ライフサイエンスコーパス: most notably

1 Most notably, 1 reacts with catechol borane to afford th

2 Most notably, 12 (67%) of the 18 genes previously identi

3 f 3 colonic catabolites of bacterial origin, most notably, 3-(3'-hydroxy-4'-methoxyphenyl)hydracrylic

4 t photoproduction rates of nitrite and HONO (most notably, 4-nitrophenol and 2-methyl-4-nitrophenol)

5 ) that generate the inositol pyrophosphates, most notably 5-diphosphoinositol pentakisphosphate (IP7)

6 es seen with broad spectrum HDAC inhibitors, most notably a block in the differentiation of rod photo

7 d bare-metal stents, some limitations apply, most notably a chronic local inflammatory reaction due t

8 Elucidation of tumor biology principles, most notably a deeper understanding of the complexity of

9 Most notably, a 400-fold rate enhancement is seen upon f

10 Most notably, a GIT1-R283W variant reported in four inde

11 to several uncultured prokaryotic lineages; most notably, a SAR406 representative is attributed with

12 symptoms over time (r=-0.33; df=47; P=0.02), most notably abnormal thought content (r=-0.442; df=47;

13 particular logistical challenges in Africa, most notably access to bioinformatics expertise and inte

14 Most notably, after mycobacterial pulmonary infection, h

15 ctin accumulation, TGF-beta expression, and, most notably, age-related impairments in mitochondrial b

16 as alignment accuracy, peak resolution, and most notably, allele-specific binding detection.

17 Most notably, allergen-reactive CD62L(lo) Th2 cells were

18 of facile oxidative bond-forming reactions, most notably allowing access to the first examples of Gr

19 fications in the methods for developing AUC, most notably, alterations in the nomenclature for approp

20 um of yearly serum concentration estimates), most notably among males 40-60 years of age.

21 ecificity can lead to unwanted consequences, most notably an enhanced susceptibility to infection.

22 able bowel syndrome include genetic factors (most notably an identified mutation of SCN5A); post-infe

23 e-metal and drug-eluting stent implantation, most notably an upregulation of aggrecan, a major ECM co

24 Most notably, an afternoon peak in cyanophage transcript

25 ting include gene disruption, which has been most notably applied to the CCR5 coreceptor gene, or the

26 that is regulated by a number of mechanisms, most notably as a target of the oncomiR, miR-21.

27 Used most notably as aids to psychotherapy for the treatment

28 n functions previously associated with Sgs1, most notably as an early recombination intermediate chap

29 razines, some furans and pyridines increased most notably at temperatures 50 degrees C.

30 arked differences between males and females, most notably at the CHRNA3 locus, and variants associate

31 marks of several neuropsychiatric disorders, most notably autism spectrum disorders.

32 changes in the responses to plant hormones, most notably auxin, strigolactone, gibberellic acid, and

33 n of several common mouse and human targets, most notably BCL9, predicted survival in HCC patients.

34 Insects, most notably bees and ants, are also impressive navigato

35 the function of manganese-dependent enzymes, most notably beta-1,4-galactosyltransferase, a Golgi enz

36 on, we demonstrate that structured elements, most notably, beta-sheets, are significantly concentrate

37 etween different cohorts or variant classes, most notably between the exome variant sets which sugges

38 itted from a range of environmental sources, most notably blood meal hosts and oviposition sites.

39 omplement to other fluorescent beta-lactams, most notably Bocillin FL.

40 Most notably, bound AMP-PNP was only observed when trapp

41 osystem function without affecting richness, most notably by affecting population densities and commu

42 and regulation of the vernalization pathway, most notably by AGAMOUS LIKE19 (AGL19), FLOWERING LOCUS

43 ic mechanisms to suppress tumor cell growth, most notably by enabling an effective antitumor immune r

44 GTP at the G protein alpha subunit (Galpha), most notably by G protein-coupled transmembrane receptor

45 t efforts have been focused on targeting it, most notably by inhibiting its AURKB kinase subunit.

