ライフサイエンスコーパス: mucosal

1 acy of neutralizing antibodies in preventing mucosal acquisition of infection.

2 pathophysiological processes, including gut mucosal adaptation.

3 uman monoclonal antibody that binds to human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) to

4 Fecal microbiota showed covariation with mucosal adherent microbiota.

5 nza HA and GPI-anchored CCL28 as antigen and mucosal adjuvant, respectively, when immunized intranasa

6 This study demonstrates that mucosal administration of CTH522 adjuvanted with chitosa

7 on-obese diabetic (NOD) mouse model reported mucosal administration of T1D-related autoantigens [proi

8 healthy control samples (34 in plasma, 39 in mucosal ALS; 13 in both sample sets).

9 ich are found within the epithelial layer of mucosal and barrier tissues.

10 ved mast cells were used as "surrogates" for mucosal and connective tissue mast cells, respectively,

11 For mucosal and cutaneous melanoma, respectively, the incide

12 r of gut microbes may provide a link between mucosal and joint immunity in patients with RA.

13 ggests abnormal macrophage switching in both mucosal and luminal areas of COPD patients, that strongl

14 represent a broader category of NK cells in mucosal and non-mucosal pathological tissues.

15 ase in expression of CCL27, one of the major mucosal and skin cytokines, was found that correlated wi

16 complex interplay of the epithelial barrier, mucosal and systemic immune response, route of exposure,

17 n the development and function of the host's mucosal and systemic immune systems.

18 testinal apical membranes and segregation of mucosal and systemic immunity.

19 pitope specificities, locations (systemic or mucosal), and effector functions of antibodies elicited

20 th were assessed including periodontal, oral mucosal, and caries status in Eastern Finland from 2014

21 Anti-TcdA26-39 mucosal antibodies obtained following immunization with

22 respective of not significantly boosting the mucosal antibody response, it augmented the frequency of

23 -anchored CCL28 induces significantly higher mucosal antibody responses, involved in providing long-t

24 Analysis revealed that all animals exhibited mucosal antigen-specific IgG and IgA with the IgA respon

25 After mucosal application, nanofibrous reservoir layers are in

26 Mucosal-associated invariant T (MAIT) cells are a recent

27 Mucosal-associated invariant T (MAIT) cells are innate T

28 Mucosal-associated invariant T (MAIT) cells might play a

29 tially affected NK, NKT (invariant NKT), and mucosal-associated invariant T cell populations in a dos

30 ng to significantly increased frequencies of mucosal-associated invariant T cells 6 mo postinfection.

31 iboflavin- and folate-related metabolites to mucosal-associated invariant T cells, but it is unknown

32 ntranasal vaccines, which deliver antigen to mucosal-associated lymphoid tissue and aim to elicit pro

33 nflammation is associated with low levels of mucosal ATP, highlighting the importance of mitochondria

34 oles in immunoregulation but their effect on mucosal autoimmunity remains largely unknown.

35 y CD8(+) T cells could impair the intestinal mucosal barrier already in the seronegative phase of acu

36 ighlight research trends at this distinctive mucosal barrier and identify crucial gaps in our current

37 signaling events activated by a compromised mucosal barrier and provide a novel in vivo screening pl

38 nce between these signaling pathways and key mucosal barrier components in regulating colon tumorigen

39 The cytokine IL-22 plays a critical role in mucosal barrier defense, but the mechanisms that promote

40 Antagonizing IL-4 prevented mucosal barrier disruption and tight junction downregula

41 portant factors in the regulation of colonic mucosal barrier function and inflammation.

42 development, possibly indicating an impaired mucosal barrier function in allergic children.

43 Mucosal barrier function was measured by uptake of fluor

44 composition of the fecal microbiota, reduced mucosal barrier function, and altered epithelial prolife

45 stability is pivotal for the maintenance of mucosal barrier function.

46 Alterations in the integrity of the mucosal barrier have been indicated as a cause for chron

47 functions of IELs in the maintenance of the mucosal barrier integrity, as well as how dysregulated I

48 untered by Shigella upon its crossing of the mucosal barrier, are also mainly targeted by injection-o

49 re, we show that loss of PGANT4 disrupts the mucosal barrier, resulting in epithelial expression of t

50 helial cells (IECs) that form the intestinal mucosal barrier.

