ライフサイエンスコーパス: mucosal immunity

1 lls, rendering the metastases susceptible to mucosal immunity.

2 directly elicit or enhance pathogen-specific mucosal immunity.

3 d IL-22, a Th17-related cytokine critical in mucosal immunity.

4 ion, implicating IL-25 as a key component in mucosal immunity.

5 of NK-22 cells in promoting B-cell-mediated mucosal immunity.

6 ceptor (AHR) and diet-derived AHR ligands in mucosal immunity.

7 interleukin-22 (IL-22), supporting a role in mucosal immunity.

8 oxO4 in the regulation of NF-kappaB-mediated mucosal immunity.

9 intestinal lamina propria play a key role in mucosal immunity.

10 reas both IL-17A and IL-17F are required for mucosal immunity.

11 rties highly suggestive of its regulation of mucosal immunity.

12 lasma cells (PCs) is a critical component of mucosal immunity.

13 ents and the use of FcRs in the induction of mucosal immunity.

14 tissue (NALT) or GALT, is thought to promote mucosal immunity.

15 n antigen uptake and subsequent induction of mucosal immunity.

16 rovide Ag-specific humoral and cell-mediated mucosal immunity.

17 per cells involved in autoimmune disease and mucosal immunity.

18 affect Ag delivery and the effectiveness of mucosal immunity.

19 y immunization facilitates the generation of mucosal immunity.

20 ogens is the induction of potent and durable mucosal immunity.

21 uggest a putative effector function in human mucosal immunity.

22 lation reverses PN-induced depression of gut mucosal immunity.

23 tical for GALT control mechanisms and intact mucosal immunity.

24 l mucosa, suggesting reconstitution of human mucosal immunity.

25 an immunomodulatory role that may impact on mucosal immunity.

26 PV potency may lead to even higher levels of mucosal immunity.

27 heir GC responses may uniquely contribute to mucosal immunity.

28 tence of non-MAdCAM-1 mechanisms to preserve mucosal immunity.

29 antly impairs the generation of IgA-mediated mucosal immunity.

30 cells and thus might play a similar role in mucosal immunity.

31 ens requires an effective adjuvant to induce mucosal immunity.

32 ntramuscular, or intrarectal route to induce mucosal immunity.

33 play an important role in the development of mucosal immunity.

34 pathogens and they play an important role in mucosal immunity.

35 ucosal immunity and/or the actively acquired mucosal immunity.

36 tranasally for the induction of systemic and mucosal immunity.

37 instead of i.v. maintains NT anti-influenza mucosal immunity.

38 K cells may participate in the regulation of mucosal immunity.

39 al secretions and plays an important role in mucosal immunity.

40 asmids are packaged, could generate specific mucosal immunity.

41 qualitative differences between systemic and mucosal immunity.

42 icles in primates, with a focus on eliciting mucosal immunity.

43 levels, and impaired antiviral IgA-mediated mucosal immunity.

44 ng molecules that target neuronal tissues in mucosal immunity.

45 etermine their potential effects on adaptive mucosal immunity.

46 ons in both normal, as well as pathological, mucosal immunity.

47 expression of the pIgR, a central player in mucosal immunity.

48 ed explanation for reduction in diet-induced mucosal immunity.

49 bile and biliary epithelial cells (BECs) in mucosal immunity.

50 Immune-nonimmune cell interactions modulate mucosal immunity.

51 l population that plays a front-line role in mucosal immunity.

52 ransient ablation of the microbiota restores mucosal immunity.

53 involvement of the enteric nervous system in mucosal immunity.

54 oader context of tissue compartment-specific mucosal immunity.

55 omes in nonhematopoietic cells contribute to mucosal immunity.

56 ation suggests an important role for IRE1 in mucosal immunity.

57 thelial barrier plays a critical role in the mucosal immunity.

58 e sex work is associated with changes in the mucosal immunity.

59 Innate immune responses are critical for mucosal immunity.

60 e outside world and are at the front line of mucosal immunity.

61 known about the influence of asthma on host mucosal immunity.

62 or significantly enhanced human NoV-specific mucosal immunity.

