ライフサイエンスコーパス: motif

1 g aromatic amino acids, the caveolin-binding motif.

2 ture yet share the same RE4(mu3-OH)4 cluster motif.

3 ecognition/interaction amino acid consensus" motif.

4 nding domain: motif-1, motif-2, and the hook motif.

5 erence for a low-affinity, secondary binding motif.

6 ining a 5' terminal oligopyrimidine (5' TOP) motif.

7 ical hairpin, and bipartite helix-turn-helix motif.

8 genesis in cells expressing the mutated IVVY motif.

9 phenylalanines (FF) in an acidic tract (AT)] motif.

10 erformed to achieve the required uronic acid motif.

11 se(s) compared to the corresponding template motif.

12 CDGSH domain that is followed by the "NEET" motif.

13 he upstream motif and RRM1 to the downstream motif.

14 y site located in close proximity to the RGD motif.

15 mpared with models based on known TF binding motifs.

16 of digesting genomic DNA at defined sequence motifs.

17 ucture-fitness relationships in other common motifs.

18 f G-repeats on the formation of tetrameric i-motifs.

19 moters harboring canonical and variant MEF2C motifs.

20 ersified to recognize unique phosphorylation motifs.

21 and application to the synthesis 1,3-polyol motifs.

22 pression through inhibiting chaos-generating motifs.

23 rol through conserved cholesterol-responsive motifs.

24 sites, which are enriched for NR recognition motifs.

25 folding properties of individual structural motifs.

26 up to three copies of hAgo via its three GW motifs.

27 acting factors to cis-localized DNA sequence motifs.

28 ere significantly associated across multiple motifs.

29 n of RAB GTPases that contain C-terminal CXC motifs.

30 hese lists, we can find co-TFs for candidate motifs.

31 rs/collaborators and discovering enriched TF motifs.

32 quate knowledge of cell-specific DNA binding motifs.

33 sidues that confer specificity towards CC/TC motifs.

34 ation of two independent secondary structure motifs.

35 are hard to explain via evolutionary mating motives.

36 /WG repeats in its Argonaute-binding domain: motif-1, motif-2, and the hook motif.

37 Our group previously identified Tripartite Motif 14 (TRIM14) as a component of a prognostic multige

38 lving leaving group stabilization by H155 in motif 2 and water coordination by N89 in motif 3 is prop

39 ts in its Argonaute-binding domain: motif-1, motif-2, and the hook motif.

40 in motif 2 and water coordination by N89 in motif 3 is proposed.

41 ork, we have extended a previously described motif (4 x 5) by expanding the structure to a system tha

42 ke and metalloproteinase with thrombospondin motifs-4) is a secreted proteinase involved in inflammat

43 An enhancer with amalgamated E-box and GATA motifs (+9.5) controls expression of the regulator of he

44 ome-wide methylation and highlight conserved motifs across three Trichodesmium isolates and two Trich

45 The modular motif affords efficient syntheses using building blocks

46 free energy landscape containing all binding motifs allows determination of the ligand mechanical foo

47 s hypothesis, we carried out a comprehensive motif analysis on the prognostic GSs from five cancer ty

48 The current database, combined with motif analysis, can be used by researchers and regulator

49 can illustrate co-TF binding affinities for motif analysis.

50 revealed the importance of the conserved DDE motif and a W residue.

51 re of FBXW7 bound to the DISC1 phosphodegron motif and exploit this information to prove that disrupt

52 RRM2 binds to the upstream motif and RRM1 to the downstream motif.

53 enabled the discovery of subdominant binding motifs and an integrative analysis quantifying the contr

54 V) domain with a pocket that can bind PT/SAP motifs and another pocket that can bind Ub.

55 ntify that PrimPol possesses two RPA-binding motifs and ascertained the key residues required for the

56 The effects of structural motifs and cluster-cage interactions on formation of com

57 s therefore critical in directing structural motifs and dictating the resulting hydrogen and halogen

58 e of this analysis, highly conserved protein motifs and domains within each of the AARS loci were ide

59 ounds reveals the key role of VO4 structural motifs and electronic band-edge character in efficient p

60 e.g. presence/absence of mutations, binding, motifs and epigenetic marks) and continuous data (e.g. g

61 e can identify functionally relevant circuit motifs and generalize the framework to solve other categ

62 compounds with potentially reactive chemical motifs and poor physicochemical properties are published

63 ased features coming from both within the G4 motifs and their flanking regions.

