ライフサイエンスコーパス: multicellular

1 ariation in oxygen concentration in a viable multicellular 3D human tumour model.

2 logical tools have been unable to probe this multicellular 3D interface to determine the stop signal.

3 DeltaPfmaE mutant restored pigmentation and multicellular adherence of the conidia.

4 In a multicellular aggregate of hPSCs, intracellular apicosom

5 As a rapidly created multicellular aggregate with a polymerized fibrin matrix

6 Here, we developed size-controlled multicellular aggregates ("microtumors") of subtype-spec

7 microvilli-like structures on the surface of multicellular aggregates (MCAs) are removed by treatment

8 raperitoneally disseminating tumor cells and multicellular aggregates (MCAs) present in ascites fluid

9 uences behavior of both individual cells and multicellular aggregates (MCAs).

10 in endogenous cellular forces within growing multicellular aggregates remain unknown.

11 Multicellular aggregation and spheroid formation are str

12 ing atomic force microscopy and validated by multicellular aggregation assays.

13 eparated pairs of flagella isolated from the multicellular alga Volvox has shown that hydrodynamic co

14 transcriptome analysis across eight uni- and multicellular amoebozoan genomes, we find that 80% of pr

15 itis through complex interactions within the multicellular and neurochemical in vivo milieu.

16 The capacity to migrate is fundamental to multicellular and single-celled life.

17 activity of genes at the interfaces between multicellular and unicellular regions of human gene regu

18 e multiple prerequisites to the evolution of multicellular animal life, including the generation of m

19 sms necessary for the development of complex multicellular animals have been found in sponges.

20 ll-established players in the development of multicellular animals.

21 and in stem cells and germ cells of diverse multicellular animals.

22 An abnormal multicellular architecture is a defining characteristic

23 n positions and orientations, and consequent multicellular arrangements.

24 social behaviours, such as forming transient multicellular assemblages with properties and adaptive a

25 maging membrane dynamics in single cells and multicellular assemblies.

26 Our results show that PTEN controls multicellular assembly through a membrane-associated reg

27 nes are also required for the development of multicellular axillary hairs on the gametophyte of the m

28 e during which bacteria clonally expand into multicellular bacterial communities within the cytoplasm

29 Here, we report that self-assembling multicellular BBB spheroids display reproducible BBB fea

30 cus xanthus, a model organism for studies of multicellular behavior in bacteria, moves exclusively on

31 The transition from single-cell to multicellular behavior is important in early development

32 context of P. aeruginosa gene expression and multicellular behavior.

33 upon individual cells to ensure coordinated multicellular behavior.

34 Swarming motility is a flagella-driven multicellular behaviour that allows bacteria to colonize

35 The shaping of a multicellular body and repair of adult tissues require f

36 In a mouse model of temporal lobe epilepsy, multicellular calcium imaging revealed that disease emer

37 protein complex and physical forces spanning multicellular clusters, which further promotes the expan

38 ough different migration programs, including multicellular, collective, and single-cell mesenchymal o

39 Biofilms are multicellular communities of microorganisms living as a

40 bacteria primarily live in surface-attached, multicellular communities, termed biofilms (1-6) .

41 Such conditions arise in multicellular communities, where the formation of chemic

42 ture system that viably preserves the normal multicellular composition of the mouse intestine, with l

43 hough the organizational properties of these multicellular configurations remain poorly understood.

44 ne PfmaE and showed that it is essential for multicellular conidial pigmentation and development in a

45 cterize cell size and growth regulation in a multicellular context, we developed a 4D imaging pipelin

46 to understand the metabolic organization of multicellular cyanobacteria and provides a platform for

47 e that this work highlights the utility of a multicellular cyanobacterium as a model for the study of

48 e vicinity of genes with regulatory roles in multicellular development and differentiation.

49 s converge to activate, enhance, and inhibit multicellular development in a choanoflagellate.

50 Multicellular development is driven by regulatory progra

51 Type III CHDs are required for multicellular development of animals and Dictyostelium b

52 served as a model organism for the study of multicellular development of bacteria, and a remarkable

53 Multicellular development produces patterns of specializ

54 is up-regulated and likely secreted at late multicellular development stages of D. discoideum when m

55 The bacterium Myxococcus xanthus undergoes multicellular development when starved.

56 ucleosome repositioning during Dictyostelium multicellular development, establish an in vivo function

57 ghly signal-responsive GRN to enable complex multicellular development.