51 l transepithelial migration utilizing airway mucosal barriers differentiated from primary human airwa

52 nto the impact of DMPA and vaginal drying on mucosal barriers.

53 Ionization of mucosal biomass occurs directly from a standard rayon sw

54 nd postintervention stool samples and rectal mucosal biopsies were collected and used to quantify cal

55 healthy subjects); 232 fecal samples and 59 mucosal biopsy samples were collected and analyzed by 16

56 r an acute response (luminal obstruction and mucosal blanching); 2 other patients had a delayed wheal

57 ycle immunodeficiency virus, followed by two mucosal boosts with either recombinant adenovirus (rAd)

58 Thus, the mucosal bottleneck selects for viruses that are able to

59 d as yet unresolved, question is whether the mucosal bottleneck selects for viruses with increased tr

60 f subjects developing at least 1 small-bowel mucosal break at week 2.

61 To dissect the role of neutrophils during mucosal candidiasis, we took advantage of a new, transpa

62 All subjects with high airway mucosal CCL26 expression and moderate-to-severe asthma h

63 a minority (36%) of subjects with low airway mucosal CCL26 expression.

64 and 87% negative predictive value for airway mucosal CCL26-high status.

65 g HIV and had increased numbers of activated mucosal CD4(+) T cells compared to those with Lactobacil

66 gnal for MPECs and development of protective mucosal CD8 T cell memory.

67 In vivo, poly(I.C)-induced neutrophilia and mucosal chemokine production are blocked by a small-mole

68 ha-defective strains attained high levels of mucosal colonization but failed to induce robust vaginal

69 erienced severe disease, including increased mucosal colonization by C. rodentium, prolonged pathogen

70 anisms required for GBS to transition from a mucosal commensal lifestyle to bloodstream invasion, we

71 Candida albicans is a ubiquitous mucosal commensal that is normally prevented from causin

72 to be critical for their entry to these lung mucosal compartments.

73 ere constructed for the adjacent luminal and mucosal compartments.

74 the risk of Zika virus transmission through mucosal contact in rhesus macaques.

75 luding saliva, but transmission risk through mucosal contact is not well known.

76 roperties in parallel with analysis of local mucosal cytokine responses induced by nasal allergen exp

77 Our data indicate that the reduction in mucosal damage occurs through decline in stem/clonogenic

78 ing MCs were associated with the severity of mucosal damage, and their numbers were increased in pati

79 chemokine expression, neutrophil influx, and mucosal damage.

80 ids that are resistant to proteolytic/acidic mucosal delivery conditions.

81 duced increases in gut permeability, colonic mucosal destruction, and colonic IL-1beta expression.

82 paranasal sinuses was performed to look for mucosal disease of the paranasal sinuses, drainage pathw

83 An ex vivo human mucosal disease tissue model was used for artificial inf

84 r location within the abomasum, being either mucosal-dwelling (MD) or lumen-dwelling (LD).

85 1 in the ileum, those lacking Mdr1 displayed mucosal dysfunction and induced Crohn's disease-like ile

86 Skin and mucosal epithelia deploy antimicrobial peptides (AMPs) t

87 anisms underlying disease progression on all mucosal epithelia, including those in the mouth, lungs,

88 Transplantation of cultured oral mucosal epithelial cells (OMECs) is a promising treatmen

89 lammatory signaling pathways associated with mucosal epithelial damage.

90 co-culture system consisting of a polarized mucosal epithelium and human neutrophils can provide a v

91 barrier, including increased permeability of mucosal epithelium and reduced production of important a

92 -ILK-dependent inflammatory signaling in the mucosal epithelium can be therapeutically targeted by th

93 amily, was used to infect equine respiratory mucosal explants and primary equine respiratory epitheli

94 EHV1 binding to and infection of mucosal explants was greatly enhanced upon destruction o

95 ural infection occurs through oral and nasal mucosal exposure to infectious prions.

96 those with colon-only CD based on increased mucosal expression of genes that mediate type 2 and type

97 th Crohn's disease and leprosy and implicate mucosal factors and the innate immune response to microb

98 at the modified preserved nasal and lacrimal mucosal flap technique in EES-DCR for treating PANDO is

99 Modified preserved nasal and lacrimal mucosal flap technique in EES-DCR was applied in all 27

100 We conclude that esophageal mucosal food allergen injections induce acute and/or del

101 fficient technique facilitating ocular, oral mucosal, gastrointestinal, ungual and vaginal drug admin

102 The discovery that GLP-2 promotes mucosal growth in the intestine is described, and key fi

103 route with respect to efficacy were s.c. >/= mucosal > i.m.