63 studies of the role of specific cytokines in mucosal immunity.

64 We assessed the efficacy of IPV in boosting mucosal immunity.

65 OPV-vaccinated individuals boosts intestinal mucosal immunity.

66 tion of IgA and IgM, which are important for mucosal immunity.

67 ing the potentially distinct consequences in mucosal immunity.

68 2, IFN, and TNFalpha, cytokines important in mucosal immunity.

69 this previously uncharacterized mechanism of mucosal immunity.

70 healthy fish, suggesting a potential role in mucosal immunity.

71 elp resolve unsettled paradigms of mammalian mucosal immunity.

72 immunity, plays the prevailing role in skin mucosal immunity.

73 influence the innate and adaptive phases of mucosal immunity.

74 mediated transcription of genes required for mucosal immunity.

75 tes are now emerging as important players in mucosal immunity.

76 ling and inductive sites that help establish mucosal immunity.

77 inst commensals are an integral component of mucosal immunity.

78 d) vectors can stimulate adenovirus-specific mucosal immunity after replication, oral delivery of rep

79 n potentially capable of inducing protective mucosal immunity against C. trachomatis infection.

80 these Ikaros-mutant mice conferred enhanced mucosal immunity against Citrobacter rodentium infection

81 to mediating autoimmunity, have key roles in mucosal immunity against extracellular pathogens.

82 )17 cells, which are essential for effective mucosal immunity against fungi.

83 over the role of enteric alpha-defensins in mucosal immunity against HIV-1 infection.

84 ulin receptor (pIgR) plays a crucial role in mucosal immunity against microbial infection by transpor

85 T-cells play an important role in promoting mucosal immunity against pathogens, but the mechanistic

86 s include a lack of information in humans on mucosal immunity against pneumococci and a lack of suita

87 g chemokine gradients that are essential for mucosal immunity against pulmonary bacterial pathogens.

88 Ab responses, which could provide protective mucosal immunity against Streptococcus pneumoniae infect

89 Studies directed at vaccine development and mucosal immunity against Streptococcus pyogenes would be

90 moniae, we hypothesized that ethanol impairs mucosal immunity against this pathogen by disrupting IL-

91 be critical in the development of long-term mucosal immunity against V. cholerae O1.

92 ets, limited immune activation and preserved mucosal immunity, all of which contribute to the avoidan

93 ous immunization was able to induce specific mucosal immunity and a more balanced T helper type 1 and

94 ulation has transformed our understanding of mucosal immunity and allergy.

95 mples can provide information about rates of mucosal immunity and allow estimation of the poliovirus

96 oducing CD4(+) helper T cells (Th17) mediate mucosal immunity and are involved in the pathogenesis of

97 hape the intestinal environment by affecting mucosal immunity and bacterial colonization.

98 hway in innate immune cells orchestrates gut mucosal immunity and commensal homeostasis by regulating

99 o unrelated agents can alter the dynamics of mucosal immunity and disease course in response to a pat

100 s is not sufficient per se to induce loss of mucosal immunity and disease progression during a primat

101 enhanced CD4(+) Th2-type, cytokine-mediated mucosal immunity and increased lymphoid-type dendritic c

102 Parenteral nutrition (PN) impairs mucosal immunity and increases the risk of infection in

103 , we examine the role of FoxO4 in intestinal mucosal immunity and inflammatory bowel disease (IBD).

104 n intestinal immune homeostasis by promoting mucosal immunity and limiting chronic inflammation.

105 a variety of host immune functions, such as mucosal immunity and oral tolerance.

106 mechanism by which ambient pollutants alter mucosal immunity and promote disorders such as asthma.

107 se molecules are critical factors for innate mucosal immunity and provide barrier protection.

