ライフサイエンスコーパス: motor protein

1 ch regulation can be achieved by any mitotic motor protein.

2 e dynactin complex, a cofactor for dynein, a motor protein.

3 utions similar to myosin, the major cellular motor protein.

4 wly discovered conformational state for this motor protein.

5 is assisted in D loop formation by the Rad54 motor protein.

6 t of the chicken homolog of prestin, the OHC motor protein.

7 s to the nucleus, with the aid of the dynein motor protein.

8 that is distinct from any reported for a DNA motor protein.

9 Arabidopsis mitochondrial-localized kinesin motor protein.

10 nt chain-ribosome complex or the SecA ATPase motor protein.

11 ther the CheA chemotaxis kinase or flagellar motor proteins.

12 isms seen in ion channels, transporters, and motor proteins.

13 ath of single budding yeast kinesin-8, Kip3, motor proteins.

14 irected movement on microtubules mediated by motor proteins.

15 ella is driven by forces generated by dynein motor proteins.

16 bules in association with multiple copies of motor proteins.

17 d an unusual structural element in kinesin-5 motor proteins.

18 in cells is facilitated by microtubule-based motor proteins.

19 nodevices operating with surface-immobilized motor proteins.

20 ing with microtubule dynamics and associated motor proteins.

21 ntation are spatially separated by molecular motor proteins.

22 microtubule trackways by kinesin and dynein motor proteins.

23 ein can occur in a manner unimpeded by other motor proteins.

24 anelles and vesicles actively transported by motor proteins.

25 c peptide motifs, cytoskeletal elements, and motor proteins.

26 havior of biological molecular machines like motor proteins.

27 ntin function in cell migration to myosin II motor proteins.

28 sed to monitor the activity of DNA-dependent motor proteins.

29 ament sliding mechanisms described for other motor proteins.

30 e host cytoskeleton via cellular adaptor and motor proteins.

31 cargo along microtubular tracks via kinesin motor proteins.

32 ven by teams of plus- and minus-end-directed motor proteins.

33 the working mechanisms of microtubule-based motor proteins.

34 and is distinct from previously investigated motor proteins.

35 had active super-diffusive motions driven by motor proteins.

36 rs that recruit downstream mediators such as motor proteins.

37 ces imposed on the microtubules by molecular motor proteins.

38 ntous actin (F-actin) with myosin-associated motor proteins.

39 d organelles are transported by ensembles of motor proteins.

40 ibility of using molecular sorters driven by motor proteins.

41 hanical work by polymerization processes and motor proteins.

42 New work shows that two kinesin-4 motor proteins act to shorten the domain of overlapping

43 The ability to coordinate the timing of motor protein activation lies at the center of a wide ra

44 Tight modulation of motor protein activity is necessary, but little is known

45 e dynamics of the Myxococcus xanthus gliding motor protein AglR, a homolog of the Escherichia coli fl

46 MglA directly interacts with the motor protein AglR, and the spatial distribution of AglR

47 Here, we have used the bacterial SecA ATPase motor protein and SecYEG channel complex to address this

48 essivity has not been observed for any other motor protein and suggests that kinesin-3 motors are evo

49 ics of mitochondria are regulated by several motor proteins and a microtubule network.

50 mechanotransduction mechanism is mediated by motor proteins and by the enhancement of microtubule-, a

51 nvolves the combined action of ATP-dependent motor proteins and histone chaperones.

52 anosensitive biological nanomachines such as motor proteins and ion channels regulate diverse cellula

53 crotubule-related proteins such as molecular motor proteins and microtubule severing enzymes, as well

54 t transient attachments of plus-end-directed motor proteins and nonmotile cross-linker proteins are n

55 tions between active forces from an array of motor proteins and passive mechanical resistance from th

56 , and helicases/translocases that operate as motor proteins and play central roles in genome maintena

57 f fluorescently labeled, processive, dimeric motor proteins and propose a unified algorithm to correc

58 found in a wide range of proteins, including motor proteins and structural proteins, that are known t

59 n and Dynein, but interactions between these motor proteins and their mechanisms of action are unclea

60 ospring to human myosin VI, a mechanosensory motor protein, and demonstrate nanometre-precision singl

61 ins from the cell cytoskeleton, myosins from motor proteins, and fibrin from blood clot.