58 of proteins essential for the development of multicellular Dictyostelia are already present in their

59 (KNOX) proteins regulate development of the multicellular diploid sporophyte in both mosses and flow

60 and emphasize the importance of considering multicellular effects in the numerical models used for s

61 ut of methods have been used to recapitulate multicellular environments in silico.

62 tion of the downstream signaling events in a multicellular eukaryote.

63 mutation rates are similar to those in other multicellular eukaryotes (about 4 x 10(-9) per site per

64 that the Gaoyuzhuang fossils record benthic multicellular eukaryotes of unprecedentedly large size.

65 ess, but whether this mechanism functions in multicellular eukaryotes remains unclear.

66 ) is a recently identified NAT found only in multicellular eukaryotes.

67 al AGO paralogs have been well documented in multicellular eukaryotes.

68 owth in nonglucose medium and abolishment of multicellular features.

69 AT genes of Physcomitrella results in larger multicellular filamentous networks due to increased elon

70 ansition between a unicellular yeast form to multicellular filaments is crucial for budding yeast for

71 thus critical to understanding evolution of multicellular forms.

72 The small RNA (sRNA) Pxr negatively controls multicellular fruiting body formation in the bacterium M

73 We use OhmNet to study multicellular function in a multi-layer protein interact

74 This separation of unicellular and multicellular functions appeared to be mediated by 12 hi

75 they synchronize their behaviours to conduct multicellular functions is an expanding field of researc

76 cognition of self are critical to coordinate multicellular functions.

77 eered to perform the complex biosynthesis of multicellular fungi, opening up the possibility of using

78 ha L. is required for the development of the multicellular gas exchange structure: the air pore compl

79 te the stable coexistence of unicellular and multicellular genotypes, underscoring the importance of

80 Multicellular glandular trichomes are epidermal outgrowt

81 The formation of multicellular glandular trichomes of the xerophytic shru

82 citrinoviride populations shifted away from multicellular growth toward increased dispersal by produ

83 We quantify multicellular growth with single-cell resolution and sho

84 and a life cycle with an alternation between multicellular haploid and diploid generations that facil

85 Multicellular hypothesis for the pathogenesis of Alzheim

86 myeloid and lymphoid cell types, coordinates multicellular immunity, and facilitates memory responses

87 ll-derived cardiomyocytes; (3) 3-dimensional multicellular in vitro or in vivo contractile tissues, s

88 ure (OTC) is an innovative three-dimensional multicellular in vitro platform that recapitulates norma

89 d light on the evolutionary history of other multicellular innovations and evolutionary transitions.

90 These multicellular interactions are initiated by insoluble ta

91 emporal effects of therapies on simultaneous multicellular interactions in the cancer-bone microenvir

92 cellular processes, regulatory networks, and multicellular interactions.

93 Like the other multicellular kingdoms, Fungi evolved increased size, co

94 outcome, rather than a driver, of incipient multicellular life cycles.

95 a clear distinction between unicellular and multicellular life is visible in the intrinsically encod

96 The evolution of multicellular life requires cooperation among cells, whi

97 velopment of aerobic respiration and complex multicellular life.

98 ity for cellular identity and homeostasis in multicellular life.

99 niversally important after the transition to multicellular life.

100 to have influenced the emergence of complex multicellular life.

101 tions conducive for the evolution of complex multicellular life.

102 an genome, is in fact a universal feature of multicellular life.

103 ial interactions among kin, thus stabilizing multicellular lifestyles.

104 ms of the transition between unicellular and multicellular living forms.

105 However, precise coding of 3D multicellular living materials is challenging due to the

106 Brown algae are photosynthetic multicellular marine organisms.

107 Thus, proper assembly of multicellular mechanosensory organs requires a double-ne

108 also be critical to efforts to build complex multicellular models of the liver.

109 Multicellular monolayer cultures have proven useful for

110 l culture viability, cellular mechanisms and multicellular movements.

111 ant question and demands that we examine the multicellular nature of plant-pathogen interactions.

112 activated" phenotype, which defends against multicellular nematodes and fungi.

113 n cancer cells resulting in the formation of multicellular network structures.

114 ells to interconnect to one large, resistant multicellular network.

115 These results suggest that multicellular networks sit at a point in parameter space

116 as a module within the greater context of a multicellular neurovascular unit (NVU) that includes neu

117 ng of normal, aqueous physiology: how does a multicellular organism avoid lethal cellular collapse in

118 However, the fitness of a multicellular organism depends not just on how functiona

119 tion and cellular specification required for multicellular organism development.