46 lays an integral role in cellular signaling, most notably by modulating proteins bound at chromatin a

47 y a variety of small transmembrane peptides, most notably by phospholamban in cardiac muscle and sarc

48 ffer from chronic bacterial lung infections, most notably by Pseudomonas aeruginosa, which persists f

49 ctivators, phosphodiesterase inhibitors, and most notably by stimulation of G protein-coupled recepto

50 egeneration of several neuronal populations, most notably CA3 pyramidal neurons of the hippocampus, w

51 es have occurred in several Candida species, most notably Candida glabrata and more recently Candida

52 er of cytokine and chemokine receptor genes, most notably CCR8, were upregulated in tumor-resident Tr

53 us's ability to spread between immune cells, most notably CD4 T lymphocytes.

54 the causative agents of many human cancers, most notably cervical cancer.

55 le pairs of flies follow a distinct pattern, most notably characterized by an activity trough at dusk

56 portant features of primate ZEBOV infection, most notably, coagulation abnormalities.

57 t signaling is at the root of many diseases, most notably colorectal cancer, and although we understa

58 nished in proportion to depression severity, most notably connectivity strength in the left ventral s

59 Th1 and T-effector markers, and chemokines, most notably CX3CL1 (fractalkine).

60 ulation of T follicular helper cell markers, most notably CXCR5 and its ligand CXCL13, and immunohist

61 mponents and functions of the immune system, most notably cytokine production and immune cell migrati

62 Most notably, depletion of CD8(+) T cells in solidly pro

63 Psychotherapies, most notably dialectical behavior therapy and psychodyna

64 to its local effects in various brain areas, most notably distinct regions of the amygdala.

65 ncordant with levels of DLL3 expression and, most notably, DLL3 immunoPET yielded rank-order correlat

66 of algae biomass by heterotrophic bacteria, most notably during massive marine algae blooms.

67 through a variety of environmental pathways, most notably during wastewater transport and disposal, a

68 Most notably, E4 is associated with earlier onset and in

69 sitive targets encode extracellular factors, most notably enhancers of Activin/pSMAD2 signaling.

70 with strongly biased amino acid composition, most notably enriched for Q or N.

71 more than the other, and identified others - most notably, environmental novelty - that merit further

72 applied to several neurological conditions (most notably epilepsy and movement disorders), but wides

73 ular sarcoma types, certain fusion partners, most notably EWSR1, are not tumor specific (and may, in

74 nclude intermittent bioenergetic challenges, most notably exercise and dietary energy restriction, ca

75 Here, we describe recent advances, most notably expansion to 4150 total families including

76 The red cell membranes were abnormal, most notably expressing reduced amounts of CD44 and, con

77 with decreasing kidney function in controls, most notably factor VIII and von Willebrand factor.

78 l plugs in mice was abolished by Ned-19 and, most notably, failed to occur in Tpcn2(-/-) mice, but wa

79 e that solid-phase ligands in oxic sediment, most notably Fe oxides, may have a critical role in cont

80 ation often requires large amounts of water, most notably for cooling thermoelectric power generators

81 large (>500 kb) CNVs in BD compared with SZ, most notably for deletions >1 Mb (P=9 x 10(-4)).

82 s of formation of certain reaction products, most notably for HCOO(-), C2H4, and C2H5OH over Cu(100)-

83 t variation exists in the management of AAA, most notably for iAAA diameter at repair, use of EVAR, a

84 ines involved in intestinal innate immunity (most notably for members of the interleukin-1 family), w

85 pread use in bioinorganic chemistry, perhaps most notably for modeling the Mn4Ca site in the oxygen e

86 d between the membrane and solution systems, most notably for the gating residues and channels that c

87 Most notably for the lowest intelligibility level, perce

88 erapeutic efficacy in human clinical trials, most notably for those in patients with hemophilia B (re

89 Most notably, forced claudin-7 expression in poorly diff

90 carboxylic acids, nucleobases, sugars, and, most notably, four nucleosides: cytidine, uridine, adeno

91 key evolutionary transitions of Hymenoptera, most notably from phytophagy to parasitoidism and predat

92 Some combinations of substitutions, most notably G219S and K58I, resulted in relatively high

93 Most notably, Gata2 expression was significantly higher

94 ing the longest linear sequence and, perhaps most notably, generating the antimycin A C7-C8-C9 stereo

95 Most notably, genes regulating early tissue patterning a

96 phosphorylation of specific Akt substrates, most notably glycogen synthase kinase 3beta (Gsk-3beta).

