair.

70 We found that depletion of MSH2 impairs PCNA monoubiquitination and the formation of foci containing

71 the FA nuclear core complex, regulate FANCD2 monoubiquitination and the telomeric localization of FAN

72 CD2 and RAD51 have an important role in PCNA monoubiquitination and TLS in a FANCD2 monoubiquitinatio

73 or proliferating cell nuclear antigen (PCNA) monoubiquitination and TLS polymerase recruitment; howev

74 APC/C(Cdh1) in modulating the status of PCNA monoubiquitination and UV DNA repair before S phase entr

75 ubunits (PSMD4, PSMD14, and PSMB3) inhibited monoubiquitination and/or nuclear foci formation of FANC

76 Furthermore, this mutant accumulates H2B monoubiquitination, and has decreased levels of H3K36 tr

77 e of a proper DNA ligand in FANCD2 and FANCI monoubiquitination, and reveal regulatory mechanisms tha

78 inducing proliferating cell nuclear antigen monoubiquitination, and suppressing mutagenesis.

79 ) cells and that gammaH2AX, PCNA, and FANCD2 monoubiquitinations are induced by oxaliplatin in parent

80 nd RAD18, the E3 ligase responsible for PCNA monoubiquitination, are specifically required for ATM si

81 ese experiments identify RAD18-mediated PCNA monoubiquitination as a central hub for the mobilization

82 Our results illustrate monoubiquitination as a reversible regulatory mechanism

83 ding to ubiquitinated targets, and permanent monoubiquitination, as mimicked by a ubiquitin-UCH-L1 fu

84 showed that USP7 is also a key regulator for monoubiquitination at H2A Lys-119 as both knockdown and

85 recruitment of 53BP1 to DNA damage and H2AX monoubiquitination at K13/15.

86 ism of Ras activation is distinct from K-Ras monoubiquitination at Lys-147, which leads to impaired r

87 and/or WW and Hect domains that favors WWP1 monoubiquitination at the expense of its polyubiquitinat

88 related with increased levels of histone H2B monoubiquitination, at the reelin promoter.

89 Human Bre1, an E3 ligase for H2B monoubiquitination, binds p53 and enhances activator-dep

90 is dispensable for ICL unhooking and FANCD2 monoubiquitination but is essential for HR, confirming t

91 USP1 ablation increases FANCD2 and PCNA monoubiquitination but unexpectedly results in DNA cross

92 absence of FANCD2, DNA also stimulates FANCI monoubiquitination, but in a FANCL-independent manner.

93 ed for the maintenance of high levels of H2B monoubiquitination, but not for H3K4 and H3K79 trimethyl

94 FL118 inhibits p53 polyubiquitination and monoubiquitination by Mdm2-MdmX E3 complex in cells and

95 First, we determined that PCNA monoubiquitination by RAD18 is necessary for efficient b

96 Second, we showed that in addition to PCNA monoubiquitination by RAD18, the Fanconi anemia core com

97 maging agents elicits lysine 164-linked PCNA monoubiquitination by Rad6-Rad18.

98 Histone H2B monoubiquitination by Rad6/Bre1 is required for both H3K

99 Histone H2B monoubiquitination by Rad6/Bre1 is required for the trim

100 Whereas monoubiquitination by Rad6/Rad18 mediates TLS, extension

101 esting that USP7 facilitates UV-induced PCNA monoubiquitination by stabilizing Poleta.

102 Among these is monoubiquitination, catalyzed by the NEDD4 family ubiqui

103 Although monoubiquitination commonly confers nondegradative activ

104 The ID2 complex is a poor substrate for monoubiquitination, consistent with the published crysta

105 Here, we demonstrate that histone H2B monoubiquitination controls the binding of Cps35 with CO

106 reas HSV-1 productive growth was impaired in monoubiquitination-defective FA cells, this restriction

107 by specialized DNA polymerases in both PCNA monoubiquitination-dependent and -independent fashions.

108 In this review, the process of histone H2B monoubiquitination-dependent and -independent histone H3

109 atin of COMPASS-regulated genes in a H2BK123 monoubiquitination-dependent but Set1-independent manner

110 ferases; however, dSet1/COMPASS is the major monoubiquitination-dependent H3K4 di- and trimethylase i

111 ogether, our findings demonstrate a distinct monoubiquitination-dependent mechanism that is required

112 Monoubiquitination did not cause Gsk3beta degradation no

113 t be degraded via APC/C(Cdh1) inhibited PCNA monoubiquitination during G1, likely compromising the re

114 cellular activator that converts Mdm2 from a monoubiquitination E3 ligase to a polyubiquitination E3

115 a ubiquitin-APE1 fusion gene suggested that monoubiquitination enhanced the gene suppression activit

116 ork serves as the trigger for the activating monoubiquitination event.