62 iding across a surface coated with kinesin-1 motor proteins, and that energetic considerations sugges

63 tion of unconventional functions for kinesin motor proteins, and we propose that Kif13b kinesin acts

64 und that chromatin remodeling-defective Chd1 motor proteins are able to catalyze ATP-dependent chroma

65 of the interior of cells, microtubule-based motor proteins are able to deliver cargoes rapidly and r

66 study of kinesin-1 has shed new light on how motor proteins are able to move along microtubules insid

67 Both ATP-driven molecular motor proteins are able to translocate nucleosomes along

68 Motor proteins are active enzymatic molecules that suppo

69 Although motor proteins are essential cellular components that ca

70 Cytoskeletal motor proteins are essential to the function of a wide r

71 Motor proteins are nature's solution for directing movem

72 Molecular motor proteins are responsible for long-range transport

73 , forces generated at the molecular level by motor proteins are transmitted by disordered fiber netwo

74 While interactions with and functions for MT motor proteins are well characterized and extensively re

75 observed to glide over surfaces coated with motor proteins, are important tools for studying the bio

76 ied Myo1c, an unconventional F-actin-binding motor protein, as a major G-actin-interacting protein.

77 les, which we correlate with the activity of motor proteins, as predicted by existing theories of act

78 However, the physical basis for how motor proteins behave in these highly crowded environmen

79 Kinesin-5 is a slow homotetrameric motor protein best known for its essential role in the m

80 we show that kinesin-6, a microtubule-based motor protein best known for its role in cytokinesis, al

81 substitution that directly alters a kinesin motor protein binding site.

82 A motor protein called Klp10A ensures that germline stem c

83 ong with numerical simulations, reveal how a motor protein can function as an analog converter, "read

84 their interaction with the cytoskeleton and motor proteins can lead to novel classes of antivirals t

85 ensembles of kinesin-5, a conserved mitotic motor protein, can push apart overlapping antiparallel m

86 re is generated by two bipolar arrays of the motor protein cardiac myosin II extending from the thick

87 from reduced levels of the centromere-linked motor protein CENP-E has been reported to increase the i

88 equired for the mRNA splicing of the mitotic motor protein CENP-E.

89 ucing expression of the kinesin-like mitotic motor protein CENP-E.

90 Kinesin-1 is a dimeric motor protein, central to intracellular transport, that

91 maturation and chromatin remodelling by the motor protein Chd1 are distinct, separable enzymatic act

92 ssive movement as a heterodimer with the non-motor proteins Cik1 or Vik1.

93 RecBCD always overwhelms FtsK when these two motor proteins collide while traveling along the same DN

94 function provided by pRNA is carried on the motor protein components in other phages.

95 Kinesin motor proteins comprise an ATPase superfamily that works

96 Myosin motor proteins convert chemical energy into force and mo

97 rone, the imitation switch (ISWI) ATP-driven motor protein, core histones, template DNA, and ATP.

98 The minus-end directed microtubule motor protein cytoplasmic dynein contributes to many asp

99 capsid protein, hexon, directly recruits the motor protein cytoplasmic dynein following virion entry.

100 capsid protein hexon recruits the molecular motor protein cytoplasmic dynein in a pH-dependent manne

101 r et al provide compelling evidence that the motor protein cytoplasmic dynein provides the necessary

102 and spindle positioning, are mediated by the motor protein cytoplasmic dynein, which produces force o

103 include adhesive receptors, immunoreceptors, motor proteins, cytoskeletal proteins, and their associa

104 The presence of a microtubule-crosslinking motor protein decreased the number of accessible types o

105 tracellular transport of Tau protein suggest motor protein-dependent co-transport with microtubule fr

106 Kinesin-8 motor proteins destabilize microtubules.

107 A single motor protein, dimeric kinesin-1, is conjugated to vario

108 Kinesin motor proteins drive intracellular transport by coupling

109 All six IFT-A components and their motor protein, DYNC2H1, have been linked to human skelet

110 In addition, inhibition of the motor protein dynein blocked paclitaxel-induced subcellu

111 The motor protein dynein drives autophagosome motility from

112 cell cortex and involve cortically anchored motor protein dynein.