104 re present in 16.3% of patients with IBD and mucosal healing (15.4% of patients with CD, 17.4% with U

105 The primary endpoint was mucosal healing (CDEIS <4) with absence of deep ulcers 4

106 of IECs in mice with colitis and accelerates mucosal healing by activating STAT1.

107 n this cutoff, 36.2% of patients with IBD in mucosal healing have increased intestinal permeability.

108 ures of inflammatory bowel disease, complete mucosal healing occurs in fewer than 50% of patients.

109 eability in patients with symptomatic IBD in mucosal healing vs patients with asymptomatic IBD in muc

110 Mucosal healing was defined as CD Endoscopic Index of Se

111 oing bowel symptoms in patients with IBD and mucosal healing with 95.2% sensitivity and 97.6% specifi

112 stinal permeability in patients with IBD and mucosal healing, we associated impaired intestinal perme

113 healing vs patients with asymptomatic IBD in mucosal healing.

114 t; at day 0, after reinstitution of gingival/mucosal health; at days 7, 14, and 21, during stent-medi

115 nital bacteria increase HIV risk by inducing mucosal HIV target cells.

116 ese gut bacteria, fungi, and viruses mediate mucosal homeostasis via their composite genes (metagenom

117 t maintain and restore gastrointestinal (GI) mucosal homeostasis.

118 TK (TAM) receptor family, in regulating oral mucosal homeostasis.

119 populations critical for the maintenance of mucosal homeostasis.

120 esolution of inflammation and contributes to mucosal host defense of the nasopharyngeal niche, a rese

121 rafish model a unique tool for understanding mucosal host-pathogen interactions.

122 romised ME bacterial clearance and prolonged mucosal hyperplasia.

123 Mucosal IgA or secretory IgA (SIgA) are structurally equ

124 o define type 2 inflammation based on airway mucosal IL-13-driven gene expression and how this relate

125 in regulating functional responses of human mucosal ILC3s to IL-23 plus IL-1beta stimulation.

126 The ocular surface is a unique mucosal immune compartment in which anatomical, physiolo

127 ry 'dipstick' tests to assess non-accessible mucosal immune development and identify early precursors

128 , possibly due to antigen digestion prior to mucosal immune exposure.

129 es, avidities, and functions of systemic and mucosal immune responses elicited by a vaccine regimen c

130 Importantly, prominent mucosal immune responses in CCR7-deficient mice increase

131 Increased antigen-specific mucosal immune responses were induced in the lungs and t

132 h the mucoadhesive polymer chitosan enhances mucosal immune responses.

133 ells; thus, they are crucial participants in mucosal immune surveillance.

134 malian gastrointestinal tract and associated mucosal immune system harbor a large repertoire of metab

135 ternal environment; however, the role of the mucosal immune system in chronic lung diseases is incomp

136 The host's mucosal immune system must tolerate commensals while fig

137 One of the mechanisms used by the mucosal immune system to maintain homeostasis is the sec

138 the GI tract by focusing on the ENS and the mucosal immune system.

139 testinal epithelial cells and the underlying mucosal immune system.

140 ation promotes competent innate and acquired mucosal immune systems, epithelial renewal, barrier inte

141 than inactivated vaccines by eliciting local mucosal immunity and systemic B cell- and T cell-mediate

142 Mucosal immunity is considered important for protection

143 Mucosal immunity remodeled with increased in anti-inflam

144 ent for IgA nephropathy targeting intestinal mucosal immunity upstream of disease manifestation.

145 nature of antipneumococcal antibody-mediated mucosal immunity while informing vaccine development.

146 Induction of mucosal immunity with vaccines is attractive for the imm

147 lls, rendering the metastases susceptible to mucosal immunity.