120 Growth of a complex multicellular organism requires coordinated changes in d

121 icellular organism, or of a cell type from a multicellular organism, as the collection of cellular co

122 one of best-described transcriptomes of any multicellular organism.

123 ideally involve all cell types present in a multicellular organism.

124 ents present in multiple cell types within a multicellular organism.

125 or small RNA regulatory circuit studies in a multicellular organism.

126 to the correct assembly of tissues within a multicellular organism.

127 Cell types are the basic building blocks of multicellular organisms and are extensively diversified

128 nt functional role emerged with the earliest multicellular organisms and has been maintained to varyi

129 ere is a substantial lack of such studies in multicellular organisms and their complex phenotypes suc

130 and the evolution of a dedicated germline in multicellular organisms are critical landmarks in eukary

131 Methods for in vivo visualizing ribosomes in multicellular organisms are desirable in mechanistic inv

132 Intercellular contacts in multicellular organisms are maintained by membrane recep

133 recedented insights on metabolic outcomes in multicellular organisms at single-cell resolution.

134 Multicellular organisms can generate and maintain homoge

135 While most cells in multicellular organisms carry the same genetic informati

136 Multicellular organisms contain a large number of differ

137 ry form of cell death that not only protects multicellular organisms from invading pathogenic bacteri

138 The immune system has evolved to protect multicellular organisms from the attack of a variety of

139 In multicellular organisms gradient sensing plays an import

140 onsive transcription factor (TF) networks in multicellular organisms have been limited.

141 ton in single cells in culture, tissues, and multicellular organisms including various neurodevelopme

142 The biology of multicellular organisms is coordinated across multiple s

143 Tissue patterning in multicellular organisms is the output of precise spatio-

144 A fundamental characteristic of multicellular organisms is the specialization of functio

145 Hundreds of different species colonize multicellular organisms making them "metaorganisms".

146 To form and maintain organized tissues, multicellular organisms orient their mitotic spindles re

147 Many innovations among multicellular organisms originated in the sea during or

148 Many multicellular organisms produce two cell lineages: germ

149 Effective antiviral protection in multicellular organisms relies on both cell-autonomous a

150 The development of multicellular organisms relies on the precise regulation

151 Multicellular organisms rely on cell adhesion molecules

152 intracellular signaling in intact cells and multicellular organisms remain limited.

153 rtion, but the physiological significance in multicellular organisms remains to be resolved.

154 mbionts or multicellular organisms; in turn, multicellular organisms sometimes assemble into yet othe

155 ect to this form of regulation in tissues of multicellular organisms such as plants and humans, in th

156 highlights the dynamic biologic response of multicellular organisms to deguelin perturbation.

157 iological processes, from the development of multicellular organisms to information processing in the

158 thway, from germ-line surveillance in simple multicellular organisms to its pluripotential role in hu

159 All multicellular organisms undergo a decline in tissue and

160 new units of biological organization (e.g., multicellular organisms).

161 In multicellular organisms, a stringent control of the tran

162 ns serve pivotal roles in the development of multicellular organisms, acting as structural matrix, ex

163 n accumulation and somatic cell mosaicism in multicellular organisms, and is also implicated as an un

164 transport is essential for the growth of all multicellular organisms, and its dysregulation is implic

165 In multicellular organisms, autophagy is induced as an inna

166 ies are built on models of selection between multicellular organisms, but a full understanding of agi

167 o wound healing and embryonic development in multicellular organisms, groups of living cells must oft

168 oding RNAs (lincRNAs) have been described in multicellular organisms, however the origins and functio

169 The performance of these methods in multicellular organisms, however, is degraded by sample-

170 onary features with other photosynthetic and multicellular organisms, including a carbohydrate-rich c

171 As regulators of gene expression in multicellular organisms, microRNAs (miRNAs) are crucial

172 In multicellular organisms, single-fluorophore imaging is o

173 In multicellular organisms, the PN is regulated at the cell

174 Although these issues are universal to all multicellular organisms, they can be effectively tackled

175 importance in chromosome segregation and, in multicellular organisms, transcription regulation.

176 In contrast to multicellular organisms, where GnTII activity is essenti

177 is known about the somatic mutation rate in multicellular organisms, which remains very difficult to

178 the pathogenic roles of genetic mosaicism in multicellular organisms, with a focus on cancer.

