ライフサイエンスコーパス: morbid

1 rbid genes are incorrectly classified as non-morbid.

2 ferences make it possible to classify as non-morbid 34% of human genes with unknown morbidity, when o

3 Associations persisted when pre-morbid ability was adjusted for, but as expected were no

4 PC1) gene is associated with early-onset and morbid adult obesity.

5 be associated with extreme (early-onset and morbid-adult) obesity and type 2 diabetes independent of

6 BS and other functional GI disorders with co-morbid affective disorders and temporal association of s

7 or frailty (Clinical Frailty Score) were non-morbid, age- and gender-matched to survivors.

8 onal self-regulation (DESR) is prevalent and morbid among patients with attention deficit hyperactivi

9 rgical site infection (SSI) is a potentially morbid and costly complication following major colorecta

10 We used the same subjects for morbid and moderate obesity association studies.

11 n-small cell lung cancer (NSCLC) is a highly morbid and mortal cancer type that is difficult to eradi

12 Nevertheless, public knowledge of PAD as a morbid and mortal disease has not been previously assess

13 ate with this progress has been a decline in morbid and mortal events.

14 increases, so does the occurrence of highly morbid and mortal outcomes, including heart failure and

15 Head and neck cancer remains a morbid and often fatal disease and at the present time f

16 Stroke is a morbid and potentially mortal complication among patient

17 Group B Streptococcus causes a variety of morbid and sometimes fatal conditions affecting individu

18 isional hernia (IH) remains a common, highly morbid, and costly complication.

19 Delirium is a common, morbid, and costly postoperative complication.

20 neous coronary intervention (PCI) is common, morbid, and costly; increases patients' mortality risk;

21 squamous cell carcinoma (HNSCC) is a common, morbid, and frequently lethal malignancy.

22 l aortic aneurysm (AAA) disease is a common, morbid, and highly lethal pathology.

23 Obliterative bronchiolitis is a frequent, morbid, and usually refractory complication of lung tran

24 The surgery is complex and often highly morbid, and where possible patients should be given peri

25 pression Scale (HADS) was used to measure co-morbid anxiety and depression.

26 5% were overweight and 47% were obese by pre-morbid BMI measured 4.3 +/- 3.1 years before HF diagnosi

27 measured >/=6 months before incident HF (pre-morbid BMI) to evaluate the association of overweight (B

28 ociated osteonecrosis of the jaw (BONJ) is a morbid bone disease linked to long-term bisphosphonate u

29 lume (TICV) as a quantitative measure of pre-morbid brain size and a vicarious indicator of reserve.

30 xpands on the genetic basis of this rare and morbid cardiomyopathy.

31 Despite the rise in co-morbid cardiovascular disease risk factors like hyperlip

32 -traumatic stress disorder (PTSD) exhibit co-morbid chronic pain and amygdala dysregulation.

33 While data suggest a number of costly and morbid chronic sequelae associated with these infections

34 A vocabulary-based test estimated pre-morbid cognitive ability.

35 y in other genetic mutant mouse models of co-morbid cognitive and autistic-like disabilities.

36 predictive capacity for the most common and morbid complication after PD - clinically relevant pancr

37 reatic fistula (CR-POPF)-the most common and morbid complication after PD.

38 OPF occurrence, which is the most common and morbid complication following pancreatoduodenectomy.

39 GVHD remains a lethal and morbid complication of allogeneic bone marrow transplant

40 Pulmonary hypertension (PH) is a common and morbid complication of left heart disease with 2 subtype

41 VTE is an underappreciated and potentially morbid complication of SCD.

42 Pneumonia is a morbid complication of stroke, but evidence-based strate

43 The most frequent morbid complication was wound infection, more commonly o

44 nction of the gut, and the avoidance of such morbid complications as abdominal compartment syndrome a

45 nsion and injury are particularly common and morbid complications of neonatal cardiac surgery.

46 ection are at risk for developing costly and morbid complications, although the actual prevalence of

47 nately, these treatments are associated with morbid complications.

48 y can be life-saving, but is associated with morbid complications.

49 ipheral neuropathy is a highly prevalent and morbid condition affecting 2% to 7% of the population.

