ライフサイエンスコーパス: morphinan

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1 ties compared to the univalent 2-substituted morphinans.

2 an ester moiety as the spacer in the dimeric morphinans.

3 say, ligands 13, 17, and 19 and their parent morphinans 1 and 2 stimulated [(35)S]GTPgammaS binding m

4 and chemical characterization of a series of morphinans 3a-c, structural analogues of cyclorphan [(-)

5 al structure of the murine muOR bound to the morphinan agonist BU72 and a G protein mimetic camelid a

6 peptide antagonist (Dmt-Tic) and a mu/kappa morphinan agonist butorphan (MCL 101) through a two meth

7 olic group of the potent mu and kappa opioid morphinan agonist/antagonists cyclorphan and butorphan w

8 Morphinan alkaloids from the opium poppy are used for pa

9 gy is applied to a formal total synthesis of morphinan alkaloids.

10 or molecular modeling of interaction between morphinans and the mu receptor.

11 5alpha-epoxy-3,14-dihydroxy-6,7:2',3'-indolo morphinans), and the effect of the N-substituent on opio

12 use micro-OR in complex with an irreversible morphinan antagonist.

13 ed enantiomeric analogues of traditional (-)-morphinans as having TLR9 antagonist properties on repor

14 The identification of a morphinan-based novel small-molecule structure with TLR9

15 A series of aminothiazole-derived morphinans, benzomorphans, and morphine were synthesized

16 The direction of metabolites to morphinan biosynthesis requires isomerization of (S)- to

17 Bivalent morphinan compounds containing ester linkers were synthe

18 ovel series of kappa agonists related to the morphinan (-)-cyclorphan (3a) and the benzomorphan (-)-c

19 he results of the present study suggest that morphinan derivatives related to 16 and 14 may provide u

20 nt kappa-OR-selective ligands, including the morphinan-derived antagonists norbinaltorphimine and 5'-

21 tions were investigated at the 3-OH group of morphinans: levorphanol (2a), cyclorphan (2b), and MCL-1

22 tein-coupled receptors published so far, the morphinan ligand binds deeply within a large solvent-exp

23 potent opioid agonist activity (N-pentyl) in morphinan-like ligands which interact with the mu-recept

24 presentative aminothiazolomorphinan with the morphinan mixed-KOR/MOR agonist butorphan (MCL-101) on b

25 t a hydroxyl group at the 14-position of the morphinan moiety displayed agonist activity at the micro

26 The C(3)-substituent in morphinan opioids is of critical importance; the 3-OH gr

27 Ligand 12, a compound containing only one morphinan pharmacophore and a long-chain ester group, ha

28 which were formed by coupling two identical morphinan pharmacophores (cyclorphan (1) or MCL 101 (2))

29 osition and ligands 8 and 9 in which the two morphinan pharmacophores were coupled by ether moieties

30 ion protein STORR may enable microbial-based morphinan production.

31 hexadienone that generates three of the four morphinan ring junction stereocenters in one step.

32 ubsets of residues, despite sharing a common morphinan scaffold.

33 Although most of the 2-substituted morphinans showed considerably lower affinities compared

34 Position 6 of the morphinan skeleton plays a key role in the mu-opioid rec

35 with the aminothiazole on the C-ring of the morphinan skeleton.

36 of the address moiety with the C ring of the morphinan structure enhances delta antagonist potency an

37 oxamido replacement (compounds 46-48) in the morphinan subseries resulted in similar affinities compa

38 t appropriate molecular manipulations of the morphinan templates could provide ligands with mixed mic

39 A novel series of morphinans were synthesized, and their binding affinity

40 ese dimeric ligands can be viewed as dimeric morphinans, which were formed by coupling two identical

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