ライフサイエンスコーパス: mucociliary

1 g valuable opportunities for the analysis of mucociliary activity in relation to bacteria recruitment

2 ells achieved terminal differentiation, with mucociliary activity strongly selecting for full gliding

3 human bronchial epithelium (NHBE) exhibiting mucociliary activity.

4 f the ostiomeatal complex, playing a role in mucociliary activity.

5 hed in vitro model of human pseudostratified mucociliary airway epithelium (HAE).

6 hed in vitro model of human pseudostratified mucociliary airway epithelium (HAE).

7 were investigated in a fully differentiated, mucociliary airway epithelium model.

8 Reduced mucociliary allergen clearance exacerbated Stat6-depende

9 aging agents is reduced by the action of the mucociliary apparatus and by formation of a physical bar

10 The data support a model in which the mucociliary apparatus impairs colonization yet cilia pro

11 rway-on-a-chip' containing a differentiated, mucociliary bronchiolar epithelium and an underlying mic

12 pertension (in Liddle syndrome) and impaired mucociliary clearance (in cystic fibrosis).

13 es within the airway surface liquid regulate mucociliary clearance (MCC) activities, the primary inna

14 ondrial iron loading, showed impaired airway mucociliary clearance (MCC) and higher pulmonary inflamm

15 drial dysfunction, airspace enlargement, and mucociliary clearance (MCC) disruption during CS exposur

16 AC6 inhibitor were protected from CS-induced mucociliary clearance (MCC) disruption.

17 tides are among the most potent mediators of mucociliary clearance (MCC) in human lungs.

18 Mucociliary clearance (MCC) in subjects with CB was nega

19 Mucociliary clearance (MCC) is a critical host innate de

20 Mucociliary clearance (MCC) is a major airway host defen

21 Mucociliary clearance (MCC) is the primary physical airw

22 The efficiency of the mucociliary clearance (MCC) process that removes noxious

23 port to adjust ASL volume to maintain proper mucociliary clearance (MCC).

24 us barrier traps and eliminates them through mucociliary clearance (MCC).

25 Significant improvements in mucociliary clearance (P < 0.001), gastrointestinal pH (

26 cells promotes purinergic receptor-regulated mucociliary clearance activities necessary for innate lu

27 lammatory cell recruitment, mucus secretion, mucociliary clearance and airway surface liquid composit

28 nnate immune activity has been attributed to mucociliary clearance and antimicrobial polypeptides of

29 fibrosis (CF) is characterized by defective mucociliary clearance and chronic airway infection by a

30 t NO production, resulting in stimulation of mucociliary clearance and direct antibacterial effects.

31 l and nasopharyngeal gland deficits, reduced mucociliary clearance and impaired auditory tube gating

32 o clinical consequences on respiratory-tract mucociliary clearance and lung function, fertility, and

33 include loss of lysozyme secretion, reduced mucociliary clearance and overgrowth of nasal commensal

34 ier in the airway in order to overcome rapid mucociliary clearance and reach the underlying epitheliu

35 cerebrospinal fluid flow, sensory reception, mucociliary clearance and renal physiology indicate that

36 p uniquely allows dynamic in vivo imaging of mucociliary clearance and steady-state immune cell behav

37 opment of fetal and neonatal lung, affecting mucociliary clearance and Th1 responses.

38 tion and suggests therapeutic improvement of mucociliary clearance as a novel treatment strategy for

39 These data show that mucociliary clearance associated with mild chronic bronc

40 Defective mucociliary clearance associated with the absence of the

41 particular, epithelial mucins facilitate the mucociliary clearance by physically trapping inhaled mic

42 particular, epithelial mucins facilitate the mucociliary clearance by physically trapping the inhaled

43 The rates of mucociliary clearance by pretreatment with amiloride and

44 Impaired mucociliary clearance contributes to the pathophysiology

45 onic obstructive pulmonary disease and other mucociliary clearance defects.

46 Effective mucociliary clearance depends on adequate airway hydrati

47 an Multicilin that cause a severe congenital mucociliary clearance disorder due to reduced generation

48 on of multiple motile cilia (RGMC) is a rare mucociliary clearance disorder.

49 lial cell dysfunction, cilia shortening, and mucociliary clearance disruption.