113 intermediate filament network and retrograde motor protein dynein.

114 embrane and organelle motility utilizing the motor proteins dynein and kinesin is commonplace in anim

115 laments (e.g., actin) that are acted upon by motor proteins (e.g., myosin).

116 comparisons between different populations of motor proteins (e.g., with distinct mutations or linked

117 nd that Abeta(1-42) inhibits the microtubule motor protein Eg5/kinesin-5.

118 e and an endogenous target gene, the mitosis motor protein, Eg5.

119 with partial reduction or overexpression of motor proteins enabled us to test with high precision ex

120 with this finding, FOXJ1-regulating axonemal motor protein expression is absent in respiratory cells

121 ularly robust to abundance variations of the motor protein FliM.

122 ular photodynamic steps, action of molecular motors, protein folding, diffusion, etc. down to the pic

123 eavy chain 7 (Myh7), which encodes molecular motor proteins for heart contraction.

124 Va myosins comprise a unique group of myosin motor proteins found in apicomplexan parasites, includin

125 Myosins are a family of actin-based motor proteins found in many organisms and are categoriz

126 e, we show that these PS-mediated effects on motor protein function are via a pathway that involves g

127 hat PS and GSK-3beta are required for normal motor protein function.

128 nner, as did motors in cells deleted for the motor protein gene fliL or for genes in the chemotaxis s

129 Mitotic motor proteins generate force to establish and maintain

130 dle is proposed to depend on nanometer-sized motor proteins generating forces that scale with a micro

131 resolved structures of the bacteriophage T4 motor protein gp17 suggests that this motor generates la

132 (MT) motility by surface-tethered kinesin-1 motor proteins has been widely studied, as well as appli

133 Two forms of an unconventional myosin motor protein have separate functions in the growth and

134 systems based on cytoskeletal filaments and motor proteins have become promising tools for a wide ra

135 the structures and chemomechanical cycles of motor proteins have been extensively investigated, the s

136 We measured the density of the adsorbed motor protein (heavy meromyosin, HMM) using quartz cryst

137 eins implicated in D loop disruption are DNA motor proteins/helicases that act by moving DNA junction

138 ellar transport (IFT) is mediated by kinesin motor proteins; however, the function of the homodimeric

139 identify the minus end-directed microtubule motor protein HSET as a direct binding partner of CEP215

140 e microtubule dependent, with 19 microtubule motor proteins implicated in at least one nuclear behavi

141 ae Mph1, a member of the FANCM family of DNA motor proteins important for DNA replication fork repair

142 s the primary minus-end-directed microtubule motor protein in animal cells, performing a wide range o

143 stin (SLC26a5) has evolved, now serving as a motor protein in outer hair cells (OHCs) of the mammalia

144 ermine the mechanokinetic properties of this motor protein in situ.

145 ions in DYNC1H1, which encodes a microtubule motor protein in the dynein-dynactin complex and one of

146 lated by phosphorylation of cytoskeletal and motor proteins in addition to changes in mitochondrial m

147 volution to cope with the lack of processive motor proteins in bacteria.

148 Because motor proteins in chromatin assembly also function as ch

149 foreseen level of specificity in the role of motor proteins in chromatin assembly.

150 alled carbon nanotubes targeted to kinesin-1 motor proteins in COS-7 cells.

151 sociated with reductions of axonal transport motor proteins in Parkinson's disease and support the hy

152 of nanometer-scale movements of DNA and RNA motor proteins in real time.

