ライフサイエンスコーパス: morpholino

1 afish through injection of a splice-blocking morpholino.

2 ovel zebrafish model of CNM2 using antisense morpholinos.

3 sgenic insertions, genes with antibodies and morpholinos.

4 slation blocking and splice-site interfering morpholinos.

5 rine kidney explants with Wt1 antisense vivo-morpholinos.

6 ockdown approach with two different splicing morpholinos.

7 HMT expression was knocked down by antisense morpholinos.

8 a are absent [MZovl injected with a Su(H)1+2 morpholino].

9 Mice fed D- threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP), an inhibitor of glucosyl

10 ynthesis, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP), solubilized in vehicle (

11 ibitors (dl-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol and phospholipase C), we demonstra

12 1-(3,4-dichlorophenyl)-3-(4-methoxyphenyl)-4-morpholino-1H-pyrrole-2,5-dione, named RI-2 (referred to

13 sphere of a terpyridine ligand (Tpy(BN) = 6-morpholino-2,2':6',2''-terpyridine-6''-boronic acid pina

14 ore (e.g., 2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]th io-phen-

15 ization of a series of 8-(1-anilino)ethyl)-2-morpholino-4-oxo-4H-chromene-6-carboxamides as PI3Kbeta/

16 Analogues of (dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-one (NU7441), a potent inhibitor

17 This work resulted in the discovery of the 5-morpholino-7H-thieno[3,2-b]pyran-7-one system as the fou

18 Injection of a morpholino against dysferlin leads to a decrease of endo

19 Morpholinos against N-terminal zebrafish Ahi1, orthologo

20 Moreover, zebrafish treated with morpholinos against tubgcp4 were found to have reduced h

21 suppression of IL10 using an antisense IL10 morpholino also extended the tumor growth delay induced

22 Importantly, NEDD9 inhibition by Vivo-Morpholinos, an antisense therapy, decreases primary tum

23 function with dominant-negative Rab4 or Rab4 morpholino and constitutive activation of Rab5 decreases

24 Using morpholino and mutant zebrafish models, we show that POU

25 stage and antiangiogenic drugs such as Vegf morpholino and sunitinib could potentially interfere wit

26 -injecting sub-phenotypic dosages of the two morpholinos and could be rescued by human USB1 RNA.

27 Importantly, knockdown of ZF gamma1 with morpholinos and disruption of oligomers with the molecul

28 erexpression enhances differentiation, while morpholino- and siRNA-induced knockdown diminishes it.

29 cs, phenotypes, genotypes, gene expressions, morpholinos, antibodies, anatomical structures and publi

30 Using a morpholino antisense approach, we demonstrate a strong k

31 nt of the conceptus, we conducted an in vivo morpholino antisense oligonucleotide (MAO)-mediated knoc

32 Duchenne muscular dystrophy (DMD), employing morpholino antisense oligonucleotides (PMO-AO) to exclud

33 and the effects of reducing expression, with morpholino antisense oligonucleotides, on biliary develo

34 slation of the RNA-binding protein Nanos2 by morpholino antisense oligonucleotides, or knockout of th

35 Moreover, inhibition of miR-183 with morpholino antisense oligos in cochlear organotypic cult

36 Morpholino-antisense-mediated depletion of fibulin-7B, a

37 Using a morpholino-antisense-oligonucleotide-based zebrafish mod

38 Suppression of CD47 by morpholino approach suppressed growth of HCC in vivo and

39 n adult killifish and demonstrates that vivo-morpholinos are a valuable genetic tool for this environ

40 Co-injection of tuba and cdc42 morpholinos at low doses, which alone had no effect, res

41 ), gene knockdown of either CBS or CSE using morpholinos attenuated the hypoxic ventilatory response.

42 , locked nucleic acid, or phosphorodiamidate morpholino backbones.