50 Falling is a common and morbid condition among elderly persons.

51 ey transplantation (NODM) is an important co morbid condition that is associated with inferior graft

52 ed acute kidney injury (AKI) is a common and morbid condition that is distinguishable from typical is

53 hemic rest pain and tissue loss, is a highly morbid condition that leads to the loss of ambulation an

54 osttransplant malignancy is an expensive and morbid condition that warrants attention in efforts to i

55 Acute PEH represents a highly morbid condition, and treatment in high-volume centers p

56 ence for the management of infants with this morbid condition.

57 ation has decreased, but it remains a highly morbid condition.

58 imated prevalences and prevalence ratios for morbid conditions affecting the women during a 1-year po

59 The extent of surgery and co-morbid conditions also have a major impact.

60 reus (MRSA) continues to be a major cause of morbid conditions and death.

61 Co-morbid conditions and their prevalence were: hypertensio

62 ker of renal failure and, possibly, of other morbid conditions in full-term and very low birth weight

63 regression coefficients for the impact of 98 morbid conditions on PF.

64 may have a role in the detection of nonrenal morbid conditions such as sepsis.

65 IMIDs may impact these co-morbid conditions through shared genetic risks, common e

66 Symptoms and co-morbid conditions were similar among those whose IgA tTG

67 ologic causes of anxiety, underrecognized co-morbid conditions, and medical illnesses that masquerade

68 Periodontitis and type 2 diabetes are co-morbid conditions, both characterized by infectious susc

69 de is accompanied by an increased risk of co-morbid conditions, including the intersection of diabete

70 are attempted on patients with increasing co-morbid conditions, it will be important to both utilize

71 rations in cardiac performance related to co-morbid conditions, preoperative myocardial insults and i

72 with mortality, even after adjustment for co-morbid conditions, systolic function, and medications (a

73 maintenance of these disorders (ie, sex, co-morbid conditions, types of trauma exposure, and behavio

74 cause premature death indirectly through co-morbid conditions.

75 tes mellitus, and the lack of significant co-morbid conditions.

76 of a biventricular assist device (BiVAD) for morbid congestive heart failure (MCHF) has been question

77 and their caregivers about the very real and morbid consequences of being this sick is essential.

78 tissue contraction after injury can lead to morbid contractile scarring in the body.

79 Morbid coronary events occur despite statin therapy and

80 ough the causes remain poorly understood, co-morbid depression and the first 6 months after epilepsy

81 erve as a useful genetic animal model for co-morbid depressive disorder and parkinsonism.

82 ulness of this platform in costly and highly morbid diabetic wounds by identifying a subpopulation of

83 e need for additional costly and potentially morbid diagnostic evaluation.

84 of hopefully avoiding progression to highly morbid, difficult to treat, and quite often irreversible

85 of physiological reserve and severity of co-morbid disease are required to improve risk stratificati

86 Digit OM is an expensive and morbid disease.

87 argeted fashion offer promise in this highly morbid disease.

88 ry to develop preventive strategies for this morbid disease.

89 nal and extraintestinal), family history, co-morbid diseases and conditions associated with celiac di

90 They might also have co-morbid disorders including intellectual impairment, seiz

91 amily focused grief therapy is to reduce the morbid effects of grief among families at risk of poor p

92 ard ratio 1.51, 95% CI 1.2 to 1.9) and first morbid event (hazard ratio 1.53, 95% CI 1.28 to 1.84) wa

93 interval, 1.014 to 1.019; P<0.001) and first morbid event (hazard ratio, 1.020; 95% confidence interv

94 o 2.26; P=0.94), as was the hazard for first morbid event (HR 1.26, 95% CI 1.01 to 1.57 versus HR 1.4

95 nterval [CI] 1.01 to 1.62, P=0.05) and first morbid event (HR 1.28, 95% CI 1.06 to 1.55, P=0.01).

96 with the risks of future mortality and first morbid event also after adjustment for clinical prognost

97 velopment of subsequent local recurrences, a morbid event decreasing functional outcomes and the most

98 ithout CKD and reduced the risk of the first morbid event in patients with CKD, which suggests its be

99 The cumulative likelihood of death and first morbid event increased with increasing quartile of CRP.

100 ghtened risk of acute limb ischemia (ALI), a morbid event that may result in limb loss.