50 ed UTP and amiloride in combination improved mucociliary clearance from the peripheral airways of the

51 volume of airway surface liquid, we measured mucociliary clearance in 16 normal subjects after inhala

52 ar ATP and its metabolite adenosine regulate mucociliary clearance in airway epithelia.

53 Mucociliary clearance in conducting airways, reduction o

54 r agonist, is effective at acutely enhancing mucociliary clearance in healthy, nonsmoking adults.

55 The impaired mucociliary clearance in individuals with Cystic Fibrosi

56 Mucociliary clearance in mammalian respiratory airways d

57 let cell metaplasia and diminishes efficient mucociliary clearance in mice with AAD, resulting in inc

58 There is no evidence for a primary defect in mucociliary clearance in most patients with CRS.

59 iquid are associated with increased rates of mucociliary clearance in normal subjects.

60 he rheology of airway secretions and enhance mucociliary clearance in patients with CF.

61 se) reduces airflow obstruction and improves mucociliary clearance in patients with cystic fibrosis (

62 (CFTR), which regulates anion transport and mucociliary clearance in the airways.

63 experience demonstrates that restoration of mucociliary clearance in the lungs after transplantation

64 ted information on its actions on the airway mucociliary clearance in vivo.

65 Mucociliary clearance is composed of three components (i

66 Mucociliary clearance is determined by ciliary activity

67 Mucociliary clearance is one of the major lines of defen

68 Mucociliary clearance is one of the major lines of defen

69 icate that the antigen-induced impairment of mucociliary clearance is partly dependent on increased e

70 nearly sterile lower respiratory tract when mucociliary clearance mechanisms are functioning effecti

71 ects of inhaled vehicle and UTP/amiloride on mucociliary clearance of [99mTc] iron oxide particles fr

72 Mucin MUC5AC plays an important role in mucociliary clearance of bacterial pathogens.

73 a chloride channel that is essential for the mucociliary clearance of respiratory pathogens in humans

74 me, effects that would be proposed to reduce mucociliary clearance of respiratory pathogens.

75 Mucociliary clearance of whole and peripheral lung was i

76 cycle in the propagation of purine-mediated mucociliary clearance on human airway epithelial surface

77 ollowing inhalation of 99mTc aerosol, or for mucociliary clearance or the rate of clearance of the ra

78 mately 1.4% per minute) approached the rapid mucociliary clearance rates (approximately 2.0% per minu

79 Pretreatment with amiloride increased mucociliary clearance rates (approximately twofold) afte

80 Subsequently, mucociliary clearance rates were measured by gamma scint

81 mbrane nucleotide-release coordinates airway mucociliary clearance responses (mucin and salt, water s

82 from human airway epithelial cells regulates mucociliary clearance through cell surface nucleotide re

83 Mucociliary clearance was measured using gamma scintigra

84 A 2.5-fold increase in mucociliary clearance was seen in response to UTP alone

85 Mucociliary clearance was slowed 4 hours postchallenge i

86 onstriction is associated with impairment of mucociliary clearance with a time course that is consist

87 rosolized UTP +/- amiloride clearly enhances mucociliary clearance without acute adverse effects in n

88 To test the hypothesis that mucociliary clearance would increase after inhalation of

89 Recently, we demonstrated that reduced mucociliary clearance, a characteristic feature of asthm

90 the well-described physical barrier and the mucociliary clearance, a variety of systems, including t

91 It is hypothesized that alterations in mucociliary clearance, abnormalities in the sinonasal ep

92 vironment, diminished cough reflex, impaired mucociliary clearance, altered alveolar macrophage funct

93 ne regulates epithelial functions supporting mucociliary clearance, an important airway defense mecha

94 ability, stimulate mucus secretion, decrease mucociliary clearance, and appear capable of recruiting

95 CFTR) protein function on airway physiology, mucociliary clearance, and establishment of Pseudomonas

96 mechanisms including antimicrobial peptides, mucociliary clearance, and phagocytic cells.

97 ration, causing mucus dehydration, decreased mucociliary clearance, and recurrent acute bacterial inf

98 of LABA/LAMA combinations on hyperinflation, mucociliary clearance, and symptom severity may all cont

99 on, excessive mucus production with impaired mucociliary clearance, and symptom severity.