43 (E1), located upstream of SMN2 exon 7 using Morpholino-based antisense oligonucleotides (E1(MO)-ASOs

44 Feeling a bit cagey: morpholino-based antisense reagents have been caged thro

45 Morpholino-based experimentation confirmed that modulati

46 idate genes for angiogenesis, we performed a morpholino-based genetic screen in zebrafish and identif

47 Morpholino-based knockdown and rescue experiments reveal

48 Morpholino-based knockdown of a zebrafish PYCR2 ortholog

49 based on two-photon microscopy revealed that morpholino-based knockdown of glutaredoxin 2 in zebrafis

50 Morpholino-based knockdown of the Xenopus ortholog of CC

51 Morpholino-based loss of cdk10 expression caused apoptos

52 Here we report a morpholino-based PMM2-CDG model in zebrafish.

53 ic tissues that mimics phenotypes seen using morpholino-based targeted gene knockdowns.

54 infusion of farnesoid X receptor (FXR) Vivo-morpholino before AOM injection.

55 activity relationship studies on 7-methoxy-4-morpholino-benzothiazole derivatives featured by aryloxy

56 Thus, this morpholino can be used for concurrent suppression of hem

57 ef2ca;mef2cb double mutants are ablated by a morpholino capable of knocking down other Mef2s.

58 sor is made of a monolayer of charge-neutral morpholino capture probes on an indium tin oxide (ITO)-c

59 Knockdown of Dvr1 by morpholino causes dramatically reduced or absent express

60 Xtgfbi knockdown by anti-sense morpholinos causes defective organizer induction, patter

61 Morpholino co-injection experiments identify ccm2l as an

62 ROS in NOX4 embryos were attenuated by NOX4 morpholino co-injection, treatments of the embryos with

63 normal and BDL rats treated with AANAT Vivo-Morpholino, compared to controls.

64 ment for cardiac phenotypes as compared with morpholino controls.

65 Live-cell imaging and morpholino depletion of axonemal Paralyzed Flagella 16 i

66 , whereas the remaining PMO analogues having morpholino, dimethylamino, or N-methylamino phosphorodia

67 Conversely, a Vivo-Morpholino directed at mouse Gls had no antitumor activi

68 knockdown of Lmx1b and FoxC orthologs using morpholino doses that caused no or minimal phenotypic ch

69 Treating optic cups with an antisense morpholino effectively blocked aberrant splicing and res

70 o-injected embryos vs. 0/152 (0%) of control morpholino embryos].

71 Both ATG and splice-blocking PEAR1 morpholinos enhanced thrombopoiesis, without affecting e

72 In one crystal form, a molecule of Mes [2-(N-morpholino)ethane sulfonic acid] mimics the target uridi

73 Embryos injected with an nkx2.5 morpholino exhibited SHF phenotypes caused by compromise

74 Using a morpholino for in vivo knock-down of G6f-like levels in

75 However, the anti conformation of 8-morpholino-GMP is selected by Bs-FtsZ, while Mj-FtsZ bin

76 This is the first report of the use of vivo-morpholinos in adult killifish and demonstrates that viv

77 ing endogenous iE(B) function with antisense morpholinos in live mouse and zebrafish animal models.

78 biting RIP3 protein induction with antisense morpholinos in wild-type animals or using RIP3-deficient

79 Inhibition of Hif-1alpha by antisense morpholinos in Xenopus laevis or zebrafish embryos led t

80 include using conditional mutant mice, using morpholinos in zebrafish and using hypomorphic mutants i

81 Knocking down of otogl with morpholinos in zebrafish leads to sensorineural hearing

82 that suppression of CD47 using an antisense morpholino increases survival of mice exposed to lethal

83 d that mutant human NNT failed to rescue nnt morpholino-induced heart dysfunction, indicating a proba

84 Morpholino-induced knockdown of KCNE4 depolarized mesent

85 Morpholino-induced knockdown of sgol1 in zebrafish recap

86 Finally, morpholino-induced knockdown of znf408 in zebrafish reve

87 Morpholino-induced knockdown of zSTARS alters atrial and

88 Morpholino-induced loss of heparanase 2 caused embryonic

89 re we describe the phenotype associated with morpholino-induced otoferlin knockdown in zebrafish and

90 mRNA transcripts were able to rescue abcc6a morpholino-induced phenotype of zebrafish.