101 (42%) who experienced one or more short-term morbid event(s) (1.8 events/patient experiencing any eve

102 The 2 primary outcomes were death and first morbid event, defined as death, sudden death with resusc

103 ntly (P<0.0001) associated with the risks of morbid event, mortality, and hospitalization for heart f

104 erval, 1.001 to 1.014; P=0.02) but not first morbid event.

105 usted increased risk for every postoperative morbid event: mortality (odds ratio [OR], 1.77; 95% conf

106 t hospitalization (hazard ratio [HR], 1.47), morbid events (HR, 1.41), and death (HR, 1.6) compared w

107 ose exposure, prolonged hospitalization, and morbid events after complex congenital heart surgery.

108 ociated with increased risk of postoperative morbid events after isolated coronary artery bypass graf

109 cardiovascular abnormalities eventuating in morbid events are detectable in the arteries and heart b

110 Mortality and morbid events are insensitive guides to the efficacy and

111 Efforts to prevent atherosclerotic morbid events have focused primarily on risk factor prev

112 For morbid events of coronary heart disease or stroke, diure

113 standardized orifice size, and postoperative morbid events on postoperative DASI.

114 The beneficial effect of valsartan on first morbid events was similar in those with and without CKD

115 nd perioperative variables and postoperative morbid events were prospectively collected concurrently

116 slow progression and delay or prevent future morbid events.

117 the general population and unaffected by co-morbid factors.

118 at the heterogeneity of both the core and co-morbid features predicts a heterogeneous pattern of neur

119 s-related lung injury is the most common and morbid form of acute lung injury.

120 's disease patients, only two had primary co-morbid FTD-spectrum pathology (progressive supranuclear

121 hort further identified mutations in a novel morbid gene TXNDC15, encoding a thiol isomerase, based o

122 indings strongly suggest that CCDC88B is the morbid gene underlying the pleiotropic effect of the 11q

123 ith unknown morbidity, when only 5% of known morbid genes are incorrectly classified as non-morbid.

124 ng complementary information to characterize morbid genes at infectious and inflammatory disease loci

125 Morbid genes evolve more slowly, have wider phylogenetic

126 We compared 18 parameters in 1273 human morbid genes, known to cause diseases, and in the remain

127 Finally, we show that the morbid genome of ciliopathies encompasses many founder m

128 Our study increases our understanding of the morbid genome of ciliopathies.

129 Our results expand the morbid genome of ID and support the adoption of genomics

130 conditions; however, our knowledge of their morbid genome, pleiotropy, and variable expressivity rem

131 rovide a foundational map of large SV in the morbid human genome and demonstrate a previously underap

132 GS pipeline dealing with the analysis of the morbid human genome.

133 therefore warrant a careful assessment of co-morbid illness seemingly unrelated to the bleed.

134 hese predictors were independent of other co-morbid illnesses.

135 n behavioral abnormalities could reflect pre-morbid individual differences in the cognitive domain of

136 imulation (TMS) to explore the impact of pre-morbid individual differences on post-lesion performance

137 approach to understanding the impact of pre-morbid individual variation on post-lesion outcomes that

138 Staphylococcus aureus (MSSA) bacteremia is a morbid infection.

139 a critical pathophysiologic event in highly morbid inflammatory conditions such as sepsis and acute

140 rus; to clarify the relationship between pre-morbid language organization and susceptibility to unila

141 ly diagnosis and intervention to prevent the morbid manifestations of the disease including organomeg

142 e table of genes and genetic phenotypes, the Morbid Map.

143 otypic presentation of mood disorders and co-morbid medical conditions in this family.

144 In the current study, a co-morbid model of AKI was developed to better mimic the pa

145 f sequelae, such as coagulopathy, infection, morbid myocardial events, and death after surgery.

146 ldhood obesity (P = 0.0003) and common adult morbid obesity (0.0003 < P < 0.007).

