ライフサイエンスコーパス: motivation

1 s (e.g., reward valuation, anticipation, and motivation).

2 (i.e., those who likely had higher intrinsic motivation).

3 insight into the multidimensional nature of motivation.

4 nding of the neurocircuitry of female sexual motivation.

5 r as an intensifier of goal-related approach motivation.

6 ystem, and their overall research themes and motivation.

7 , BLA ChR2 pairing failed to enhance cocaine motivation.

8 ry nucleus in Meth-facilitated female sexual motivation.

9 mics in nuclei relevant to motor control and motivation.

10 e found no support for gender differences in motivation.

11 CeA circuitry is needed for ordinary cocaine motivation.

12 tive control group matched for enjoyment and motivation.

13 Pain is mostly not reported as the primary motivation.

14 ese pathways regulate specific components of motivation.

15 orexin neurons may help promote arousal and motivation.

16 plicated in reward learning, drug abuse, and motivation.

17 nt model of Meth-induced increases in sexual motivation.

18 ocity, without affecting action selection or motivation.

19 the brain powerfully influence movement and motivation.

20 pression, but do show clear signs of reduced motivation.

21 l motivation, but higher levels of emotional motivation.

22 s critical for movement control, reward, and motivation.

23 (VS), due to its association with incentive motivation.

24 a pivotal brain region underlying reward and motivation.

25 its prevalence, associated demographics, and motivations.

26 nto dopaminergic neurons underlies incentive motivation, a willingness to exert high levels of effort

27 These findings indicate that reward motivation alters offline post-learning dynamics between

28 uitry involved in reinforcement learning and motivation, although the intervening mechanisms remain u

29 More intense interventions (assessing motivation and assisting) were not significantly associa

30 As release of serotonin signals changes in motivation and attention states, axonal HCN channels pro

31 the process by which cues gain control over motivation and behavior.

32 n dopamine (DA) is unambiguously involved in motivation and behavioral arousal, yet the contributions

33 ion during learning is associated with trait motivation and behavioral performance in the post-learni

34 ts to the habenula as a key brain region for motivation and decision-making.

35 ns underlies behavioral processes related to motivation and drug addiction.

36 gene mPer2 within brain areas that regulate motivation and emotion.

37 l striatum (VS), a brain region critical for motivation and goal-directed behavior, may buffer agains

38 atal reward circuitry to lead to deficits in motivation and goal-directed motor behavior.

39 critical substrates of reward processing and motivation and have been repeatedly linked to addictive

40 mygdala) and homeostatic (hypothalamus) food motivation and hyperactivation in cognitive control (ant

41 n impaired sense of smell, even though their motivation and mobility behaviors remain normal.SIGNIFIC

42 tinct neural substrates mediating actions on motivation and mood.

43 gic and glutamatergic pathways that regulate motivation and motor activity as well as the sensitivity

44 t basal ganglia function to lead to impaired motivation and motor activity.

45 ventral and dorsal striatum associated with motivation and motor control.

46 These deficits in motivation and motor function are associated with altera

47 ammatory stimuli on the brain in relation to motivation and motor function.

48 ovel therapeutic strategies to treat reduced motivation and motor symptoms in patients with high infl

49 triatal dopaminergic signaling that mediates motivation and movement.SIGNIFICANCE STATEMENT The frequ

50 l for reward receipt and omission related to motivation and neural dopamine responsiveness.

51 also depends on intrinsic processes, such as motivation and physiological state.

52 sults may be explained by an enhanced homing motivation and possibly an enriched olfactory environmen

53 erstanding of fundamental behaviors, such as motivation and reward processing, as well as several dis

54 Incentive motivation and reward sensitivity were measured using th

55 arly life caused enduring effects on feeding motivation and sensitivity to reward loss/gain consisten

56 life methyl donor supplementation increased motivation and shortened the minimum stimulus length req

57 Differences in motivation and skills between men and women have long be

58 of which correlated with symptoms of reduced motivation and/or motor retardation.

59 e explore attitudes toward open science, the motivations and disincentives to participate, the role o

60 human intelligence has to incorporate human motivations and emotions.

61 ir members, but teasing apart its underlying motivations and neural mechanisms poses a serious challe

62 Here I discuss my motivations and their impact on how I conduct my researc

63 both directional and activational aspects of motivation, and activational aspects (i.e. speed and vig

64 integrate social and hormonal signals, tune motivation, and coordinate social interactions.

65 PVT GLP-1R agonism reduced food intake, food-motivation, and food-seeking, while blocking endogenous

66 n structure relate to cognition, affect, and motivation, and how these processes are perturbed in cli

67 optimize these circuits and enhance reward, motivation, and learning to improve therapeutic outcomes

68 s likely work in concert to promote arousal, motivation, and other behaviors.