91 Minimal rescue of the morpholino-induced phenotype was achieved with eight of

92 sted in zebrafish, and minimal rescue of the morpholino-induced phenotype was found.

93 erent genes failed to recapitulate published Morpholino-induced phenotypes (morphants).

94 Morpholino-induced silencing of SKI paralogs in zebrafis

95 In a zebrafish model, overexpression or morpholino-induced suppression of foxc1 induced cerebral

96 Morpholino-induced transient gene knockdown was performe

97 use cornea, subconjunctival injection of the morpholino-inhibited corneal angiogenesis and lymphangio

98 Reducing expression of TRPC1 by antisense morpholinos inhibits the effects of MS channel blockers

99 Electron microscopy analysis revealed that morpholino-injected embryos lacked a lamina densa and la

100 ormal cardiac phenotypes in 126/164 (77%) of morpholino-injected embryos vs. 0/152 (0%) of control mo

101 bution of rods in lor/tbx2b(p25bbtl) or six7 morpholino-injected larvae protect from pde6c(w59)-induc

102 Disruption of ccm2l by morpholino injection causes dilation of the atrium and i

103 Depletion of CenpH by morpholino injection decreased cyclin B1 levels, resulti

104 Intravitreal morpholino injection suppressed laser choroidal neovascu

105 reduced by knockdown of TGF-beta1 by in vivo morpholinos injections.

106 e by first generating boranephosphoroamidate morpholino internucleotide linkages followed by oxidativ

107 wn of complexin by injection of an antisense morpholino into zebrafish embryos prevented photorecepto

108 in branchial arch ectoderm and endoderm, and morpholino knock-down of foxi1 also causes apoptosis of

109 Morpholino knock-down of zebrafish alx1 expression cause

110 We use morpholino knockdown and a Clstn-1 mutant to show that C

111 onfidence cardiac predictions using targeted morpholino knockdown and initial blinded phenotyping in

112 in Xenopus tropicalis, where ZIP12 antisense morpholino knockdown impairs neural tube closure and arr

113 y homologs and can engulf V. coralliilyticus Morpholino knockdown indicates that Nv-TLR also has an e

114 F60a or BAF60b expression and are rescued by morpholino knockdown of BAF60a or BAF60b.

115 Morpholino knockdown of COLXIV-A provoked a skin detachm

116 Morpholino knockdown of cspp1 in zebrafish caused phenot

117 n the nascent mesoderm and neurectoderm, and morpholino knockdown of either causes defects in differe

118 In addition, morpholino knockdown of flna in zebrafish embryos signif

119 Consistent with its expression, morpholino knockdown of Gtpbp2 causes defects in ventral

120 he BMP branch of the TGFbeta superfamily, as morpholino knockdown of Gtpbp2 decreases, and overexpres

121 Morpholino knockdown of matrilin-1 results both in overa

122 on of Notch signaling activity by DAPT or by morpholino knockdown of Notch1a is sufficient to rescue

123 By using zebrafish morpholino knockdown of PCD candidate genes as an in viv

124 owth and elongation appear normal, antisense morpholino knockdown of pcdh18b results in dose-dependen

125 Morpholino knockdown of peroxidasin in zebrafish reveale

126 Using morpholino knockdown of PmTPCs and PmARC in the oocytes,

127 Morpholino knockdown of RNF207 in zebrafish embryos resu

128 encodes a transcription factor and for which morpholino knockdown of the ortholog in zebrafish result

129 Morpholino knockdown of the zebrafish homologue dachsous

130 Morpholino knockdown of ttc26 in zebrafish embryos cause

131 Morpholino knockdown significantly reduced the expressio

132 A series of morpholino knockdown studies specifically identified not

133 tients with the deletions, we used zebrafish morpholino knockdown to test the function of each orthol

134 Using a PADI1-specific inhibitor and Padi1-morpholino knockdown, we found that citrullination of hi

135 Using morpholino knockdown, we show that NMIIA and NMIIB are b

136 established a zebrafish model of PN using a morpholino-knockdown approach with two different splicin

137 Using morpholino-mediated ablation of Slc38a8 in medaka fish,

138 In an in vivo model, we show that morpholino-mediated dpy30 knockdown resulted in severe d

139 ith none of the side effects associated with morpholino-mediated Duox1 knockdown.