179 on of signaling circuits in intact cells and multicellular organisms.

180 coordination of cell-fate decision making in multicellular organisms.

181 , but remain technically challenging in live multicellular organisms.

182 cell-surface adhesion receptors essential in multicellular organisms.

183 gical changes taking place within developing multicellular organisms.

184 govern a multitude of signalling pathways in multicellular organisms.

185 ubcellular resolutions in tissue samples and multicellular organisms.

186 sms require a smaller degree of control than multicellular organisms.

187 precise subcellular location of proteins in multicellular organisms.

188 ral role in developmental gene regulation in multicellular organisms.

189 the spreading of morphogens and vesicles in multicellular organisms.

190 epithelial cells is a fundamental process in multicellular organisms.

191 CE occurs during the development of most multicellular organisms.

192 Cell death is a vital process for multicellular organisms.

193 central to the growth and development of all multicellular organisms.

194 e produced as a first line of defense by all multicellular organisms.

195 ntiation is essential for the development of multicellular organisms.

196 rotein-protein interaction in live cells and multicellular organisms.

197 e double bind that makes aging inevitable in multicellular organisms.

198 ectly led to the emergence of eukaryotic and multicellular organisms.

199 e implementation of this technology in other multicellular organisms.

200 most diverse group of signaling molecules in multicellular organisms.

201 that control patterns of gene expression in multicellular organisms.

202 cal and forensic studies of humans and other multicellular organisms.Single-cell genomics can be used

203 semble into groups, such as endosymbionts or multicellular organisms; in turn, multicellular organism

204 bstrate affects contractility and long-range multicellular organization and dynamics.

205 Cellular and multicellular organization are defended by the immune re

206 te human pluripotent stem cells into a large multicellular organoid-like structure that contains dist

207 ll-derived and pluripotent stem cell-derived multicellular organoids.

208 rs a new theoretical framework to understand multicellular pattern formation and enables the wide-spr

209 velopment, cancer metastasis, and many other multicellular phenomena, motile cells group into a colle

210 werful carbohydrate active enzymes to reduce multicellular plant tissues to humus and simple sugars.

211 al environments, N2-fixing symbioses involve multicellular plants, but in the marine environment thes

212 Angiogenesis is a complex, multicellular process that is critical for bone developm

213 ological innovations that characterize these multicellular red algae.

214 ell wall remodeling, suggesting a global and multicellular response to lithotrophic conditions.

215 -flight, to comprehensively characterize the multicellular response to trauma.

216 A multicellular, rhythmic patterning system termed the seg

217 rmadillo-related ARABIDILLO proteins promote multicellular root branching.

218 es, the closest living relatives of animals, multicellular rosette development is regulated by enviro

219 Formation and resolution of multicellular rosettes can drive convergent extension (C

220 sulfonolipid that induces S. rosetta to form multicellular "rosettes." In this study, we report the i

221 that is, allows for dynamic testing of >600 multicellular samples or compounds per hour, and yields

222 icellular systems, especially in relation to multicellular self-organization.

223 We develop a computational model of multicellular sensing and migration in which groups of c

224 heir environment, and although the limits to multicellular sensing are becoming known, how this infor

225 ental data to estimate the effective size of multicellular sensory groups involved in gradient sensin

226 inally, embedding our homeostasis model in a multicellular simulation to assess the spatial effect of

227 ocial amoeba Dictyostelium discoideum into a multicellular slug is known to result from single-cell c

228 in six species of amoebae, five of which are multicellular social amoebae from the order of Dictyoste

229 a novel epigenetic regulator in a variety of multicellular species, including rodents; however, its c

230 However, only few multicellular species, limited to a handful of plants an

231 ferent types of expression data from diverse multicellular species.

232 SPIM can facilitate cell biology research in multicellular specimens by studying left-right symmetry

233 croscopy, high-resolution 3D live imaging of multicellular specimens remains challenging.

234 er cell line MCF7: a) a 3D collagen embedded multicellular spheroid tumor model, which reflects the a

235 the present study, we have developed a novel multicellular spheroid-based hepatic differentiation pro

236 for combinatorial screening of stem-cell and multicellular-spheroid cultures.

