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1 inactivated subunit vaccine (ISV) targeting monovalent 2009 pandemic influenza A(H1N1) virus or live
3 er AS03(B)-adjuvanted subunit or whole virus monovalent A(H1N1)pdm09 vaccine and describe the antibod
6 ive K(+) channels, do not discriminate among monovalent alkali cations and are permeable also to seve
7 he divalent GLP-1 analogues were superior to monovalent analogues with respect to control of glucose
8 as implemented and validated for both simple monovalent and biomimetic divalent ligands, which have r
10 aratopic nanobodies were superior over their monovalent and bivalent counterparts in terms of potency
12 o estimate the effect of the introduction of monovalent and bivalent OPV on vaccine-induced serotype-
13 electivity and permeation properties to both monovalent and divalent cations under perfused two-elect
14 on of -0.96 +/- 0.03 and -0.52 +/- 0.01 with monovalent and divalent cations, respectively, and these
17 ge had a relatively low rejection (6-46%) of monovalent and divalent salts, it exhibited a moderate r
20 monovalent (single binding site) Pproxy and monovalent and multivalent (multiple equivalent and inde
21 methods are currently available to study how monovalent and multivalent GAG.protein bonds respond to
22 the one-step fluorescence detection of both monovalent and multivalent proteins has been developed.
23 l model of B cell affinity maturation during monovalent and polyvalent vaccinations that predicts the
26 manner for POPA and PIP2 lipids; and 6) the monovalent anion type has little influence on the lipid
28 CCs) regulate the flow of chloride and other monovalent anions across cellular membranes in response
30 dated using a clinically available blocking, monovalent anti-CD28 antibody (FR104) whose effects in a
31 2009 and 1 October 2011 to mothers receiving monovalent AS03-adjuvanted H1N1 influenza vaccine (Pande
32 requirement for stable immobilization, while monovalent attachment is reversible and, in the case of
33 have predicted and measured varied from the monovalent binding interaction by several orders of magn
34 ce plasmon resonance measurements revealed a monovalent binding mode for the interaction of Pex5p and
37 Here, we describe a new strategy for making monovalent bispecific heterodimeric IgG antibodies in ma
38 ytotoxicity enhancement could be embedded in monovalent bispecific heterodimeric IgG to make best-in-
45 icable, leading to a number of unprecedented monovalent boron species with different Lewis basic grou
46 ab-arm exchange, leading to the formation of monovalent but bispecific antibodies, and it interacts p
47 times lower than those required for similar monovalent catalysts and displays unique kinetic paramet
49 that PFL-AE binds a catalytically essential monovalent cation at its active site, yet another parall
50 centrations within the reported intranuclear monovalent cation concentration range, and are partly co
51 t that shear stress indirectly activates the monovalent cation current carried by transient receptor
55 is selective toward the ionic radius of the monovalent cation, accepting those larger than Na(+).
56 (14C)-citrate anion, as well as the organic monovalent cation, ethidium, but not its divalent analog
59 first time, to our knowledge, that a nuclear monovalent cationic channel (NMCC) is prominently expres
62 e of divalent cations (Ca(2+) and Ba(2+)) as monovalent cations (K(+)), but a viroporin defective mut
64 strongly depend on the cation employed, with monovalent cations (Na(+) and K(+)) leading to the highe
65 nducts Zn(2+), Mg(2+), and Ca(2+) as well as monovalent cations and contains a functional serine/thre
66 Kd approximately 1.6 mM) compared with other monovalent cations and relevant, considering lithium dos
69 ter membrane, whereas LPS in the presence of monovalent cations forms highly mobile negatively-charge
70 ity: (i) PFL-AE in the absence of any simple monovalent cations has little-no activity; and (ii) amon
72 t metals such as Ca(2+), Mg(2+), and Zn(2+), monovalent cations often function as efficient and selec
74 channels in TAL: a cldn10b-based channel for monovalent cations such as Na(+) and a spatially distinc
77 ference interaction site (3D-RISM) model for monovalent cations surrounding DNA and RNA helices, and
80 irst, we employed subsequent replacements of monovalent cations transiently captured within Syt1 Ca(2
81 h selectivity ratios of over 100 and conduct monovalent cations up to 5 times more rapidly than dival
82 ivalent cations are preferentially lost over monovalent cations upon A.C protonation, providing exper
83 been used to characterize the interaction of monovalent cations with 26-basepair DNA oligomers contai
85 cy Mg(2+)-selective channel, fully excluding monovalent cations, and Ca(2+), whereas in absence of Mg
87 may or may not interact preferentially with monovalent cations, depending on the relative number of
88 crystallized in the presence of a variety of monovalent cations, including Na(+), Cs(+), and dimethyl
90 ionally wide filter but is only permeable to monovalent cations; filter residue Gln973 is essential i
91 nd to HIV-infected target cells coupled to a monovalent CD3 binding arm designed to engage cytolytic
94 ypes that were specific to each of the three monovalent components of the trivalent influenza vaccine
