ライフサイエンスコーパス: monozygotic twin

1 ange in z score from 1 to 6 mo, P = 0.008 in monozygotic twins).

2 erum anti-topo I antibody and in her healthy monozygotic twin.

3 layed-onset generalized dystonia syndrome in monozygotic twins.

4 ombat veterans and their non-combat-exposed, monozygotic twins.

5 , among siblings within families and between monozygotic twins.

6 similar to the concordance rate for Canadian monozygotic twins.

7 ntrolled by studying HIV-discordant pairs of monozygotic twins.

8 ons in five individuals, including a pair of monozygotic twins.

9 ed by zygosity, which remained similar among monozygotic twins.

10 atypical early onset of XLRS in 3-month-old monozygotic twins.

11 found that the correlation of scores between monozygotic twins (0.70) was more than double the dizygo

12 nificantly higher in dizygotic twins than in monozygotic twins (1.5 [1.1-2.2]) consequent on a risk f

13 ce) and that have high concordance rates for monozygotic twins (30-50%) and high risks to first-degre

14 an absolute 14% (95% CI, 12%-16%) higher in monozygotic twins (46%; 95% CI, 44%-48%) whose twin also

15 marker, revealing 12.51% similarity between monozygotic twins, 5.14% between dizygotic twins, and 4.

16 rain as an explanation of the discordance in monozygotic twins, a proximate cause of mental disorders

17 Here, we studied a family with a pair of monozygotic twins affected by TLE and two unaffected sib

18 gival plaque microbiome of 485 dizygotic and monozygotic twins aged 5-11.

19 e suggesting that the schizophrenia-affected monozygotic twins alone experienced a time-specific and

20 Monozygotic twin and other epidemiologic studies indicat

21 regulates Asc pool size, affects the rate of monozygotic twinning and polycotyly.

22 describes the first example of gene-directed monozygotic twinning and shows that Asc regulates cell p

23 pisodes of middle ear effusion were 0.04 for monozygotic twins and 0.37 for dizygotic twins (P = .01)

24 tions were 13.2% and 47.9%, respectively, in monozygotic twins and 14.6% and 32.8%, respectively, in

25 probandwise concordance rate of SZ is 33% in monozygotic twins and 7% in dizygotic twins.

26 Studies in monozygotic twins and archived blood spots have provided

27 pression differences at heterozygous loci in monozygotic twins and in unrelated individuals.

28 y) in human ulcerative colitis, by comparing monozygotic twins and other patient cohorts.

29 ews of genotypic and phenotypic diversity in monozygotic twins and suggest that CNV analysis in pheno

30 samples collected from healthy adult female monozygotic twins and their mothers at three time points

31 tently represented in the gut microbiomes of monozygotic twins and their mothers than components for

32 measured discordant gene expression between monozygotic twins, and estimated the stability of gene e

33 ular cancer in dizygotic twins compared with monozygotic twins, and in monozygotic and dizygotic twin

34 among sib pairs, parent-offspring pairs, and monozygotic twins, and we employ a slightly different de

35 or even the most heritable mental disorders, monozygotic twins are discordant at a significant rate.

36 Monozygotic twins are genetically matched and offer an a

37 Because associations among monozygotic twins are largely independent of shared gene

38 ears without an opportunity arising to use a monozygotic twin as a donor.

39 similar to that seen in pregnancy-discordant monozygotic twins, at 0.22 (95% CI=0.19, 0.26).