117 Simple monoubiquitination events coexist with more complex form

118 n a FANCE-deficient cell line, allows FANCD2 monoubiquitination, FANCD2 foci assembly, and normal S-p

119 to di- and trimethylation requires prior H2B monoubiquitination followed by recruitment of the Cps35

120 hocyte priming through removal of inhibitory monoubiquitination from ZAP70.

121 unravel a unique molecular mechanism whereby monoubiquitination governs the trafficking and life span

122 sed chromosomal aberrations, enhanced FANCD2 monoubiquitination, H2AX phosphorylation, p53 activation

123 methylation of histone H3 Lys4 (H3K4) by H2B monoubiquitination (H2Bub) has been widely studied, with

124 Histone H2B monoubiquitination (H2Bub1) is centrally involved in gen

125 In contrast, persistent PCNA monoubiquitination has negligible impact on DNA repair o

126 The cellular regulation of FANCD2/I monoubiquitination, however, remains poorly understood.

127 ures of FA cells, including defective FANCD2 monoubiquitination, hypersensitivity to DNA crosslinking

128 ow that the H2AX K120R mutant abolishes H2AX monoubiquitination, impairs the recruitment of p-ATM (Se

129 Here we report that Stx3 undergoes monoubiquitination in a conserved polybasic domain.

130 These data reveal a new role for monoubiquitination in controlling Rad18 function and sug

131 genitors and an unrecognized role of protein monoubiquitination in mediating proteasomal degradation.

132 ed proliferating cell nuclear antigen (PCNA) monoubiquitination in Poleta-proficient but not in Polet

133 ni anemia (FA) core complex, promotes FANCD2 monoubiquitination in response to DNA damage, and suppre

134 51, but not BRCA2, is also required for PCNA monoubiquitination in response to HU, suggesting that th

135 ng proliferating cell nuclear antigen (PCNA) monoubiquitination in response to ultraviolet (UV) damag

136 hase and interacted with PCNA to promote its monoubiquitination in response to UV-induced damage for

137 capsid protein) was found to be targeted for monoubiquitination in transfected mammalian cells.

138 promote efficient DNA damage-induced FANCD2 monoubiquitination in vertebrate cells, suggesting an im

139 nction as an E3 ubiquitin ligase to activate monoubiquitination in vitro of Jagged1, but not other ma

140 ound to target histone H2B at lysine 120 for monoubiquitination in vitro.

141 CL and Ube2T, and is not required for FANCD2 monoubiquitination in vitro.

142 This monoubiquitination, in turn, contributes to the activity

143 formation without detectable changes in PCNA monoubiquitination, indicating that MSH2 can regulate po

144 In sum, histone H2B monoubiquitination is an important chromatin modificatio

145 Importantly, FANCI and FANCD2 monoubiquitination is co-dependent, suggesting a novel m

146 x-independent manner, suggesting that FANCD2 monoubiquitination is dispensable for its interaction wi

147 The resulting constitutive lysine-867 monoubiquitination is essential for SETDB1's enzymatic a

148 Here we show that Pax3 monoubiquitination is mediated by the ubiquitin-activati

149 ires FANCD2 deubiquitination, whereas FANCD2 monoubiquitination is not dependent on USP1 autocleavage

150 However, the loss of H2B monoubiquitination is not suppressed by this mutation, w

151 required for this enhanced interaction, its monoubiquitination is not.

152 patients, inactivation of PolH by Pirh2 via monoubiquitination is one of the mechanisms by which Pol

153 Ube2t and the FANCL protein, revealing that monoubiquitination is stimulated by a conserved RWD-like

154 tion of Bre1, the E3 ligase required for H2B monoubiquitination, leads specifically to reduced bulk H

155 to have a substantial effect on histone H2B monoubiquitination levels or COMPASS and Paf1 complex ph

156 Our study demonstrates that the monoubiquitination machinery and Cps35/Swd2 function to

157 ubiquitin and the NLS, we show that CCTalpha monoubiquitination masks its NLS, resulting in cytoplasm

158 t, indicate that deregulation of histone H2B monoubiquitination may contribute to cancer development.