148 Thus, mucosal immunization with FWPV-based vaccines should be

149 malonate, phenylacetylglycine, alanine) and mucosal immunoglobulin (IgM) and cytokine (IL-10, IL-4)

150 ssed the impact of the genital microbiota on mucosal immunology in ACB women and microbiome-HSV-2 int

151 In the current study, we examined mucosal infection in several immunocompetent and immunoc

152 ty may display differential activity against mucosal infection.

153 ee strains of immunocompetent mice supported mucosal infections.

154 (grade 3 acne [n=1] and intolerable grade 2 mucosal inflammation [n=1]); hence, doses of 200 mg and

155 During Salmonella-induced gastroenteritis, mucosal inflammation creates a niche that favors the exp

156 r study of the role of RNASET2 in regulating mucosal inflammation may lead to development of novel th

157 intestinal microbiota affect development of mucosal inflammation or inflammatory bowel disease.

158 Allergic rhinitis (AR) is characterized by mucosal inflammation, driven by activated immune cells.

159 r a specific parasite protein that increases mucosal inflammation, expands our knowledge of host-para

160 environment in pathological processes, like mucosal inflammation, preneoplasia, and neoplasia, altho

161 th IBD vs controls; some were independent of mucosal inflammation.

162 stable before and during the development of mucosal inflammation.

163 n contribute to innate IEL activation during mucosal inflammation.

164 ropathy (and possibly other gastrointestinal mucosal inflammatory diseases).

165 tion allowed measurement of RSV load and the mucosal inflammatory response in infants.

166 The mucosal inflammatory response induced by Salmonella sero

167 -10 was rapidly induced following intestinal mucosal injury and was required for optimal intestinal m

168 histologic evidence of significant duodenal mucosal injury, latiglutenase did not improve histologic

169 Further, following mucosal injury, macrophage-derived IL-10 resulted in epi

170 In response to acute GI mucosal injury, TFF peptides accelerate cell migration t

171 e to have symptoms and have small intestinal mucosal injury.

172 superficial wounds in the colon and impaired mucosal innate immune responses against C. rodentium inf

173 activity arising from acid-sensitive general mucosal innervation by comparing acid-evoked c-Fos in wi

174 iceptors, suggesting that trigeminal general mucosal innervation carries information about acids in t

175 l and glossopharyngeal nerves, while general mucosal innervation is carried by the trigeminal and glo

176 We observe that EMT silences protective mucosal interferon (IFN)-I and III production associated

177 reproductive tract (FRT) is one of the major mucosal invasion sites for HIV-1.

178 erently in SI; Mf3 formed a dense network in mucosal lamina propria, whereas Mf4 was enriched in subm

179 The mucosal layer of conducting airways is the primary tissu

180 part of the host diet, lining the intestinal mucosal layer, and decorating the surface of other micro

181 aniasis (LCL), which heals spontaneously, or mucosal leishmaniasis (ML), characterized by chronic and

182 of teeth, dental plaque, or detectable oral mucosal lesions and PD risk, although there was a sugges

183 points were the change in the mean number of mucosal lesions and the number of subjects with large er

184 t role of C. difficile flagella in eliciting mucosal lesions as long as the toxins exert their action

185 estive association with Candida-related oral mucosal lesions in males (hazard ratio = 1.56, 95% CI: 0

186 Active EPIT significantly reduced gastric mucosal lesions induced by PPE oral intake (macroscopic

187 ramural nodules, continuous or discontinuous mucosal lining and cholelithiasis may indicate XGC rathe

188 The upper aerodigestive tract mucosal lining is often disrupted during surgery, which

189 inated field and the need to reconstruct the mucosal lining.

190 jority of cases (22/30) showed discontinuous mucosal lining.

191 ng a transparent juvenile zebrafish to model mucosal lung infection and show that C. albicans and P.

192 Purpose Mucosal melanoma is an aggressive malignancy with a poor

193 data for anti-programmed death-1 therapy in mucosal melanoma to date.

194 lone, and although the activity was lower in mucosal melanoma, the safety profile was similar between

195 NRAS and NF1 in acral melanoma and SF3B1 in mucosal melanoma.

196 ofiling, the mutational landscape of primary mucosal melanomas (PMM) remains unclear.

197 However, acral and mucosal melanomas were dominated by structural changes a

198 ucoadhesion between polymeric substances and mucosal membranes, widely exploited in the pharmaceutics

199 sponsible for the modification of the cancer mucosal metabonome.