100 d the structure of motile cilia and impaired mucociliary clearance, barrier function, and epithelial

101 easured tracheal mucus velocity, a marker of mucociliary clearance, before and for 8 hours after anti

102 Substudies evaluated mucociliary clearance, beta-adrenergic sweat secretion r

103 characterized by abnormal ion transport and mucociliary clearance, but TGF-beta1 is also associated

104 ay mucus to mediate the critical function of mucociliary clearance, cleansing the airways of inhaled

105 Mucociliary clearance, driven by the engine of ciliary b

106 stal axis to meet local functional needs for mucociliary clearance, hydration, host defense, and gas

107 nce and tracheal mucus velocity, a marker of mucociliary clearance, in allergic and nonallergic sheep

108 n tracheal mucus velocity (TMV), a marker of mucociliary clearance, in sheep and (2) if the ET-1-indu

109 motile cilia and flagella govern respiratory mucociliary clearance, laterality determination and the

110 Rimantadine had no effect on nasal patency, mucociliary clearance, nasal signs, or on symptoms and s

111 tion of Splunc1 in mouse airways affects the mucociliary clearance, resulting in decreased innate imm

112 ss mucin production, however, overwhelms the mucociliary clearance, resulting in defective mucosal de

113 an inherited disorder that leads to impaired mucociliary clearance, to repeated chest infections, and

114 tional motility that is essential for proper mucociliary clearance.

115 ated with altered mucus rheology and reduced mucociliary clearance.

116 tributes to CF lung disease by impairment of mucociliary clearance.

117 n of bronchial lymphoid tissue and decreased mucociliary clearance.

118 Thus, gliding may be necessary to overcome mucociliary clearance.

119 e production to increase ciliary beating and mucociliary clearance.

120 tory agents, and new approaches that improve mucociliary clearance.

121 logical changes consistent with insufficient mucociliary clearance.

122 ysical forces such as coughing, sneezing and mucociliary clearance.

123 retory epithelial cells that are involved in mucociliary clearance.

124 ce liquid (ASL) volume and the efficiency of mucociliary clearance.

125 ciliary structure and function and impaired mucociliary clearance.

126 Nase reduces airflow obstruction or improves mucociliary clearance.

127 B48 and HCoV-OC43, altered cilia beating and mucociliary clearance.

128 s ciliary beat frequency (CBF) and speeds up mucociliary clearance.

129 es with improved airway hydration status and mucociliary clearance.

130 defects in ciliogenesis and complete loss of mucociliary clearance.

131 x1) channels to release ATP, which regulates mucociliary clearance.

132 across the lung mucosal barrier, as well as mucociliary clearance.

133 as well as airway surface liquid volume and mucociliary clearance.

134 respiratory dysfunction caused by defective mucociliary clearance.

135 itor that protects this key component of the mucociliary defense system was also uncovered.

136 of CFTR, an ion channel required for airway mucociliary defense.

137 In 16HBE14o- and primary mucociliary differentiated human bronchial epithelial ce

138 of squamous NHTBE cells compared with normal mucociliary differentiated NHTBE cells.

139 In both 16HBE14o- and primary mucociliary-differentiated cells, preincubation with H.

140 in mediating early biological effects in the mucociliary differentiation of bronchial epithelia.

141 UP variations can cause mucociliary drainage and ventilation problems, causing c

142 could prevent and/or reverse antigen-induced mucociliary dysfunction in allergic sheep.

143 Therefore, we propose that TGF-beta1-induced mucociliary dysfunction in CF airways is associated with

144 of Duox2, representing a novel mechanism for mucociliary dysfunction in inflammatory airway diseases.

145 ired in CF, thereby possibly contributing to mucociliary dysfunction in this disease, at least during

146 sis and primary ciliary dyskinesia, in which mucociliary dysfunction predisposes subjects to high rat

147 onchospastic actions, can also contribute to mucociliary dysfunction, a central component of the path

148 ways, may be a source of agents for treating mucociliary dysfunction.

149 hibitors may be useful in protecting against mucociliary dysfunction.

150 tes to the acute (0 to 6-hr) antigen-induced mucociliary dysfunction.

151 Airway inflammation causes mucociliary dysfunction.

152 Mucociliary epithelia are essential for homeostasis of m

153 our understanding of pathological changes in mucociliary epithelia that accompany diseases such as as

154 the development and function of mucosal and mucociliary epithelia.