97 However, the isotropic orientation of GBNs, most notably graphene oxide (GO), in previous experiment

98 Most notably, groups differed on a putative measure of c

99 ntly higher rates of common adverse effects, most notably hand-foot skin reaction, diarrhea, and hype

100 uption of DNA binding of TRalpha and TRbeta, most notably heart rate, body temperature, blood glucose

101 esponse to high-risk etiological challenges, most notably hepatitis virus.

102 HIFalpha transcription factors, most notably HIF2alpha (also known as EPAS1), are expres

103 ctivation of hypoxia-inducible factor (HIF), most notably HIF2alpha.

104 Most notably, higher levels of beneficial gut bacteria c

105 Most notably, highly intransitive communities comprising

106 enotypes were also ameliorated by treatment, most notably hippocampal cell size and lifespan.

107 uccessfully addressed off-target activities, most notably human pregnane X receptor (hPXR) transactiv

108 Most notably, human cytomegalovirus (HCMV) protein pUL21

109 eripheral phenotypes were observed, however, most notably hypo-activity, exercise fatigue and bone ab

110 mpanied by elevated production of cytokines, most notably IL-6.

111 Most notably, immediately upstream of the transcription

112 henotypes that are shared with some cancers, most notably immortalization, hyperproliferation, and di

113 rtners affecting several cellular processes, most notably immune regulation and DNA repair, but also

114 rdination sphere leads to unique properties, most notably, improved stability toward moisture in solu

115 We show that in several of these polymers, most notably in a recently reported, indacenodithiophene

116 Most notably in both patients and rats, all drilling too

117 damental insights into biological processes, most notably in developmental biology.

118 phagosomes and a disruption of cell adhesion most notably in elongated spermatids due to a loss of ac

119 h higher nonlinear variation in north China, most notably in Heilongjiang Province, the major grain b

120 ith DS show a variety of cognitive deficits, most notably in hippocampal learning and memory, and dis

121 als of mixed ancestry has many applications, most notably in identifying disease-susceptible loci tha

122 y distinct from the other five Rpt subunits, most notably in its pore loop region.

123 hagocytic cells of the innate immune system, most notably in myeloid cells capable of mounting potent

124 fers significant new research opportunities, most notably in physiology and medicine, isotope biogeoc

125 man cancer cell lines and cancers, including most notably in prostate and ovarian cancers.

126 tempts show that some high profile results---most notably in psychology, but in many other discipline

127 re found along many coasts around the world, most notably in south and southeast Asia but also in the

128 gnificant differences in several parameters, most notably in temporal processing.

129 signaling is common in human breast cancers, most notably in the basal molecular subtype, as well as

130 This patient had multiple joint deformities, most notably in the bilateral metacarpophalangeal joints

131 rstanding of inhibition in many brain areas, most notably in the cerebral cortex.

132 ical diagnostics and therapeutic monitoring, most notably in the context of circulating tumor cells.

133 eposits have been confirmed in brain tissue, most notably in the dentate nuclei and globus pallidus.

134 d that Wnt/beta-catenin pathway is activated most notably in the dermis of the wound bed early (d 2)

135 r, bacteria themselves suffer from diseases, most notably in the form of viral pathogens termed bacte

136 n a range of gold-catalyzed transformations, most notably in the gold-catalyzed cycloisomerization of

137 lt stem cells in several epithelial tissues, most notably in the intestinal crypts, and is highly up-

138 hibitors significantly reduced tumor burden, most notably in the IRS-1-deficient group.

139 d conformation of a growing microtubule tip, most notably in the number of protofilament curls.

140 lectively expressed in stratified epithelia, most notably in the oesophagus where the Nanog promoter

141 been implicated in autoinflammatory disease, most notably in the PAPA syndrome: pyogenic sterile arth

142 group compared with that in the sCON group, most notably in the PCC (P < .05 corrected).

143 several unique challenges and opportunities, most notably in the perioperative setting.

144 um enolates in several classes of reactions, most notably in transformations forming tetrasubstituted

145 range of technical parameters was reported, most notably in tube current.

