ライフサイエンスコーパス: mouse hepatitis virus

1 ted neurotropic coronavirus (rJ2.2 strain of mouse hepatitis virus).

2 ing infection of p85beta-deficient mice with mouse hepatitis virus.

3 l infection by the neurotropic JHM strain of mouse hepatitis virus.

4 S infection by the neurotropic JHM strain of mouse hepatitis virus.

5 alphavirus chikungunya virus and coronavirus mouse hepatitis virus.

6 egion of the positive-stranded RNA genome of mouse hepatitis virus.

7 ternative receptor for the mouse coronavirus mouse hepatitis virus.

8 central nervous system by the JHM strain of mouse hepatitis virus.

9 bute to the persistence of the JHM strain of mouse hepatitis virus.

10 nucleocapsid protein of a model coronavirus, mouse hepatitis virus.

11 control acute infection with the cytopathic mouse hepatitis virus.

12 Intranasal mouse hepatitis virus-1 (MHV-1) infection of susceptible

13 Mouse hepatitis virus, a beta-CoV in group A, uses the g

14 Intracerebral infection of mice with mouse hepatitis virus, a member of the Coronaviridae fam

15 rmine the role of MDA5 during infection with mouse hepatitis virus, a murine coronavirus used to mode

16 ssibility was examined in mice infected with mouse hepatitis virus, a well-described model of virus-i

17 Surprisingly, two beta-CoVs in group A, mouse hepatitis virus and HKU1, have evolved to use diff

18 central nervous system (CNS) by neurotropic mouse hepatitis virus but do not suffice to achieve ster

19 I Ag presentation, H-2d-restricted HIV-1 and mouse hepatitis virus CTL epitopes were linked via vario

20 stem segment mutations on the replication of mouse hepatitis virus defective interfering RNAs.

21 ysis of mice infected with the JHM strain of mouse hepatitis virus demonstrated that, in contrast to

22 CCL3(-/-) mice infected with mouse hepatitis virus exhibited a significant reduction

23 d of the 3' untranslated region (UTR) of the mouse hepatitis virus genome contains two essential and

24 IP-10(-/-) mice infected with a neurotropic mouse hepatitis virus had an impaired ability to control

25 gnals of the SARS-associated coronavirus and mouse hepatitis virus have evolved to promote optimal fr

26 he pathogenesis of the neurotropic strain of mouse hepatitis virus in Fas-deficient mice suggested th

27 ein, encoded by ORF6, enhanced the growth of mouse hepatitis virus in tissue culture cells and in mic

28 rected against CCL5 to mice with established mouse hepatitis virus-induced demyelination and impaired

29 orates rather than perpetuates JHM strain of mouse hepatitis virus-induced demyelination.

30 To determine functional significance, mouse hepatitis virus-infected mice were treated with an

31 astrocytes during acute encephalomyelitis in mouse hepatitis virus-infected mice, and the majority of

32 Mouse hepatitis virus infection of mice provides a usefu

33 a) in contributing to a Th1 response against mouse hepatitis virus infection of the CNS.

34 infection with the neurotropic JHM strain of mouse hepatitis virus is inhibited in the absence of CD4

35 The MHV-JHM strain of the murine coronavirus mouse hepatitis virus is much more neurovirulent than th

36 Mouse hepatitis virus is used as well studied examplar t

37 For example, C57BL/6 (B6) mice infected with mouse hepatitis virus (JHM strain, JHMV) develop severe

38 ures containing CNS cells were infected with mouse hepatitis virus-JHM, which causes fatal encephalit

39 cephalomyelitis induced by the JHM strain of mouse hepatitis virus (JHMV) and sustained during viral

40 infected with the neurotropic JHM strain of mouse hepatitis virus (JHMV) clear infectious virus; nev

41 infected with the neurotropic JHM strain of mouse hepatitis virus (JHMV) develop acute and chronic d

42 ystem (CNS) by the neurotropic JHM strain of mouse hepatitis virus (JHMV) induces an acute encephalom

43 oculation with the neurotropic JHM strain of mouse hepatitis virus (JHMV) into the central nervous sy

44 al nervous system (CNS) by the JHM strain of mouse hepatitis virus (JHMV) is a rodent model of the hu

45 The neurotropic JHM strain of mouse hepatitis virus (JHMV) produces an acute CNS infec

46 Control of neurotropic mouse hepatitis virus (JHMV) requires the collaboration

47 infection with the neurotropic JHM strain of mouse hepatitis virus (JHMV) resulted in an acute enceph

48 mouse CNS with the neurotropic JHM strain of mouse hepatitis virus (JHMV) results in an immune-mediat

49 f the CNS with the neurotropic JHM strain of mouse hepatitis virus (JHMV) was examined.

