ライフサイエンスコーパス: mucosal tissue

1 moval force of ~4.5 N cm(-2) from intestinal mucosal tissue.

2 ion assay, did not fully predict activity in mucosal tissue.

3 cells (DCs) that reside within epidermal and mucosal tissue.

4 rap the bacteria both inside and outside the mucosal tissue.

5 endothelial- epithelial crosstalk pathway in mucosal tissue.

6 mune cell behavior within the complex airway mucosal tissue.

7 nd HbetaD2 from colonic epithelial cells and mucosal tissues.

8 eric virus in primary human target cells and mucosal tissues.

9 e primarily CD8(+) and numerous in blood and mucosal tissues.

10 S727P each contribute to SIV's targeting to mucosal tissues.

11 sues, including lung, lymph nodes, and other mucosal tissues.

12 to innate immunity, including protection of mucosal tissues.

13 d targeted drug and nucleic acid delivery to mucosal tissues.

14 cules and that preferentially resides within mucosal tissues.

15 t and/or detection of pathogenic bacteria in mucosal tissues.

16 al system for effector and memory T cells in mucosal tissues.

17 her viral infections that enter the body via mucosal tissues.

18 roteins, lipids, and genomic DNA in skin and mucosal tissues.

19 RNA expression predominantly in lymphoid and mucosal tissues.

20 (+) T cells in lymphoid and gastrointestinal mucosal tissues.

21 the systemic circulation and trafficking to mucosal tissues.

22 tion of X4-tropic strain transmission across mucosal tissues.

23 te to the hydrophilic character of mucins in mucosal tissues.

24 tion of memory CD4 T cells in peripheral and mucosal tissues.

25 heir potential to block ex vivo challenge of mucosal tissues.

26 itment of IgA ASC varies dramatically within mucosal tissues.

27 ss and deliver heterologous antigens to host mucosal tissues.

28 ication and repair and regenerate intestinal mucosal tissues.

29 ion by DCs indirectly controls MCp homing to mucosal tissues.

30 l types to encounter virus in the peripheral mucosal tissues.

31 cells isolated from blood, lymph nodes, and mucosal tissues.

32 y CD8 T cell quality and surveillance within mucosal tissues.

33 enotypes and functions of dendritic cells in mucosal tissues.

34 ubsets, activated B lymphocytes, and various mucosal tissues.

35 le in host-pathogen interactions in skin and mucosal tissues.

36 ld-type mice due to defective transport into mucosal tissues.

37 c cells (DCs) significantly increased in the mucosal tissues.

38 of inducing both T cell and Ab responses in mucosal tissues.

39 requency SIV-specific CTL responses in these mucosal tissues.

40 e, and IL-5 production was skewed toward the mucosal tissues.

41 ignaling pathways in inflammation focused on mucosal tissues.

42 ry attachment of the bacterial cell to human mucosal tissues.

43 ions appear to characterize most diseases of mucosal tissues.

44 es that are expressed at different levels in mucosal tissues.

45 cell type 2 (Th2) responses in systemic and mucosal tissues.

46 cular mechanism regulating K13 expression in mucosal tissues.

47 pathophysiology of allergic inflammation in mucosal tissues.

48 of tissue resident memory CD8 T cells within mucosal tissues.

49 al attachment of the bacterial cell to human mucosal tissues.

50 a is expressed predominantly in inflamed and mucosal tissues.

51 osis of immunogens, as demonstrated in other mucosal tissues.

52 ne blistering disease that primarily affects mucosal tissues.

53 tance to systemic, cutaneous, and nongastric mucosal tissues.

54 poorly protective against HIV-1 infection of mucosal tissues.

55 present in the inner mucus layer and invaded mucosal tissues.

56 are active within hours after infections in mucosal tissues.

57 ns very differently in the context of intact mucosal tissues.

58 bicans is a well-tolerated resident of human mucosal tissues.

59 tissue structure and function, especially in mucosal tissues.

60 r functions at peripheral sites, such as gut mucosal tissues.

61 macrophage chemoattractant that operates in mucosal tissues.

62 s during viral transmission, particularly in mucosal tissues.