140 CNG-modulin in phototransduction in vivo in morpholino-mediated gene knockdown zebrafish.

141 ed loss of function analysis using antisense morpholino-mediated gene knockdown.

142 Morpholino-mediated inhibition of Qk translation confirm

143 We show that morpholino-mediated inpp5k loss of function in the zebra

144 Its morpholino-mediated knockdown affects neural crest precu

145 es, we show that pharmacological inhibition, morpholino-mediated knockdown and CRISPR/cas9-mediated k

146 Morpholino-mediated knockdown and transient overexpressi

147 Importantly, a morpholino-mediated knockdown in Xenopus revealed that p

148 This study employed expression analysis and morpholino-mediated knockdown in zebrafish in concert wi

149 Morpholino-mediated knockdown of each expressed Wnt liga

150 in vivo multiphoton microscopy, we show that morpholino-mediated knockdown of enox1 increases NADH le

151 loss of function during development, we used morpholino-mediated knockdown of its zebrafish ortholog,

152 In contrast, morpholino-mediated knockdown of nrp2a caused fin overgr

153 Morpholino-mediated knockdown of NvecGrl1 causes develop

154 Morpholino-mediated knockdown of plxna1 did not cause cx

155 Morpholino-mediated knockdown of s1pr1 causes global and

156 Last, morpholino-mediated knockdown of slc41a1 expression in z

157 Morpholino-mediated knockdown of the two MYO9A orthologu

158 Morpholino-mediated knockdown of TNFalpha expression bef

159 We demonstrate by morpholino-mediated knockdown that MIP signals via this

160 ecular screens and tests of gene function by morpholino-mediated knockdown, we identified SoxC and Br

161 Using morpholino-mediated knockdown, we specifically targeted

162 To study protein function, we used morpholino-mediated knockdowns in zebrafish and short ha

163 Morpholino-mediated loss-of-function experiments show th

164 with the phenotypes of RP2 knockout mice and morpholino-mediated RP2 knockdown zebrafish.

165 Morpholino-mediated Sesn3 knockdown in zebrafish confirm

166 Morpholino-mediated suppression of Enox1 in Tg(fli1-eGFP

167 Using morpholino-mediated translation inhibition, we demonstra

168 Vivo-morpholino-mediated WT1 knockdown decreased Kdr transcri

169 antitative RT-PCR, in situ hybridization and morpholinos-mediated knockdown.

170 3-amino-2-oxazolidinone (AOZ) and 3-amino-5-morpholino-methyl-2-oxazolidinone (AMOZ) side-chains of

171 ed and then reversibly surface bonded onto a morpholino microarray for hybridization.

172 ydroxylase (encoded by cyp11b1), and cyp11b1 morpholino (Mo) knockdown significantly reduced basal an

173 We have evaluated a morpholino (MO) oligomer against ISS-N1 [HSMN2Ex7D(-10,-

174 ntration device incorporating charge-neutral morpholino (MO) probes: as DNA analyte is concentrated i

175 We performed antisense morpholino (MO) studies in Danio rerio to characterize t

176 ent, a zebrafish model was generated through morpholino (MO)-mediated targeting of the zebrafish chd7

177 Injection of morpholino (MO)-modified antisense oligonucleotides spec

178 specific antagonists and, respectively, with morpholinos (MO) against S1PR2 and S1PR5a-which represen

179 When compared with morpholino, molecular beacon is 2 orders of magnitude mo

180 bryos using splice- and translation-blocking morpholinos (MOs) caused pronephric cysts, hydrocephalus

181 rface hybridization reaction between DNA and morpholinos (MOs) for enhanced detection.