69 ships between brain activation, task-related motivation, and questionnaire rated anhedonia.

70 tive ways, have adverse work and educational motivation, and report lower personal and physical well-

71 to each transplant recipient's unique needs, motivations, and barriers rather than offer a one size f

72 the hope that a description of the process, motivations, and results will provide a convincing argum

73 e regulation, feeding, addiction, reward and motivation, anxiety and depression, cardiovascular regul

74 unclear which specific processes underlying motivation are altered.

75 ever, the neural mechanisms underlying human motivation are far from being understood.

76 ts, but that affective empathy and emotional motivation are underpinned by the same latent factor.

77 g, intracerebroventricular infusion) affects motivation as measured in the intracranial self-stimulat

78 isorders associated with reduced empathy and motivation as well as the understanding of these process

79 ly important in endogenous priming of reward motivation at different times of day, with the pattern o

80 This could suggest that the motivations behind hominin anthropophagy may not have be

81 ome phrases that may help clinicians explore motivations behind nondisclosure requests and gently con

82 SE = 0.148, t = -1.773; P = .09) and partner motivation (beta = -0.328, SE = 1.024, t = -0.320; P = .

83 duces the BOLD signal in reward-related food motivation brain regions, providing a potential neurobio

84 logical blockade of LH GLP-1R increased food motivation but only in male rats.

85 Serotonin (5-HT) is associated with mood and motivation but the function of endogenous 5-HT remains c

86 associated with lower levels of behavioural motivation, but higher levels of emotional motivation.

87 Mating motivations can explain attractiveness benefits, but wha

88 he development of treatments for the loss of motivation commonly seen in psychiatric and other neurol

89 ain more weight or show increased appetitive motivation compared with wild-type mice in a standard en

90 separate progressive ratio test of incentive motivation confirmed that CeA ChR2 amplified rats' motiv

91 ts that were learned in high- and low-reward motivation contexts.

92 y we can find talented young scientists with motivation, cultivate them with resources, provide them

93 (B6D2F1/J) from HFD-fed dams have decreased motivation (decreased progressive ratio breakpoint) and

94 to glucocorticoids (iuGC) triggers prominent motivation deficits but nothing is known about the impac

95 -MSN loss-of-function is a possible cause of motivation deficits in neurodegenerative diseases.

96 In this review, we consider the motivation, design, and implementation of N-of-1 trials

97 unt the chances of success, strategic mating motivations do imply a bias not toward the most attracti

98 Learned motivation drives circadian physiology in the absence of

99 for 2 weeks in drinking water did not affect motivation due to a tolerance effect.

100 connections also each reduced responding and motivation during a progressive ratio test but had no ef

101 income but fewer days of employment, reduced motivation (e.g., sense of purpose, greater anhedonia),

102 we tested whether sex differences in social motivation emerge in infant monkeys (n = 48) reared in a

103 The interaction of motivation, emotion, and cognition is the real strength

104 TA) dopamine system is important for reward, motivation, emotion, learning, and memory.

105 e, a measure that includes sense of purpose, motivation, emotional and social interactions, role func

106 s successfully implemented in EMR due to the motivation, engagement, and cooperation of immunization

107 Behaviorally, we found that reward motivation enhanced 24 h associative memory.

108 This affiliative motivation ensures that people experience an artwork as

109 ssion/anxiety (F1,438 = 5.41; P = .02), more motivation (F1,272 = 4.63; P = .03), and less improvemen

110 cuitry in the amplification and narrowing of motivation focus for intravenous cocaine.

111 udies have been conducted on health workers' motivation, focusing on formal sector staff but not CHWs

112 Addiction is often characterized by intense motivation for a drug, which may be narrowly focused at

113 ation were identified that could provide the motivation for a wide range of research.

114 MMP-9 expression, correlated with increased motivation for alcohol in alcoholics.

115 Motivation for alcohol in human subjects was assessed on

116 l tegmental area neurons, MORs also moderate motivation for appetitive stimuli within forebrain circu

117 overexpression of PLCgamma1 both reduces the motivation for cocaine and reverses dendritic spine dens

118 tivity to cocaine reinforcement and enhances motivation for cocaine in self-administering male rats.

119 ine density intact but markedly enhances the motivation for cocaine, an effect mediated by specific l

120 dendritic spine density along with enhanced motivation for cocaine, but a functional relationship be

121 diction, we used NOP (-/-) rats to study the motivation for cocaine, heroin, and alcohol self-adminis

122 mine neurons, which subsequently enhance the motivation for cocaine.