63 LDL receptor-related protein 6 (LRP6) in the mucosal tissues.

64 om 50 samples of normal pancreas or duodenal mucosal tissues, 7 samples of chronic pancreatitis, and

65 Cancers arising in mucosal tissues account for a disproportionately large f

66 ough the penile, rectal, or vaginal/cervical mucosal tissue after sexual exposure.

67 rease in the total magnitude of TRM in mouse mucosal tissues after boosting, suggesting that the memo

68 n-specific responses were mainly confined to mucosal tissues, again regardless of the route of immuni

69 Changes in host mucosal tissue and commensals posttransplant have been a

70 oding interleukin-10 safely penetrated local mucosal tissue and had therapeutic benefit in this DSS m

71 e expansion of B-lineage cells in the airway mucosal tissue and lead to the formation of inducible ly

72 tains the swift lymphocyte-based invasion of mucosal tissue and lymphatic organs, whereas C sustains

73 ivation, TNF production, and NO synthesis in mucosal tissue and macrophages, as well as systemic dysr

74 es to a given viral pathogen within the same mucosal tissue and reveal a specialized role for monocyt

75 oduced in response to microbial infection of mucosal tissue and skin.

76 ta7 by a vaccine approach that replicates in mucosal tissue and suggest that induction of virus-speci

77 D4(+) T cells producing IL-2 predominated in mucosal tissues and accumulated as central memory subset

78 microbes and other environmental insults at mucosal tissues and are thus thought to play a local imm

79 with decreased expression in peripheral and mucosal tissues and DNA hypermethylation in CD patients

80 lls in mammals that reside preferentially in mucosal tissues and express an invariant Valpha paired w

81 ate and antigen-specific memory responses in mucosal tissues and in the blood.

82 causes a localized acute viral infection in mucosal tissues and induces a recall response, since mos

83 ion molecules that are associated with other mucosal tissues and inflammatory sites, which suggests t

84 ely expressed by epithelial cells in diverse mucosal tissues and is known to attract a variety of imm

85 ly in blood and BM and at variable levels in mucosal tissues and LNs.

86 pregulated on T cells in both peripheral and mucosal tissues and maintained at high levels on SIV-spe

87 subset of T cells associated with epithelial mucosal tissues and play a prominent role in both promot

88 a by conferring protection against injury to mucosal tissues and positively calibrating the responsiv

89 s by first promoting their accumulation into mucosal tissues and second by sustaining expression of B

90 th effector and memory T cells in intestinal mucosal tissues and showed higher frequencies of systemi

91 ld (M) cells are epithelial cells present in mucosal tissues and specialized for the capture of lumin

92 The drug concentration in the receptive mucosal tissues and target immune cells for HIV is criti

93 dies are synthesized in preference to IgG in mucosal tissues and why the IgE is so tenaciously retain

94 e very abundant in humans, tend to reside in mucosal tissues and, therefore, were named mucosal-assoc

95 d on tumour when compared to adjacent normal mucosal tissue, and fusobacteria and beta-Proteobacteria

96 colon cancers compared with those in normal mucosal tissue, and low levels of RIP140 expression in a

97 nd potently respond to pathogen infection in mucosal tissues, and are prominently induced by both tub

98 t play important roles in innate immunity in mucosal tissues, and in the maintenance of tissue and me

99 elite control, robust cellular responses in mucosal tissues, and no disease.

100 Dissociated cells taken from adult rat nasal mucosal tissues (ANM cells) were plated onto a feeder la

101 pe is widespread, as goblet cells of several mucosal tissues appear engorged and Clara cells accumula

102 Mucosal tissues are major sites of HIV entry and initial

103 ctivated CD4 T cells present in lymphoid and mucosal tissues are major targets for infection.

104 Mucosal tissues are subject to frequent pathogen exposur

105 Mucosal tissues are the primary route of transmission fo

106 Mucosal tissues are the primary site of natural HIV tran

107 summarize recent reports incriminating these mucosal tissues as the initial site of autoantibody gene

108 e and esophageal submucosa compared with gut mucosal tissues, as well as detectable TGF-beta1 in norm

109 a critical role in the development of other mucosal tissue-associated innate lymphocytes.