147 of overweight (39.8%), obesity (26.6%), and morbid obesity (3.6%) were similar in most geographic lo

148 nfidence interval (CI): 1.14, 3.20), whereas morbid obesity (BMI >/= 40) was suggestive of increased

149 cant predictors of a wound complication were morbid obesity (BMI >30), having had a MT, low preoperat

150 Morbid obesity (body mass index > or =40 kg/m(2)) is an

151 We examined the prevalence of morbid obesity (body mass index [BMI] >/= 40 kg/m(2)) am

152 nts who do not meet body weight criteria for morbid obesity (body mass index [BMI], <35 kg/m), but la

153 gn pathology (n = 48) and gastric bypass for morbid obesity (n = 40) were assessed.

154 egion in 3q29; we designated this region the morbid obesity 1 (MO1) locus.

155 Morbid obesity added 48 minutes to OT (P = 0.018), 1.1 u

156 Morbid obesity alters drug dose requirement and time cou

157 the prevalence and clinical implications of morbid obesity among patients undergoing PCI.

158 the prevalence and clinical implications of morbid obesity among patients undergoing percutaneous co

159 t effective method to curtail the effects of morbid obesity and all of its comorbid conditions.

160 iary protein CEP19 in humans and mice causes morbid obesity and defines a target for investigating th

161 ion of inflammation resolution prevents from morbid obesity and hyperglycemia under dietary overload

162 considered the most effective treatment for morbid obesity and its comorbidities; however, a systema

163 ective in the treatment of fully established morbid obesity and its endocrine and metabolic consequen

164 device may be suitable for the treatment of morbid obesity and its related comorbidities.

165 f the most efficient procedures for treating morbid obesity and results in weight-loss and improvemen

166 is a reasonable choice for the treatment of morbid obesity and should be covered by both public and

167 at macrophages in WAT play an active role in morbid obesity and that macrophage-related inflammatory

168 (LAMB3) gene showing strong association with morbid obesity and thereby risk of type 2 diabetes.

169 rt were patients with a primary diagnosis of morbid obesity and who underwent laparoscopic Roux-en-Y

170 Severe and morbid obesity are still relatively rare in France, with

171 epresent what we believe is a novel model of morbid obesity associated with an improved metabolic pro

172 Paradoxically, even morbid obesity associates with better outcomes in studie

173 switch as the primary surgical treatment of morbid obesity at a single institution during the 10-yea

174 oux-en-Y gastric bypass for the treatment of morbid obesity between 1999 and 2002 (n = 24,166).

175 ry laparoscopic gastric bypass operation for morbid obesity between May 1, 2007, and September 30, 20

176 obese controls and accounted for 0.7% of our morbid obesity cases (body mass index (BMI) >or= 40 kg m

177 ass is the procedure of choice when GERD and morbid obesity coexist.

178 age points) also was observed in adults with morbid obesity compared with normal-weight controls.

179 The number of patients with obesity and morbid obesity continues to increase.

180 ic gastric banding as a primary treatment of morbid obesity has been widely accepted, the effects of

181 Morbid obesity has no clinically significant impact on t

182 The prevalence of morbid obesity has risen sharply in recent years, even a

183 Roux-en-Y gastric bypass (RYGB) surgery for morbid obesity in a large nationwide cohort.

184 The prevalence of obesity, and morbid obesity in particular, continues to rise rapidly

185 ght to evaluate the prognostic impact of pre-morbid obesity in patients with HF.

186 ency coding variant that was associated with morbid obesity in the LAMB3 gene.

187 shift in the type of procedure performed for morbid obesity in the United States toward sleeve gastre

188 d duodenal switch procedure as performed for morbid obesity involves a 75% subtotal greater curvature

189 Morbid obesity is a barrier to kidney transplantation du

190 Morbid obesity is a global health epidemic.

191 Morbid obesity is also associated with an increased risk

192 Morbid obesity is an epidemic in the United States and p

193 Morbid obesity is associated with higher mortality on th

194 Morbid obesity is increasing in prevalence among patient

195 The number of bariatric interventions for morbid obesity is increasing worldwide.

196 Morbid obesity is increasingly becoming a major public h

197 frequently used and effective treatment for morbid obesity is Roux-en-Y gastric bypass surgery (RYGB

198 The surgical treatment of morbid obesity leads to dramatic improvement in the como

199 Morbid obesity may be accompanied by diabetes and painfu

200 Morbid obesity occurs frequently in patients with renal

201 and differing socio-cultural perceptions of morbid obesity on racial disparities.