64 tly conjugated to Dha through its piperidine motif, and its antibody-mediated intracellular delivery

65 gh recognition of a short phenylalanine-rich motif, and the presence of similar motifs in other small

66 Miner2 contains two CDGSH motifs, and each CDGSH motif hosts a [2Fe-2S] cluster vi

67 , identifies export-promoting ALYREF-binding motifs, and reveals CstF64- and PABPN1-mediated coupling

68 the crystallographically-defined recognition motif, apparently as a consequence of non-specific elect

69 lly modified with a simple aromatic boronate motif are actively trafficked to the nucleus via the imp

70 Several natural product-relevant motifs are accessed in enantioenriched form for the firs

71 These motifs are challenging to identify, but once found they

72 The two structural motifs are connected through an acetylene linkage.

73 et of variables provides fine control of how motifs are placed into sequences, thereby allowing the i

74 organization, not a precise array of heptad motifs, as important to CTD function.

75 ur analyses reveal that a conserved diacidic motif (Asp-Glu) in these proteins is necessary for their

76 of a previously unknown high-affinity AICE2 motif at a human single-nucleotide polymorphism (SNP) of

77 revealed a cenH3 nucleosome binding CENPC-k motif at the C terminus of Arabidopsis thaliana KNL2, wh

78 based on the biorecognition of complementary motifs at cell surface resulting in receptor crosslinkin

79 ith RFX footprints uniformly disrupt the RFX motifs at high-information content positions.

80 tations within a PMS2 C-terminal (721)QRLIAP motif attenuate or abolish human MutLalpha interaction w

81 um-range order is detected with crystal-like motifs based on the B2 CuZr structure and its distorted

82 remaining more predictive of expression than motif-based networks.

83 tering, using it to increase the accuracy of motif-based TFBS searching for an example TF.

84 A short-linear interaction motif between residues 337-343 of AKAP79 is the sole PP2

85 d that variants lacking the minimal sequence motif bind competitively with consensus RNA.

86 ata establish that cargoes containing Yxxphi motif, but not dileucine motif, play a critical role in

87 investigated whether a mutation in the CX3C motif by insertion of an alanine, A(186), within the CX3

88 -rich DNA, here we show that this structural motif can be exploited to guide the self-assembly of nap

89 ir interaction network presents a regulatory motif characteristic of a "feedback-amplified domineerin

90 ssential for recognizing conserved molecular motifs characteristic of pathogenic microbes.

91 levels of interleukin-6, interleukin-8/C-X-C motif chemokine ligand 8, and monocyte chemoattractant p

92 sequences harboring distinct cis-regulatory motifs, constitute much of cell-type-specific splicing,

93 Although tripartite motif-containing (TRIM)-28 is known to have an immunosup

94 hypomethylated region mapping to Iqgap2 (IQ motif-containing GTPase activating protein 2) and F2rl2

95 itination by the ubiquitin ligase tripartite motif-containing protein 32 (Trim32).

96 diately flanking the previously defined AICE motif controlled the affinity of BATF-IRF4 for direct bi

97 homodimers revealed that 72% of heterodimer motifs correspond to conjoined half-sites preferred by p

98 We hypothesized that the conserved motif could be a necessary and sufficient minimal motif

99 e use of allosterically regulated C-terminal motifs could be a common mechanism for PilZ adaptor prot

100 inter called Detecting Footprints Containing Motifs (DeFCoM).

101 With MPRA Motif design, a set of variables provides fine control o

102 approximately 20 residues downstream of this motif determines the size of the resultant hetero-oligom

103 Mutations of this motif directly modulate proof-reading by eliminating or

104 mple and intuitive and is the basis for many motif discovery algorithms.

105 Because existing motif-discovery tools typically miss these position-spec

106 Finally, modification of the i-motif DNA at G14 diminished RRM1-DNA interaction, as wel

107 ely to be involved in interaction with the i-motif DNA, and His24 and Arg26 were chosen for modificat

108 ential ability to interact with G14 of the i-motif DNA.

109 sed to study binding affinity for the BCL2 i-motif DNA.

110 lutionary psychology is laudable, but mating motives do not explain the beauty premium.