182 lated mRNAs or gene-specific oligonucleotide morpholinos (MOs), respectively.

183 Neutralization by morpholinos of Ptena, but not of Ptenb, phenocopied the

184 Peptide-conjugated phosphorodiamidate morpholino offers significantly higher efficiency than p

185 rdiac trabeculation; (b) injection of gata1a morpholino oligomer (gata1aMO) suppressing hematopoiesis

186 transporter, Vivo, can effectively carry the Morpholino oligomer (MO) across the chorion, enter the e

187 ely affected SMA mice by delivering low-dose morpholino oligomer (PMO25) into the existing severe SMA

188 Here we show that an antisense morpholino oligomer directed against the exon 13-intron

189 Zebrafish embryos injected with an elavl1 morpholino oligomer or miR-200b mimic showed angiogenesi

190 In addition, miR-200b and HuR morpholino oligomer suppressed the activity of a zVEGF 3

191 nding protein or changing its composition to morpholino oligomer that does not interact with helicase

192 AVI-7288 is a phosphorodiamidate morpholino oligomer with positive charges that targets t

193 el studies, eteplirsen, a phosphorodiamidate morpholino oligomer, enabled dystrophin production in Du

194 l genome such as modified phosphorodiamidate morpholino oligomer-based compounds and small interferin

195 upstream 5' splicing site with an antisense morpholino oligomer.

196 re we present evidence for successful use of morpholino oligomers (MO) to mediate degradation of targ

197 ic administration of both phosphorodiamidate morpholino oligomers (PMO) and 2'-O-methyl phosphorothio

198 tide-mediated delivery of phosphorodiamidate morpholino oligomers (PMOs) has shown great promise for

199 that co-administration of phosphorodiamidate morpholino oligomers (PMOs) with glucose enhances exon-s

200 Here, we focus on phosphorodiamidate morpholino oligomers (PMOs), ASOs that are especially st

201 Peptide-conjugated phosphorodiamidate morpholino oligomers (PPMOs) are synthetic DNA/RNA analo

202 Based on experiments with antisense morpholino oligomers as well as pharmacological agonists

203 Knockdown of mat2aa in zebrafish via morpholino oligomers disrupted cardiovascular developmen

204 d by the external guide sequences, which are morpholino oligomers in the conjugates.

205 Treatment of mdx mice with morpholino oligomers to induce exon skipping of dystroph

206 By contrast, blocking ASPN function with a morpholino oligonucleotide (ASPN-MO) inhibits eye format

207 A cell-penetrating peptide (CPP)-morpholino oligonucleotide (MO) conjugate (PMO) that has

208 Disruption of rab5ab expression by antisense morpholino oligonucleotide (MO) knockdown abolishes noda

209 of two nanoconjugates: (1) a single-stranded morpholino oligonucleotide (MORF1) attached to an anti-C

210 be the conjugation of two phosphorodiamidate morpholino oligonucleotide (PMO) SSOs to a single CPP fo

211 f 2 mutation-specific antisense molecules (a morpholino oligonucleotide [MO] and an engineered U7 sma

212 e silencing of gGlcT1 synthesis by antisense morpholino oligonucleotide abolished ESV production and

213 mbryos, knockdown of slc2a10 using antisense morpholino oligonucleotide injection caused a wavy notoc

214 of defective heart valve formation caused by morpholino oligonucleotide knockdown of UGDH, transcript

215 ep approach in which nanotubes modified with morpholino oligonucleotide sequences bind to cancer cell

216 e intravitreously injected an antisense Vivo-Morpholino oligonucleotide targeting hnRNP K.

217 Here we focus on the zebrafish morpholino oligonucleotide technology, the (platelet-spe

218 Morpholino oligonucleotide-mediated knockdown of CCP1 an

219 form of ILK or by injecting an ILK antisense morpholino oligonucleotide.