123 eptor subunits, AMPA responsiveness, and the motivation for cocaine.

124 even by the same rats in which it amplified motivation for cocaine.

125 multiple ARGs that have a role in modulating motivation for cocaine.

126 ceptors in the VTA, and this effect enhances motivation for cocaine.

127 cribe several facets of qAOPs, including (a) motivation for development, (b) technical considerations

128 , including escalation of intake, sensitized motivation for drug, continued drug use in the face of a

129 emand and seeking in rats with the strongest motivation for drug.

130 s modeled after BE procedures used to assess motivation for drugs in humans with addiction.

131 and their inefficient processing is the main motivation for exploring a new methodology for the extra

132 egies adopted to treat KS and PEL, a primary motivation for exploring and evaluating the therapeutic

133 TA), which may affect dopamine signaling and motivation for feeding.

134 chemistry, and electrophysiology, that raise motivation for forming a viable pathophysiological hypot

135 d BRG1 in oligodendrocytes in regulating the motivation for heroin.

136 penditure for Rewards Task (EEfRT), in which motivation for high-effort/high-reward trials vs low-eff

137 Increased motivation for highly rewarding food is a major contribu

138 rence effects in mesoscopic rings provides a motivation for investigating ring currents in molecules

139 In this Perspective, we detail the motivation for large-scale engineering, discuss the prog

140 The most commonly reported motivation for misuse was to relieve physical pain (63.4

141 physical pain was the most commonly reported motivation for misuse.

142 o correct these neuroadaptations and restore motivation for non-drug rewards.

143 r in DIO-prone rats, including 1) heightened motivation for palatable food; 2) excessive intake; and

144 their owners by providing social support and motivation for physical activity.

145 Motivation for reward drives adaptive behaviors, whereas

146 als, loss of sleep often results in enhanced motivation for reward, which has direct implications for

147 Ethanol-induced CTA strongly decreased motivation for saccharin in an operant task to obtain th

148 to research communities were the predominant motivation for studying interruptions, the research ques

149 ng about their genetic risk of cancers was a motivation for testing (colorectal, 88%; prostate, 95%;

150 We propose that this sentiment is a powerful motivation for the "open-source" movement in scientific

151 After introducing the main motivation for the development of such processes, we fir

152 f TrkB signaling affects cocaine intake, the motivation for the drug, and reinstatement of drug takin

153 This connection provides a formal motivation for the success of personalized PageRank in s

154 A key motivation for this update was to include new informatio

155 In this tutorial, we discuss the motivations for doing two-dimensional liquid chromatogra

156 on opioid use, misuse, and use disorders and motivations for misuse among U.S. adults.

157 There are both fundamental and practical motivations for studying whether quantum entanglement ca

158 Data on surgical decisions, motivations for those decisions, and knowledge were incl

159 I first discuss the motivations for using dynamic animal social networks.

160 Female rats showed greater demand (i.e., motivation) for meth compared with male rats.

161 ct to forebrain sites involved in reward and motivation function.

162 empathy was associated with higher levels of motivation generally across behavioural, social and emot

163 Motivation has been defined as the process that allows o

164 Reward motivation has been demonstrated to enhance declarative

165 accumbens) and its role in mood, reward, and motivation has been the focus of significant research.

166 These changes in sexual motivation have a greater impact on women due to their l

167 Most theories of motivation have highlighted that human behavior is guide

168 dy uncovers two distinct mechanisms by which motivation impacts behaviour, and helps refine current m

169 ation at a dose of 2 ng/kg of body weight on motivation in 21 healthy human subjects in a double-blin

170 However, they decreased motivation in a breakpoint assay and did not promote rev

171 tributed to the hypothesis of reduced social motivation in ASD.

172 lementation alters cognitive performance and motivation in female offspring from high-fat diet-fed da

173 rd on offer provided quantifiable metrics of motivation in healthy subjects as well as patients.

174 t supplementation of methyl donors increased motivation in HFD-fed offspring and those who previously

175 extrinsic incentives can crowd out intrinsic motivation in many contexts.

176 ies have argued that there is a key role for motivation in modulating empathic experiences.

177 e striatum has been associated with abnormal motivation in neuropsychiatric disorders, including schi

178 f-grooming, motor coordination, and apparent motivation in operant conditioning, as well as spine mor

179 f biomimetic actuators has been an essential motivation in the study of smart materials.

180 ed and have opposing functions in reward and motivation in the ventral tegmental area (VTA).

