ライフサイエンスコーパス: motivational

1 area (VTA) is required for the rewarding and motivational actions of opioids and activation of dopami

2 tegrated function for orexins in translating motivational activation into organized suites of psychol

3 higher cognitive functions with and without motivational and affective significance; and in a subgro

4 Alterations in reward processes may underlie motivational and anhedonic symptoms in depression and sc

5 and that these latter structures mediate the motivational and cognitive components of specific PIT, r

6 Motivational and cognitive deficits are core features of

7 unselected populations enables a read-out of motivational and decision variables not emphasized by in

8 sed in brain areas involved in regulation of motivational and emotional processes.

9 olvement of the subthalamic nucleus (STN) in motivational and emotional processes; however, participa

10 Motivational and motor deficits are common in patients w

11 dopaminergic treatment strategies to improve motivational and motor deficits in patients with increas

12 Motivational and NAc dopaminergic deficits were not asso

13 ll ultimately lead to improved treatment for motivational and psychomotor symptoms in psychiatry and

14 Together, these findings suggest motivational and valence processing systems interact to

15 underlie indoor tanning, including positive (motivational) and negative (deterrent) beliefs.

16 ly ideally positioned to regulate emotional, motivational, and cognitive behaviors.

17 ality, a complex incorporation of emotional, motivational, and cognitive processes.

18 cterizes habits in terms of their cognitive, motivational, and neurobiological properties.

19 ed that medial frontal areas are involved in motivational aspects of behavior, whereas lateral fronta

20 LepRb) signaling also reduces appetitive and motivational aspects of feeding, and that these effects

21 hat this pathway may transduce the affective motivational aspects of pain.

22 ng a role of postsynaptic DA D2 receptors in motivational aspects of reinforcement learning may apply

23 set of behavioral alterations; however, its motivational aspects remain poorly explored in humans.

24 rther investigate effects of inflammation on motivational behavior in psychiatric and chronic illness

25 This impoverished encoding of motivational behavior, even after abstinence from the dr

26 (LPS) affected two dissociable constructs of motivational behavior, ie, effort and reward sensitivity

27 and the neuromodulatory circuits that govern motivational behaviors.

28 es interactions between individual cognitive-motivational biases and the form of the drug cue encount

29 Such motivational biases have been proposed to reflect cue-ba

30 Here, we assess whether motivational biases may also arise from asymmetrical ins

31 Computational analyses showed that motivational biases reflect both Pavlovian and instrumen

32 magery not only enhanced neural responses in motivational centers (ventral striatum and extended amyg

33 mmation induced by LPS administration causes motivational changes in young healthy subjects, which ar

34 ness but might also account for maladaptive, motivational changes that underpin the association betwe

35 ce paradigm to evaluate inflammation-induced motivational changes.

36 We examined motivational characteristics of two separate neuron popu

37 bstrate for ILPFC/BA25 linking affective and motivational circuitry dysfunction in MDD.

38 PGE2-mediated modulation of the dopaminergic motivational circuitry is a key mechanism underlying the

39 ction represents a dramatic dysregulation of motivational circuits that is caused by a combination of

40 ons is then discussed, along with emotional, motivational, cognitive, and behavioral pathways of thes

41 neural mechanisms that directly modulate the motivational component of aggressive behaviour.

42 neural computations related to the affective-motivational component of pain.

43 bly, neurons having activity correlated with motivational condition could be distinguished from neuro

44 arger proportion of neurons activated in low motivational conditions in the dlPFC than in the ACC, an

45 ivities were significantly slower in the low motivational conditions than in the other conditions.

46 neral motor activity were measured under two motivational conditions: food-deprived rats given standa

47 intensity, but in both cases only if a high motivational conflict was present.

48 short of explaining the phenomena, including motivational conflict, that it sets out to.

49 eptual pain modulation by varying degrees of motivational conflicts and the role of subjective utilit

50 ature of such physiological events and their motivational consequences.

51 influenced by information with affective or motivational content in powerful ways.

52 influenced by information with affective or motivational content.

53 These findings underscore how the motivational context underlying neural sensitivity to re

54 n V1 depending on the animal's behavioral or motivational context, complementing other known state-de

55 on of individual feeding bouts regardless of motivational context.

56 Such motivational "context-contamination" leads to voluntaril

57 maging studies implicate the striatum in the motivational control of behavior.

58 sociated with cocaine preferentially acquire motivational control over behavior in different individu

59 in regions involved in emotional regulation, motivational control, and addiction vulnerability-eg, th

60 randomly assigned to receive either monthly motivational counselling calls and weekly personalised t

61 muli induce a time-dependent increase in the motivational craving state (incubation of craving).