220 Knockdown of scube1 by morpholino-oligonucleotide down-regulated the expression

221 analyzed its function by injecting antisense morpholino-oligonucleotide into embryos.

222 Spectrally differentiated caged morpholino oligonucleotides (cMOs) and wavelength-select

223 Reduction of blood viscosity via gata1a morpholino oligonucleotides (MO) reduced shear stress, r

224 For over 15 years, antisense morpholino oligonucleotides (MOs) have allowed developme

225 Down-regulation of Amer2 by specific morpholino oligonucleotides altered neuroectodermal patt

226 iption activator-like effector nucleases and morpholino oligonucleotides confirmed that the ecl mutan

227 Depletion of PL1 and PL2 by morpholino oligonucleotides decreased cell proliferation

228 Knock-down experiments using antisense morpholino oligonucleotides directed against hesx1 and f

229 ckdown of lurap1, p190RhoGEF and Golgin45 by morpholino oligonucleotides disrupts dystrophin localiza

230 Knockdown of amigo1 expression using morpholino oligonucleotides impairs the formation of fas

231 n of downstream intron splicing by antisense morpholino oligonucleotides inhibited NMD and rescued th

232 ppression of camk2g1 expression by antisense morpholino oligonucleotides or inhibition of CaMK-II act

233 Knockdown of Dhrs3 by antisense morpholino oligonucleotides resulted in a phenotype of s

234 , knockdown of zebrafish scube3 by antisense morpholino oligonucleotides specifically suppressed the

235 f72 was performed using 2 specific antisense morpholino oligonucleotides to block transcription.

236 aper, we have used small interfering RNAs or morpholino oligonucleotides to deplete the LICs in human

237 We used antisense morpholino oligonucleotides to target the orthologous Da

238 Nrf2a expression had been knocked down with morpholino oligonucleotides were more sensitive to tert-

239 cloning, insertional mutagenesis, antisense morpholino oligonucleotides, targeted re-sequencing, and

240 2a or Apobec2b was knocked down by antisense morpholino oligonucleotides, the proliferative response

241 ent was validated in zebrafish embryos using morpholino oligonucleotides.

242 Knockdown of IoDpp by morpholino oligos prevents the development of all struct

243 Depletion with morpholino oligos showed that this extracellular gradien

244 In vivo blockade of YAP/TAZ translation by morpholino oligos significantly reduced endothelial infl

245 We have developed and characterized morpholino oligos targeting the most efficiently edited

246 Using splice site-specific antisense morpholino oligos, we inhibited n1-src splicing, while p

247 tion assays (via microinjection of antisense morpholino or CRISPR-Cas9) confirm that AChE is specific

248 the co-injection of ror2-TM mRNA and a wnt11 morpholino or the coexpression of ror2 and wnt11 in zebr

249 nzyme activity using Bhmt-specific antisense morpholinos or a selective BHMT inhibitor resulted in de

250 rgized with coexpressed Xwnt8, whereas Ripk4 morpholinos or catalytic inactive Ripk4 antagonized Wnt

251 CRISPR-based gene editing, RNA interference, morpholinos or pharmacological inhibition) can have a ma

252 Here we use morpholino- or dominant negative-mediated interference t

253 NSC305787 mimicked the ezrin morpholino phenotype, and NSC668394 caused a unique deve

254 t an advanced peptide-oligonucleotide, Pip6a-morpholino phosphorodiamidate oligomer (PMO), which demo

255 Phosphorodiamidate morpholinos (PMOs) and PMO-DNA chimeras have been prepar

256 ingle dose of the peptide-phosphorodiamidate morpholino (PPMO) antisense oligonucleotides that induce

257 wn of zebrafish otg using specific antisense morpholino promoted nuclear accumulation of beta-catenin

258 We study Cu(II) FSCV responses in 3-(N-morpholino)propanesulfonic acid (MOPS) buffer and charac

259 in zebrafish embryos using a splice-blocking morpholino (rad21a).