40 .95 mm Hg per change in z score, P = 0.01 in monozygotic twins; b = -1.64, P = 0.82 in dizygotic twin

41 ln mg/dL per change in z score, P = 0.31 in monozygotic twins; b = 0.79, P = 0.01 in dizygotic twins

42 The subjects were 14 pairs of monozygotic twins between the ages of 5 and 14 years old

43 c mutation from an "experiment of nature" in monozygotic twins both prevented anemia and reduced HSP9

44 Although phenotypic differences in monozygotic twins can exist, immunosuppression may be un

45 c differences between individuals, including monozygotic twins, can account for disparate phenotypes

46 Our study was conducted in a monozygotic twin cohort of adult twin pairs (n = 21) all

47 icular disease was 14.5 (95% CI, 8.9-23) for monozygotic twins compared with 5.5 (95% CI, 3.3-8.6) fo

48 igher risk for congenital heart defect among monozygotic twins compared with dizygotic twins, and the

49 This effect was almost doubled in monozygotic twins compared with dizygotic twins, suggest

50 Associations were stronger in female monozygotic twins compared with male twins (tetrachoric

51 ggregation, a 2%-3% sibling recurrence rate, monozygotic twin concordance >20%, association with seve

52 ficiencies, as well as familial aggregation, monozygotic twin concordance >20%, lambdas > 10, purport

53 mline mutation by whole-genome sequencing of monozygotic twins concordant for ASD and their parents.

54 ne responses to "shared epitope" antigens in monozygotic twin couples shows that, despite significant

55 The low concordance rate of 33% in monozygotic twins demonstrates that illness vulnerabilit

56 of alcohol use disorder is substantial, but monozygotic twin discordance indicates a role for nonher

57 s were actually discounted because of a high monozygotic twin discordance rate found in studies that

58 High monozygotic twin discordance rates for common diseases s

59 e measured algorithmically for nine pairs of monozygotic twins discordant for ADHD.

60 r differential function of T cell subsets in monozygotic twins discordant for asthma that are regulat

61 Relying on a cohort of monozygotic twins discordant for asthma we sought to det

62 The study of monozygotic twins discordant for attention deficit hyper

63 In previous studies of monozygotic twins discordant for autism, more than 75% o

64 tem parameters was conducted for 22 pairs of monozygotic twins discordant for CFS and 9 healthy pairs

65 is of lymphoblastoid cell lines derived from monozygotic twins discordant for diagnosis of autism and

66 wer levels, in female (2.29) and male (2.19) monozygotic twins discordant for dSLE exposure.

67 ere statistically significantly different in monozygotic twins discordant for LBP.

68 n cousins, half siblings, full siblings, and monozygotic twins discordant for marital status were as

69 Using whole-genome sequencing of a pair of monozygotic twins discordant for MLL (also called KMT2A)

70 Studies of monozygotic twins discordant for schizophrenia may help

71 In the present study of monozygotic twins discordant for schizophrenia, the affe

72 However, in full siblings and especially monozygotic twins discordant for smoking, risk for nonaf

73 In monozygotic twins discordant for trauma exposure, we fou

74 Indeed, we have shown in fibroblasts from monozygotic twins discordant for trisomy 21 that levels

75 criptome of fetal fibroblasts from a pair of monozygotic twins discordant for trisomy 21.

76 ide epigenetic studies in disease-discordant monozygotic twins emphasize the power of this design to

77 pared with dizygotic twin mothers but not in monozygotic twin fathers.

78 method has excellent power to differentiate monozygotic twins, full sibs, parent-offspring pairs, se

79 The monozygotic twin group was a cohort of children with nar

80 lity in young adults, disease discordance in monozygotic twins has been interpreted to indicate envir

81 Transplantation between monozygotic twins has been successfully performed using

82 , genetic and epigenetic differences between monozygotic twins have been described, challenging the a

83 001), and this effect was more pronounced in monozygotic twins (hazard ratio, 1.30; 95% confidence in

84 Finally, comparisons of epigenomes from monozygotic twins help dissect genetic and environmental

85 the individuals sampled were three pairs of monozygotic twins in which one twin had never smoked and

86 hors conducted a co-twin control study of 22 monozygotic twins in which one twin met criteria for CFS

87 e to those previously reported for a pair of monozygotic twins infected with the same strain of human

88 e of MLL-rearranged acute leukemia in infant monozygotic twins is not universal.

