ライフサイエンスコーパス: mossy fiber

1 at arise from the rhombic lip and that issue mossy fibers.

2 ct vestibular primary and secondary afferent mossy fibers.

3 s generated by antidromic stimulation of the mossy fibers.

4 ptic staining was conspicuous in hippocampal mossy fibers.

5 ancelled by non-auditory signals conveyed by mossy fibers.

6 esponse to direct inputs from collaterals of mossy fibers.

7 dant in the synaptic vesicles of hippocampal mossy fibers.

8 n of function begins with the segregation of mossy fibers across 10 distinct lobules over the rostroc

9 ignaling changed linearly with the number of mossy fiber action potentials.

10 ental networks, were transiently paired with mossy fiber activation in such a way that the two events

11 Patterned mossy fiber activity induces rhythmic Golgi cell activit

12 n that resemble the activity of Purkinje and mossy fiber afferents that is predicted to occur during

13 Mossy fiber afferents to cerebellar granule cells form t

14 cell zones and the topographic targeting of mossy fiber afferents.

15 ediate heterosynaptic metaplasticity between mossy fiber and associational-commissural synapses.

16 conditioned using electrical stimulation of mossy fiber and climbing fiber afferents as CS and US, w

17 feedforward and feedback inhibition through mossy fiber and parallel fiber synapses.

18 r learning requires context information from mossy fibers and a teaching signal through the climbing

19 ng information begins at the synapse between mossy fibers and granule cells, a synapse that is strong

20 nflammation caused damage of the hippocampal mossy fibers and neuronal apoptotic death.

21 ed phosphorylation of tau in hippocampal CA3 Mossy fibers and spinal motoneurons in a hypothermia-ind

22 ion independently activates primary afferent mossy fibers and tertiary afferent climbing fibers that

23 proprioception are randomly mixed in spinal mossy fibers and that properties of granule cells are co

24 nuclei/spinal cord neurons that give rise to mossy fibers--and promotes GABAergic synapse formation a

25 However, the most prevalent targets of mossy fibers are GABAergic interneurons and SynCAM 1 los

26 eport that subthreshold potentials evoked by mossy fibers are sufficient to induce synaptic plasticit

27 Specifically, mossy fibers are thought to both directly excite nuclear

28 ate CN activity; collaterals of climbing and mossy fibers are two, and the remaining two are provided

29 uit often assume that input signals from the mossy-fibers are expanded and recoded to provide a found

30 tostimulation to mimic their excitation by a mossy fiber as it occurs in vivo.

31 gic synapses from cholecystokinin-expressing mossy fiber-associated cells that did not innervate the

32 In hippocampal slices kainate potentiates mossy fiber axon excitability.

33 stochemical (IHC) studies of the hippocampal mossy fiber axons and boutons using an antibody selectiv

34 tivity within granule cells was found within mossy fiber axons and giant synaptic boutons.

35 m channel gating and density in unmyelinated mossy fiber axons appear to be specialized for robust AP

36 te stereotyped pruning of murine hippocampal mossy fiber axons during postnatal development.

37 vesicular zinc activates TrkB in hippocampal mossy fiber axons under physiological conditions.

38 te to the pathologic retrograde sprouting of mossy fiber axons, both hallmarks of temporal lobe epile

39 brief trains of low-frequency stimulation of mossy fiber axons.

40 s drive retrograde sprouting of granule cell mossy fiber axons.

41 itical for generating PC protein stripes and mossy fiber bands, and that PC striped gene expression i

42 We used mossy fiber bouton to GABA neuron paired recordings in t

43 als such as the calyx of Held or hippocampal mossy fiber bouton.

44 ed the length of the presynaptic membrane of mossy fiber boutons, associated with a de novo formation

45 subunit-containing GABA(A)Rs depolarized rat mossy fiber boutons, enhanced action potential-dependent

46 onversely, blocking GABA(A)Rs hyperpolarized mossy fiber boutons, increased their input resistance, d

47 tive two-photon Ca(2+) imaging in cerebellar mossy fiber boutons, which fire at exceptionally high ra

48 heterogeneous amplitudes observed in single mossy fiber boutons.