159 ve normal levels of H3K4me3, suggesting that monoubiquitination may not directly stimulate COMPASS bu

160 B, FANCL, and FAAP100) that functions as the monoubiquitination module.

161 ycin C and ionizing radiation induced FANCD2 monoubiquitination, neither could induce the association

162 Therefore, monoubiquitination not only is a prerequisite for degrad

163 e FA core ubiquitin ligase complex-dependent monoubiquitination of 2 interacting FA proteins, FANCI a

164 clear complex (FA core complex) required for monoubiquitination of a downstream FA protein, FANCD2.

165 We show MID1-dependent monoubiquitination of alpha4 triggers calpain-mediated c

166 says, individual MID1 E3 domains facilitated monoubiquitination of alpha4, whereas full-length MID1 a

167 raction occurs in the cytoplasm and requires monoubiquitination of an evolutionarily conserved lysine

168 ecular Cell now describes the E3-independent monoubiquitination of certain proteins.

169 Monoubiquitination of CHIP by Ube2w stabilizes the inter

170 Expression of CDK5 enhanced monoubiquitination of endogenous APE1.

171 tivation in HSV-1-infected cells resulted in monoubiquitination of FA effector proteins FANCI and FAN

172 a and Rad3-related (ATR) kinase, followed by monoubiquitination of FANCD2 and FANCI by the FA core co

173 the FA core complex that is responsible for monoubiquitination of FANCD2 and FANCI.

174 stalled replication forks by catalyzing the monoubiquitination of FANCD2 and FANCI.

175 complex functions as a signaling machine for monoubiquitination of FANCD2 and FANCI.

176 eins (A/B/C/E/F/G/L/M), is essential for the monoubiquitination of FANCD2 and FANCI.

177 sslinking drug, mitomycin C, but not for the monoubiquitination of FANCD2 and FANCI.

178 le the FA E3 ligase complex, which catalyzes monoubiquitination of FANCD2 and is essential for replic

179 Monoubiquitination of FANCD2 and PCNA promotes DNA repai

180 form a core enzyme complex, required for the monoubiquitination of FANCD2 and the assembly of FANCD2

181 A critical step in the pathway is the monoubiquitination of FANCD2 by the RING E3 ligase FANCL

182 NA translocase (FANCM), and is essential for monoubiquitination of FANCD2 in response to DNA damage.

183 However, depletion of Tip60 did not reduce monoubiquitination of FANCD2 or its localization to nucl

184 However, how monoubiquitination of FANCD2 promotes ICL repair at the

185 s were hypersensitive to MMC and MMC-induced monoubiquitination of FANCD2 was impaired.

186 The FA core complex catalyzes the monoubiquitination of FANCD2, and this event is essentia

187 that the proteasome function is required for monoubiquitination of FANCD2, foci formation of 53BP1, p

188 Central to this pathway is the monoubiquitination of FANCD2, which coordinates multiple

189 int kinase ATR is required for the efficient monoubiquitination of FANCD2, while another checkpoint k

190 in-binding domain (UBZ), the ID complex, and monoubiquitination of FANCD2.

191 that dsDNA ends are not required to trigger monoubiquitination of FANCD2.

192 critical event in activating this pathway is monoubiquitination of FANCD2.

193 Like FANCD2, monoubiquitination of FANCI requires the FA core complex

194 ubiquitination, which significantly precedes monoubiquitination of FANCI; moreover, monoubiquitinatio

195 on to evaluate S phase checkpoint integrity, monoubiquitination of Fanconi protein D2, ATM protein ex

196 found that Wnt stimulation induced prolonged monoubiquitination of Gsk3beta and Gsk3beta-beta-TrCP in

197 Rather, increased monoubiquitination of Gsk3beta/Gsk3beta-beta-TrCP associ

198 2A-HUB catalyzes monoubiquitination of H2A at lysine 119, functioning as

199 demonstrate that UbE2E1 is critical for the monoubiquitination of H2A at residue Lys-119 (uH2AK119)

200 idic patch on histone H4 to achieve specific monoubiquitination of H2A.

201 A damage response (DDR) factor that promotes monoubiquitination of H2A/H2AX at K13/15, facilitates re

202 damage-dependent manner and is required for monoubiquitination of H2AX at Lys(119)/Lys(120).