111 Determination of preferential protease motifs during podocyte damage indicated activation of ca

112 ern, identified transcription factor binding motifs enriched in each cluster, and generated a model G

113 Two of the cis sequence motifs enriched in the PREs are cognate binding sites fo

114 odularity between sparsely connected network motifs, Escherichia coli (E. coli) appears to favor cros

115 terplay between transcription factor binding motif evolution and GRN topology.

116 Here we identified a Y/F-x-x-Y/L/F-x-Y/F motif, evolutionarily conserved from the first tetrapods

117 Different pairs of motifs follow different interaction rules, including sub

118 yl ether linkage as a novel dynamic covalent motif for dynamic material design.

119 he hexapeptide motif in repeat R3, a crucial motif for fibril formation, shows strikingly low variabi

120 lization signal motifs, they represent a new motif for INM trafficking.

121 could be a necessary and sufficient minimal motif for translocation.

122 ted a highly specific sequence and structure motif for Vts1 binding.

123 recognition were identified and recognition motifs for 6 uncharacterized Thermus-family enzymes were

124 sing this approach we developed quantitative motifs for a selection of kinases from each branch of th

125 se susceptibility and biological-recognition motifs for cell adhesion and angiogenesis.

126 cterized by enrichment for consensus binding motifs for Nr4a and NFAT transcription factors.

127 These mRNAs' 3'UTRs have enriched binding motifs for several RNA-binding proteins, which implies e

128 ion factors (TFs), and enrichment of binding motifs for these TFs in alphaTC1/betaTC6 cis-regulatory

129 nnels and lacks the TVGYG selectivity filter motif found in these channels.

130 In addition, the sequence motifs found in the potential branch-point region differ

131 ficantly overrepresented in the cross-linked motifs found within E. coli.

132 B-lymphocytes activated by un-methylated CpG motifs, found in bacterial DNA, and beta-glucans, found

133 sualization of position-specific ultra-short motifs from a set of aligned sequences.

134 compared with in silico predictions based on motifs from methods such as protein-binding microarrays

135 parate nickase enzyme that recognizes a 7-bp motif genome-wide.

136 The double crossover (DX) design motif has demonstrated versatility in synthesizing arbit

137 The Patescibacteria LexA-binding motif has unusual direct-repeat structure, and comparati

138 Five disease-causing variations in these motifs have been identified in ABCB4 (G535D, G536R, S107

139 promoter region containing the GCN4/Skn1/RY motif highlights its importance for HvPAPhy_a expression

140 tro studies here show that at the same shift motif HIV reverse transcriptase generates -1 and +1 inde

141 r2 contains two CDGSH motifs, and each CDGSH motif hosts a [2Fe-2S] cluster via three cysteine and on

142 and broad peak calling, peak annotation, and motif identification for ChIP-seq, differential gene exp

143 rsensitive site mapping, site annotation and motif identification for DNase-seq, analysis of nascent

144 t couple RNA and ATP binding to the protein (Motif III).

145 Hyperphosphorylation of a serine-rich motif immediately after the PH domain decreases both Ptd

146 EPIYA-C motifs or the presence of an EPIYA-D motif impacted early changes in host cell elongation; ho

147 ce, surrounded by five encephalitic-specific motifs implicated in receptor binding.

148 Vicinal diamines are a common structural motif in bioactive natural products, therapeutic agents,

149 rom double crossover (DX) tiles, a canonical motif in DNA nanotechnology.

150 t PIN1 binds the phosphorylated Thr(187)-Pro motif in p27 and reduces p27's interaction with cyclin A

151 ing the importance of the fac-C,N,S-iron(II) motif in promoting enzyme-like reactivity.

152 By contrast, the hexapeptide motif in repeat R3, a crucial motif for fibril formation

153 l analysis of a cyclin F-specific amino acid motif in the C-terminal region of Vif indicated rescue o

154 KII) strongly interacts with a novel binding motif in the N-terminal domain of CaV1 LTCC alpha1 subun

155 1 trafficking and identified an Snx3 sorting motif in the Neo1 N-terminus.