153 There was a decline in axonal transport motor proteins in sporadic Parkinson's disease that prec

154 s a remarkable example that demonstrates how motor proteins in the kinesin superfamily diversify thei

155 Depletion of myosin-IXA, a RhoGAP and actin motor protein, in collectively migrating cells led to al

156 TPX2, and HURP [7, 10-12], Ran also controls motor proteins, including Kid and HSET/XCTK2 [13, 14].

157 Nonmuscle myosin II (NM-II) is an important motor protein involved in cell migration.

158 dition, FAM120A associated with kinesins and motor proteins involved in cargo movement along microtub

159 lation of non-muscle Myosin II, but how this motor protein is spatiotemporally controlled is incomple

160 is widely accepted that movement of kinesin motor proteins is accomplished by coupling ATP binding,

161 ucidating the mechanisms that regulate these motor proteins is central to understanding genome mainte

162 Dynein, the retrograde motor protein, is essential for the transport of cargo a

163 s from one anchor site to another, mimicking motor proteins, is realized through a toehold-mediated D

164 The mitotic kinesin motor protein KIF14 is essential for cytokinesis during

165 a yeast two-hybrid screen, we identified the motor protein Kif15 as a potential interacting partner o

166 aNrxns, but both depended on the microtubule motor protein KIF1A and neuronal activity regulated the

167 terozygous missense mutations in the kinesin motor protein KIF21A or in the beta-tubulin isotypes TUB

168 Here we identified the key cellular motor protein KIF3A as a cellular substrate phosphorylat

169 We identified the type II kinesin motor protein KIF3A as a critical kinesin factor in the

170 Here we show that genetic deletion of the motor protein Kif3a in dental mesenchyme results in an a

171 sported to overlap zones, which required two motor proteins, Kif4A and a Kif20A paralog.

172 or overexpression depends on the microtubule motor protein kinesin 1 (KIF5).

173 oaches by focusing on its application to the motor protein kinesin, which undergoes several conformat

174 een identifies KIF5B, the heavy chain of the motor protein kinesin-1, as a new PA-binding protein.

175 -dependent manner, driven by the microtubule motor protein kinesin-1.

176 The motor proteins kinesin and dynein transport organelles,

177 s nidulans reveal a complex interplay of the motor proteins kinesin-3 and dynein, which co-operate to

178 an kinesin-like protein KIF14, a microtubule motor protein, localizes at the midbody to finalize cyto

179 ning the biophysical actions of cytoskeletal motor-protein machines that move cargo within cells, con

180 We hypothesize that motor proteins may be adapted to operate in crowded envi

181 The kinesin-13 motor protein MCAK is a potent microtubule depolymerase.

182 as a model for understanding fundamentals of motor protein mechanochemistry and for interpreting func

183 nvestigated whether prestin, an OHC-specific motor protein, might be involved.

184 ises from the coordinated activity of dynein motor protein molecules arrayed along microtubule double

185 s motility by interacting with the flagellar motor protein MotA and that yuxH is under the negative c

186 ntribute to cytoskeleton-based regulation of motor protein motility, we extracted intact microtubule

187 y little is known regarding how nucleic acid motor proteins move along the crowded DNA substrates tha

188 ers serve as one-dimensional tracks on which motor proteins move to perform their biological roles.

189 In physiological settings, all nucleic acids motor proteins must travel along substrates that are cro

190 Moreover, inhibiting the motor protein myosin II by blebbistatin decreased membra

191 We also show that Rab11 and the associated motor protein Myosin V play essential roles in both endo

192 Here we show that the unconventional motor protein myosin Va (MyoVa) is an effector of Rab8A

193 Mutations in the motor protein Myosin Vb (Myo5B) or the soluble NSF attac

194 ent on Rab4, Rab11, and the Ca(2+)-sensitive motor protein myosin Vb.

195 Mutations in the MYO7A gene, encoding the motor protein myosin VIIa, can cause Usher 1B, a deafnes

196 Various forms of the actin-specific motor protein myosin XI exist in plant cells and might b

197 We find that the molecular motor protein myosin-1c (Myo1c) regulates the dynamic st

198 emonstrate a role for the filopodia-inducing motor protein Myosin-X (Myo10) in mutant p53-driven canc

199 studies demonstrate that the unconventional motor protein myosin5B motor (Myo5B) works in associatio

200 the molecular switch Rab8A connects with the motor protein MyoVa to mobilize GLUT4 vesicles toward th

201 The motor protein non-muscle myosin II is a major driver of

202 w PARs regulate the behavior of the cortical motor protein nonmuscle myosin (NMY-2) to complement rec

203 The motor protein nonmuscle myosin II (NMII) must undergo dy

204 lts imply that the first use of prestin as a motor protein occurred early in amniote evolution and wa

205 Prestin is the motor protein of cochlear outer hair cells.

206 used to generate inhibitable versions of any motor protein of interest.