110 placebo, histological examination of gastric mucosal tissue biopsies provided good sensitivity and sp

111 not only able to inhibit direct infection of mucosal tissue but was able to prevent dissemination of

112 subsets of CD4+ T cells that are abundant in mucosal tissues but rare in peripheral lymphoid tissues.

113 lumen of the genital tract than in cervical mucosal tissue, but lumen TLR mRNA levels did not change

114 knockout not only decreased Cdc42 levels in mucosal tissues, but it also inhibited repair of damaged

115 Lymphocytes were also assessed in GI mucosal tissues by in situ staining in histologic specim

116 al tract, which enables invasion of delicate mucosal tissues by pathogenic organisms.

117 is a mechanism by which C. albicans invades mucosal tissues by promoting the proteolytic degradation

118 ose (10 mg) infused intraduodenally prior to mucosal tissue collection.

119 g antigen-specific CD8(+) T lymphocytes in a mucosal tissue compartment.

120 ynamic (PD) model was developed by measuring mucosal tissue concentrations of tenofovir, emtricitabin

121 Our in vitro 3D oral mucosal tissue construction studies further demonstrated

122 immunoregulatory lectin widely expressed in mucosal tissues, contributes to Y. enterocolitica pathog

123 nique T-cell receptor (TCR)-bearing cells in mucosal tissues could influence the selection and expans

124 C. difficile infection, as are parameters of mucosal tissue damage and inflammation.

125 Previous studies have implicated hypoxia in mucosal tissue damage resulting from both acute and chro

126 ranscriptase-PCR products obtained from oral mucosal tissues, disclosing three mucosal alpha-defensin

127 Microbial colonization of mucosal tissues during infancy plays an instrumental rol

128 has been shown to be secreted in intestinal mucosal tissues during inflammation, its potential role

129 tected at high frequency in second-trimester mucosal tissues (e.g., the intestine and lung).

130 lative inhibition of parasite replication in mucosal tissues early after oral T. cruzi challenge, usi

131 it is generally accepted that epithelial and mucosal tissue egress is regulated by expression of the

132 hoalveolar lavage, respectively), as well as mucosal tissue (endobronchial biopsies).

133 In intact mucosal tissues, epithelial cells are anatomically posit

134 In mucosal tissues, epithelial M cells capture and transpor

135 ial structure, e.g. soils, sediments, animal mucosal tissue, etc.

136 Few T cells in any mucosal tissue examined express CCR10.

137 lamina propria mononuclear cells (LPMCs) and mucosal tissue explants were incubated with otelixizumab

138 sis assays, and cell-associated infection of mucosal tissue explants.

139 >/=98% of the population achieved protective mucosal tissue exposure by the third daily dose of tenof

140 n diverse gastrointestinal and nonintestinal mucosal tissues express the chemokine MEC/CCL28.

141 he vast majority of IgA production occurs in mucosal tissue following T cell-dependent and T cell-ind

142 delta2)T cells proliferate and accumulate in mucosal tissues following microbial activation.

143 uniform and longer-lasting drug delivery to mucosal tissues following topical administration.

144 ne gun-mediated delivery of foreign DNA to a mucosal tissue for the induction of an immune response.

145 eration sequencing of normal-looking colonic mucosal tissue from mice treated with the carcinogen azo

146 onstitutive expression of trout IL-17A/F2 in mucosal tissues from healthy fish, suggesting a potentia

147 Similarly, colonic mucosal tissues from mice exposed to dextran sulfate sod

148 of investigation have separately implicated mucosal tissues from varying anatomic locations as possi

149 cosal epithelia from the hDsg3 mice, but not mucosal tissues from WT mice, as detected by indirect im

150 ssion of human MAdCAM-1 RNA is restricted to mucosal tissues, gut-associated lymphoid tissues and spl

151 of the HIV-specific CD8+ T-cell responses in mucosal tissues has been described, few studies have inv

152 HIV-1 infected individuals, its role in the mucosal tissues has not been investigated.

153 ntibody blocking of HIV-1 acquisition within mucosal tissue have not been defined.

154 ular sites implicated in disease initiation, mucosal tissues have garnered increasing attention.

155 findings thus suggest that DC subsets within mucosal tissues have unique immune inductive capacities.