200 In analyzing fecal and mucosal microbiota from patients with IBS and healthy in

201 The 10% CP dietary treatment damaged ileal mucosal morphology, and decreased the expression of biom

202 binant gluten-targeting proteases, to reduce mucosal morphometric measures in biopsy specimens from p

203 ic formation of lymphocyte aggregates within mucosal nonlymphoid tissues, including the FRT.

204 Mucosal or epicutaneous delivery of vaccines helps targe

205 Animals challenged with SHIVAD8-EO by mucosal or intravenous routes received a single 2-week c

206 both innate and adaptive immune responses in mucosal organs.

207 cted to be a valuable model for the study of mucosal papillomavirus disease, progression, and host im

208 Images from the vermillion and/or mucosal part of the lip were recorded from 10 patients w

209 r the diagnosis of MEL of the vermillion and mucosal part of the lip.

210 tory syncytial virus (RSV) is an exceptional mucosal pathogen.

211 ader category of NK cells in mucosal and non-mucosal pathological tissues.

212 n one major etiologic factor involved in the mucosal pathology.

213 IL-4, IFN-gamma, and TNF-alpha enhanced mucosal permeability in mice.

214 of IL-4, IL-13, IFN-gamma, and TNF-alpha on mucosal permeability was tested in vivo.

215 termine if the same macaques maintained high mucosal plasma cell frequencies postinfection and if thi

216 l and contrast the potential contribution of mucosal plasma cells to mediate protection at sites of i

217 bodies for preventing HIV-1 infection at the mucosal portals of infection.

218 Jejunum mucosal pressure increased 5-HT release and short-circui

219 hypothesis that smoking increases bronchial mucosal production of IL-17A which acts on bronchial epi

220 sis, but its exact role in the regulation of mucosal repair after injury remains unknown.

221 Bone marrow (BM) chimera mice revealed that mucosal repair depended on TNF production by BM-derived

222 ic submucosal dissection than for endoscopic mucosal resection (EMR).

223 Endoscopic mucosal resection of two polyps from the cardia and duod

224 Colonization of mucosal respiratory surfaces is a prerequisite for the h

225 LC-DG and its PB attenuate the inflammatory mucosal response in an ex-vivo organ culture model of PI

226 Lung mucosal responses in CB2-deficient (CB2(-/-) ) mice were

227 The respiratory mucosal route for delivery of VV vaccine in Hu-mice, but

228 is a risk of Zika virus transmission via the mucosal route, but that the risk posed by oral secretion

229 e exposed white-tailed deer to CWD prions by mucosal routes and performed serial necropsies to assess

230 LC2 numbers significantly increased in nasal mucosal samples and decreased in blood at the time of CO

231 We collected fecal and mucosal samples from adult patients who met the Rome III

232 type 17 immune response (IL17A and IL23) in mucosal samples from patients with UC compared with pati

233 In the present study, luminal and mucosal samples taken along the longitudinal axis of the

234 healthy subjects); 46 fecal samples, but no mucosal samples, were collected and analyzed.

235 Existing respiratory mucosal sampling methods are flawed, particularly in a p

236 tivation of Vgamma9/Vdelta2 T cells promoted mucosal secretion of IL-22 and ICOSL/TNF-alpha-dependent

237 rd currents, 5-HT release and an increase in mucosal secretion.

238 lla typhimurium that passed through from the mucosal side to the serosal side of the tissue.

239 y colonizing the upper airways, at the human mucosal site of the disease.

240 The surface of the eye is also a mucosal site, but proof of a living, resident ocular mic

241 ymphocytes and T cell subsets in lymphoid or mucosal sites did not vary with clinical state, and was

242 es but developed persistent infection at the mucosal sites including those of the anogenital region a

243 Mucosal sites such as the intestine, oral cavity, nasoph

244 whereas it arises in internal body surfaces (mucosal sites) and on the hands and feet (acral sites) i

245 id arthritis (RA), immunological triggers at mucosal sites, such as the gut microbiota, may promote a

246 to play an important role in host defense at mucosal sites, where it prevents invasion of pathogens b

247 owed active infections at both cutaneous and mucosal sites.