156 the recognition of the hexanucleotide AAUAAA motif in the pre-mRNA polyadenylation signal by the clea

157 by integrating transcription factor binding motifs in a machine learning framework, we identify EOR-

158 By identifying shared motifs in core sequences, we were able to highlight key

159 ealed that intact PIN domain and Zinc finger motifs in human hUTP23 are essential for 18S rRNA matura

160 RBM10 recognizes a diverse set of RNA motifs in introns and exons and regulates alternative sp

161 nine-rich motif, and the presence of similar motifs in other small Tim proteins predicts robust degra

162 N'-ethylpiperazines are important structural motifs in several medicinally relevant compounds.

163 eals occurrences of protein and drug binding motifs in the HERV RNA ensemble that do not occur in min

164 Here the authors identify short RNA motifs in the parechovirus genome that bind capsid prote

165 e a local seeding model where the kinked GGA motifs in the stem region of TGGAA repeat DNA act as hot

166 s) zinc finger protein binds these GA repeat motifs, increases chromatin accessibility, enhances hist

167 Due to the impracticality in obtaining motif instances, the significance of their contribution

168 wo self-complementary beta-hairpin enhancing motifs into a short polyQ sequence to generate a mutant,

169 n both species and are often associated with motifs involved in the Nrd1-Nab3-Sen1 termination pathwa

170 The GACTTTT motif is enriched in the promoters of both these gene se

171 GPA levels, indicating that the GCN4/SKn1/RY motif is not the only element responsible for the level

172 erestingly, a Cd(S-Au-S)3 "paw-like" surface motif is observed for the first time in nanocluster stru

173 ns of plant lines with mutations within this motif is significantly reduced.

174 This motif is subject to GSK-3 phosphorylation, promoting ER

175 This structural motif is unusually consistent across all species from al

176 he infectious clone, which contains the VNDT motif, is highly pathogenic and causes lethality in a mo

177 2, although containing a cholesterol binding motif, is not raft associated.

178 th SpyTag C-terminal to the SrtA recognition motif, it can be covalently captured by an immobilized S

179 s in the sequence N-X-S/T (X not equal P), a motif known as an N-glycosylation'sequon'.

180 lel with evolution of consensus RNA sequence motifs known to be associated with the enzymatic complex

181 lt from a common set of recurring structural motifs, leading to the perspective that a generalizable

182 BEESEM is capable of selecting the optimal motif length and calculating the confidence intervals of

183 ition, Spliceman2 integrates with RNAcompete motif libraries to provide a prediction of which trans -

184 (LBP), C-reactive protein (CRP), ILT-4, C-C motif ligand 18 (PARC), and sialic acid-binding Ig-like

185 rosis factor-alpha, IL-1beta, chemokine (C-C motif) ligands 2 and 3, macrophage inhibitory factor, an

186 ies using thymidine nucleotides to lock in i-motif loop lengths support the conclusion that the most

187 the library contained a 5-residue consensus motif, LRLLR in positions 5-9.

188 However, the peptide containing the selected motif, LRLLRWC, was not the fastest; sequence context is

189 talloproteinase with a thrombospondin type 1 motif, member 13) activity (>10%).

190 Consistently, the IVVY motif mutant triggered up-regulation of recombinant reco

191 rtion of an alanine, A(186), within the CX3C motif, mutating it to CX4C ((182)CWAIAC(187)), known to

192 ionarily conserved, truncated leucine zipper motif near the N terminus as well as a strictly conserve

193 The di-lysine ER retention motif of AnkB-Paris is indispensable for function; most

194 blies describe not only the basic structural motif of G-quadruplexes formed by, e.g., telomeric DNA s

195 at the N terminus of rice CCR4 and the PXLXP motif of rice CAF1 play critical roles in OsCCR4-OsCAF1

196 de evidence that 6mA occurs mostly in the AT motif of the linker DNA regions.

197 The location and surrounding sequence motifs of a PAS appear to differentiate its regulation b

198 mploys two separate pockets to bind distinct motifs of Cdc13.

199 nalysis of transcription factor-binding site motifs of differentially dysregulated genes uncovered di

200 data suggest that the Walker A and Walker B motifs of Rrp2 are involved in the control of another un

201 heir promoters were enriched for the binding motifs of TFAP2 (which was identified in promoters of T,

202 centration (0, 2, 5 at.%) but the structural motifs of the medium-range ordered clusters become more

203 mediated by an evolutionarily conserved ETGE motif on CDK20.