207 Motor proteins of the conserved kinesin-14 family have i

208 the motility of single fluorescently labeled motor proteins on these cytoskeletons.

209 port without interfering with the underlying motor proteins or cytoskeletal network through biochemic

210 mains unclear how cytoskeletal filaments and motor proteins organize into cellular scale structures a

211 l differences depend on the myosin family of motor proteins, particularly myosin II.

212 Motor protein phenomena have inspired theoretical models

213 Kinesin microtubule motor proteins play essential roles in division, includi

214 Members of the conserved FANCM family of DNA motor proteins play key roles in genome maintenance proc

215 SecA ATPase motor protein plays a central role in bacterial protein

216 (HSET), a member of the kinesin-14 family of motor proteins, plays an essential role in centrosomal b

217 Although the OHC-specific, somatic motor protein prestin is required for cochlear amplifica

218 The motor protein, prestin, which evolved from the SLC26 ani

219 hanism: sliding of microtubules, driven by a motor protein previously thought to be deployed only in

220 function in eucaryotic cells, facilitated by motor proteins-proteins converting chemical energy into

221 re generated by non-muscle myosin II (MyoII) motor proteins pulling filamentous actin (F-actin).

222 ontrol of apical nuclear migration occurs by motor protein recruitment and identify a role for nucleu

223 , microtubule-associated proteins (MAPs) and motor proteins regulate microtubule growth, shrinkage, a

224 ly how the various cargoes are linked to the motor proteins remains unclear.

225 nt progress in understanding how DNA-binding motor proteins respond to the presence of other proteins

226 Cytoplasmic dynein is the major motor protein responsible for microtubule minus-end-dire

227 mic dynein is a homodimeric microtubule (MT) motor protein responsible for most MT minus-end-directed

228 reducing the level of either of two Kinesin motor proteins responsible for anterograde vesicle trans

229 As with many ring-shaped motor proteins, Rho activity is modulated by a variety o

230 nding Rubisco inhibitors are released by the motor protein Rubisco activase (Rca).

231 To study this motor protein's mechano-chemical properties, we used a r

232 The motor protein SecA is a core component of the bacterial

233 n comes from ATP hydrolysis by the cytosolic motor-protein SecA, in concert with the proton motive fo

234 transcriptional regulators, cytoskeletal and motor proteins, secretory and endocytic pathways, cell c

235 h disrupts the back-to-front gradient of the motor protein, slowing down locomotion but promoting ant

236 CD4(+) T cells in DCs, including the dynein motor protein Snapin.

237 into canonical nucleosomes by an ATP-driven motor protein such as ACF or Chd1.

238 be converted into canonical nucleosomes by a motor protein such as ACF.

239 ore the mechanochemical cycles of processive motor proteins such as kinesin-1, but it has proven diff

240 s and ribosomes) to intracellular transport (motor proteins such as kinesins or dyneins).

241 In many cases, the activity of motor proteins such as nonmuscle myosins is required for

242 echniques for measuring the motion of single motor proteins, such as FRET and optical tweezers, are l

243 SNF2-like motor proteins, such as ISWI, cooperate with histone cha

244 sport in a nerve cell, where small groups of motor proteins, such as kinesins and cytoplasmic dynein,

245 Such complexity is present in myosin motor protein systems, and computational modeling is ess

246 Motor proteins tether and move cargos along microtubules

247 Myosin Va is a widely expressed actin-based motor protein that binds members of the Rab GTPase famil

248 ocytosis occurred when blocking myosin II, a motor protein that can be phosphorylated upon MLCK activ

249 catalytic portion of ATP synthase, a rotary motor protein that couples proton gradients to ATP synth

250 Prestin is the membrane motor protein that drives outer hair cell (OHC) electrom

251 Eg5 is a homotetrameric kinesin-5 motor protein that generates outward force on the overla

252 hedral prohead shell is catalyzed by TerL, a motor protein that has ATPase, endonuclease, and translo

253 Myosin IC (myo1c), a widely expressed motor protein that links the actin cytoskeleton to cell

254 Cytoplasmic dynein is a dimeric AAA(+) motor protein that performs critical roles in eukaryotic

255 ntial for the function of Kif1a, a kinesin-3 motor protein that traffics synaptic vesicles.