62 Catecholamines modulate the impact of motivational cues on action.

63 may illuminate the neural process that links motivational cues to desires and urges to obtain goals.

64 function underlies this hypersensitivity to motivational cues.

65 Motor dysfunction (e.g., bradykinesia) and motivational deficit (i.e., apathy) are hallmarks of Par

66 Our results suggest that motivational deficits in depression may stem partly from

67 dence from clinical studies of cognitive and motivational deficits in patients with basal ganglia les

68 her altered NAc dopamine release accompanies motivational deficits in the Q175 knock-in HD mouse mode

69 Here, we tested whether motivational deficits observed in mice with upregulated

70 sfunction, we show that iuGC animals present motivational deficits that are rescued by selective opto

71 ical to goal-directed behaviors, accompanies motivational deficits, one of the most common early HD s

72 al conditions are characterized by motor and motivational deficits, which both result in reduced beha

73 predicted clinical improvement in motor and motivational deficits.

74 smission at D2-MSN-to-VP synapses normalized motivational deficits.

75 ansitions in DA neuron firing in response to motivational demands may cause a modulatory switch from

76 apeutic efficacy of CBD for the treatment of motivational disorders such as drug addiction, anxiety,

77 merging research into emotional, social, and motivational domains provides some evidence for preserva

78 NP is mediated by a motivational dopamine signal that increases in response

79 We further found that as motivational drive decreases throughout a session, the a

80 Decreased sensitivity to the motivational drive of hunger may explain the ability of

81 e) can depend on the temporal primacy of one motivational drive relative to the onset of a competing

82 halamic circuits linking energy state to the motivational drive, hunger, and, finally, limbic and cog

83 ior in the continued presence of a competing motivational drive, such as threat avoidance, or whether

84 r impairment and could be overcome by strong motivational drive.

85 ce [1] but also on the presence of competing motivational drives [2] and learned cues signaling food

86 tent brain networks associated with internal motivational drives and emotional states that are modula

87 dge about the neural basis of effort-related motivational dysfunction, and it is hoped that this rese

88 d patient navigation (barrier assessment and motivational education for patients who declined screeni

89 um and extended amygdala) but also exerted a motivational effect in the imagery network itself.

90 ced inhibitory response control and a larger motivational effect on performance in ADHD already at th

91 People who are more susceptible to these motivational effects of food cues may have a higher risk

92 me brain region to signaling of the negative motivational effects of nicotine withdrawal.

93 mine to be a key neuromodulator in mediating motivational effects of reward.

94 We compared these opposing motivational effects with effects on mood using the forc

95 visual effects of novelty are related to its motivational effects.

96 ion of the lateral hypothalamus (LH) has two motivational effects: long trains of stimulation induce

97 on of perceptual, mnemonic, prospective, and motivational elements.

98 ve eating through the integration of complex motivational, emotional, and cognitive constructs is war

99 contributes to reinforcement of actions and motivational enhancement of motor vigour.

100 corporating behavior contingency management, motivational enhancement, and academic, organizational,

101 out infants' ability to reason about agents' motivational, epistemic, and counterfactual states.

102 synergism between both representational and motivational factors and is unlikely to be accounted for

103 anize, focusing on transient situational and motivational factors that promote dehumanizing perceptio

104 unction has long recognized the relevance of motivational factors.

105 ion, contribute to the sensory and affective-motivational features of CNBP.

106 ng the neural basis of negative and positive motivational feedback in motor learning.

107 tion that motor adaptation is independent of motivational feedback, and raise new questions regarding

108 of synaptic AMPA receptors that enhance the motivational for cocaine.SIGNIFICANCE STATEMENT Dopamine

109 wider variety of representational forms with motivational force and to entertain the intriguing possi

110 The motivational force of social mobilization is amplified b

111 sly, we showed that aripiprazole may protect motivational function by preserving reinforcement-relate

112 much deeper understanding of the breadth of motivational function.

113 ic decision theory, to dissect the motor and motivational functions of dopamine in humans.

114 Considering the cognitive and motivational functions of gender stereotypes helps us un

115 ort, which is employed for both learning and motivational functions.

116 ue-P3 and Nogo-P3), which were recorded in a motivational go/nogo task, indicated diminished attentio

117 um and caudate, striatal nodes implicated in motivational goal-directed social behavior.