204 ar mechanism of a novel mutation at the SUMO motif on signal transducer and activator of transcriptio

205 tigate the effect of distinct intramolecular motifs on xylan conformation and on the interaction with

206 Interestingly, NCgl2760 lacks any motifs or homology to other proteins of known function.

207 ies were bound with N ligand as eta(2) bound motifs or phosphonate ligand as a monodentate, as well a

208 The number of EPIYA-C motifs or the presence of an EPIYA-D motif impacted earl

209 the presence of a short protospacer adjacent motif (PAM) flanking the target site, and subsequent R-l

210 utations in the seed or protospacer adjacent motif (PAM) of the target sequence cause immune failure

211 tide sequence, called a protospacer adjacent motif (PAM), for target recognition.

212 nd orientation from the protospacer adjacent motif (PAM).

213 Since only subsets of Phe/Gly motifs, particularly those within Nup62, Nup98, and Nup1

214 ediated by its phosphoinositide (PI)-binding motif (PBM).

215 SAV-) and Class II (-(595)CLDM-) PDZ-binding motifs (PBMs).

216 The other motif peptides do not induce lipid flip-flop, suggesting

217 This bridging motif perturbs the NU-1000 framework structure, drawing

218 s containing Yxxphi motif, but not dileucine motif, play a critical role in the earliest stages of AP

219 rt the conclusion that the most stable dCn i-motifs possess one nucleotide in each of the three loops

220 es data, either from ChIP-seq experiments or motif predictions, and outputs active TF-gene links as w

221 t in mice DND1 binds a UU(A/U) trinucleotide motif predominantly in the 3' untranslated regions of mR

222 ions offer potential entry to key structural motifs present in bioactive natural products.

223 its and four arene-Ru clips, into a cofacial motif previously demonstrated with free-base, Zn(II), an

224 file, position weight matrix profile, Markov motif profile and polypyrimidine tract profile.

225 webs have been found to exhibit remarkable "motif profiles", patterns in the relative prevalences of

226 RNA binding motif protein 25 (RBM25) is a putative splicing factor s

227 ction mutations in ORGANELLE RNA RECOGNITION MOTIF PROTEIN6 (ORRM6) result in the near absence of RNA

228 These interaction motifs provide hypotheses for fungal-driven dynamics beh

229 of the exon-intron structures and conserved motifs provided further insight into the evolutionary re

230 The concept of motifs provides a fresh perspective for studying local p

231 ultiple key residues in the receptor-binding motif (RBM) of RBD and demonstrated their strong cross-r

232 on-inducing cysteine-rich protein with kazal motifs (Reck) was identified to be one of the target gen

233 We show that R-motif regulates translation in response to pattern-trigg

234 became resistant to degradation when its SQ motifs required for ATR-mediated phosphorylation were mu

235 We describe how the FADS motif responds to signals in the manner of a bistable to

236 The structural motifs responsible for activation and regulation of euka

237 APC/C subunit Apc15 mimics mutations in this motif, revealing a shared function.

238 eracting protein (RIP) homotypic interaction motifs (RHIM) play a key role in cell death and inflamma

239 2 forms a tight complex with the polyproline motif-rich protein Aim21, which interacts physically wit

240 We report that many members of the ykkC motif RNA, the longest unresolved riboswitch candidate,

241 Several variants of a nucleic acid binding motif (RRM1) of putative transcription factor hnRNP LL c

242 in diverse RNAs through two RNA-recognition motifs, RRM1 and RRM2, and post-transcriptionally regula

243 gmentation within the second RNA recognition motif (RRM2) of TDP-43 has been observed in patient tiss

244 tif were identified from the network via the motif's enrichment or biased distribution towards transc

245 The Swellix motif search reveals occurrences of protein and drug bin

246 tors for slippage at slippage-prone template motif sequence 3' of such 'slippage-stimulatory' structu

247 ned by binding first to protospacer adjacent motif sequences on DNA, which is followed by reversible

248 nes with deletions located downstream of the motif show even lower MGPA levels, indicating that the G

249 fied within the NEP degradation site ("RPRL" motif) showed improved in vitro proteolytic stability wh

250 f the 14-3-3 dimer, with both 14-3-3 binding motifs simultaneously participating in protein associati

251 Interestingly, we found that the motif stabilizing the compact structure between ZFs 3 an

252 e marked by H3K4me1, Ep300, and Fox/Sox/Smad motifs, suggesting interplay between these factors in ge

253 transcriptional coactivator with PDZ binding motif (TAZ) and Yes-associated protein (YAP) proteins vi

254 transcriptional coactivator with PDZ-binding motif (TAZ) expression, which is required for osteoblast

255 N cooperated with a hitherto uncharacterized motif, termed AcidicN, to confer H4-tail sensitivity and

256 Here we identify an additional motif that drives VE-cadherin endocytosis and pathologic

257 for function; most likely as an ER retention motif that enables anchoring to the ER-derived LCV membr

258 of TRPC6 is embedded in a basophilic kinase motif that is highly conserved across species.