156 ations were increased in nasal secretion and mucosal tissue homogenates in patients with chronic rhin

157 eukocytes in the human body are localized in mucosal tissues; however, the roles of eosinophils in hu

158 istration of MPA prior to viral infection of mucosal tissue impairs DC activation, virus-specific T c

159 ip with human hosts, probably by adhering to mucosal tissue in a variety of physiological conditions.

160 Nitric oxide synthesis by mucosal tissue in Collins-flushed segments subjected to

161 epithelial cell monolayers and human colonic mucosal tissue in vitro In contrast, ursodeoxycholic aci

162 FcRn thus has a primary role within mucosal tissues in activating local immune responses tha

163 e the role of human mast cells isolated from mucosal tissues in mediating HIV-1 trans-infection of CD

164 Rarely, LS has been observed to affect mucosal tissues in the mouth and the penile urethra.

165 sors had limited innate immune activation in mucosal tissues in the periphery, which was associated w

166 GPR35 is expressed in mucosal tissues, in CXCL17-responsive monocytes, and in

167 years in both peripheral blood and multiple mucosal tissues, including colorectal, duodenal, and vag

168 mRNA is constitutively expressed in numerous mucosal tissues, including human gingiva and submandibul

169 CD8 T cell responses both in systemic and in mucosal tissues, including intraepithelial and lamina pr

170 n-specific CD8(+) T cells that accumulate in mucosal tissues, including the female genital and respir

171 ls may provide a novel mechanism to regulate mucosal tissue inflammation.

172 In human mucosal tissue, inflammation increased the secretion of

173 accumulation, prostaglandin E(2) production, mucosal tissue injury, and markers of oxidative stress w

174 an initial hypoperfusion-related intestinal mucosal tissue injury.

175 ibute to anti-helminth immunity, maintaining mucosal tissue integrity, and adipose tissue browning.

176 tent humoral and cellular immune response in mucosal tissue is important for the development of an ef

177 The ability of Candida albicans to invade mucosal tissues is a major virulence determinant of this

178 of circulating CD8(+)gammadelta T cells for mucosal tissues is due, at least in part, to selective d

179 zed CD4+ T cell depletion from the blood and mucosal tissues is not sufficient to induce AIDS in this

180 infections even though their migration into mucosal tissues is tightly regulated.

181 ly, characterized by hyphal invasion of oral mucosal tissue, is the most common opportunistic infecti

182 , which is expressed by epithelia in diverse mucosal tissues, is selectively chemotactic for IgA Ab-s

183 In genital-mucosal tissues, it initiates colonization of epithelial

184 in Th17 cell lineage priming in the skin and mucosal tissues, it was not required for Th17 cell primi

185 However, despite their abundance in mucosal tissue, little information is available about th

186 with enhanced FcRn binding has increased gut mucosal tissue localization, which improves protection a

187 t distribution, maturation, and migration in mucosal tissues (lungs, intestines), associated lymph no

188 ntibody blocking of HIV-1 acquisition within mucosal tissue may prove critical to effective vaccine d

189 ular immune responses in both peripheral and mucosal tissues may be important for the development of

190 d replication across a range of cellular and mucosal tissue models.

191 Mucosal tissue myeloperoxidase (MPO) activity, a biochem

192 six decades of life in blood, lymphoid, and mucosal tissues obtained from 56 individual organ donors

193 In addition, normal mucosal tissues obtained from four normal individuals we

194 ue analysis of human T cells in lymphoid and mucosal tissues obtained from individual organ donors, r

195 icant T-cell lymphopenia was observed in the mucosal tissue of patients with ICL by flow cytometry an

196 can be reproducibly sampled from intestinal mucosal tissue of rhesus monkeys obtained under endoscop

197 e used flow cytometric analysis of sinonasal mucosal tissues of 29 CRS patients and 5 controls to qua

198 oimmune vesiculobullous disease that affects mucosal tissues of adults and rarely presents in childre

199 y the dendritic cells (DC) isolated from the mucosal tissues of aging animals.

200 en-specific CD8(+) T cells were found in the mucosal tissues of all immunized macaques regardless of

201 elling evidence that the microenvironment of mucosal tissues of allergic disease favors class switchi

202 These cells accumulate in mucosal tissues of allergic reactions, where immunoglobu

203 These GI mucosal tissues of chronically SIVmac-infected rhesus mo

204 Compared with mucosal tissues of controls, mucosa from patients with I

205 in human gastric cancer tissues and gastric mucosal tissues of H. pylori infected C57BL/6 mice.