118 nsistencies in human actions and the role of motivational goals in behavior, as it is based on an unp

119 nomenon showing how animals can update their motivational goals without any new learning or condition

120 accumbens core (NAc) is known to mediate the motivational impact of reward-predictive cues, but littl

121 Curiously, fatigue and motivational impairment evolve rapidly, suggesting acute

122 tive and affective factors implicated in the motivational impairments seen in many people with schizo

123 it decision making may shed new light on the motivational impairments seen in many people with schizo

124 re obtained, and withdrawal can be seen as a motivational incentive because due to allostatic referen

125 and maintaining abstinence, plus prize-based motivational incentives contingent on abstinence and tre

126 ivered behavioral intervention that includes motivational incentives, as a clinician-extender in the

127 important actors in integrating and relaying motivational information arising from various modalities

128 al reinforcers and serves as a substrate for motivational information processing.

129 e in the BLA can encode the outcome-specific motivational information provided by reward-predictive s

130 hose actions invigorated by outcome-specific motivational information provided by the reward-predicti

131 udy how LC neuronal responses are related to motivational intensity, we recorded 121 single neurons f

132 Consistent with a motivational interpretation, participants freely chose b

133 ly assigned to brief advice (n = 200), brief motivational intervention (BMI) (n = 203), or BMI plus a

134 A 20- to 30-minute manual-guided motivational intervention (recorded and monitored for fi

135 cember 2014 to assess the effectiveness of a motivational intervention for IPV-involved female ED pat

136 g IPV and heavy drinking, the use of a brief motivational intervention in the ED compared with assess

137 These findings do not support a brief motivational intervention in this setting.

138 located to the intervention group received a motivational intervention to reduce alcohol intake from

139 Overall, these findings demonstrate that a motivational intervention with parents can have importan

140 uring the 12-week period following the brief motivational intervention, there were no significant dif

141 the effectiveness of a program consisting of motivational interviewing (MI) and feedback of urine cot

142 A counseling approach, motivational interviewing (MI), is potentially useful in

143 Motivational interviewing as a component of an individua

144 oked (n=30) were randomised into two groups: motivational interviewing based intervention (n=15) and

145 Motivational interviewing based intervention consisted o

146 lifestyle modification program that included motivational interviewing delivered by an experienced nu

147 ped collaborative care intervention included motivational interviewing elements targeting risk behavi

148 ation messages and provided counseling using motivational interviewing for the caregivers including c

149 tic reviews covering depression and obesity, motivational interviewing for weight management, metabol

150 Findings have been used to adapt a motivational interviewing intervention, which is being e

151 This study found a beneficial effect of motivational interviewing on nurses' smoking cessation.

152 f care coordination with case management and motivational interviewing techniques over 6 months.

153 ompetent, youth-friendly care, and intensive motivational interviewing training.

154 is a 30- to 45-minute intervention based on motivational interviewing with a 20- to 30-minute booste

155 Brief interventions based on motivational interviewing with a telephone booster using

156 All patients at risk should receive brief motivational interviewing with an objective, nonjudgment

157 s received a single brief intervention using motivational interviewing, a handout and list of substan

158 Outcomes were variable, although motivational interviewing, which involves individuals in

159 at hospital discharge to receive either (1) motivational interviewing-based health coaching plus a w

160 l coding of prediction error signals driving motivational learning.

161 The same reward can possess different motivational meaning depending upon its magnitude relati

162 formation about recent rewards to adjust the motivational meaning of a CS.

163 istory to support the flexible assignment of motivational meaning to sensory cues.

164 iological mechanisms mediating assignment of motivational meaning, we recorded the activity of neuron

165 Here we describe the motivational mechanism by which the forebrain thirst cir

166 The relevant computational and motivational mechanisms that underlie its heterogeneity,

167 ss it specifies the subserving cognitive and motivational mechanisms.

168 m relief of pain, is encoded by brain reward/motivational mesocorticolimbic circuitry.

169 eased as mice became sated, showing a strong motivational modulation of licking bout initiation and t

170 known pathological adaption in a key node of motivational neural circuitry that is required for one o

171 Although this influence must involve the motivational neural system that initiates and encodes th

172 largely speculative and that a reverse, more motivational, path is equally plausible; and (3) that th

173 is article reviews research that adopts this motivational perspective on work design, and it emphasiz

174 may be more effective when they harness the motivational power of that group's existing strongly hel

175 ronizing circadian oscillators that modulate motivational processes and behavioral output.

176 m homeostasis are critical for survival, but motivational processes engaged by physiological need sta

177 The role of basal ganglia in motivational processes has been under scrutiny in recent

178 uang & Bargh's (H&B's) theory of unconscious motivational processes to psychopathology.