259 cid residues and a minimal fusogenic peptide motif that is necessary for promoting cell-cell fusion w

260 Heterochromatin Protein 1 (HP1) interaction motif that mediates direct binding between KDM2A and HP1

261 method for accessing the beta-amino carbonyl motif that remains underdeveloped.

262 repeats are also small cysteine-rich protein motifs that can be O-glycosylated by several ER-localize

263 networks, it is possible to identify network motifs that lead to functional outputs such as bistabili

264 Analyses of enriched DNA sequence motifs that may act as cis-regulatory elements in the pr

265 The beta1 cytoplasmic tail has two NPxY motifs that mediate functions by binding to cytoplasmic

266 Riboswitches are widespread RNA motifs that regulate gene expression in response to fluc

267 is reflected in people's minds as dominance motives that underpin ideologies and actions that ultima

268 respond to known nuclear localization signal motifs, they represent a new motif for INM trafficking.

269 at the frequency of a small number of linear motifs three amino acids in length can accurately identi

270 Fusing the KalbTG recognition motif to an antibody allowed for site-specific and ratio

271 unusual conformation that allows this short motif to be bound directly by both CPSF-30 and WDR33.

272 The use of this simple motif to provide active intracellular targeting provides

273 ng process, eVP40 utilizes its PPXY L-domain motif to recruit a specific subset of host proteins cont

274 Arpin, which uses VCA-related acidic (A) motifs to interact with the Arp2/3 complex, induced the

275 e assembly codes emerge in this microcircuit motif under spike timing-dependent plasticity.

276 TFs with winged helix-turn-helix (wHTH) motifs use an alpha helix to read the base sequence in t

277 Several motif variant peptides translocate into synthetic vesicl

278 so overcomes the limitations of conventional motif-visualization tools in handling positional interde

279 nd that the DAT carboxy-terminal PDZ-binding motif was required for DAT recycling and exit from retro

280 ous chain lengths of ethylene-bridged BODIPY motifs was discovered.

281 typically miss these position-specific short motifs, we developed kpLogo, a probability-based logo to

282 Target genes of a cis-regulatory motif were identified from the network via the motif's e

283 metallosupramolecules possessing star-shaped motifs were prepared based on the careful design of meta

284 The motifs were ranked according to a one-dimensional Bayesi

285 fications were evident, and known functional motifs were recovered.

286 to identification of a recurring structural motif where lysine NH3(+) group interacts with backbone

287 f an incoherent feed-forward loop, a network motif where two interconnected pathways or transcription

288 is not due to an alteration of the triacidic motif, which rather affects the efficiency of hemITAM ph

289 e analysis showed that mutations within this motif, which suppressed channel binding and its effects

290 1L and MAF1S, are regulated by the C-box YSY motif, which, when mutated, alters species stoichiometry

291 AP1-motifs, which bind JUN and FOS transcription factor fami

292 e analysis also reveals the presence of this motif with critical residues in the homolog of other Hel

293 d-state structure shows an eclipsed stacking motif with the electron-poor ammonium methyl groups occu

294 ks inferred by integrating sequence-specific motifs with expression have substantially greater agreem

295 m for the analysis and description of glycan motifs with high complexity.

296 ic amphipathic lipid packaging sensor (ALPS) motif within HOPS Vps41, a target of the vacuolar kinase

297 th alphabeta-tubulin through a small peptide motif within its MT-binding domain.

298 ctivity requires the sumoylation-interacting motif within p150N, which is also required for the nucle

299 sferase (Lgt) recognizes a conserved lipobox motif within the prolipoprotein signal sequence and cata

300 ane-proximal internal tyrosine-based sorting motif YXXL as a determinant that can affect the incomple