108 Lack of enteral stimulation with PN impairs mucosal immunity and reduces IgA levels through depressi

109 than inactivated vaccines by eliciting local mucosal immunity and systemic B cell- and T cell-mediate

110 investigated, and provocative insights into mucosal immunity and the enteric microbiota are now bein

111 nderstanding specialized aspects of acquired mucosal immunity and the importance of cross-talk betwee

112 hat has been implicated in the regulation of mucosal immunity and the pathogenesis of airway inflamma

113 substantial insight into the maintenance of mucosal immunity and the pathogenesis of inflammatory bo

114 he crucial regulatory role of fibroblasts in mucosal immunity and their potential as targets for ther

115 ew, we first sketch out our understanding of mucosal immunity and then compare the herpes simplex vir

116 needed tools to establish how CFTR regulates mucosal immunity and to test directly the effect of phar

117 semimature DCs that seem to locally regulate mucosal immunity and tolerance in a species lacking lymp

118 Development of mucosal immunity and tolerance requires coordinated expr

119 n regulating the homeostatic balance between mucosal immunity and tolerance, we have examined the exp

120 el to explain the paradoxical roles of B7 in mucosal immunity and tolerance.

121 may provide new opportunities for enhancing mucosal immunity and treating autoimmune disease.

122 ld provide novel opportunities for enhancing mucosal immunity and treating intestinal inflammation.

123 , and show an important association with CMV mucosal immunity and viral control.

124 at PRO 2000 has little deleterious effect on mucosal immunity and, if validated by clinical experienc

125 (IELs) are likely to play a key role in host mucosal immunity and, unlike other T cells, have been pr

126 ween SFB and the passively acquired maternal mucosal immunity and/or the actively acquired mucosal im

127 s that L-Sel is important for development of mucosal immunity, and absence of L-Sel is protective aga

128 stablish an intimate link between autophagy, mucosal immunity, and chronic inflammatory diseases.

129 thway in regulating intestinal inflammation, mucosal immunity, and commensal homeostasis.

130 phoid cells (ILCs) are critical mediators of mucosal immunity, and group 1 ILCs (ILC1 cells) and grou

131 an alternative pathway for the induction of mucosal immunity, and if the activity is evident in huma

132 cells involved in lymphoid tissue formation, mucosal immunity, and inflammation and (b) type 2 ILCs t

133 The role of cellular and humoral immunity, mucosal immunity, and other local factors in determining

134 mediated regulation of T cell activation and mucosal immunity, and that the loss of these functions i

135 lation pathway, anti-glycan immune response, mucosal immunity, antigen processing and presentation, a

136 timum strategies to elicit both systemic and mucosal immunity are critical for the development of vac

137 lymphocytes, IL-22 plays a critical role in mucosal immunity as well as in dysregulated inflammation

138 cantly to circulating natural antibodies and mucosal immunity as well as to immunoregulation.

139 DC play a critical role in the regulation of mucosal immunity, as well as the development of central

140 cytokines and the role they may play in gut mucosal immunity, as well as the emergence of new concep

141 ling pathway during oral infection, in which mucosal immunity assumes a predominant role, has not bee

142 piratory tract, an RSV vaccine should elicit mucosal immunity at upper and lower respiratory tracts i

143 hanisms by which Vitamin D and VDR influence mucosal immunity, bacterial infection, and inflammation.

144 amuscularly, it would be desirable to induce mucosal immunity by delivery through alternative routes.

145 Thus, GALT-DC shape mucosal immunity by modulating B cell migration and effe

146 ions, and plays a significant role in normal mucosal immunity by modulating T cell activation and reg

147 en shown to be essential to induce effective mucosal immunity by non-replicating vaccines.

148 -4 response is required for the induction of mucosal immunity by oral QS-21 as adjuvant.

149 role for this cytokine in the initiation of mucosal immunity by oral QS-21.

150 Previous stimulation of mucosal immunity by SFB did not prevent the translocatio

151 PN impairs innate mucosal immunity by suppressing luminal sPLA2 activity a

152 otential "Trojan horse" approach to modulate mucosal immunity by systemically immunizing with sFliC.

153 Impaired airway mucosal immunity can contribute to increased respiratory

154 The induced mucosal immunity can neutralize the pathogen on the muco

155 k of enteral stimulation creates a defect in mucosal immunity characterized by loss of IgA-mediated d

156 ificantly augmented VLP-induced systemic and mucosal immunity compared to the responses induced by lo

157 TPN causes depression of mucosal immunity compared with enterally fed animals, wh

158 Mucosal immunity depends on regulatory signals; nutritio

159 rtant since it illustrates the importance of mucosal immunity for complete protection against CDI.