179 hether this reflects prolonged modulation of motivational processes underpinning fatigue or separate

180 onship of attentional, cognitive control and motivational processes with DNA methylation patterns of

181 been implicated in a number of cognitive and motivational processes, but understanding how individual

182 ic dopamine system is strongly implicated in motivational processes.

183 d that this subset has an inhibitory role in motivational processes.

184 lness, including homeostatic, circadian, and motivational processes.

185 hemistry mediating their abnormal underlying motivational processes.

186 , indicating a selective effect on incentive motivational processes.

187 edly been linked to associative learning and motivational processes.

188 ehaviour likely rooted in atypical affective/motivational processing, as opposed to an inability to j

189 nhibit the earliest type of drug cue-induced motivational processing-that which occurs outside of awa

190 egions important for cognitive executive and motivational processing.

191 amine (DA) neurotransmission is critical for motivational processing.

192 Cues associated with reward can acquire motivational properties (i.e., incentive salience) that

193 or agonist, remifentanil) acquires incentive motivational properties differently in STs and GTs, as i

194 e is, however, considerable variation in the motivational properties of such stimuli, both as a funct

195 This role of Hcrtr-1 in the reinforcing and motivational properties of WIN55,212-2 was confirmed in

196 s than GTs; (2) the attribution of incentive motivational properties to an opioid cue is dopamine dep

197 d with drugs can acquire Pavlovian incentive motivational properties, and acting as incentive stimuli

198 n conjunction with empirical research on the motivational psychology of parental care.

199 strate independence, including affective and motivational reactions to rudimentary inputs, and the gu

200 nment can be formed if the environment is of motivational relevance to the animal.

201 ly mediate behavior under situations of high motivational relevance, such as during physiological nee

202 wo central subsets of stimulation sites with motivational relevance.

203 Text messages provided advice, motivational reminders, and support to change lifestyle

204 Motivational responses are mediated in part by NAc AMPA

205 tion, these studies also illuminate people's motivational responses to intentional harms.

206 mechanism through which inflammation impairs motivational responses to novelty.

207 cleus accumbens (NAc) mediates cue-triggered motivational responses, and activations in the NAc trigg

208 a key brain region regulating emotional and motivational responses, we observed a decrease in the ra

209 elated to the offer, but affect also induces motivational responses.

210 neuronal activity or plasticity in adaptive motivational reward or addiction.

211 These results help to disambiguate the motivational role of prodopaminergic medications: they a

212 tify predominantly sensory-attentional (N1), motivational salience (feedback-related negativities [FR

213 speed, the quantitative relationship between motivational salience and decision speed, measured by re

214 ledge, the quantitative relationship between motivational salience and faster decision speed, they al

215 e quantitative coupling relationship between motivational salience and more precise RT.

216 Here we investigated how cues imbued with motivational salience can invigorate motor imagery netwo

217 Here we show that the neural correlate of motivational salience in the basal forebrain (BF), defin

218 While it is generally believed that motivational salience increases decision speed, the quan

219 drawal signals from the body potentiates the motivational salience of reward cues through the recruit

220 his attentional competition is influenced by motivational salience of sounds is, however, not well-un

221 We examined two markers of the motivational salience of the pictures: the P300 and slow

222 result from the functional impairment of the motivational salience signal encoded by the poorly under

223 Artificially augmenting the BF motivational salience signal via electrical stimulation

224 decision step is dictated largely by the BF motivational salience signal.

225 in faster RT distributions with stronger BF motivational salience signals.

226 er RTs were tightly coupled with stronger BF motivational salience signals.

227 s performing a reward-biased simple RT task, motivational salience was encoded by BF bursting respons

228 on appears to be important in attribution of motivational salience.

229 ntexts, consistent with a role in increasing motivational salience.

230 agnetic resonance imaging to examine whether motivational-salient cues could exert a differential imp

231 native analysis of inhibitory control toward motivational-salient cues.

232 hronically and temporarily - is essential if motivational scientists are to achieve genuine theoretic

233 is therefore useful to consider whether the motivational self is attempting to balance between confl

234 conflict with each other, and the role of a motivational self is to consciously or unconsciously pri

235 present evidence in favor of an overarching motivational self: a mental function that regulates expr

236 ion (2-h food deprivation), and also after a motivational shift to a 'high-drive' condition (18-h foo

237 gs suggest that aging may not affect primary motivational signaling in the reward network, but may ra

238 ecture is proposed that embeds emotional and motivational signals into perception and cognition throu

239 mediate this process must register both the motivational significance and location of visual stimuli

240 n implicated in appraising the affective and motivational significance of errors and other types of s

241 where in the brain do we store the affective/motivational significance of sensory stimuli acquired th

242 If representing the motivational significance of sensory stimuli within a sp

243 res of the environment are often imbued with motivational significance, and the relative importance o

244 re surgery and reliably produces somatic and motivational signs of dependence.