89 e of MLL-rearranged acute leukemia in infant monozygotic twins is thought to be 100% with a very shor

90 a S), parent-offspring pairs (lambda O), and monozygotic twins (lambda M) and in terms of the recombi

91 ry PDL cell cultures from patients with HPP (monozygotic twin males) were established to assay ALP ac

92 The sample included 30 monozygotic twins matched to 72 control participants and

93 at CNV analysis in phenotypically discordant monozygotic twins may provide a powerful tool for identi

94 autobiographical interviews with 14 pairs of monozygotic twins (mean age 51.2) rigorously discordant

95 in vivo neuroanatomic imaging on 14 pairs of monozygotic twins (mean age 9.7, s.d. 1.9 years), we fou

96 fferences in neuroanatomy between discordant monozygotic twins might be associated with the narrow an

97 only 33% of responding centers would allow a monozygotic twin minor to donate a kidney to his or her

98 ple of 684 subjects took part, consisting of monozygotic twins (n = 410, with 51 patients from concor

99 n the Social Reciprocity Scale were 0.73 for monozygotic twins (N=98 pairs) and 0.37 for dizygotic tw

100 sibling pair sample (full siblings: n = 513; monozygotic twins: n = 207; dizygotic twins: n = 189), t

101 c aetiology; appropriate clinical action for monozygotic twins needs consideration.

102 The cumulative risk by age 40 years in monozygotic twins of men with testicular cancer was 14%

103 The very high incidence in monozygotic twins of patients indicates that a high prop

104 The incidence in a prospective study of monozygotic twins of patients was approximately constant

105 isk of breast cancer was 34.7 (9.5-126.5) in monozygotic twins of women in whom breast cancer had occ

106 ders have higher than expected prevalence of monozygotic twinning, of assisted reproductive technolog

107 Analysis of mRNA in two haemophilic monozygotic twins offers novel information on the organi

108 aneous occurrence of the long QT syndrome in monozygotic twin offspring of unaffected parents.

109 s: This case series included 2 pairs of male monozygotic twins; one pair was aged 51 years and the ot

110 between psoriasis and obesity was diluted in monozygotic twins (OR, 1.43; 95% CI, 0.50-4.07; P = .50)

111 AUTS2) that spans the 7q11.2 breakpoint in a monozygotic twin pair concordant for autism and a t(7;20

112 ferences were detected within, than between, monozygotic twin pair genomes.

113 rt the genome sequences of one MS-discordant monozygotic twin pair, and messenger RNA transcriptome a

114 tic features, but cases include a discordant monozygotic twin pair, individuals with idiopathic devel

115 t the first case of discordance in an infant monozygotic twin pair.

116 onfidence interval [95% CI] 0.65-0.80) among monozygotic twin pairs and 0.47 (95% CI 0.39-0.55) in di

117 s contain notes with incorrect pitch, to 136 monozygotic twin pairs and 148 dizygotic twin pairs.

118 eDIP-seq) in whole-blood-derived DNA from 27 monozygotic twin pairs and follow up results with replic

119 om 124 unrelated individuals, as well as six monozygotic twin pairs and their mothers, and generate c

120 n, but not over the 10 yr from 12 to 22; and monozygotic twin pairs are statistically not more simila

121 The subjects were 16 monozygotic twin pairs between the ages of 5 and 14 year

122 twin pairs discordant for schizophrenia, 13 monozygotic twin pairs concordant for schizophrenia, and

123 negativity, P300, and P50 suppression in 16 monozygotic twin pairs concordant for schizophrenia, nin

124 enome-wide analysis of DNA methylation of 18 monozygotic twin pairs discordant for alcohol use disord

125 control analyses among 643 dizygotic and 365 monozygotic twin pairs discordant for asthma to ascertai

126 Half-siblings, full-siblings, and monozygotic twin pairs discordant for AUD were obtained

127 k (and a prosaccade control condition) by 10 monozygotic twin pairs discordant for DSM-IV schizophren

128 We replicated our results in 31 monozygotic twin pairs discordant for renal function.

129 e obtained by established procedures from 26 monozygotic twin pairs discordant for schizophrenia, 13