49 esulted in an increased volume of the axonal mossy fiber bundle projecting from dentate granule cells

50 Thus, STDP can bind plasticity to the mossy fiber burst phase with high temporal precision.

51 by modulating the frequency and duration of mossy fiber bursts, probably because STDP expression inv

52 y cells were less likely to be innervated by mossy fibers, but the amplitudes of mossy fiber EPSCs we

53 contrast to the CA3-CA1 pathway, LTP in the mossy fiber-CA3 projection did not depend on MMP-3, indi

54 Long-term potentiation of the mossy fiber-CA3 pyramid synapse was impaired in slices o

55 on plays a central role in plasticity at the mossy fiber-CA3 synapse of the hippocampus.

56 Thus, bidirectional NMDAR plasticity at mossy fiber-CA3 synapses could substantially contribute

57 bidirectional long-term NMDAR plasticity at mossy fiber-CA3 synapses in rat hippocampal slices.

58 on both P/Q- and N-type VGCCs at hippocampal mossy fiber-CA3 synapses, the specific contribution of V

59 ermits efficacious homeostatic adjustment of mossy fiber-CA3 synapses, while preserving synaptic weig

60 ffer collateral-CA1 synapses, but not at the mossy fiber-CA3 synapses.

61 suppressed PKC potentiation of NMDA EPSCs at mossy fiber-CA3 synapses.

62 h the induction of long-term potentiation at mossy fiber-CA3 synapses.

63 r collateral-CA1 synapses without effects at mossy fiber-CA3 synapses.

64 d by changes in short-term plasticity at the mossy fiber/CA3 circuit.

65 nsory and motor signals conveyed by distinct mossy fiber classes and (2) that Purkinje-like cells exh

66 In addition, we found that mossy fiber clustering, which is a common anatomical pat

67 d action of inputs to cerebellar nuclei from mossy fiber collaterals and incompletely blocked Purkinj

68 Our results show that mossy fibers contact the perisomatically projecting fast

69 these responses are more sluggish than their mossy fiber counterparts.

70 orm of plasticity imparts bimodal control of mossy fiber-driven CA3 burst firing and spike temporal f

71 , we found that BDNF derived from excitatory mossy fiber endings controls their differentiation.

72 impacts both AMPA and NMDA components of the mossy fiber EPSC.

73 Long-term potentiation (LTP) of mossy fiber EPSCs in the cerebellar nuclei is controlled

74 This low-frequency potentiation of mossy fiber EPSCs requires postsynaptic mGlu1 receptors

75 vated by mossy fibers, but the amplitudes of mossy fiber EPSCs were large and the transmission probab

76 an be released from these cells and modulate mossy fiber excitability through activation of GABAB aut

77 at facilitate filter construction are direct mossy fiber excitation of Golgi cells, variability of sy

78 ked phasic and spillover inhibition prior to mossy fiber excitation.

79 orm modeling of sparse and filopodia-bearing mossy fibers, finding that these circuit features unique

80 ced by high-frequency synaptic excitation by mossy fibers followed by synaptic inhibition by Purkinje

81 Our results suggest that, although sprouted mossy fibers form recurrent excitatory circuits with som

82 erved alpha7 nAChR-mediated calcium rises at mossy fiber giant terminals, indicating the presence of

83 urons to determine the effect of nicotine on mossy fiber glutamatergic synaptic transmission.

84 lar layer, here, we shift attention onto the mossy fiber granule cell (GrC) relay.

85 t, helping to shape signal processing at the mossy fiber-granule cell relay.

86 ing at 6 Hz can optimally induce STDP at the mossy fiber-granule cell synapse in rats.