206 antiviral factors would be most abundant in mucosal tissues of HIV controllers.

207 that (i) Gag-specific responses dominate in mucosal tissues of HIV controllers; (ii) there is extens

208 peptides are found in both myeloid cells and mucosal tissues of many vertebrates and invertebrates.

209 Mucosal tissues of mice are enriched in T cells that exp

210 tion with Streptococcus pneumoniae the nasal mucosal tissues of mice support two populations of pneum

211 s of p53 and PUMA were increased in inflamed mucosal tissues of mice with colitis and in patients wit

212 ; however, anti-TNP responses in noninflamed mucosal tissues of mice with colitis exhibited dominant

213 In mucosal tissues of normal rhesus macaques, we found CD4(

214 GF and NTRK1, are significantly increased in mucosal tissues of patients with IBS.

215 to the Gag 181 tetramer, particularly in the mucosal tissues of some of the macaques infected by SIV(

216 V) inoculation are earliest and strongest in mucosal tissues of the genital tract and lowest in syste

217 We show that the CD8(+) T cell repertoire in mucosal tissues of uninfected rhesus monkeys is oligoclo

218 ous antigen, can manifest in practically any mucosal tissue or as a systemic response.

219 tors that are important for migration to the mucosal tissues particularly the small intestine.

220 e of inflammation as a controller of enteric mucosal tissue patterning requires understanding the und

221 Three regulatory factors associated with mucosal tissues, PGE(2), IL-10, and TGFbeta, inhibited t

222 y combining an in vitro efficacy target with mucosal tissue pharmacokinetic (PK) data and mathematica

223 Because it is thought that mucosal tissues play a fundamental role in early HIV/SIV

224 Both activated and resting CD4(+) T cells in mucosal tissues play important roles in the earliest pha

225 on was pronounced in lymphoid and colorectal mucosal tissues, preferential sites of virus replication

226 ry, this study confirms that cells in airway mucosal tissue produce RANTES but that the level of prod

227 mation of functional resident CD8 T cells in mucosal tissues protected mice from a model of CD8 T cel

228 s microenvironmental stimuli in lymphoid and mucosal tissues provide support for HIV-1 replication.

229 by dendritic cells (DCs) that patrol various mucosal tissues remains unclear.

230 or 2 (TFF2), a well-established regulator of mucosal tissue repair.

231 Mucosal tissues require constant immune surveillance to

232 Innate resistance to Candida albicans in mucosal tissues requires the production of interleukin-1

233 ons with viruses, such as HIV-1, that target mucosal tissue result in intestinal epithelial barrier b

234 Challenge of primary human mucosal tissues revealed significantly higher levels of

235 ation, restored the injured gastrointestinal mucosal tissues, reversed diarrhea and weight loss, and

236 by this method in the histologically normal mucosal tissues sampled at the margin of resection dista

237 proteins in relation to PMN infiltration in mucosal tissue samples from patients with active IBD.

238 of phospho-Smad2 (days 3 and 7) in IEC from mucosal tissue sections of B. vulgatus-monoassociated ra

239 lymphoid cells (ILCs) serve as sentinels in mucosal tissues, sensing release of soluble inflammatory

240 ficking pathways shared between systemic and mucosal tissues should facilitate vaccine strategies aim

241 copy of S. aureus incubated with human nasal mucosal tissue showed minimal binding to ciliated respir

242 Gene profiling of oral mucosal tissue showed strong induction of Th17 signature

243 istochemical data on hBD2 expression in oral mucosal tissue shows that hBD2 is constitutively express

244 higher, compared with nonischemic tissue or mucosal tissue subjected to cold ischemia without reperf

245 iety of sites throughout the body, including mucosal tissues such as the lung.