146 ics may be susceptible to biotransformation, most notably in vivo proteolytic truncation, and it is v

147 applications in cardiovascular biomedicine, most notably in: 1) the discovery of circulating protein

148 Most notably, in mammals pausing is positively correlate

149 Most notably, in postnatal growing mice, the Gli1(+) cel

150 rmance or likelihood of adverse events, but, most notably, in the long-term neurological outcome.

151 enhanced autophagic degradation of proteins, most notably including AQP2, is an early event in hypoka

152 ated with several distinct neural processes, most notably increased activity in the default mode netw

153 over large parts of maritime southeast Asia, most notably Indonesia, releasing large amounts of terre

154 ific borrelial plasmids has been identified; most notably, infections of the tick vector and mammalia

155 ams specific cellular pathways in monocytes, most notably innate immune responses, which may play a r

156 Most notably, interneurons in the olfactory bulb, which

157 antial contributions to quantitative traits, most notably intracellular amino acid concentrations, gr

158 Carbapenem-resistant Klebsiella pneumoniae, most notably isolates classified as multilocus sequence

159 Most notably, it provides the first method for reliable,

160 , supervised machine learning has drawbacks, most notably its dependence on a priori knowledge of exp

161 identified components of the Notch pathway, most notably Jagged 1 (Jag1), as targets of PM induction

162 ons were detected in key signaling pathways, most notably JAK/STAT, that leukemia cells require for p

163 n by mutations in the hemopoietic stem cell, most notably JAK2(V617F), CALR, and MPL.

164 ed levels of certain antimicrobial proteins, most notably lactoferrin, have been found in sinus secre

165 ral predicted membrane-spanning (M) helices, most notably M4, M9, and M11, as important determinants

166 eprogramming, as well as diseases, including most notably malignant brain tumors.

167 Robots have transformed many industries, most notably manufacturing, and have the power to delive

168 Most notably, MarA activates expression of genes require

169 Most notably, MDA-MB-231 tumor xenographs and cell metas

170 uitylase BAP1 is mutated in several cancers, most notably mesothelioma and melanoma, where it is thou

171 ndothelial cells, and choroid plexus cells), most notably microglia and/or macrophages.

172 changes in climate and industrial pollution (most notably, mid-19th century increases in mercury poll

173 Most notably, miR-190b expression showed high statistica

174 Most notably, miR-34a showed significant upregulation in

175 argely been confined to a few model species, most notably mouse, zebrafish, Drosophila melanogaster a

176 cant additive gene-environment interactions, most notably NAT2 (P = 7 x 10(-4)) and UGT1A6 (P = 8 x 1

177 and are associated with metabolic syndrome, most notably NATpost and NATsc in women.

178 wide variety of C-C bond-forming reactions, most notably Negishi, Suzuki-Miyaura, Stille, Kumada and

179 ant for tackling several types of addiction (most notably nicotine addiction) and other compulsive be

180 excessive proinflammatory hypercytokinemia, most notably of interleukin-6.

181 athway and can drive formation of melanomas, most notably of rare melanomas that occur on volar and m

182 tic insight into the enhanced AR activation, most notably of the recently identified AR variants, inc

183 cts with proteins in addition to dentilisin, most notably, oligopeptide-binding proteins (OBPs) and t

184 Most notably, oMAP4 is required for paraxial microtubule

185 y during the synthesis and processing of GO, most notably on filtration with anodized aluminium oxide

186 a role in the building of glycan structures (most notably on the protein alpha-dystroglycan) that all

187 Most notably, our analysis reveals the co-dependency of

188 Most notably, our experiments demonstrate that moderate

189 are greater numbers of human infections, and most notably outbreaks linked to extreme weather events

190 cell lines in the NCI 60 human cancer panel, most notably ovarian cancer and leukemia, but exerted li

191 nesis of several neurodegenerative diseases, most notably Parkinson disease.

192 al nervous system by acting on ion channels, most notably pentameric ligand-gated ion channels.

193 Most notably, Pep2.5 prevented the down-regulation of SE

194 s via the induction of various coactivators, most notably PGC-1alpha.