87 ikes at 6-10 Hz reliably induced STDP at the mossy fiber-granule cell synapse, with potentiation and

88 Simple spikes (SSs) are often ascribed to mossy fiber-granule cell-parallel fiber inputs to Purkin

89 ore, slow inhibition reduces the gain of the mossy fiber --> granule cell input-output curve, while f

90 putative collateral branches terminating as mossy fibers in the cerebellar cortex.

91 r reorganization, including the sprouting of mossy fibers in the dentate gyrus; they establish aberra

92 the epileptic brain, inhibited sprouting of mossy fibers in the hippocampus, and prevented the progr

93 ression in loose clusters of spinocerebellar mossy fibers in the mouse AZ/PZ, whereas in rat CART imm

94 One million mossy fibers in the rat provide individually sparse but

95 creased in axons but not synaptic boutons of mossy fibers in ZnT3 knockout mice that lack vesicular z

96 reduced aberrant Timm staining (a marker of mossy fibers) in the granule cell layer and molecular la

97 findings show that activation of hippocampal mossy fibers induces pre- and postsynaptic structural ch

98 imary conveyors of sensory and motor-related mossy fiber information to Purkinje cells.

99 ons and helps to expand the dynamic range of mossy fibers information transfer.

100 combinatorial diversity saturates quickly as mossy fiber input diversity increases, and that this sat

101 e cerebellum receives sensory information by mossy fiber input from a multitude of sources that requi

102 We found that theta-burst stimulation of mossy fiber input in lobule 9 granule cells lowered the

103 to regulate the response of granule cells to mossy fiber input in lobules 2 and 9 of the rat cerebell

104 e found that long-term potentiation (LTP) of mossy fiber input invoked a large increase in granule ce

105 Mossy fiber input is known to exhibit a long-term potent

106 elation of these subtypes to the response to mossy fiber input is not clear.

107 stsynaptic mechanisms contributing to LTP of mossy fiber input is unknown.

108 ular cerebellar cortex receive glutamatergic mossy fiber input on an elaborate brush-like dendrite.

109 drites received significantly more recurrent mossy fiber input through their apical dendrites, indica

110 sized that if SLRs are evoked by the sensory mossy fiber input to the IN and cerebellar cortex, then

111 In contrast, sparse, coincident mossy fiber input triggered a mixture of excitation and

112 tput became evident in response to bursts of mossy fiber input, revealing that Kv4 control of intrins

113 As granule cells receive mossy fiber input, they represent a key stage at which p

114 tely 2 ms before Purkinje cells, following a mossy fiber input.

115 granule cell spike timing during persistent mossy fiber input.

116 ule cell activity as a function of timing of mossy fiber input.

117 anule cells (GrCs) sample approximately four mossy fiber inputs and are thought to form a combinatori

118 Because the mossy fiber inputs appear to convey the activity of burs

119 on whether individual granule cells receive mossy fiber inputs from multiple precerebellar nuclei or

120 s support that SynCAM 1 modulates excitatory mossy fiber inputs onto both interneurons and principal

121 simulation, cessation of one of two ongoing mossy fiber inputs produces a robust temporal code in th

122 events, so that cells with weak but numerous mossy fiber inputs received high rates of spontaneous sy

123 Cerebellar granule cells receive mossy fiber inputs that convey information on different

124 pendence of the numbers and strengths of the mossy fiber inputs to CA3 GABAergic cells on the postsyn

125 Using stimulation of mossy fiber inputs to the cerebellum as training stimuli

126 es spatiotemporal information transmitted by mossy fiber inputs with a wide variety of firing pattern

127 receive segregated and functionally distinct mossy fiber inputs, enabling Golgi cells to regulate the

128 codes the interval between the offset of two mossy fiber inputs.

129 pses and (2) long-term potentiation (LTP) at mossy fiber-interpositus nucleus synapses.

130 h more likely to send at least one recurrent mossy fiber into the molecular layer.