50 infection with the neurotropic JHM strain of mouse hepatitis virus (JHMV).

51 tillation with the neurotropic JHM strain of mouse hepatitis virus (JHMV).

52 The 5' 140 nucleotides of the mouse hepatitis virus (MHV) 5' untranslated region (5'UT

53 We used mouse hepatitis virus (MHV) A59 as a model to gain insig

54 The endoribonuclease activity of the mouse hepatitis virus (MHV) A59 Nsp15 was also increased

55 here the outcome of viral encephalomyelitis [mouse hepatitis virus (MHV) A59, Theiler's encephalomyel

56 Infection with the murine coronavirus mouse hepatitis virus (MHV) activates the pattern recogn

57 pathogens, including the murine coronavirus mouse hepatitis virus (MHV) and Haemophilus influenzae,

58 wo viruses within the genus Betacoronavirus, mouse hepatitis virus (MHV) and MERS-CoV, encode 2',5'-p

59 of the 5' untranslated regions (5'UTRs) from mouse hepatitis virus (MHV) and severe acute respiratory

60 evere acute respiratory syndrome (SARS)-CoV, mouse hepatitis virus (MHV) and the human CoV OC43 S2 su

61 The subgenomic mRNAs of the coronavirus mouse hepatitis virus (MHV) are composed of a leader seq

62 Receptors for murine coronavirus mouse hepatitis virus (MHV) are members of the murine ca

63 The p28 and p65 proteins of mouse hepatitis virus (MHV) are the most amino-terminal

64 e glycoprotein (S) of the murine coronavirus mouse hepatitis virus (MHV) binds to viral murine CEACAM

65 Some strains of mouse hepatitis virus (MHV) can induce chronic inflammat

66 The neurotropic JHM strain of mouse hepatitis virus (MHV) causes acute encephalitis an

67 Murine coronavirus mouse hepatitis virus (MHV) causes demyelination of the

68 Murine coronavirus mouse hepatitis virus (MHV) causes persistent infection

69 ve interfering (DI) RNA of the JHM strain of mouse hepatitis virus (MHV) consist of three discontinuo

70 2 (SL2) of the 5'-untranslated region of the mouse hepatitis virus (MHV) contains a highly conserved

71 The coronavirus mouse hepatitis virus (MHV) contains a large open readin

72 positive-sense RNA genome of the coronavirus mouse hepatitis virus (MHV) contains sequences that are

73 ve (ts) mutant helper virus, two coronavirus mouse hepatitis virus (MHV) defective interfering (DI) R

74 Mouse hepatitis virus (MHV) does not induce interferon (

75 ired for clearance of the murine coronavirus mouse hepatitis virus (MHV) during acute infection.

76 tep toward understanding the function of the mouse hepatitis virus (MHV) E protein, we carried out cl

77 on with the recombinant JHM (RJHM) strain of mouse hepatitis virus (MHV) elicits a weak CD8(+) T-cell

78 e replicase gene (gene 1) of the coronavirus mouse hepatitis virus (MHV) encodes two co-amino-termina

79 Various strains of mouse hepatitis virus (MHV) exhibit different pathogenic

80 Most strains of murine coronavirus mouse hepatitis virus (MHV) express a cleavable spike gl

81 Using the recombinant murine coronavirus mouse hepatitis virus (MHV) expressing the T cell-chemoa

82 While the 5' cis-acting sequence of mouse hepatitis virus (MHV) for genomic RNA replication

83 Murine coronavirus mouse hepatitis virus (MHV) gene 1 encodes several nonst

84 ithin the 3'-terminal 166 nucleotides of the mouse hepatitis virus (MHV) genome and assessed their fu

85 The mouse hepatitis virus (MHV) genome's 3' untranslated reg

86 The 3'-end of mouse hepatitis virus (MHV) genomic RNA contains a recog

87 ream of the leader at the 5' terminus of the mouse hepatitis virus (MHV) genomic RNA, contains a sequ

88 ction of murine astrocytoma (DBT) cells with mouse hepatitis virus (MHV) has been established.