195 variety of posttranslational modifications, most notably phosphorylation by cyclin-dependent kinase

196 Most notably, phylogenetic inference supported by the st

197 Most notably, PK7088 increased the expression levels of

198 Most notably, procurement areas changed through time.

199 atly improve genome-wide RNAi libraries and, most notably, provides the only broadly applicable means

200 Most notably, Pt-DA and Pt-G4K(+)B hydrogels show select

201 hADSCs differed between young and aged rats, most notably reduced migration to the aged spleen.

202 ents in early postentry stages of infection, most notably reverse transcription.

203 Odor responses in several neurons, most notably RIA, are altered in imprinted animals.

204 ion observed for all steps of the mechanism, most notably Schiff base formation and hydrolysis.

205 ltiple tumors in the central nervous system, most notably schwannomas, and meningiomas.

206 de that is a marker of a number of diseases, most notably several of the mucopolysaccharidoses (MPS).

207 Human coronaviruses, most notably severe acute respiratory syndrome (SARS)-Co

208 is, they have more chronic comorbidities and most notably similar short-term and long-term mortality.

209 f SlBOP function causes pleiotropic defects, most notably simplification of inflorescences into singl

210 many types of human infections and syndromes-most notably skin and soft tissue infections.

211 ns deletions of tumour suppressor gene loci, most notably SMAD4, which is homozygously deleted in nea

212 Several lifestyle factors, most notably smoking and alcohol, are associated with SP

213 ome early in life are generally lacking, and most notably so in primate models.

214 Vertebrate SoxE paralogues, most notably Sox9/10, are essential for NC induction, de

215 ization or infection by pathogenic microbes, most notably Staphylococcus aureus and herpes simplex vi

216 location of Parkin and subsequent mitophagy, most notably sterol regulatory element binding transcrip

217 Some microbial species (most notably Streptococcus anginosus) seem to characteri

218 antages over hybridization-based approaches, most notably superior sensitivity and the capacity for d

219 licated in the pathogenesis of autoimmunity, most notably systemic lupus erythematosus (SLE), diabete

220 nsion shows strong lineage-specific aspects, most notably that hypomethylated intervals around transc

221 t features of the electronic structure of 3, most notably, that the mu-oxo bridge facilitates communi

222 typical BCG measurement shows several waves, most notably the "I", "J", and "K" waves.

223 to the unique features of the hydride anion, most notably the absence of valence p orbitals.

224 es have been made in pediatric rheumatology, most notably the alpha interferon signature of systemic

225 cleavage of several transmembrane proteins, most notably the amyloid precursor protein that results

226 they are likely to be due to nearby vessels, most notably the basal vein of rosenthal (BVR).

227 quently expanded to include other effectors (most notably the betaarrestins).

228 acquisition of mature brain vascular traits, most notably the blood-brain barrier.

229 ght the extent to which the molecular clock, most notably the core clock proteins BMAL1, CLOCK, and R

230 The DILT1D trial results, most notably the early altered trafficking and desensiti

231 re identifies known and novel co-repressors, most notably the ETO2 and IRF2BP2 proteins, involved in

232 Sb5 exudates, most notably the fractions larger than 3 kDa, promoted p

233 Our data indicate that some marine bacteria, most notably the highly abundant Pelagibacter ubique and

234 nsic features of antibody primary structure, most notably the interspersed segments of variable and c

235 or the structure-activity relationship data, most notably the lack of enantiospecificity and the tole

236 but display important differences, including most notably the lack of TMBS2 and the presence of a C-t

237 that may be important to anion specificity, most notably the necessity of a positive charge near the

238 iple laminated cerebral structures affecting most notably the neocortex, hippocampus, cerebellum, and

239 in embryonic fibroblasts and primary DSRCT, most notably the neural reprogramming factor ASCL1.

240 rentially expressed genes across conditions, most notably the nuclear factor kappa-light-chain-enhanc

241 trongly determined by anthropogenic effects, most notably the number of species introduced (i.e., "co

242 and realized pharmaceutical value, including most notably the opiates such as codeine and morphine.