131 sensorimotor information carried by incoming mossy fibers is transformed before it is conveyed to Pur

132 Here, we acutely reconstitute mossy fiber long-term potentiation (mfLTP) de novo in th

133 cle pool distribution, impaired induction of mossy fiber long-term potentiation and deficits in hippo

134 splayed a major impairment in cAMP-dependent mossy-fiber long-term potentiation (LTP) in the CA3 regi

135 nstream effector of cAMP that contributes to mossy fiber LTP (MF-LTP), but the potential contribution

136 sults provide insights into the mechanism of mossy fiber LTP and demonstrate a useful acute approach

137 ufficient to impair the function of Syt12 in mossy-fiber LTP, suggesting that cAMP-dependent phosphor

138 l configurations for inducing and monitoring mossy-fiber LTP.

139 on serine-97 contributes to the induction of mossy-fiber LTP.

140 Mossy fibers make excitatory inputs onto postsynaptic sp

141 Down-regulation of Kv3.4 in mossy fibers may contribute to enhanced presynaptic exci

142 f sensory-motor context, which is encoded by mossy fiber (MF) activity.

143 to the distinct molecular properties of the mossy fiber (MF) and associational-commissural (AC) syna

144 ls (GrCs) and are driven both by feedforward mossy fiber (mf) and feedback GrC excitation.

145 The mossy fiber (MF) axons of the dentate granule cells conv

146 echanisms underlying information transfer at mossy fiber (mf) connections between the dentate gyrus (

147 (PFs) from granule cells (GCs) that receive mossy fiber (MF) input derived from precerebellar nuclei

148 tivation of dentate gyrus PIIs by excitatory mossy fiber (MF) inputs induces Hebbian long-term potent

149 The mossy fiber (MF) pathway is critical to hippocampal func

150 ansmission and long-term potentiation of the mossy fiber (MF) pathway.

151 Hippocampal mossy fiber (MF) synapses on area CA3 lacunosum-molecula

152 CA3 region of the hippocampus, glutamatergic mossy fiber (MF) synapses onto CA3 pyramidal cells (PCs)

153 et-specific synapse formation at hippocampal mossy fiber (MF) synapses, which connect dentate granule

154 The hippocampal mossy fiber (MF) terminal is among the largest and most

155 sibility that the physiological diversity of mossy fiber (MF) to granule cell (GC) synapses in the mo

156 eceive a single glutamatergic synapse from a mossy fiber (MF), which makes them an ideal model to stu

157 ngs the kinetics of KAR-mediated currents at mossy fiber (MF)-CA3 pyramidal cell synapses.

158 r slow channel kinetics, most prominently at mossy fiber (MF)-CA3 synapses in the hippocampus.

159 The mossy fiber (MF)-granule cell (GC) pathway conveys multi

160 mice display severe presynaptic deficits at mossy fiber (MF)-to-CA3 synapses in the hippocampus, a m

161 the hypothesis that zinc within vesicles of mossy fibers (mf) contributes to mf-LTP, a classical for

162 GoCs are excited by mossy fibers (MFs) and grcs and provide feedforward and

163 Electrical stimulation of mossy fibers (MFs) as well as microinjection of NMDA in

164 The mossy fibers (MFs) corelease glutamate and GABA onto pyr

165 ber projections to CA3 pyramidal cells place mossy fiber NMDARs in a prime position to influence CA3

166 Moreover, we found that mossy fiber NMDARs mediate heterosynaptic metaplasticity

167 ng AP initiation in unmyelinated hippocampal mossy fibers of adult mice, we recorded sodium currents

168 gnatures of the specialized contacts between mossy fibers of dentate granule cells and thorny excresc

169 co-localize in the terminals of hippocampal mossy fibers, olfactory sensory neuron axons, and growth

170 odial extensions, demonstrating that not all mossy fibers originate from the dentate gyrus.