246 c IgA Ab-forming cells were also detected in mucosal tissues such as the nasal passages (NPs), the su

247 de lymph nodes, spleen, Peyer's patches, and mucosal tissues such as the nasal-associated lymphoid ti

248 In mucosal tissue, such as the lung and intestine, endothel

249 Mucosal tissues, such as the lung, are continually expos

250 Its strategic expression in mucosal tissues suggests that it is involved in innate i

251 opical plasmid DNA vaccine delivery to human mucosal tissue surfaces, and that this application may p

252 In mucosal tissues, surprisingly, Rh-alpha4beta7 did not im

253 respective study drug was injected into the mucosal tissue surrounding the surgical site prior to su

254 We present here an analysis of lymphoid and mucosal tissue T cells derived from pediatric organ dono

255 ctor alpha was low and was even lower in the mucosal tissue than in blood or spleen of some SIV(mac25

256 sponse, with a magnitude that was greater in mucosal tissues than in peripheral blood.

257 ocytes, eosinophils and basophils into nasal mucosal tissue that results in the late-phase allergic r

258 IgA is produced primarily by PCs residing in mucosal tissues that are also thought to circulate in th

259 adhesion protein expressed on endothelium in mucosal tissues that has been shown to play an important

260 of PD-1 expression in lymph nodes and rectal mucosal tissue, the major sites of virus replication, wa

261 In mucosal tissues, the earliest demonstrable FIV-bearing c

262 They include the homing of mast cells to mucosal tissues, the local synthesis of IgE, the inducti

263 st cells are strategically positioned within mucosal tissues, the major interface with the external e

264 n of memory CD4+ T cells occurs primarily in mucosal tissues, the major reservoir for memory CD4+ T c

265 sure that allergic reactions are confined to mucosal tissues, thereby minimizing the risk of systemic

266 responding to an infection of peripheral or mucosal tissues they were designed to protect.

267 and restoration of homeostatic functions of mucosal tissues through the pleitropic activities of NGF

268 Mast cells are found in connective and mucosal tissues throughout the body.

269 T mice, induces suprabasilar acantholysis in mucosal tissues, thus confirming the pathogenicity of mP

270 n addition to its proinflammatory actions in mucosal tissue, TNF is important for liver regeneration.

271 o understand the virus-specific responses in mucosal tissues to facilitate devising strategies to pre

272 an be ferried via normal DC trafficking from mucosal tissues to lymphoid organs in vivo.

273 from 10(4)-10(5) single cells from blood or mucosal tissues using dense arrays of subnanoliter wells

274 cell population maintained in the peripheral mucosal tissues was attributable to a MA delivered AdHu5

275 estigate the effects of BPs on cells of oral mucosal tissue, we studied the effect of pamidronate (PA

276 way hyperreactivity are allergic diseases of mucosal tissues, we determined whether an allergic disea

277 HIV-1 DNA copies in foreskin and cervical mucosal tissue were compared and the infected cell pheno

278 Mast cells isolated from gut mucosal tissues were found to express a variety of HIV-1

279 Vmac251 acquisition, whereas virus levels in mucosal tissues were inversely correlated with antienvel

280 nt mice, although Th2 cytokine elevations in mucosal tissues were unaffected.

281 migrate to and reside within connective and mucosal tissues, where they differentiate and respond to

282 entium infection, NK cells were recruited to mucosal tissues, where they expressed a diversity of imm

283 ility, such as the semipermeable surfaces of mucosal tissues which are adapted for adsorption of nutr

284 s biofilms on indwelling medical devices and mucosal tissues, which serve as an infectious reservoir

285 re also efficient in preventing infection of mucosal tissues, while the protective efficacy of bnAbs

286 ation and suggest that directed targeting to mucosal tissues will be needed for effective vaccination

287 the chronic phase of HIV infection supplies mucosal tissues with short-lived CCR5+ CD4+ effector cel

288 overlap between CD8(+) T cells in blood and mucosal tissues, with responses to immunodominant epitop

289 mavirus (HPV) infection across cutaneous and mucosal tissues within individuals has not been examined

290 ection and removal of memory CD4+ T cells in mucosal tissues within the first three weeks of infectio

291 PPs allow enhanced drug and gene delivery to mucosal tissues without diminishing the protective funct

292 induce strong HIV-specific CD8(+) T cells in mucosal tissues without increasing the availability of t

293 ow that IL-15 complexes delivered locally to mucosal tissues without reinfection is an effective stra

294 t induce potent cellular immune responses in mucosal tissue would have broad application for vaccines