89 Previous work with the prototype coronavirus mouse hepatitis virus (MHV) has shown that a major deter

90 Many strains of the murine coronavirus mouse hepatitis virus (MHV) have distinct, S-dependent o

91 Previous studies have demonstrated that mouse hepatitis virus (MHV) hepatotropism is determined

92 o the nonessential gene 4 of the coronavirus mouse hepatitis virus (MHV) in order to test the applica

93 constructed mutants of the model coronavirus mouse hepatitis virus (MHV) in which all or part of the

94 , we constructed a mutant of the coronavirus mouse hepatitis virus (MHV) in which the ectodomain of t

95 of 17Cl-1 cells with the murine coronavirus mouse hepatitis virus (MHV) induced caspase-dependent ap

96 The murine coronavirus mouse hepatitis virus (MHV) induced the expression of ty

97 The coronavirus mouse hepatitis virus (MHV) induces a minimal type I int

98 induced demyelination, including coronavirus mouse hepatitis virus (MHV) infection in mice.

99 Thus, during mouse hepatitis virus (MHV) infection, hepatitis, which

100 encephalomyelitis virus (TMEV) infection and mouse hepatitis virus (MHV) infection.

101 Mouse hepatitis virus (MHV) is a 31-kb positive-strand R

102 The M protein of mouse hepatitis virus (MHV) is an integral membrane prot

103 RNA synthesis by the prototype coronavirus mouse hepatitis virus (MHV) is carried out by a replicas

104 processing of the replicase gene product of mouse hepatitis virus (MHV) is essential for viral repli

105 The 3C-like proteinase (3CLpro) of mouse hepatitis virus (MHV) is predicted to cleave at le

106 Mouse hepatitis virus (MHV) isolates JHM.WU and JHM.SD p

107 binds specifically to the plus strand of the mouse hepatitis virus (MHV) leader RNA.

108 rotective roles of specific ISGs against the mouse hepatitis virus (MHV) members of the coronaviruses

109 Mouse hepatitis virus (MHV) neurotropism varies by strai

110 ave demonstrated that the murine coronavirus mouse hepatitis virus (MHV) nonstructural protein 2 (ns2

111 uclear magnetic resonance (NMR) structure of mouse hepatitis virus (MHV) nsp3a and show, using isothe

112 The coronavirus mouse hepatitis virus (MHV) performs RNA replication on

113 Murine coronavirus mouse hepatitis virus (MHV) produces a genome-length mRN

114 Infection of the CNS with the mouse hepatitis virus (MHV) provides a unique model situ

115 Mouse hepatitis virus (MHV) receptor, the receptor for t

116 Mouse hepatitis virus (MHV) replicase products nsp3, nsp

117 Mouse hepatitis virus (MHV) replication in actively grow

118 on of cultured cells with murine coronavirus mouse hepatitis virus (MHV) resulted in activation of th

119 ed that infection of rat oligodendrocytes by mouse hepatitis virus (MHV) resulted in apoptosis, which

120 Intracranial infection of C57BL/6 mice with mouse hepatitis virus (MHV) results in an acute encephal

121 Intracerebral infection of mice with mouse hepatitis virus (MHV) results in an acute encephal

122 (hnRNP) A1 has previously been shown to bind mouse hepatitis virus (MHV) RNA at the 3' end of both pl

123 The 3'-untranslated region (3'-UTR) of mouse hepatitis virus (MHV) RNA regulates the replicatio

124 shown to function as regulatory factors for mouse hepatitis virus (MHV) RNA synthesis as a result of

125 Mouse hepatitis virus (MHV) RNA synthesis is mediated by

126 The 3' cis-acting element for mouse hepatitis virus (MHV) RNA synthesis resides entire

127 Mouse hepatitis virus (MHV) RNA transcription is regulat

128 e leader RNA and intergenic (IG) sequence of mouse hepatitis virus (MHV) RNA.