171 s short-term plasticity in a Purkinje cell's mossy fiber/parallel-fiber input pathways; 2) complex-sp

172 Local blockade of zinc or MAPK in the mossy fiber pathway of wild-type mice impairs contextual

173 astrocyte engagement in the fully developed mossy fiber pathway was slow and territorial, contrary t

174 n leu-enkephalin and dynorphin levels in the mossy fiber pathway, particularly within the hilus, and

175 ng to, or regulating, single synapses in the mossy fiber pathway.

176 xplore astrocyte activity in the hippocampal mossy fiber pathway.

177 entate gyrus and in its efferent fibers, the mossy fiber pathway.

178 pmental gene expression characteristics with mossy fiber precerebellar nuclei that arise from the cau

179 nd disorganized infrapyramidal bundle of the mossy fiber projection from the dentate gyrus to CA3.

180 que functional properties of both NMDARs and mossy fiber projections to CA3 pyramidal cells place mos

181 ed recordings in the CA3 to demonstrate that mossy fibers provide cell type-specific innervation to d

182 In agreement, mossy fiber refinement in CA3 was impaired in SynCAM 1 K

183 Brush Cells (UBCs), which generate intrinsic mossy fibers relaying vestibular inputs to the cerebella

184 ptic response with a subsequent subthreshold mossy fiber response induced long-term potentiation at C

185 taneous recordings of Golgi cells and nearby mossy fibers revealed that Golgi cells have the opposite

186 istry for NKCC1, KCC2, and ectopic recurrent mossy fiber (rMF) sprouting as well as telemetric electr

187 have the opposite directional tuning of the mossy fiber(s) that likely drive their responses, and th

188 the substrate for phase-dependent binding of mossy fiber spikes to repetitive theta-frequency cycles

189 with rapamycin displayed significantly less mossy fiber sprouting (42% of vehicle-treated animals),

190 ed DGCs exhibiting hilar basal dendrites and mossy fiber sprouting (MFS) when observed 4 weeks after

191 d status epilepticus in mice, would suppress mossy fiber sprouting and affect the development of spon

192 Furthermore, loss of tamalin blunts mossy fiber sprouting and dendritic arborization caused

193 chronic phase of mTOR activation and reduced mossy fiber sprouting and epilepsy but not neurogenesis

194 In addition, mossy fiber sprouting and mossy cell death were correlat

195 However, correlations between the extent of mossy fiber sprouting and seizure frequency are weak.

196 Mossy fiber sprouting creates an aberrant positive-feedb

197 If it were possible to block mossy fiber sprouting from developing after epileptogeni

198 Previous attempts to block mossy fiber sprouting have been unsuccessful.

199 t would not have been detected by markers of mossy fiber sprouting in previous studies include surviv

200 ycin (mTOR) signaling pathway and suppresses mossy fiber sprouting in rats.

201 These findings suggest mossy fiber sprouting is neither pro- nor anti-convulsan

202 on of adult-born granule cells to functional mossy fiber sprouting is unknown, primarily due to techn

203 Infusion for 2 months inhibited mossy fiber sprouting more.

204 in sea lions was unilateral in 79% of cases, mossy fiber sprouting was a common neuropathological abn

205 eactivity or Timm-stained, and the extent of mossy fiber sprouting was measured stereologically.

206 Global suppression of mossy fiber sprouting was not observed; however, ESNP-de

207 ossy fiber sprouting, although the effect on mossy fiber sprouting was reversible after stopping rapa

208 Consistent with mossy fiber sprouting, a higher proportion of glutamate-

209 apamycin decreased neuronal degeneration and mossy fiber sprouting, although the effect on mossy fibe

210 age of hilar ectopic DGCs, (2) the amount of mossy fiber sprouting, and (3) the extent of mossy cell

211 eveloped hippocampal sclerosis, granule cell mossy fiber sprouting, and chronic epilepsy, but not the

212 e-induced neuronal cell death, neurogenesis, mossy fiber sprouting, and the development of spontaneou

213 re hilar ectopic granule cells, mossy cells, mossy fiber sprouting, astrogliosis, and GABAergic inter

214 granule cells also contributed to functional mossy fiber sprouting, but exhibited less synaptic depre

215 ith TLE and evaluated graft differentiation, mossy fiber sprouting, cellular morphology, and electrop

216 ls, the number of mossy cells, the extent of mossy fiber sprouting, the extent of astrogliosis, or th

217 m mice, associated with abnormal hippocampal mossy fiber sprouting.