160 ive responses systemically, the induction of mucosal immunity generally requires local Ag exposure.

161 also resisted DIO, demonstrating that intact mucosal immunity guides diet-induced changes to the micr

162 djuvant for stimulating protective antiviral mucosal immunity has been examined.

163 changed that concept as our understanding of mucosal immunity has evolved and as we have come to unde

164 The role of RANTES in adaptive mucosal immunity has not been studied.

165 immunization, the induction of regional and mucosal immunity has often been more challenging.

166 Dendritic cells (DCs) that orchestrate mucosal immunity have been studied in mice.

167 ambda (IFN-lambda) is a central regulator of mucosal immunity; however, its signaling specificity rel

168 In addition to enhancing mucosal immunity, IgD class-switched B cells enter the c

169 nal APCs in the induction and maintenance of mucosal immunity implicates SIRPalpha(+) antigen-present

170 (5) Is mucosal immunity important for an effective AIDS vaccine

171 nd flagellin on stimulation of antibacterial mucosal immunity in a lethal murine Pseudomonas aerugino

172 ted antimicrobial peptide (CRAMP), to innate mucosal immunity in a mouse model of Gram-negative pneum

173 To better delineate the role of mucosal immunity in colorectal cancer, we evaluated the

174 y assays can serve as markers of humoral and mucosal immunity in future trials of BCG and newer atten

175 The role of mucosal immunity in human papillomavirus (HPV)-related c

176 infection of the gastrointestinal tract and mucosal immunity in humans.

177 amined the degree and duration of intestinal mucosal immunity in India by measuring the prevalence of

178 These data highlight the importance of mucosal immunity in mediating optimal protection against

179 that the vaccine induced robust systemic and mucosal immunity in mice.

180 icantly enhances antipoliovirus systemic and mucosal immunity in mice.

181 has been shown to mediate nasotracheal (NT) mucosal immunity in normal immune BALB/c mice.

182 d transmission, suggesting the importance of mucosal immunity in preventing influenza virus transmiss

183 he current information regarding the role of mucosal immunity in prevention of HIV transmission and d

184 There is a role for the measurement of mucosal immunity in response to candidate vaccines and,

185 Nevertheless, induction of mucosal immunity in such a manner would be an attractive

186 pment, and recent evidence implies a role in mucosal immunity in the adult.

187 Uncontrolled mucosal immunity in the gastrointestinal tract of humans

188 nal inflammation, commensal homeostasis, and mucosal immunity in the gut are unclear.

189 Mucosal immunity in the lung and intestine is controlled

190 s an important contributor to effective host mucosal immunity in the lung in response to Gram-negativ

191 al immune responses, but how this applies to mucosal immunity in the lung is not clear.

192 To address the problem of eliciting mucosal immunity in the lung, we utilized macroaggregate

193 ell responses may be prevalent in modulating mucosal immunity in the lungs, Th1 cell responses contri

194 with Escherichia coli; however, its role in mucosal immunity in the respiratory tract is unknown.

195 points: first, there appears to be localized mucosal immunity in the secretory system of PBC; second,

196 To investigate how MAIT cells contribute to mucosal immunity in vivo, we used a murine model of pulm

197 s a host advantage by providing heterologous mucosal immunity independent of serotype-specific antibo

198 There have been no studies related to the mucosal immunity induced against this orally acquired pa

199 ntally, complex diets prevent impairments in mucosal immunity induced by IV TPN.

200 The mucosal immunity induced by OPV in India varies by locat

201 Studies of mucosal immunity induced by oral poliovirus (OPV) or ina

202 fecal-oral transmission relies on intestinal mucosal immunity induced by oral poliovirus vaccine (OPV

203 Mucosal immunity induced by oral poliovirus vaccine (OPV

204 ia, has raised questions about the degree of mucosal immunity induced by oral poliovirus vaccine (OPV

205 tor (SLPI), an anti-inflammatory mediator of mucosal immunity, inhibits human immunodeficiency virus

206 inpoint HVEM as an important orchestrator of mucosal immunity, integrating signals from innate lympho

207 hese genes included genes involved in innate mucosal immunity, intracellular signaling, and cellular

208 ciated with intestinal barrier functions and mucosal immunity involved in microbiome homeostasis.