181 One of the key motivations in producing 3D structures has always been t

182 eral aspects of reinforced behavior, such as motivation, incentive salience, and cost-benefit calcula

183 is study tested the hypothesis that periodic motivation induced by rhythmically pairing 2 reinforcing

184 previous organization/committee involvement, motivation/insight, and overall work satisfaction.

185 Personal motivation, institutional support, and collaborators con

186 Some key motivations involved in human cooperation thus may have

187 ch have been suggested to reflect changes in motivation involving reorganization of priorities.

188 Loss of motivation is a characteristic feature of several psychi

189 As such, motivation is a complex process that is critical for sur

190 Based on evidence that impaired motivation is a major symptom in the early stages of Hun

191 logical disorders, suggesting that decreased motivation is caused by broad dysfunction of the nervous

192 on, and recent work shows that cue-triggered motivation is enhanced in obesity-susceptible rats after

193 While this motivation is increasingly being recognized, little P re

194 Impaired motivation is present in a variety of neurological disor

195 rd-predictive cues, and that their intrinsic motivation is shaped by a desire to reduce uncertainty,

196 SIGNIFICANCE STATEMENT: Reward motivation is thought to promote memory by supporting me

197 Our motivation is to understand how the metal interlayer beh

198 To evaluate patient motivations, knowledge, and decisions, as well as the im

199 ovements in patients' knowledge, skills, and motivation leading to improved biomedical, behavioural,

200 Mating motivation likely plays a role in bias to attractive ind

201 We suggest that LPS-induced changes in motivation may be due to alterations to mesolimbic dopam

202 t of ARPP-16/19 is associated with increased motivation measured on a progressive ratio schedule of f

203 n was not associated with any alterations in motivation, measured by responding in a progressive rati

204 Motivation : Meta-analysis is essential to combine the r

205 tively charged phospholipid (DPhPG) with the motivation of creating biomimetic reconstructs of PSI re

206 Notwithstanding the original motivation of MolEl, I-V traces are often not very sensi

207 The motivation of this study is two-fold.

208 The motivation of this work is to determine an approach that

209 Fathoming the motivations of the Tsavo and Mfuwe man-eaters (killed in

210 CE STATEMENT In addiction, intense incentive motivation often becomes narrowly focused on a particula

211 We investigated the effect of motivation on mice performing a GO/NOGO visual discrimin

212 re we used fMRI to test the effect of reward motivation on post-learning neural dynamics and subseque

213 tigated the influence of differential reward motivation on the selectivity of postencoding markers of

214 which this response information matches the motivation or internal state of the individual.

215 ychiatry research a new approach to studying motivation, outcome valuation, and effort-related proces

216 of the "beauty premium" based only on mating motivations overlooks adaptationist models of social val

217 d functional magnetic resonance imaging food motivation paradigm.

218 VTA) and mesolimbic networks is essential to motivation, performance, and learning.

219 esearch communities based on the community's motivations, philosophical outlook, and methods.

220 res not in DSM including changes in volition/motivation, posture/facial expression and derealization/

221 rumental behavior and suggest that avoidance motivation predicts performance and brain activity durin

222 ibers in the context of LCs, elaborating the motivation, principle and possible strategies of fabrica

223 tion confirmed that CeA ChR2 amplified rats' motivation, raising their breakpoint effort price for co

224 tood as the interplay between cognitions and motivations regarding the benefits and risks of alternat

225 Moreover, they suggest that considering the motivation-related activity of the FPC could facilitate

226 Ac and that VP neurons integrate sensory and motivation-related information received directly from ot

227 amygdala projection as a new addiction- and motivation-related projection and a potential target for

228 bridging group belongingness and altruistic motivation remain to be identified.

229 How neural activity creates this motivation remains poorly understood.

230 n's belonging in engineering, self-efficacy, motivation, retention in engineering majors, and postcol

231 ontrols multiple cognitive aspects including motivation, reward perception, decision-making and motor

232 Finally, avoidance motivation scores measured by Behavioral Inhibition/Acti

233 Five symptoms and signs (changes in volition/motivation, slowing of speech, anxiety, other physical s

234 Dose-dependent disruptions in motivation, social interaction, and attention were produ

235 autonomous learning: curiosity and intrinsic motivation, social learning and natural interaction with

236 Classical theories of motivation suggest that there are both directional and a

237 cated, in two behavioral tasks: an incentive motivation task that involved producing a physical effor

238 This paper outlines the motivations, technical and analytical issues, and the pl

239 were impaired in alcohol seeking during the motivation test and withdrawal.

240 s a reward deficiency and altered appetitive motivation that induces compulsive eating and contribute

241 e strong interactions between sleepiness and motivation, the role of sleepiness was also determined.