218 l as less severe astrogliosis and attenuated mossy fiber sprouting.

219 demonstrated that hilar EGCs contributed to mossy fiber sprouting.

220 signaling pathway suppressed development of mossy fiber sprouting.

221 and remained low in epileptic rats, despite mossy fiber sprouting.

222 ctivity, spontaneous behavioral seizures, or mossy-fiber sprouting 5-6 weeks after mossy cell degener

223 way with rapamycin blocks granule cell axon (mossy fiber) sprouting after epileptogenic injuries, inc

224 Dentate granule cell axon (mossy fiber) sprouting is a common abnormality in patien

225 Granule cell axon (mossy fiber) sprouting is a common neuropathological fin

226 KAR LTD is induced by high-frequency mossy fiber stimulation and natural spike patterns and r

227 t rabbits trained with either a tone or with mossy fiber stimulation as the conditioned stimulus lear

228 hat capillary diameter changes rapidly after mossy fiber stimulation.

229 poral fidelity of granule cell spikes during mossy fiber stimulation.

230 nomena are also observed when stimulation of mossy fibers substitutes for the conditioned stimulus, s

231 formation and differentiation of the DG-CA3 mossy fiber synapse.

232 Mossy fiber synapses act as the critical mediators of hi

233 Mossy fiber synapses are assumed to exhibit presynaptic

234 nitor fine-structural changes at hippocampal mossy fiber synapses associated with chemically induced

235 bserved at CA3 associational/commissural and mossy fiber synapses but not CA1 Schaffer collateral syn

236 Mossy fiber synapses exhibit both pronounced short-term

237 to technical barriers in isolating sprouted mossy fiber synapses for analysis.

238 d frequency-dependent facilitation, sprouted mossy fiber synapses from adult-born cells exhibited pro

239 We directly activated sprouted mossy fiber synapses from adult-born granule cells to st

240 We tested whether PTP could convert mossy fiber synapses from subdetonator into detonator mo

241 urthermore, we tested synaptic plasticity of mossy fiber synapses in area CA3 and found increased lon

242 Surprisingly, however, although healthy mossy fiber synapses in CA3 are well characterized "deto

243 ful acute approach to genetically manipulate mossy fiber synapses in the mature brain.

244 Remarkably, PTP switched mossy fiber synapses into full detonators for tens of se

245 Mossy fiber synapses on CA3 pyramidal cells are 'conditi

246 ic transmission (KAR LTD) at rat hippocampal mossy fiber synapses relieves inhibition of the sAHP by

247 pre- and postsynaptic structural changes at mossy fiber synapses that can be monitored by EM.

248 m NMDA receptor-independent LTP of local CA3 mossy fiber synapses.

249 ted synaptic transmission at rat hippocampal mossy fiber synapses.

250 long-term potentiation (LTP) at hippocampal mossy fiber synapses.

251 cellular substrate for expression of LTP at mossy fiber synapses.

252 nd GABAergic cells similarly to conventional mossy fiber synapses.

253 ) receptors (GABA(A)Rs) occur at hippocampal mossy fiber synapses.

254 ontextual memory and long-term plasticity at mossy fiber synapses.

255 ential for cAMP-dependent presynaptic LTP at mossy-fiber synapses, and a single amino-acid substituti

256 hat locomotion can be directly read out from mossy fiber synaptic input and spike output in single gr

257 ranule cells, which may result from abnormal mossy fiber synaptic plasticity.