245 describe how animals respond to conflicting motivational situations, such as the presence of tourist

246 the presence of food and the second encodes motivational state acting as a gain controller for adapt

247 Hunger is a hard-wired motivational state essential for survival.

248 of Neuron, Burgess et al. (2016) explore how motivational state interacts with visual processing, by

249 r advances understanding of how this intense motivational state is regulated.

250 could contribute to the rigid emotional and motivational state observed in alcohol dependence.

251 ngth of the unconditioned stimuli and on the motivational state of the animals.

252 the neural relationship between the aversive motivational state produced by drug withdrawal and the d

253 These findings reflect the motivational state required to learn, and show accelerat

254 Hunger is a complex motivational state that drives multiple behaviors.

255 lve the hippocampus, including cognitive and motivational state, responses to stress, and neurologica

256 Sleep profoundly affects the emotional and motivational state.

257 sing, depending on the animal's affective or motivational state.

258 ons in sensorimotor function or a diminished motivational state.

259 e characterized by an acute reorientation of motivational state; pleasurable activities are avoided,

260 levels of cognitive control under different motivational states (low vs high reward anticipation).

261 nown about the mechanisms by which intrinsic motivational states affect learning.

262 ulates brain regions important for divergent motivational states and cognition.

263 t the availability of food rewards influence motivational states and elicit food-seeking behaviors.

264 -target interactions and potency to discrete motivational states during a single self-administration

265 to probe the neural correlates of emotional/motivational states in adolescents with varying exposure

266 gnitions, cognitive operations and emotional/motivational states relevant to future-oriented cognitio

267 racted to such cues and these cues can evoke motivational states that instigate and maintain drug-see

268 cholinergic neurons integrate cognitive and motivational states with behavior.

269 dial prefrontal cortex and the generation of motivational states.

270 by subcortical circuits that drive specific motivational states.

271 ted in several cocaine-induced emotional and motivational states.

272 these neurons would be a key node regulating motivational status.

273 t response suppression can be triggered by a motivational stimulus, thus providing a richer model of

274 Using fMRI, we found untrained participants' motivational strategies failed to consistently activate

275 roup received a novel glaucoma education and motivational support package using behaviour change coun

276 sion and other disorders show effort-related motivational symptoms, such as anergia, psychomotor reta

277 o evaluate the effects of D3R antagonists on motivational symptoms, which are not improved by current

278 ch tasks could be useful as animal models of motivational symptoms.

279 logical imbalance between earlier developing motivational systems and later developing top-down contr

280 gical products of evolutionarily fundamental motivational systems and thus are phenotypic manifestati

281 ess-related disorders through alterations in motivational systems including the mesolimbic dopamine (

282 individuals over evolutionary time, and our motivational systems may have been naturally selected to

283 increases its capacity to suppress competing motivational systems, such as thirst, anxiety-related be

284 We explore how three motivational systems-compassion, self-interest, and envy

285 ch enables activity in motor, cognitive, and motivational systems.

286 in the striatum of two monkeys performing a motivational task, in which they had to develop a variab

287 s that it is important to continue to refine motivational theories.

288 n feeding behavior in light of psychological motivational theory and highlights the importance of mid

289 enous enkephalins primarily set a background motivational tone regulating feeding behavior, whereas b

290 ive behaviors in the wild as well, but their motivational underpinnings are unclear.

291 l area (VTA) may contribute to the increased motivational valence of drug-associated cues triggering

292 D2 MSNs, which encode positive and negative motivational valences, respectively.

293 Here, we investigated whether a positive motivational value associated with sounds could bias the

294 iscrete opioid cue attains greater incentive motivational value in STs than GTs; (2) the attribution

295 ks: progressive ratio (PR), which assays the motivational value of an incentive, and differential rei

296 tions, both the value of salt itself and the motivational value of its predictive cues.

297 nula encodes the previously learned negative motivational value of stimuli.

298 t enable an initially neutral cue to acquire motivational value that increases over time, an effect t

299 ues, with some individuals attaching greater motivational value to cues than others.

300 opamine levels covaried with reward rate and motivational vigor.