202 Morbid obesity predicted higher post-LT mortality before

203 pproximately 1% of eligible individuals with morbid obesity receive bariatric surgery.

204 in leptin-deficient adults with established morbid obesity results in profound weight loss, increase

205 As the number of people with morbid obesity rises, so will the number of bariatric pr

206 Roux-en-Y gastric bypass, in the Adolescent Morbid Obesity Surgery (AMOS) study.

207 adhere to practice guidelines that consider morbid obesity to be a contraindication to liver transpl

208 A NASH Clinical Scoring System for Morbid Obesity was derived to predict the probability of

209 sence of 5 conditions commonly comorbid with morbid obesity were examined for morbidly obese patients

210 The relationship of morbid obesity with LT outcomes and survival benefit in

211 In addition, morbid obesity's impact on many organ systems decreases

212 For type 2 diabetes, moderate and morbid obesity, and for both the Q121 and three-marker h

213 Baseline depressive symptoms, morbid obesity, and intensive care unit benzodiazepine d

214 sm, nonalcoholic steatohepatitis (NASH), and morbid obesity, and may contribute to liver disease.

215 nsity and angiogenic capacity decreased with morbid obesity, and subcutaneous, but not visceral, adip

216 term (<2 years) efficacy of RYGB surgery for morbid obesity, corroborated by meta-analytic techniques

217 18-month-old female child who presented with morbid obesity, decreased linear growth, and reversal of

218 Leptin deficiency in mice and humans causes morbid obesity, diabetes, and various neuroendocrine ano

219 past year have focused on three broad areas: morbid obesity, gastric cancer, and peptic ulcer disease

220 94 to 2003 was performed using the key words morbid obesity, laparoscopy, bariatric surgery, pneumope

221 though some individual offspring suffer from morbid obesity, others escape the malprogramming.

222 P = 0.46 for type 2 diabetes, moderate, and morbid obesity, respectively).

223 elucidating the key networks associated with morbid obesity, response to RYGB, and disease as a whole

224 ed by infantile hypotonia, short stature and morbid obesity, results from deficiencies in multiple ge

225 th null mutations in a single gene producing morbid obesity, the new models develop a more moderate o

226 Among patients with morbid obesity, the use of vagal nerve block therapy com

227 Medline search using "perioperative care," "morbid obesity," "thromboembolic complications," "preope

228 Morbid obesity-adjusted rates of surgery were then calcu

229 hepatic fibrosis in patients with severe to morbid obesity.

230 astric bypass surgery-induced weight loss in morbid obesity.

231 routine coverage for SG for the treatment of morbid obesity.

232 c fat using 3T magnetic resonance imaging in morbid obesity.

233 nd db/db mice in the absence of diabetes and morbid obesity.

234 receptor-deficient (db/db) mice that develop morbid obesity.

235 ral tissue, but this capacity decreases with morbid obesity.

236 festyle changes alone in treating adolescent morbid obesity.

237 based on the complicating issues surrounding morbid obesity.

238 tes in patients who do not meet criteria for morbid obesity.

239 in 48 of 1282 patients (3.7%) after RYGB for morbid obesity.

240 , and may have implications for treatment of morbid obesity.

241 patients with gastric motility disorders or morbid obesity.

242 in the ob gene causes leptin deficiency and morbid obesity.

243 f death increased 7.4 times in patients with morbid obesity.

244 in 48 of 904 patients (5.3%) after RYGBP for morbid obesity.

245 a spectrum of NAFLD that may prelude NASH in morbid obesity.

246 Deficiency of either leptin or LRb causes morbid obesity.

247 fter gastric bypass surgery for treatment of morbid obesity.

248 aused by hepatic pathology that results from morbid obesity.

249 ctive primary procedure for the treatment of morbid obesity.

250 t mechanisms of cardiovascular protection in morbid obesity.

251 ]) for the classification of liver injury in morbid obesity.