258 A decreasing gradient of mossy fiber synaptic strength along the proximodistal ax

259 A-knockin impaired the long-term increase in mossy-fiber synaptic transmission induced by forskolin.

260 dentate gyrus in areas corresponding to the mossy fiber system of chronically epileptic rats.

261 Although the majority of mossy fiber targets are GABAergic cells, the functional

262 These results implicate the mossy fiber-TE synapse as an independently tunable gain

263 Although mossy fiber terminals (MFTs) are known to express glutam

264 tial patterns of calcium elevations in giant mossy fiber terminals and support short-term facilitatio

265 rain sections from both mice and rats showed mossy fiber terminals as a group of large (2-5 mum in di

266 Hippocampal giant mossy fiber terminals display extensive short-term facil

267 GABA is released as a neurotransmitter from mossy fiber terminals during development.

268 very low levels of extranuclear ERbeta-ir in mossy fiber terminals in mice, the labeling patterns in

269 labeled somata in the cerebellar nuclei and mossy fiber terminals in the cerebellar granule layer, c

270 Though, how giant mossy fiber terminals leverage distinct types of voltage

271 that, in the developing rodent hippocampus, mossy fiber terminals release GABA together with glutama

272 Postsynaptic targets of all labeled mossy fiber terminals were identified using immunohistoc

273 terminals in the same area where identified mossy fiber terminals were present.

274 CA3 granule cell axons displayed giant mossy fiber terminals with filopodial extensions, demons

275 activation of the Erk1/2 MAPK in hippocampal mossy fiber terminals, disinhibition of zinc-sensitive M

276 the morphological characteristics of typical mossy fiber terminals, the functional characteristics of

277 ssing some of the morphological hallmarks of mossy fiber terminals.

278 pDOR-ir was less frequently found in mossy fibers terminals.

279 se AZ/PZ, whereas in rat CART immunoreactive mossy fibers terminated predominantly in the CZ/NZ.

280 Mossy fiber termini in the hippocampus accumulate Zn(2+)

281 t long-term potentiation induction at single mossy fiber termini of dentate gyrus neurons in adult mo

282 ded into presynaptic vesicles in hippocampal mossy fiber termini upon KCl-induced depolarization, whi

283 xcitatory postsynaptic potential evoked by a mossy fiber that enhances NMDA receptor-mediated current

284 in axons and synaptic boutons of hippocampal mossy fibers, thereby implicating BDNF in activation of

285 and morphological maturation of hippocampal mossy fiber to CA3 pyramidal cell (mf-CA3) synapses is d

286 Excitatory synaptic strength at mossy fiber to CA3 pyramidal cell synapses is potentiate

287 A well established property of mossy fiber to CA3 pyramidal cell synapses is the extens

288 Glutamate spillover in the mossy fiber to granule cell cerebellar glomeruli has bee

289 the mossy fiber to nuclear cell synapse and mossy fiber to granule cell synapse.

290 ings of learning related potentiation at the mossy fiber to nuclear cell synapse and mossy fiber to g

291 ion of Purkinje cells, and plasticity at the mossy fiber to vestibular nuclei neuron synapse.

292 2 are necessary for the precise targeting of mossy fibers to distinct lobules, as well as their subse

293 t zinc modulation extends beyond hippocampal mossy fibers to excitatory SC-CA1 synapses.

294 However, at the mossy fiber-to-unipolar brush cell synapse in the cerebe

295 SIGNIFICANCE STATEMENT: The mossy fibers transiently corelease glutamate and GABA on

296 enhancing synaptic efficiency of hippocampal mossy fiber transmission.

297 NT The common assumption that all cerebellar mossy fibers uniformly collateralize to the cerebellar n

298 Moreover, the number of new mossy fiber varicosities in these parts of the cerebella

299 but that the BDNF protein is present within mossy fibers which originate from cells located outside

300 s through aberrant sprouting of their axons (mossy fibers), which is found in many patients and anima