130 win pairs concordant for schizophrenia, nine monozygotic twin pairs discordant for schizophrenia, and

131 association study across 406,365 CpGs in 52 monozygotic twin pairs discordant for T1D in three immun

132 DNA methylation data in adipose tissue from monozygotic twin pairs discordant for T2D and independen

133 Differences in methylation between monozygotic twin pairs discordant for T2D were subsequen

134 her validated our findings from FH(+) men in monozygotic twin pairs discordant for T2D, and 40% of 65

135 so identified copy number variants (CNVs) in monozygotic twin pairs discordant for T2D.

136 allelic expression is highly similar within monozygotic twin pairs for many loci, implying that alle

137 s with adult height in 140 height-discordant monozygotic twin pairs from the California Twin Program.

138 available for 1987 adult and 648 adolescent monozygotic twin pairs from the Netherlands Twin Registe

139 Two monozygotic twin pairs had X-inactivation ratios skewed

140 sess mismatch in placental function in seven monozygotic twin pairs naturally matched for genetic gro

141 Within monozygotic twin pairs only, associations between infant

142 stically significant, and the correlation in monozygotic twin pairs was significantly greater than th

143 ed association using pairwise analysis among monozygotic twin pairs who are discordant in their physi

144 dentified 175 male-male and 69 female-female monozygotic twin pairs who differed by at least 2 years

145 us adipose tissue (SAT) samples from healthy monozygotic twin pairs, 22.8-36.2 years of age, who were

146 The participants were 345 monozygotic twin pairs, 337 dizygotic twin pairs, 306 bi

147 on were associated with height difference in monozygotic twin pairs, independent of genome, birth len

148 For studies within monozygotic twin pairs, the combined estimate was -0.6 m

149 CD4(+) lymphocytes from three MS-discordant, monozygotic twin pairs.

150 ytes (PBL) and buccal cells from a series of monozygotic twin pairs.

151 is in the heavy-smoking member of discordant monozygotic twin pairs.

152 tween global DNA methylation and IR using 84 monozygotic twin pairs.

153 ance imaging experiments in two adult female monozygotic twins (patient 1 and patient 2) with equival

154 ak frequencies were highly correlated across monozygotic twins (r = 0.88), but not across dizygotic t

155 el of liver fibrosis also correlated between monozygotic twins (r(2) = 0.48; P < .002) but not betwee

156 ence of hepatic steatosis correlated between monozygotic twins (r(2) = 0.70; P < .0001) but not betwe

157 On all ASD measures, correlations among monozygotic twins (range, 0.77-0.99) were significantly

158 Among monozygotic twins reared apart and discordant for H. pyl

159 ly related to increased risk of asthma among monozygotic twins (relative risk for 2,000 g vs. 2,500 g

160 ected current diagnoses of eating disorders, monozygotic twins resembled one another much more in ter

161 In support of this hypothesis, studies in monozygotic twins revealed increasing epigenetic differe

162 Additional analyses with monozygotic twins revealed significant correlations with

163 ordant for schizophrenia, and several normal monozygotic twin samples.

164 In 5 of 8 monozygotic twin sets, both individuals had PBC (pairwis

165 ofound DNAm plasticity during embryogenesis, monozygotic twins show indistinguishable childhood methy

166 mmune responses and viral evolution in adult monozygotic twins simultaneously infected with the same

167 Monozygotic twin sisters, with nonhematologic symptoms o

168 Human monozygotic twin studies, animal studies, and genetic mo

169 Here, we combine the power of a within-monozygotic twin study design with longitudinal neuroima

170 ders as well as the low concordance rates in monozygotic twins suggest that a combination of other fa

171 iological studies and a discordance of MS in monozygotic twins suggest that the disorder is acquired.