256 Cytoplasmic dynein is a motor protein that walks along microtubules (MTs) and pe

257 mokinesins are microtubule plus end-directed motor proteins that bind to chromosome arms.

258 explicitly incorporates force generation by motor proteins that can act normally or tangentially to

259 3s are members of the kinesin superfamily of motor proteins that depolymerize microtubules (MTs) and

260 Kinesin-like motor proteins that directly attenuate microtubule dynam

261 The human genome encodes 45 kinesin motor proteins that drive cell division, cell motility,

262 Class 1 myosins are monomeric motor proteins that fulfill diverse functions at the mem

263 kinase C isozymes and then on the molecular motor proteins that function downstream to drive MTOC mo

264 A small molecule called EMD 57033 can repair motor proteins that have stopped working as a result of

265 bers of the kinesin superfamily of molecular motor proteins that is critical for kinesin's processive

266 the coordinated regulation of the different motor proteins that mediate dendritic vesicle transport

267 and dendrites primarily depends on molecular motor proteins that move along the cytoskeleton.

268 interactions with cortical force generating motor proteins that position the spindle during asymmetr

269 gnals that converge on a competition between motor proteins that ultimately control lysosomal movemen

270 DNA helicases are motor proteins that unwind double-stranded DNA (dsDNA) t

271 DBPs are molecular motor proteins that utilize chemical energy in cycles of

272 ies (AAA+) form a superfamily of ring-shaped motor proteins that utilize cyclical allosteric motions

273 myosin II (NMII), a family of actin-binding motor-proteins that participate in the formation of the

274 ially associate with microtubules and dynein motor protein, thereby resulting in differential taxane

275 ar trafficking by regulating the activity of motor proteins through the organization of the filament

276 o previous notions, MyRIP does not link this motor protein to SGs.

277 n diverse animal taxa by linking microtubule motor proteins to a marker protein on the cell cortex lo

278 We used an optogenetic approach to recruit motor proteins to cargo in real time within axons or den

279 The response of motor proteins to external loads underlies their ability

280 that coordinates the activities of multiple motor proteins to precisely position the spindle.

281 and provide GTP to dynamins, allowing these motor proteins to work with high thermodynamic efficienc

282 led to a proposed mechanism wherein the gp17 motor protein translocates DNA by transitioning between

283 ble doublet microtubules (DMTs), along which motor proteins transmit force for ciliary motility and i

284 ments via a variety of mechanisms, including motor protein transport, local binding, and diffusion ba

285 Cytoplasmic dynein, a microtubule-based motor protein, transports many intracellular cargos by m

286 th microtubules or coprecipitate with dynein motor protein, unlike ARv567.

287 yzed the interactions between the portal and motor proteins using a direct binding assay, mutagenesis

288 e motility of microtubules driven by kinesin motor proteins using various photoprotection strategies,

289 ycled by binding to non-muscle myosin IIA, a motor protein, via the cytoplasmic tail (CT).

290 Kinesin-1 motor proteins walk parallel to the protofilament axes o

291 dual cilia that correctly expressed axonemal motor proteins were motile and did not exhibit obvious b

292 ound that BB0286 (FlbB) is a novel flagellar motor protein, which is located around the flagellar bas

293 are controlled by nonmuscle myosin II (NMII) motor proteins, which are tightly regulated via the phos

294 However, little is known about how motor proteins, which follow individual microtubule prot

295 study of microtubule-associated proteins and motor proteins, which has been a major issue in microtub

296 he HARP2, and other domains found in certain motor proteins, which may explain why only a subset of D

297 (dynein) is a minus end-directed microtubule motor protein with many cellular functions, including du

298 Kip3 is a multifunctional motor protein with microtubule depolymerase, plus-end mo

299 late endosomes along with dynein and kinesin motor proteins within swollen TBs, and genetic analyses

300 It is understood that motor proteins work in teams enabling unidirectional and