209 ost deadly in the pneumonic form; therefore, mucosal immunity is an important first line of defense a

210 A critical step in the induction of adaptive mucosal immunity is antigen transcytosis, in which lumin

211 This defect in mucosal immunity is associated with eosinophilic, Th2-re

212 Mucosal immunity is considered important for protection

213 The induction of mucosal immunity is crucial in controlling viral replica

214 against paralytic disease, but its effect on mucosal immunity is debated.

215 cosal surfaces is the natural route by which mucosal immunity is generated, as peripheral antigen del

216 However, the role of HIF signaling in colon mucosal immunity is not known.

217 Loss of upper respiratory tract mucosal immunity is not related to serum Ab, because 10

218 Mucosal immunity is poorly activated after systemic immu

219 l proposes that the fundamental mechanism of mucosal immunity is subdiffusion resulting from adherenc

220 A key to effective mucosal immunity is the capacity for antigens administer

221 Mucosal immunity is thought to wane over time but the ra

222 ssociated lymphocytes, but their function in mucosal immunity is unclear.

223 n epithelial cells and important in skin and mucosal immunity, is pseudogenized in all African and As

224 y tract, is important for the development of mucosal immunity locally and distally to intranasally in

225 al adjuvants that induce both parenteral and mucosal immunity may be a better way to assess oral tole

226 Previous work had suggested that mucosal immunity may be affected by the stage of the est

227 Therefore, mucosal immunity may be critical to control both initial

228 , IgA antibody, which plays pivotal roles in mucosal immunity, might efficiently prevent HIV infectio

229 amebiasis subunit vaccine designed to elicit mucosal immunity mimicking that of humans cured of ALA.

230 es an important tool for detailed studies of mucosal immunity necessary for the development of mucosa

231 Initiation of adaptive mucosal immunity occurs in organized mucosal lymphoid ti

232 geal-associated lymphoreticular tissue-based mucosal immunity offers an attractive possibility to pro

233 lt3 ligand (FL) for its potential to enhance mucosal immunity or tolerance.

234 A myriad of interacting mechanisms of mucosal immunity permit the gut to corral the microbiota

235 Thus, underlying CMV infection can alter mucosal immunity, potentially increasing the tendency of

236 eminal contributions include regional innate mucosal immunity, prevention of SIV infection in macaque

237 reinstating mucosal architecture, improving mucosal immunity, promoting beneficial bacteria, and dow

238 ling, p53 may act as a negative regulator of mucosal immunity, promoting immunological tolerance by p

239 The function of this novel IgA receptor in mucosal immunity remains to be elucidated.

240 G crosses epithelial barriers to function in mucosal immunity remains unknown.

241 Mucosal immunity remodeled with increased in anti-inflam

242 ring the acute phase of infection, antiviral mucosal immunity restricts viral replication in the prim

243 Preceding mucosal infection induces mucosal immunity, resulting in at least 50-fold reductio

244 ry immunological defect or from dysregulated mucosal immunity secondary to intrinsic, nonhematopoieti

245 accines that induce high levels of effective mucosal immunity should impact viral replication rate an

246 elial transition, glycoprotein biosynthesis, mucosal immunity, signaling, and endocytic and neural re

247 to support intestinal homeostasis and shape mucosal immunity, similarly to commensal bacteria.