129 accumulation kinetics of murine coronavirus mouse hepatitis virus (MHV) RNAs early in infection by u

130 The mouse hepatitis virus (MHV) spike glycoprotein, S, has b

131 Persistent infection with mouse hepatitis virus (MHV) strain A59 in murine DBT (de

132 s are important for clearance of neurotropic mouse hepatitis virus (MHV) strain A59, although their p

133 The murine coronavirus, mouse hepatitis virus (MHV) strain A59, causes acute enc

134 C57BL/6 (B6) mice infected with mouse hepatitis virus (MHV) strain JHM develop a clinica

135 Mice infected with mouse hepatitis virus (MHV) strain JHM develop primary d

136 We observed that the nonfusogenic mouse hepatitis virus (MHV) strain MHV-2 reached a titer

137 We demonstrate that MHV-A59, a mouse hepatitis virus (MHV) strain that causes brain and

138 Mouse hepatitis virus (MHV) strains (MHV-A59, MHV-JHM, a

139 erfering (DI) RNAs of the murine coronavirus mouse hepatitis virus (MHV) suggest that a 69-nucleotide

140 have previously generated E gene mutants of mouse hepatitis virus (MHV) that had marked defects in v

141 the current studies, neurotropic strains of mouse hepatitis virus (MHV) that induce meningitis, ence

142 previously generated E gene point mutants of mouse hepatitis virus (MHV) that were defective in growt

143 s, we previously generated E gene mutants of mouse hepatitis virus (MHV) that were defective in viral

144 The coronavirus mouse hepatitis virus (MHV) translates its replicase gen

145 ort that infection by the murine coronavirus mouse hepatitis virus (MHV) triggers the proximal UPR tr

146 The mouse hepatitis virus (MHV) variant MHV/BHK can infect h

147 We previously described mouse hepatitis virus (MHV) variant V51 derived from a p

148 Antibodies directed against mouse hepatitis virus (MHV) virions and against the puta

149 ic packaging signal (PS) for the coronavirus mouse hepatitis virus (MHV) was originally identified as

150 Mouse hepatitis virus (MHV) was used as a model to study

151 In previous work with the coronavirus mouse hepatitis virus (MHV), a highly defective M protei

152 Mouse hepatitis virus (MHV), a member of the Coronavirid

153 The primary cellular receptor for mouse hepatitis virus (MHV), a murine coronavirus, is MH

154 rms of murine CEACAM1 serve as receptors for mouse hepatitis virus (MHV), a murine coronavirus.

155 lpha/beta IFN (IFN-alpha/beta) receptor with mouse hepatitis virus (MHV), a murine coronavirus.

156 is question, we used the rJHM strain (rJ) of mouse hepatitis virus (MHV), a neurotropic coronavirus t

157 he N-terminal domain (NTD) of N protein from mouse hepatitis virus (MHV), a virus most closely relate

158 encoded by the prototypical Betacoronavirus, mouse hepatitis virus (MHV), and by Middle East respirat

159 The murine coronavirus, mouse hepatitis virus (MHV), causes acute hepatitis in i

160 spectively, including the murine coronavirus mouse hepatitis virus (MHV), Haemophilus influenzae, Nei

161 For the prototype coronavirus mouse hepatitis virus (MHV), heterogeneous nuclear ribon

162 For the prototype coronavirus mouse hepatitis virus (MHV), it has previously been esta

163 The murine coronavirus, mouse hepatitis virus (MHV), JHM strain, induces a bipha

164 epitope of a highly neurovirulent strain of mouse hepatitis virus (MHV), JHM, is thought to be essen

165 Demyelination induced by mouse hepatitis virus (MHV), strain JHM, is in large par

166 Infection of mice with mouse hepatitis virus (MHV), strain JHM, results in acut

167 nhibited virus entry and cell-cell fusion of mouse hepatitis virus (MHV), suggesting the importance o

168 For the coronavirus mouse hepatitis virus (MHV), the first proteolytic proce

169 In mouse hepatitis virus (MHV), the NTD binds the transcrip

170 s study, we exploited the model coronavirus, mouse hepatitis virus (MHV), to investigate the genotype