95 rimerization that depends on the presence of monovalent copper ions and the sulfhydryl group of Cys46
96 and characterized a series of water-soluble monovalent copper ligands, MCL-1, MCL-2, and MCL-3, that
97 o the vacuolar membrane and are activated by monovalent copper or silver ions and cysteine, showing d
98 functional profile that was unique from its monovalent counterpart providing evidence of the discret
102 s of sera from recipients of live-attenuated monovalent DENV vaccine candidates revealed a strong cor
105 tions revealed significant differences among monovalent, divalent, and trivalent cation distributions
106 A systematic comparison of transport of monovalent electrolytes [potassium chloride (KCl), sodiu
109 was to determine the comparative activity of monovalent, engineered anti-Her2/neu immunotoxins fused
110 ese comparative studies demonstrate that the monovalent, engineered rGel/4D5 construct displayed comp
113 se 3 clinical trials showed that inactivated monovalent EV-A71 vaccines manufactured in China were hi
114 amorphization of natrolites (PIA) containing monovalent extra-framework cations (EFC) Li(+), Na(+), K
115 e single-domain version of FC5; bivalent and monovalent FC5 fusions with Fc exhibited similar systemi
123 that heterologous protection by the current monovalent G1P[8] HRV vaccine against emerging G9 strain
124 med active diarrhea surveillance to evaluate monovalent G1P[8] rotavirus vaccine (RV1) efficacy and u
125 We found that glycoprotein substrates and monovalent glycans containing Neu5Acalpha2-3Galbeta1-4Gl
126 nited States, we analyzed the association of monovalent H1N1 influenza vaccine (MIV) during pregnancy
130 sed the immunogenicity and safety of a novel monovalent high-dose inactivated poliovirus type 2 vacci
132 , we generated a fusion protein comprising a monovalent human FcgammaRIIIA-specific antibody linked i
135 We assessed the vaccine effectiveness of monovalent human rotavirus vaccine in preventing admissi
137 to assess the efficacy and tolerability of a monovalent human-bovine rotavirus vaccine for severe rot
140 tive antibody response in 75 recipients of a monovalent inactivated A/Shanghai/02/2013 H7N9 vaccine.
142 ified the receipt of A(H1N1)pdm09-containing monovalent inactivated influenza vaccine (MIIV) and 2010
143 rain A/Indonesia/5/2005) followed by an H5N1 monovalent inactivated vaccine boost at 4, 8, 12, 16, or
145 double-blind, placebo-controlled trial of a monovalent influenza A H1N1 vaccine to establish the saf
146 0.22-6.63) per million doses for inactivated monovalent influenza vaccine (2 cases, 1,090,279 doses g
148 c (acetic, oxalic, succinic, or citric) acid/monovalent inorganic salt mixtures was assessed by measu
151 are determined by several factors including monovalent ion composition and the precise sequence and
156 imescales are remarkably slow for individual monovalent ions and could have important implications fo
157 residence times are described, both for the monovalent ions and for the hexahydrated Mg[(H2O)6](2+)
159 including Ca(2+), inhibit the permeation of monovalent ions by directly blocking the TRPP2 channel p
162 ct closely and strongly with the RNA, unlike monovalent ions such as K(+), suggesting that an explici
163 the slower rate observed experimentally with monovalent ions, we hypothesize that the activation of t
169 es, mica, but not on silica surfaces nor for monovalent K(+) and Na(+) cations is driven by charge re
171 increased by up to 1500-fold compared to the monovalent ligand, while maintaining the selectivity for
173 ser' family, is notably more potent than the monovalent ligands and we show here that this apparently
184 The phase II study GO27819 investigated the monovalent MET inhibitor onartuzumab plus bevacizumab (O
185 , the development of fluorescent sensors for monovalent metal ions, such as sodium (Na(+)), has remai
186 ecular dynamics simulations of macroions and monovalent microions that interact via Coulombic potenti
187 ii) conjugation with DNA and purification of monovalent MPNs, (iii) modular targeting of MPNs to cell
188 with multiple reactive bonds is to insert a monovalent N fragment (nitrene or nitrenoid) into a C-H
189 y evaluating the free energies for replacing monovalent Na(+) with H3O(+) in various model selectivit
190 ding aggregation kinetics in the presence of monovalent (Na(+)) and divalent cations (Ca(2+)) show th
191 -exchange metadynamics) to study and compare monovalent (Na(+), K(+)) ion permeation in the open-acti
194 t, the extracellular loop-binding or class 2 monovalent nanobodies were of lower potency but were mor
195 avid binding by fusing multiple (different) monovalent Nanobody building blocks via linker sequences
196 ultivalent ureidopyrimidinone monomers and a monovalent naphthyridine molecule which acts as an end-c
197 s revealed that CB[7]6 is among the tightest monovalent non-covalent complexes ever reported in water
198 ty of the bivalent configuration against the monovalent one is controlled by c = h/p, where h is the
200 lso model the trade-offs of use vs nonuse of monovalent OPV (mOPV) for outbreak response considering
202 adesh, were randomized to receive 3 doses of monovalent OPV type 1 or bivalent OPV types 1 and 3 at e
203 -specific IgA were measured in stool after a monovalent OPV type 2 challenge at 18 weeks of age.