248 Humoral and mucosal immunity, soluble inhibitory factors, the cytoki

249 Genetic and mucosal immunity strongly influence the composition and

250 V) is believed to induce significantly lower mucosal immunity than oral poliovirus vaccine (OPV).

251 seasonal in India and results in intestinal mucosal immunity that appears to wane significantly with

252 HIV-1; this approach could elicit persistent mucosal immunity that may prevent HIV-1/SIV(mac251) infe

253 ic Ig receptor (pIgR) is a central player in mucosal immunity that mediates the delivery of polymeric

254 temic immunity it has potential to stimulate mucosal immunity through antigen-processing by the gut-a

255 e have shown that each is critical to intact mucosal immunity through effects on lymphocyte homing, I

256 Therefore, enhancing mucosal immunity through vaccines-strengthening that fir

257 In the field of oral mucosal immunity, through the study of patients with sel

258 n, although attractive, is poor for inducing mucosal immunity, thus limiting its protective value aga

259 Finally, evidence was found of acquired mucosal immunity to amebiasis in Bangladeshi children, o

260 d CD161(hi)CD8alpha(+) T cells contribute to mucosal immunity to bacteria and yeast.

261 Administration of IFN-gamma activated the mucosal immunity to C. rodentium infection by increasing

262 cal or stress response pathways intersect in mucosal immunity to dictate the response to pathogenic a

263 cine, will most likely not induce the needed mucosal immunity to efficiently protect the initial site

264 Th17 cells have been implicated in mucosal immunity to extracellular bacteria, and preserva

265 Mucosal immunity to gastrointestinal pathogens in early

266 haride (LPS) are the primary determinants of mucosal immunity to gram-negative enteric pathogens.

267 ave investigated the induction of protective mucosal immunity to human immunodeficiency virus type 1

268 gest that chIL-17RA has an important role in mucosal immunity to intestinal intracellular parasite in

269 memory in NALT that offers cross-protective mucosal immunity to not only H1N1 but also aH5N1 viruses

270 Mucosal immunity to reinfection with a highly virulent v

271 While mucosal immunity to ricin correlates with secretory immu

272 A are sufficient to confer both systemic and mucosal immunity to ricin.

273 ically feasible will facilitate the study of mucosal immunity to RSV as well as the study of mucosal

274 ction of the upper respiratory tract or host mucosal immunity to RSV, recent literature suggests that

275 Induction of mucosal immunity to target this local, contained replica

276 isease (IBD) has been attributed to aberrant mucosal immunity to the intestinal microbiota.

277 their potential function and contribution to mucosal immunity, tolerance, and disease.

278 ent for IgA nephropathy targeting intestinal mucosal immunity upstream of disease manifestation.

279 that the salivary gland participates in oral mucosal immunity via generation of ectopic GCs, which fu

280 the mechanisms responsible for induction of mucosal immunity vs tolerance are not yet fully delineat

281 Mucosal immunity was demonstrated by high levels of IgA

282 Our previous studies showed that mucosal immunity was impaired in 1-year-old mice that ha

283 The alpha-defensin-mediated innate mucosal immunity was maintained in PC throughout the cou

284 Mucosal immunity was measured by in-vitro neutralisation

285 ion of antigen-specific humoral and cellular mucosal immunity was not accompanied by a detectable inc

286 understand the effect of viral chemokines on mucosal immunity, we compared the affects of vMIP-II, I-

287 rther understanding of HIV-1-specific T-cell mucosal immunity, we established HIV-1-specific CD8(+) c

288 neutrophil activation and IgA antibodies in mucosal immunity, we hypothesized that FcR genetics and

289 more fully understand the induction of nasal mucosal immunity, we investigated the addressins that al

290 ular mechanisms by which FoxO4 regulates the mucosal immunity were explored through immunologic and b

291 NA and HIV DNA copy numbers, and recovery of mucosal immunity were measured before and 9 months after

292 nutrition (PN) decreases GALT cell mass and mucosal immunity when compared with enteral feeding.

293 gans, including classical inductive sites of mucosal immunity, where they effectively stimulated B an

294 press IL-22, a T(H)17 cytokine important for mucosal immunity, whereas earlier and later stages of NK

295 Therefore, enhancing pulmonary mucosal immunity (which includes a combination of innate

296 Thus, 3SL directly modulates mucosal immunity, which increases susceptibility to coli

297 nature of antipneumococcal antibody-mediated mucosal immunity while informing vaccine development.

298 ts may augment luminal surveillance to boost mucosal immunity, while others may promote microbial acc

299 e data are consistent with severely impaired mucosal immunity with IV TPN and partial impairment with

300 Induction of mucosal immunity with vaccines is attractive for the imm