203 Mechanistically, we show that monoubiquitination of H2AX induced by RING finger protei

204 Our study therefore suggests that monoubiquitination of H2AX is an important step for DNA

205 Here, we show that monoubiquitination of H2AX is induced upon DNA double st

206 Here we show that monoubiquitination of H2AX mediated by the RNF2-BMI1 com

207 These data suggest that monoubiquitination of H2AX plays a critical role in init

208 Importantly, a defect in monoubiquitination of H2AX profoundly enhances ionizing

209 ency of methylation at H3K4 and H3K79 on the monoubiquitination of H2BK123 was recently challenged, a

210 Monoubiquitination of histone H2A (H2AUb1) is a reversib

211 1 (PRC1) mediates gene silencing, in part by monoubiquitination of histone H2A on lysine 119 (uH2A).

212 of covalent histone modifications, including monoubiquitination of histone H2A, and the molecular mec

213 ent of polycomb repressive complex 1 and the monoubiquitination of histone H2A.

214 on of histone H3K4 and H3K79 is dependent on monoubiquitination of histone H2B (H2B-Ub).

215 We previously showed that monoubiquitination of histone H2B (ubH2B) is highly dyna

216 We show that Smurf2 regulates the monoubiquitination of histone H2B as well as the trimeth

217 trimethylation of H3K79 by Dot1 requires the monoubiquitination of histone H2B by the Rad6/Bre1 compl

218 litation of GGR is achieved through enabling monoubiquitination of histone H2B lysine 123 by Bre1, wh

219 Monoubiquitination of histone H2B on Lys 123 (H2BK123ub)

220 Monoubiquitination of histone H2B plays a central role i

221 r yeast homolog Bre1 as ubiquitin ligases in monoubiquitination of histone H2B.

222 he Set1 methyltransferase and requires prior monoubiquitination of histone H2B.

223 onal essential and more specific role in the monoubiquitination of histone H2B.

224 (E2) UBE2T and ubiquitin ligase (E3) FANCL, monoubiquitination of human FANCD2 and FANCI was examine

225 e defects of these mutants in both poly- and monoubiquitination of IkappaBalpha, supporting a role fo

226 Cdc34(E108A/E112A) abolished both poly- and monoubiquitination of IkappaBalpha.

227 We conclude that Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and

228 f either FANCI or FANCD2 is known to prevent monoubiquitination of its respective partner, it is uncl

229 enzymatic behaviors: Ubc4 supports the rapid monoubiquitination of multiple lysines on APC targets, w

230 09 back to the Otub1(K0) mutant restores the monoubiquitination of Otub1 and its function to stabiliz

231 T tag and non-GST-tagged Mdm2 only catalyzes monoubiquitination of p53 even at extremely high concent

232 a-dependent lesion bypass or RAD18-dependent monoubiquitination of PCNA are not necessary to promote

233 In this review, we focus on the monoubiquitination of PCNA by Rad6/Rad18 and summarize t

234 ellular DNA replication processes as well as monoubiquitination of PCNA in response to UV damage.

235 Moreover, RAD18-dependent monoubiquitination of PCNA is required for Mitomycin C a

236 quitin ligase, which activates TLS repair by monoubiquitination of PCNA, is also affected by BPLF1 de

237 biquitin-conjugation enzyme, is required for monoubiquitination of Pex20.

238 Importantly, while monoubiquitination of poleta precludes its ability to in

239 Moreover, we show that monoubiquitination of PolH alters the ability of PolH to

240 We also show that monoubiquitination of PolH inhibits the ability of PolH

241 Monoubiquitination of proliferating cell nuclear antigen

242 both the stalling of the holoenzyme and the monoubiquitination of proliferating cell nuclear antigen

243 -damaging agents elicits Rad6-Rad18-mediated monoubiquitination of proliferating cell nuclear antigen

244 hat are able to bind ubiquitin and to direct monoubiquitination of RAP80.

245 protein complex 2 (AP2)-clathrin molecules, monoubiquitination of receptors has emerged as a major e

246 Monoubiquitination of SMN has a mild effect on promoting

247 discover that Itch monoubiquitinates SMN and monoubiquitination of SMN plays an important role in reg

248 Here, we reveal the mechanism by which monoubiquitination of specific H2A lysine residues alter

249 Therefore, monoubiquitination of Syn5 in early mitosis disrupts SNA

250 rent models suggest that TLS is activated by monoubiquitination of the DNA sliding clamp PCNA.

251 (FA proteins A/B/C/E/F/G/L/M) that mediates monoubiquitination of the downstream targets FANCD2 and

252 vation of the FA-BRCA pathway occurs via the monoubiquitination of the FANCD2 and FANCI proteins, tar

253 UV-induced monoubiquitination of the FANCD2 protein and formation o

254 oteins form a ubiquitin ligase that controls monoubiquitination of the FANCD2 protein in an ATR-depen

255 A critical step is the monoubiquitination of the FANCD2 protein, and cells from

256 umor suppressor pathway is the site-specific monoubiquitination of the FANCD2 protein.