252 tical eligibility criteria for patients with morbid obesity.

253 n increasingly popular form of treatment for morbid obesity.

254 Here, we describe an autosomal-recessive morbid-obesity syndrome and identify the disease-causing

255 acic aorta remains among the most lethal and morbid of anatomic injuries.

256 water balance are among the most common and morbid of the electrolyte disturbances, and are reflecte

257 with a disproportionately higher increase in morbid or class III obesity, and obesity adversely affec

258 cision-making to prevent the occurrence of a morbid or mortal ischemic event.

259 CMV infection may contribute to risk for morbid outcomes in treated HIV infection.

260 on and are associated with increased risk of morbid outcomes.

261 ing that Cpc-PH may be a distinct and highly morbid PH subphenotype.

262 terventions to change the trajectory of this morbid phenotype.

263 To delineate some of the major morbid phenotypes that have emerged in pediatric obstruc

264 ffective management of mental illness and co-morbid physical health problems as well as consideration

265 Thrombocytopenia is a significant and morbid problem in patients with hematologic malignancy,

266 %) patients who had surgery underwent a less morbid procedure than planned.

267 Radical cystectomy is a morbid procedure with rather long hospital stay and comp

268 n made to minimize the use of disfiguring or morbid procedures in treating the primary tumor or manag

269 Short bowel syndrome is a morbid product of massive small bowel resection.

270 sm and to ameliorate its risk and that of co-morbid psychiatric conditions.

271 , the impact of DAAs on the management of co-morbid psychiatric illness and neuropsychiatric sequalae

272 nicotine dependencies (CD, ND), and their co-morbid psychopathologies.

273 arthritis is an underdiagnosed, potentially morbid reactive arthritis associated with C difficile in

274 gnificant three-way interaction between "pre-morbid" reading status, stimulation, and word type, such

275 Idiopathic pulmonary fibrosis (IPF) is a morbid, refractory lung disorder with an unknown pathoge

276 ess syndrome (ARDS) is a common, lethal, and morbid respiratory complication primarily seen in the se

277 t (P = .02) when studies that did not report morbid risk estimates were excluded (in this case, OR =

278 ars that elderly patients with additional co-morbid risk factors may benefit most from off-pump coron

279 er level of pathological worry; and a higher morbid risk for generalized anxiety disorder in first-de

280 ate the effects of double predispositions on morbid risk in the offspring, which is of interest for m

281 set schizophrenia had a significantly higher morbid risk of schizophrenia spectrum disorders (24.74%)

282 Age-corrected lifetime morbid risk was estimated in adult first-degree relative

283 e of 10.8 +/- 2.6 years.Main Outcome Measure Morbid risk.

284 y a rater blind to group membership, and the morbid risks for schizophrenia spectrum disorders in the

285 on-specific neurodevelopmental delay with co-morbid seizure disorder accounting for 33.3%, 14.8%, 18.

286 ventive efforts to reduce the chance of this morbid side effect.

287 The BDMM identified further directly co-morbid somatic disorders, e.g. irritable bowel syndrome,

288 as a museum, showcasing dried and varnished morbid specimens--human relics of the Civil War, the ins

289 ment of anxiety disorders, depression and co-morbid substance abuse.

290 th tumour responses and reduced the need for morbid surgery in patients with GCTB.

291 can help prevent unnecessary and potentially morbid surgical and ablation procedures in a substantial

292 to improvement in quality of life after this morbid surgical procedure.

293 When indicated, the selection of a less morbid surgical technique has the potential to improve o

294 undernourished, females and in those with co-morbid systemic illnesses.

295 Myomectomy is not necessarily less morbid than hysterectomy and may have a greater failure

296 n with HIPEC is an effective but potentially morbid treatment option for peritoneal surface malignanc

297 Drug dependence (DD) is commonly co-morbid with alcohol dependence (AD).

298 Alcoholism is frequently co-morbid with post-traumatic stress disorder, but it is un

299 l nodes because it is accurate and minimally morbid, yet its role for thin (<or= 1.5 mm) primary mela

300 Severe sepsis is common and highly morbid, yet the epidemiology of severe sepsis at the fro