206 ivalent metal ions and the presence of other monovalent or divalent metal ions do not affect its dete
207 ations from study participants receiving the monovalent or tetravalent live attenuated DENV vaccine (
209 ontrolled study, adults were challenged with monovalent oral poliovirus type 1 vaccine (mOPV1) and su
211 hromycin on the immunogenicity of serotype-3 monovalent oral poliovirus vaccine given to healthy infa
214 esponses to trivalent seasonal influenza and monovalent pandemic H1N1 vaccination, we sequenced gene
217 for Disease Control and Prevention-provided monovalent polyclonal botulinum antitoxins raised agains
218 kine platelet-derived growth factor) and two monovalent proteins (a Fab fragment and the transcriptio
219 orrelation forces play a central role in the monovalent Rb(+) distribution and a combination of ion-c
220 ceptin/rGel conjugate, and the corresponding monovalent recombinant immunotoxins in two orientations,
222 assess the safety and immunogenicity of the monovalent, recombinant, chimpanzee adenovirus type-3 ve
224 sits for intussusception within 7 days after monovalent rotavirus vaccination from April 2008 through
226 onfirmed intussusception within 7 days after monovalent rotavirus vaccination, as compared with the r
228 During the study period, 207,955 doses of monovalent rotavirus vaccine (including 115,908 first do
230 and later schedule on the immunogenicity of monovalent rotavirus vaccine (RV1) in a developing count
231 among the first African nations to introduce monovalent rotavirus vaccine (RV1) into its childhood im
235 ion after the administration of two doses of monovalent rotavirus vaccine was estimated to be 5.3 per
239 of intussusception among children receiving monovalent rotavirus vaccine with historical background
240 icensure study of more than 200,000 doses of monovalent rotavirus vaccine, we observed a significant
243 ainst rotavirus in Guatemala, where both the monovalent (RV1; 2-dose series) and pentavalent (RV5; 3-
249 otonic dependence of the binding affinity on monovalent salt concentration in the presence of force.
250 unfolding is a nonmonotonic function of the monovalent salt concentration of the solution, contrary
251 e-stranded DNA as a function of sequence and monovalent salt concentration to examine the effects of
253 ations in the electrolyte, NPs pairs at high monovalent salt concentrations interact via remarkably s
254 d or unoriented long-fragment DNA bundles in monovalent salt solutions as first order, with a small b
258 lates the phase diagram of DNA solutions for monovalent salts to that for polyvalent salts and sheds
260 own to bind selectively to the dockerin of a monovalent scaffoldin (ScaG), thus enabling formation of
263 fouling strategies, together with the use of monovalent selective membranes, is recommended to mainta
268 implementation of the method in the case of monovalent (single binding site) Pproxy and monovalent a
272 and green fluorescent protein, we show that monovalent Strep-Tactin is generally applicable to prote
275 te tag proved a more powerful way to isolate monovalent streptavidin, for ultra-stable labeling witho
276 play equal enzymatic activities on a soluble monovalent substrate and similar substrate specificities
278 g hemagglutination inhibition (HI) data with monovalent swine antisera and antigenic cartography to e
280 ith the binding of one (multivalent) or two (monovalent) target molecules to these elements opens the
281 se events and have reasoned that designing a monovalent targeting strategy could circumvent the infla
284 had received a median of 3 bOPV doses and 2 monovalent type 1 OPV (mOPV1) doses through campaigns an
289 valent OPV (bOPV) and IPV and challenge with monovalent type 2 OPV, and stools samples were collected
291 Infants in all groups were challenged with monovalent type 2 vaccine (mOPV2) at 18 weeks (groups 1,
293 structural (NS) proteins were observed after monovalent vaccination, T cell responses following tetra
297 mmunization with DENV1-4 VLPs as individual, monovalent vaccines elicited strong neutralization activ
299 MRV (MMRV group), or (2) MMR at dose one and monovalent varicella vaccine at dose two (MMR+V group),
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