242 Based in social-psychological and motivation theories, well-crafted interventions have pro

243 to build social bonds and may also increase motivation to "connect" with the artist.

244 d self-report measures of empathy and apathy-motivation to a large sample of healthy people (n = 378)

245 In experiments 1 and 2, we observed strong motivation to acquire operant self-administration of opp

246 an be divided into two potential components: motivation to approach humans (active tameness) and relu

247 Partner motivation to assist with SSE and relationship quality (

248 hat underlie age-dependent reductions in the motivation to be physically active.

249 Sleepiness increased motivation to choose the high-effort/high-reward mode of

250 Thus, the motivation to develop CO2-based chemistry does not depen

251 cs drives their negative emotional state and motivation to drink.

252 ure based on handgrip strength to assess the motivation to earn money (i) for oneself, (ii) for anony

253 mical substrates in cortex for enhancing the motivation to eat are discriminable from those for hedon

254 homeostatic need.SIGNIFICANCE STATEMENT The motivation to eat depends on the relative balance of act

255 The motivation to exert effort for reward is highly subjecti

256 ctive synchronization in monkeys, or lack of motivation to exhibit this behaviour?

257 required for the control of food intake and motivation to feed, and provide a new strategy to invest

258 le for LH neurons in the control of the core motivation to feed, and their activity comes under contr

259 Diminished opportunity can lower the motivation to invest in future health by reducing econom

260 approved treatment options, there was strong motivation to investigate any potential drug which had e

261 e overall dietary quality health and provide motivation to make additional dietary changes.

262 as politics, other social policies, and the motivation to maximize the credit.

263 ersed escalated cocaine intake and decreased motivation to obtain cocaine as measured in a behavioral

264 to heroin was not modified, but remarkably, motivation to obtain heroin and palatable food was enhan

265 n behavioral responses to opiates, including motivation to obtain heroin and palatable food.

266 ession of either Sox10 or BRG1 decreased the motivation to obtain heroin infusions in a progressive r

267 hat this preference may result from infants' motivation to obtain information and the expectation tha

268 articipant engaged in per week), liking, and motivation to practice.

269 ne option specifically focuses and amplifies motivation to produce intense pursuit and consumption fo

270 ho two core features of drug addiction: high motivation to seek addictive substances, despite adverse

271 sed the synaptic plasticity underpinning the motivation to seek the drug.

272 NAcsh miR-495 overexpression suppressed the motivation to self-administer and seek cocaine across pr

273 luN1 expression led to an enhancement in the motivation to self-administer cocaine as measured using

274 eases Src signaling, cocaine reward, and the motivation to self-administer cocaine.

275 Despite huge motivation to treat age-related human memory disorders,

276 ficantly related to the increased behavioral motivation to view erotic images (suggestive of higher '

277 , nurses tend to be more homogenous in their motivation to work and their work skills compared to the

278 in reward-directed learning and maintaining motivation to work for rewards.

279 nduced reinstatement of sucrose-seeking, and motivation to work for sucrose were employed following i

280 ct of each worker's reputation, workload and motivation to work on collective productivity.

281 served differences in condom use may reflect motivations to use condoms for backup pregnancy preventi

282 etic variants affect behavioral drive (i.e., motivation) to burrow and thereby affect both the develo

283 ck), presumably to increase approach-related motivation towards others who might provide support and

284 n orientation was accompanied by a change in motivation towards problem-solving, expressed in reduced

285 A central motivation towards this direction is that antiferromagne

286 essed both energy expenditure and appetitive motivation under conditions of diet-induced obesity.

287 next consider the costs and benefits of the motivation underlying giving and taking.

288 tructs and highlight the different prosocial motivations underlying economic game behaviours.

289 vestigated the role of 5-HT2CRs in incentive motivation using a mathematical model of progressive rat

290 using fast-scan cyclic voltammetry, whereas motivation was assessed using a progressive ratio reinfo

291 Motivation was higher for meditation (11.20 [0.40] sessi

292 Food motivation was reduced by activation of LH GLP-1R.

293 ely injured or killed may provide sufficient motivation when the costs to participants are low.

294 haviors, sickness allows increased incentive motivation when the effort is deemed worthwhile.

295 pain and maximizing pleasure are conflicting motivations when pain and reward co-occur.

296 l cortical activation predicted task-related motivation, which in turn predicted anhedonia severity i

297 nursing and testing potential differences in motivation with the likelihood of working nightshifts an

298 group affiliation, in dovetailing altruistic motivations with neural valuation systems in real-life i

299 on/planning, initiation, emotional-affective/motivation) with specific neuroanatomical and cognitive

300 dum (VP) reflected the strength of incentive motivation, with the greatest neural responses occurring