243 to interior basins during past warm periods, most notably the Pliocene epoch, causing several metres

244 or spectroscopy of nanomaterial dispersions; most notably the possibility of observing solvent photol

245 web services have had several enhancements, most notably the provision of a dynamic new interactive

246 gions associated with other clinical events, most notably the regions harboring CKMT2 gene (creatine

247 diets revealed several significant changes, most notably the significant upregulation of VGF-derived

248 show dramatic changes in kinetic properties, most notably the slowing of the apparent ATP hydrolysis

249 e transcription of a set of genes, including most notably the stem cell factor SOX9, that promote pro

250 the genetic bases of many viral phenotypes, most notably the susceptibility to neutralization by a p

251 considered oversimplistic and conservative; most notably the unit refill rate.

252 major challenges will need to be confronted, most notably the very low levels of public expenditure;

253 l responses to several Ebola virus proteins, most notably the viral nucleoprotein.

254 cover surprising features of STAT5 behavior, most notably the wholesale redistribution that occurs wh

255 Most notably, the beta-hairpin region resembles that of

256 n into distinct genotypes and lineages, and, most notably, the convergent evolution observed in recen

257 Perhaps most notably, the device manufacturing is significantly

258 Most notably, the fatty acyl chain-dependent differentia

259 Most notably, the FOURIER (Further Cardiovascular Outcom

260 g and interpreting nutrient or energy levels-most notably, the insulin/insulin-like growth factor 1 (

261 Most notably, the method allows accurate fitting of the

262 Most notably, the original ED2 produced unrealistically

263 t varies with the changes in the environment-most notably, the pH of the surrounding solution.

264 Most notably, the radical ion pair state lifetime of the

265 Most notably, the reduced bone volume and bone formation

266 Most notably, the relative abundance of Fusobacterium in

267 Most notably, there is an order of magnitude more hetero

268 Most notably, there was a substantial reduction in predo

269 Most notably, there was no dermal elastic fiber involvem

270 Most notably, these findings uncover new roles for Notch

271 F-VADs have several favorable features, but, most notably, they allow the effective temporary stabili

272 damage and protect the intracellular milieu, most notably thiol peroxidases, which are abundant and c

273 Cancer-associated KNSTRN mutations, most notably those encoding p.Ser24Phe, disrupt chromati

274 at modulate a variety of cellular processes, most notably those involving actin dynamics.

275 eurotransmitter and neuromodulator circuits, most notably those involving cholinergic transmission, a

276 was reflected in the gene expression levels (most notably those of NDL1, CHALCONE SYNTHASE, and MYB D

277 targeting this pathway have been developed, most notably through inhibition of Smoothened (SMO).

278 ss scales exhibits remarkable commonalities, most notably through the approximate validity of Kleiber

279 our understanding of the fluctuation regime, most notably to nature of the pseudogap state in high-te

280 mitigated the innate inflammatory response, most notably tumor necrosis factor-alpha-mediated signal

281 CA2 predispose to common human malignancies, most notably tumors of the breast and ovaries.

282 large body of experimental quantifications, most notably ultrafast spectroscopy and quantum yield me

283 Most notably, unfolding in both directions is rate-limit

284 regulation of M30 in epilepsy toward health, most notably valproic acid, whose effect on M30 expressi

285 Most notably, vWF showed additional prognostic value bey

286 at are semi-transparent to greenhouse gases, most notably water vapour.

287 Most notably we found that ARID3B expression is decrease

288 Most notably we observed that the enzyme can perform oxi

289 Most notably, we also show that the transmembrane helix

290 Most notably, we find reaction diffusion behavior, slow

291 Most notably, we found that the subset previously define

292 Most notably, we predict and characterize novel alloster

293 transitions within Platyhelminthes: perhaps most notably, we propose a novel scenario for the interr

294 Most notably, we report evidence of bowhead whale exploi

295 lycerol and glycerophospholipid homeostasis, most notably with an increase in fatty acid saturation.

296 ate functional groups into oligonucleotides, most notably with lipophilic anchors, enabled a widespre

297 ntially in England in the past five decades, most notably with the advent of effective conjugate vacc

298 Myc 3' WRE suppressed colonic tumorigenesis, most notably within the cecum.

299 n microbiota in their various body habitats, most notably within the gastrointestinal tract (GIT).

300 Most notably, xenogeneic silencing proteins bind incomin