172 ncluding discordant diabetes incidence among monozygotic twins suggested a role for epigenetics in di

173 ning handedness of the progeny of discordant monozygotic twins suggests that lefties are one gene apa

174 risks of these cancers in dizygotic than in monozygotic twins support a prenatal aetiology, and are

175 zygotic twins is similar to that in pairs of monozygotic twins, supporting a role of non-genetic risk

176 Resemblance was greater in the monozygotic twins than in the dizygotic twins or in the

177 alyze genetic differences between 2 pairs of monozygotic twins that had discordant aortic valve morph

178 Twin studies show the concordance in monozygotic twins to be between 65-70%, compared to betw

179 for AUD onset given divorce among discordant monozygotic twins to equal 3.45 and 3.62 in men and wome

180 ic mechanisms, we generated human iPSCs from monozygotic twins to investigate how genetic background,

181 the similarity of sexual orientation in the monozygotic twins to the similarity in the same-sex dizy

182 in control analyses among disease-discordant monozygotic twins, tuberculosis risk was 46% lower for e

183 tism and 84 singleton controls, we find high monozygotic twin-twin concordance (0.91) and relatively

184 Measures: Genetic coding variations between monozygotic twins using whole-exome sequencing and targe

185 imate of discordance of an episode of AOM in monozygotic twins was 0.04 compared with 0.49 in dizygot

186 One set of monozygotic twins was detected among the 304 meioses map

187 The proband-wise concordance rate for monozygotic twins was double that of dizygotic twins (0.

188 rate per 100,000 person-years for ASD among monozygotic twins was estimated to be 153.0 (95% CI, 56.

189 ratio for drug abuse in pregnancy-discordant monozygotic twins was even stronger, at 0.17 (95% CI=0.1

190 By studying monozygotic twins, we demonstrated that there is evidenc

191 D4(+) T and CD8(+) T-lymphocyte subsets from monozygotic twins, we quantify the impact of heritable f

192 Using high-throughput sequence analysis of monozygotic twins, we show that variation in naive V(H)

193 Only two of seven pairs of monozygotic twins were concordant for ectopic canines.

194 The neural activity patterns in monozygotic twins were significantly more similar than i

195 volumes for HME and non-HME cases, including monozygotic twins where one sibling had HME.

196 e have analyzed convergence in seven sets of monozygotic twins which suggests that genetic factors ma

197 The monozygotic twin who used cannabis frequently was more l

198 Investigating neuroanatomic differences in monozygotic twins who are discordant for autism can help

199 We present a case of monozygotic twins who are discordant for breast cancer a

200 d in peripheral blood mononuclear cells from monozygotic twins who are discordant for MS.

201 ns and growth, we interviewed the mothers of monozygotic twins who differed in self-reported adult he

202 stigate several brain regions of interest in monozygotic twins who varied in degree of phenotypic dis

203 This co-twin study investigated monozygotic twins who were discordant for schizophrenia

204 on in IRF6 in the affected twin of a pair of monozygotic twins who were discordant for VWS.

205 ldhood on the acquisition of H. pylori among monozygotic twins who were reared apart and had an ident

206 Offspring of an alcohol-abusing monozygotic twin whose co-twin was AD were also more lik

207 cted (ie, no history of abuse or dependence) monozygotic twin whose co-twin was AD were no more likel

208 Studying monozygotic twins with ALL provides a unique means of un

209 e identified and compared CNAs in 5 pairs of monozygotic twins with concordant ETV6-RUNX1-positive AL

210 Studies on monozygotic twins with concordant leukemia and retrospec

211 We studied 19 pairs of monozygotic twins with either concordant or discordant p

212 We found that monozygotic twins with focal bilateral amygdala lesions

213 Vascular programming is evident in monozygotic twins with intertwin transfusion and is alte

214 The families included 3 pairs of monozygotic twins with juvenile dermatomyositis, 11 fami

215 g 58 singletons, 132 dizygotic twins, and 98 monozygotic twins with rsfMRI scans during the first 2 y

216 wever, the striking concordance of a pair of monozygotic twins with Waardenburg syndrome (WS) and pre

217 of breast cancer in dizygotic compared with monozygotic twins younger than 30 years (odds ratio 2.3