248 may be to promote immune cell persistence at mucosal sites.Our study identifies a new regulator of IF

249 chenoid esophagitis may cause ulceration and mucosal sloughing severe enough to result in massive upp

250 rity of lesions were found in the pharyngeal mucosal space (n=16) with squamous cell carcinoma being

251 Neutrophil breach of the mucosal surface is a common pathological consequence of

252 tionship between secretory IgA (SIgA) on the mucosal surface of small airways and parameters of infla

253 role in protective immunity to infection at mucosal surface, but also mediate pathology in certain a

254 ave long been implicated in virulence at the mucosal surface, including contributions to colonization

255 a protein vaccine formulation to the vaginal mucosal surface, we used a novel vaginal ring device com

256 nological and physiological processes at the mucosal surface.

257 iated system in the protection of intestinal mucosal surface.

258 defined by an increased ability to adhere to mucosal surfaces and a decreased ability to cause diseas

259 s way readily discriminate between different mucosal surfaces and display the ability to characterize

260 ical degradation in the harsh environment of mucosal surfaces and enzymes of host or microbial origin

261 lls migrate and proliferate to cover denuded mucosal surfaces and repair the barrier defect.

262 ns between inflammation and tissue repair at mucosal surfaces in early life remain unknown.

263 Commensal bacteria co-exist on the mucosal surfaces of all vertebrates.

264 h titers in bat flies but not in blood or on mucosal surfaces of host bats.

265 perates through an altered microbiome of the mucosal surfaces of the airways.

266 trillions of microorganisms inhabiting human mucosal surfaces participate intricately in local homeos

267 is important for homeostasis in organs with mucosal surfaces that interface with the external enviro

268 tal zoonosis acquired by contact of skin and mucosal surfaces with soil and water contaminated with i

269 mbers of the microbiomes found on nearly all mucosal surfaces, and interest is growing in understandi

270 establish tolerance, prevent inflammation at mucosal surfaces, and regulate immunopathology during in

271 ies to exert local immunosurveillance at the mucosal surfaces.

272 immune crosstalk in allergic inflammation at mucosal surfaces.

273 t of Tr1 cells in various organs, and in the mucosal system during parasitic and viral infections.

274 Our findings offer new insights into mucosal T cell biology and have important implications i

275 Detectible mucosal tenofovir was lower in non-Lactobacillus women,

276 Mechanisms that elicit mucosal TH17 cell responses have been described, yet how

277 ntibody blocking of HIV-1 acquisition within mucosal tissue may prove critical to effective vaccine d

278 d replication across a range of cellular and mucosal tissue models.

279 respective study drug was injected into the mucosal tissue surrounding the surgical site prior to su

280 In human mucosal tissue, inflammation increased the secretion of

281 t distribution, maturation, and migration in mucosal tissues (lungs, intestines), associated lymph no

282 with decreased expression in peripheral and mucosal tissues and DNA hypermethylation in CD patients

283 ld (M) cells are epithelial cells present in mucosal tissues and specialized for the capture of lumin

284 knockout not only decreased Cdc42 levels in mucosal tissues, but it also inhibited repair of damaged

285 immunoregulatory lectin widely expressed in mucosal tissues, contributes to Y. enterocolitica pathog

286 n-specific CD8(+) T cells that accumulate in mucosal tissues, including the female genital and respir

287 present in the inner mucus layer and invaded mucosal tissues.

288 nd HbetaD2 from colonic epithelial cells and mucosal tissues.

289 l types to encounter virus in the peripheral mucosal tissues.

290 poorly protective against HIV-1 infection of mucosal tissues.

291 h a reduced gut microbiota diversity and low mucosal total IgA levels in infancy have been associated

292 tralizing antibodies (nnAbs) may also impact mucosal transmission events through Fc-gamma receptor (F

293 aureus can induce, under some circumstances, mucosal type 2 immune responses.

294 sease Activity Index (CDAI) of 220-450, with mucosal ulcers in the ileum or colon, or both, and a Cro

295 These findings highlight the efficacy of mucosal vaccination via this attenuated strain and will

296 mising strategy to modulate the magnitude of mucosal vaccine responses.

297 , epithelial renewal, barrier integrity, and mucosal vascularisation and innervation.

298 tertiary lymphoid organs present within the mucosal wall, along with other lymphatic diseases, such

299 jury and was required for optimal intestinal mucosal wound closure.

300 tions in linking innate immune activation to mucosal wound repair.