260 ontent, including providing full support for morpholino reagents, used to inhibit mRNA translation or

261 s of function of beta-catenin with antisense morpholinos reproducibly reduced the expression of 247 m

262 Knockdown of Elavl1a using specific morpholinos resulted in a striking loss of primitive emb

263 targeting cish.a, but not cish.b or control morpholinos, resulted in enhanced embryonic erythropoies

264 Depletion of keratin (krt8) with antisense morpholinos results in high traction stresses in followe

265 le1 using an insertional mutant or antisense morpholinos results in multiple defects, including immob

266 Trans-perturbations with anti-sense morpholinos reveal a co-dependency between six1 and gcm.

267 In zebrafish, gene knockdown using morpholinos revealed a genetic interaction between Ryk a

268 Co-injecting low doses of nkx2.5 and ltbp3 morpholinos revealed a genetic interaction between these

269 ocking galanin expression with specific vivo-morpholino sequences inhibited hyperplastic cholangiocyt

270 ciliogenesis pathway and a scrambled control morpholino showed no phenotypic effect.

271 g of Wt1 by transfection with antisense vivo-morpholinos significantly increased Adamts16 mRNA in cul

272 in a vasculogenesis assay in vivo by using a morpholino strategy in zebrafish.

273 Zebrafish morpholino studies of spag1 produced cilia-related pheno

274 ing the charge of the excluded strand with a morpholino substrate instead of DNA also dramatically in

275 es, phenotypes, genotypes, gene expressions, morpholinos, TALENs, CRISPRs, antibodies, anatomical str

276 acy of peptide-conjugated phosphorodiamidate morpholino targeting exon 23 in dystrophic mdx mice.

277 Injection of morpholinos targeting cish.a, but not cish.b or control

278 Morpholinos targeting dyx1c1 in zebrafish also caused la

279 Finally, co-injection of antisense morpholinos targeting slc2a10 and smad7 (a TGFbeta inhib

280 Morpholinos targeting two other guanine nucleotide excha

281 y, we determined that reduced expression via morpholino technologies of a single histone-modifying en

282 Blocking this signal with morpholino technology or silencing of the polyadenylatio

283 ducted loss-of-function studies by antisense morpholino technology.

284 vessels was observed with doses of the s1pr1 morpholino that alone did not cause any discernible vasc

285 Here, we show that an antisense morpholino that base-pairs to the 5' end of U1 snRNA blo

286 Moreover, a customized Vivo-Morpholino that targets human GLS mRNA markedly inhibite

287 fine gene function in zebrafish, after which Morpholinos that recapitulate respective phenotypes coul

288 in zebrafish embryos injected with antisense morpholinos that targeted zebrafish st3gal5 expression.

289 sed Giardia was transfected with anti-gGlcT1 morpholino, the enzyme activity, vesicle biogenesis, and

290 Using zebrafish morpholino to evaluate loss of function, we observed a s

291 If the animal caps carried morpholinos to either hox11/13b or foxA (endomesoderm sp

292 e for these candidate genes in vivo, we used morpholinos to reduce SYNE1, NUP37, and NUP43 gene expre

293 and del(5q) MDS in zebrafish using antisense morpholinos to rps19 and rps14, respectively, and have d

294 rategy in which mCARM1 was introduced in the morpholino-treated embryos exhibited recovery of the sen

295 50) of peptide-conjugated phosphorodiamidate morpholino was determined to be approximately 85 mg/kg.

296 , with the help of CARM1 inhibitor and CARM1 morpholinos, we show that inhibition of H3R17 methylatio

297 Using ponzr1-targeting morpholinos, we show that ponzr1 is required for formati

298 groups using inhibition by Dkk1 mRNA or Wnt8 morpholinos, which indicates that the effects of beta-ca

299 ly higher efficiency than phosphorodiamidate morpholino, with the ability to induce near-normal level

300 rad21a Morpholino zebrafish had delayed intestinal transit and