257 522, is a critical residue for mediating the monoubiquitination of the FANCD2-FANCI complex.

258 At the heart of this pathway is the monoubiquitination of the FANCI-FANCD2 (ID) complex by t

259 as ubiquitin ligase activity responsible for monoubiquitination of the FANCI-FANCD2 (ID) complex, whi

260 n studies, we found that C/EBPdelta promotes monoubiquitination of the Fanconi anemia complementation

261 ollectively, these findings suggest that the monoubiquitination of the PIV5 M protein is important fo

262 cells and in vitro, through Ube2W-catalyzed monoubiquitination of TRIM5alpha.

263 In addition, polyubiquitination (but not monoubiquitination) of MuRF1 allowed S5a to bind to MuRF

264 e show that Ufd2p catalyses K48-linked multi-monoubiquitination on K29-linked ubiquitin chains assemb

265 tabilizes BCLb protein, while also promoting monoubiquitination on multiple lysine residues and reloc

266 ectly binds to BRCA2, did not inhibit FANCD2 monoubiquitination or foci formation.

267 tiated by proliferating cell nuclear antigen monoubiquitination or less well-characterized fork rever

268 nesis, but none of the key regulators of the monoubiquitination process were known.

269 ghts into the Otub1 inhibition of E2 wherein monoubiquitination promotes the interaction of Otub1 wit

270 Depletion of C1orf124 compromises PCNA monoubiquitination, RAD18 chromatin association, and RAD

271 Here, we minimally reconstitute this monoubiquitination reaction with Ube2t and the FANCL pro

272 H3K79 methylation is solely dependent on H2B monoubiquitination regardless of any additional alterati

273 th a model whereby a cycle of Ub binding and monoubiquitination regulates the association of Rabex-5

274 Poliota monoubiquitination remains unchanged after cells are exp

275 In contrast, monoubiquitination requires the entire helicase domain o

276 cedes monoubiquitination of FANCI; moreover, monoubiquitination responses of FANCD2 and FANCI exhibit

277 rotein levels through its ability to mediate monoubiquitination, revealing a critical interaction bet

278 lecular role of Cps35 in translating the H2B monoubiquitination signal into H3 methylation.

279 Mutation of the monoubiquitination site in Jmjd1c abolishes the inhibito

280 Mutation of the monoubiquitination site of FANCD2 (K561R) preserves inte

281 ify this and another lysine residue as major monoubiquitination sites essential for PTEN import.

282 atin colocalization but did not inhibit PCNA monoubiquitination, suggesting that T2AA hinders interac

283 ating cell nuclear antigen (PCNA) and FANCD2 monoubiquitinations (surrogate markers of TLS and FA pat

284 temporal and spatial control of FANCD2:FANCI monoubiquitination that is critical for chemotherapy res

285 zation of FANCI is crucial for robust FANCD2 monoubiquitination, the putative FANCI EDGE motif is imp

286 Cbl-b binds and promotes monoubiquitination to CARMA1, a critical signaling molec

287 ect of the loss of either nuclease on FANCD2 monoubiquitination to determine if the nucleolytic proce

288 tant signaling pathway linking Cbl-b-induced monoubiquitination to NFkappaB activation in NKT cell an

289 tion stress depends on PCNA, which undergoes monoubiquitination to stimulate direct bypass of DNA les

290 ANCE act as substrate receptors and restrict monoubiquitination to the FANCD2:FANCI heterodimer in on

291 one H3 lysine 27 (H3K27) methylation and H2A monoubiquitination (ubH2A) are two closely related histo

292 posttranslational modifications (inhibitory monoubiquitination versus activatory phosphorylation), a

293 PCNA monoubiquitination via CRL4(Cdt2) is constitutively anta

294 To date, all H2B monoubiquitination was attributed to the human homolog o

295 inated and multiubiquitinated forms of ENaC, monoubiquitination was sufficient for Nedd4-2 to reduce

296 e in H3K79 methylation and a decrease in H2B monoubiquitination, which promotes transcription.

297 Dissociation coincides with FANCD2 monoubiquitination, which significantly precedes monoubi

298 Thus, WRNIP1 connects PCNA monoubiquitination with ATMIN/ATM to activate ATM signal

299 Importantly, FANCD2 monoubiquitination within the ID2 complex is strongly st

300 resulted in an increase in the level of PCNA monoubiquitination without affecting the level of FANCD2