171 ns in the N protein of the model coronavirus mouse hepatitis virus (MHV), we constructed mutants in w

172 ions of N protein domains in the coronavirus mouse hepatitis virus (MHV), we replaced the MHV N gene

173 terfering (DI) RNA of the murine coronavirus mouse hepatitis virus (MHV), when introduced into MHV-in

174 ocalization and expression is altered due to mouse hepatitis virus (MHV)-A59 infection both in vivo a

175 a group of mutants of the murine coronavirus mouse hepatitis virus (MHV)-A59, isolated from persisten

176 Mouse hepatitis virus (MHV)-infected cells contain full-

177 In this study, mouse hepatitis virus (MHV)-infected cells were fraction

178 togen-activated protein kinases (MAPKs) in a mouse hepatitis virus (MHV)-infected macrophage-derived

179 terpart in the prototype group 2 coronavirus mouse hepatitis virus (MHV).

180 piratory syndrome coronavirus (SARS-CoV) and mouse hepatitis virus (MHV).

181 icacy against a member of the Coronaviridae, Mouse hepatitis virus (MHV).

182 on (3' UTR) of the genome of the coronavirus mouse hepatitis virus (MHV).

183 curs within the CNS following infection with mouse hepatitis virus (MHV).

184 gitis virus (LCMV), vaccinia virus (VV), and mouse hepatitis virus (MHV).

185 espiratory syndrome CoV, and the murine CoV, mouse hepatitis virus (MHV).

186 in cells infected with a murine coronavirus, mouse hepatitis virus (MHV).

187 and replication of a cytoplasmic RNA virus, mouse hepatitis virus (MHV).

188 n cells infected with the murine coronavirus mouse hepatitis virus (MHV).

189 ase inhibitor in a coronavirus model system, mouse hepatitis virus (MHV).

190 trol of in vivo infection by the coronavirus mouse hepatitis virus (MHV).

191 in response to intracerebral infection with mouse hepatitis virus (MHV).

192 ralized the infectivity of the A59 strain of mouse hepatitis virus (MHV-A59) in a concentration-depen

193 N did not serve as a functional receptor for mouse hepatitis virus (MHV-A59), which is in serogroup I

194 infection with the neurotropic strain JHM of mouse hepatitis virus (MHV-JHM).

195 n of C57BL/6 mice with the V5A13.1 strain of mouse hepatitis virus (MHV-V5A13.1) results in an acute

196 Recombinant mouse hepatitis viruses (MHV) differing only in the spik

197 uced into a heterologous murine coronavirus (mouse hepatitis virus [MHV]) but is not essential for op

198 mice with a recombinant murine coronavirus (mouse hepatitis virus [MHV]) expressing the T-cell chemo

199 vation of RNase L during murine coronavirus (mouse hepatitis virus [MHV]) infection of myeloid cells

200 Murine coronavirus (mouse hepatitis virus [MHV]) nonstructural protein 2 (ns

201 infected with the neurotropic JHMV strain of mouse hepatitis virus mount potent regional CTL response

202 udied the interaction between coronaviruses (mouse hepatitis virus) of different neurovirulences with

203 Early during clearance of the JHM strain of mouse hepatitis virus, only few virus-specific Ab-secret

204 utralization is critical for maintaining JHM mouse hepatitis virus persistence within the central ner

205 cellular immunity in controlling neurotropic mouse hepatitis virus persistence within the CNS were de

206 The neurotropic coronavirus JHM strain of mouse hepatitis virus persists in oligodendroglia despit

207 tem (CNS) with the neurotropic JHM strain of mouse hepatitis virus produces acute and chronic demyeli

208 Infection by the neurotropic JHM strain of mouse hepatitis virus produces an acute demyelinating en

209 Mouse hepatitis virus receptor (MHVR) is a murine biliar

210 Detection of the mouse hepatitis virus receptor within the central nervou

211 we found that proteasome inhibitors blocked mouse hepatitis virus replication at an early step in th

212 binant CXCL10-expressing murine coronavirus (mouse hepatitis virus) resulted in protection from disea

213 most neurotropic strains of the coronavirus mouse hepatitis virus results in an immune response-medi

214 tion of the neuroattenuated OBLV60 strain of mouse hepatitis virus results in infection of mitral neu

215 on activation gene 2(-/-) mice with only non-mouse hepatitis virus-specific T cells, we show that CD8

216 al (i.n.) infection of A/J mice with the CoV mouse hepatitis virus strain 1 (MHV-1) induces an acute

217 here investigation into the genetic basis of mouse hepatitis virus strain 1 (MHV-1) pneumovirulence.