155 Here, we use an in vivo model of vertebrate mucociliary epithelial development to show that Dishevel

156 odel system for in vivo molecular studies of mucociliary epithelial development.

157 pithelial cells undergo differentiation into mucociliary epithelium in vitro, and its overexpression

158 sal cells differentiating into organoids and mucociliary epithelium in vitro.

159 erate a well-differentiated pseudostratified mucociliary epithelium to investigate whether RSV infect

160 r-liquid interface culture into an organized mucociliary epithelium with transepithelial resistance.

161 erning and in shorter multicilia in external mucociliary epithelium.

162 with lung cancer and expressed primarily in mucociliary epithelium.

163 Motile cilia are essential components of the mucociliary escalator and are central to respiratory-tra

164 sical removal of viruses and bacteria on the mucociliary escalator is an important aspect of the mamm

165 te [UTP]) activate several components of the mucociliary escalator, suggesting they may have potentia

166 ed to overcoming the clearance action of the mucociliary escalator.

167 Mucociliary flow is an important defense mechanism in th

168 ings), ASL height (confocal microscopy), and mucociliary function (by tracking the surface flow of ap

169 neic tracheal autografts demonstrated normal mucociliary function after transplantation, allogeneic r

170 ease with age, we investigated correlates of mucociliary function in subjects with PNTM infections an

171 Tracheal mucous velocity CTMV), an index of mucociliary function, was measured with a roentgenograph

172 in conducting airways for the maintenance of mucociliary function.

173 l surface fluid levels, airway hydration and mucociliary function.

174 logeneic recipients failed to achieve normal mucociliary function.

175 helial cell morphology, gene expression, and mucociliary function.

176 polarization, independent of acquisition of mucociliary function.

177 spiratory pathogens secrete toxins to impair mucociliary immunity, we examined the effects of acute e

178 y five V. fischeri cells aggregate along the mucociliary membranes of a superficial epithelium prior

179 We show that mucociliary membranes of animal epithelia can create flu

180 ke mechanosensory neurons formed part of the mucociliary sole in protostome-deuterostome ancestors an

181 Each mucociliary surface that recruits a microbiome such as t

182 However, all mucociliary surfaces are subject to the same physical an

183 sis (CF) therapies we have developed a novel mucociliary transit (MCT) measurement that uses synchrot

184 Mucociliary transport (MCT) is an innate defense mechani

185 tween periciliary liquid (PCL) hydration and mucociliary transport (MCT) rates, a relationship freque

186 Advanced CF is characterized by a deficit in mucociliary transport (MCT), a process that traps and pr

187 Increased mucociliary transport accounted for only part of the inc

188 Cby(-/-) mice exhibit a complete absence of mucociliary transport caused by a marked paucity of moti

189 body component Chibby (Cby) exhibit impaired mucociliary transport caused by defective ciliogenesis,

190 d that mucus with abnormal behavior impaired mucociliary transport in newborn CF piglets prior to the

191 ing of the regulation of ciliary beating and mucociliary transport is necessary for identifying new r

192 es simultaneous measurement of rheology with mucociliary transport parameters that we previously dete

193 g mucus rheological properties and improving mucociliary transport to relieve clinical symptoms of pa

194 cell cultures exhibiting spontaneous, radial mucociliary transport to study the movements of mucus an

195 nt for hydrating airway surfaces, supporting mucociliary transport, and serving as a fluid matrix for

196 We imaged ciliary beat frequency, mucociliary transport, apical Cl(-) permeability, and ai

197 ted secretion in patients with CF may impair mucociliary transport, contributing to increased inciden

198 action and participates in autoregulation of mucociliary transport.

199 airway mucus, facilitate airway clearance by mucociliary transport.

200 he two mucins make distinct contributions to mucociliary transport.

201 geneous mucus gels and dramatically impaired mucociliary transport.

202 ethered mucus with untethered mucus restored mucociliary transport.

203 ibrosis (CF) altered mucus properties impair mucociliary transport.

204 reased (500.1 versus 28.3 mg; p = 0.01), and mucociliary transportability increased by 30% (0.76 vers

205 as assessed by microrheometry, and secretion mucociliary transportability was measured in vitro.

206 port velocity, viscoelasticity, or secretion mucociliary transportability with either anesthetic agen

207 unction were illustrated by decreased airway mucociliary velocity and impaired bacterial clearance.