218 ially induced in primary mouse astrocytes by mouse hepatitis virus strain A59 (MHV-A59) and MHV-2.

219 The 21.7-kb replicase locus of mouse hepatitis virus strain A59 (MHV-A59) encodes sever

220 Mouse hepatitis virus strain A59 (MHV-A59) produces meni

221 Previous work showed that mouse hepatitis virus strain A59 (MHV-A59) with a mutate

222 ersistently infected with murine coronavirus mouse hepatitis virus strain A59 (MHV-A59), expression o

223 was recently established for the coronavirus mouse hepatitis virus strain A59 (MHV-A59), in which cDN

224 infectious cDNA of the group II coronavirus mouse hepatitis virus strain A59 (MHV-A59).

225 se data suggest that clearance of infectious mouse hepatitis virus strain A59 from the CNS requires A

226 Mouse hepatitis virus strain A59 infection of mice is a

227 hether B cells are important for controlling mouse hepatitis virus strain A59 infection, we infected

228 Intracerebral inoculation with mouse hepatitis virus strain A59 results in viral replic

229 ing intranasal infection with the gliatropic mouse hepatitis virus strain A59.

230 Replication of the neurotropic mouse hepatitis virus strain JHM (JHMV) is controlled pr

231 Mouse hepatitis virus strain JHM (MHV-JHM) causes acute

232 ce infected with the neurotropic coronavirus mouse hepatitis virus strain JHM (MHV-JHM) develop a chr

233 Mice infected with mouse hepatitis virus strain JHM (MHV-JHM) develop a chr

234 C57BL/6 mice infected with mouse hepatitis virus strain JHM (MHV-JHM) develop a chr

235 ons, C57BL/6 mice persistently infected with mouse hepatitis virus strain JHM (MHV-JHM) develop clini

236 Mouse hepatitis virus strain JHM causes a chronic demyel

237 Mice infected with mouse hepatitis virus strain JHM develop an inflammatory

238 The coronavirus, mouse hepatitis virus strain JHM, causes acute and chron

239 ce infected with the neurotropic coronavirus mouse hepatitis virus strain JHM.

240 nic infections, including mice infected with mouse hepatitis virus strain JHM.

241 Mice infected with the coronavirus mouse hepatitis virus, strain JHM (JHM) develop a diseas

242 Mice infected with the murine coronavirus, mouse hepatitis virus, strain JHM (MHV) develop an immun

243 C57BI/6 mice infected with mouse hepatitis virus, strain JHM (MHV-JHM) develop a ch

244 Mice infected with attenuated strains of mouse hepatitis virus, strain JHM, develop a chronic inf

245 pes recognized in C57BL/6 mice infected with mouse hepatitis virus, strain JHM, or lymphocytic chorio

246 e selected in mice chronically infected with mouse hepatitis virus, strain JHM.

247 Cs are readily infected by another strain of mouse hepatitis virus, the A59 strain (MHV-A59).

248 Intranasal mouse hepatitis virus type 1 (MHV-1) infection of mice i

249 t has recently been shown that cell entry of mouse hepatitis virus type 2 (MHV-2) is mediated through

250 ctivity of PLPs from SARS-CoV, MERS-CoV, and mouse hepatitis virus was evaluated against seven ISG15s

251 The importance of the CD (SWWSFNPETNNL) in mouse hepatitis virus was investigated with a panel of m

252 al and sublethal infections with neurotropic mouse hepatitis virus was investigated.

253 nonpathogenic (V-2) variant of a neurotropic mouse hepatitis virus, which differ in the ability to pe

254 well as mice infected with the JHM strain of mouse hepatitis virus, which exhibit CTL escape variants

255 embrane (M) protein of the model coronavirus mouse hepatitis virus with its counterpart from a hetero

256 Replication of the neurotropic JHM strain of mouse hepatitis virus within the central nervous system