237 Multicellular spheroids can be achieved within 24 h and

238 invasive behavior of mixed N-type and S-type multicellular spheroids embedded in three-dimensional co

239 We also demonstrated that multicellular spheroids may enable key hallmarks of tiss

240 not only to achieve the active control of 3D multicellular spheroids on demand, but also to establish

241 tio-temporal changes in FRET ratio in 3-D in multicellular spheroids over time in a multi-well plate

242 Multicellular spheroids serve as an excellent platform t

243 vior in 3D, only recently have studies using multicellular spheroids shown an important role for the

244 l stage and for antibacterial defense at its multicellular stages.

245 ing individual cells to reversibly enter the multicellular state and to tell apart self and nonself c

246 yote that can switch between unicellular and multicellular states.

247 istinct modes: single-cell migration and the multicellular, strand-like invasion required for angioge

248 that has been partially conserved throughout multicellular streptophytes.

249 n in single-cell root hairs as compared with multicellular stripped roots, as well as in response to

250 d fibroblasts (CAFs), are key players in the multicellular, stromal-dependent alterations that contri

251 This topological analysis of multicellular structural organization reveals higher ord

252 lopment, remodeling, and regeneration of the multicellular structure of the native tissues.

253 nematosome, which is a Nematostella-specific multicellular structure, expresses Nv-TLR and many innat

254 interactions of endothelial cells that form multicellular structures called sprouts.

255 mode of cell rearrangement involves dynamic multicellular structures called tetrads and rosettes.

256 nied by the evolution of complex tissues and multicellular structures comprising different cell types

257 of WIP proteins in the control of different multicellular structures in M. polymorpha and the flower

258 these proteins controlled the development of multicellular structures in the common ancestor of land

259 omplex biological samples, such as cells and multicellular structures of the central nervous system (

260 lates the development of the unicellular and multicellular structures that develop from individual ce

261 ted in the control of morphogenesis of novel multicellular structures that evolved during the diversi

262 and the basis for the recalcitrance of these multicellular structures to antibiotic therapy.

263 ns, such as root hairs or rhizoids [6-9], or multicellular structures, such as asexual propagules or

264 bsecond temporal resolution from deep within multicellular structures.

265 derstanding how heterogeneous cells within a multicellular system interact and affect overall functio

266 ts to the precision of gradient sensing in a multicellular system, accounting for communication and t

267 ant contributor to cell polarity in uni- and multicellular systems [1-3].

268 ommunication is essen for the development of multicellular systems and is coordinated by soluble fact

269 Multicellular systems are extremely sensitive to their e

270 y of the emergent properties associated with multicellular systems arise already in small networks [1

271 Multicellular systems develop from single cells through

272 generate large-scale maps of cell lineage in multicellular systems for normal development and disease

273 interest in applying synthetic approaches to multicellular systems, especially in relation to multice

274 critical to the emergent properties of many multicellular systems, including microbial self-organiza

275 olution that is required to describe complex multicellular systems.

276 ation has evolved independently in dozens of multicellular taxa but is absent in unicellular species.

277 Ixmyelocel-T is an expanded, multicellular therapy produced from a patient's own bone

278 ould be used in the future to assemble other multicellular, thick, 3D, functional tissues.

279 Similarly, establishing a multicellular three-dimensional model of human oral muco

280 cal properties of their surroundings to form multicellular, three-dimensional tissues of appropriate

281 NG2(+) glia and pericytes caused significant multicellular tissue changes, including altered astrocyt

282 mbly of a fundamental architectural unit for multicellular tissue genesis.

283 To uncover the mechanisms by which multicellular tissues align their surrounding ECM before

284 Our data suggest that multicellular tissues align their surrounding matrix by

285 stem cell differentiation for reconstructing multicellular tissues in vitro.

286 The rapid ability of multicellular tissues to physically remodel their matrix

287 ells, but in the more complex environment of multicellular tissues, data have been lacking.

288 development, homeostasis and regeneration of multicellular tissues.

289 ristics and formation methods for applicable multicellular tumor spheroid culture models and recent s

290 d in both a 2D monolayer cell model and a 3D multicellular tumor spheroid model.

291 Multicellular tumor spheroid models serve as an importan

292 Multicellular tumor spheroids (MCTS) are valuable in vit

293 D morphologic and physiologic information of multicellular tumor spheroids (MCTS) growing from approx

294 of 3D tumor cell culture models, especially multicellular tumor spheroids (MCTS), has increased sign

295 high spatial resolution elemental imaging of multicellular tumor spheroids and an approach to account

296 the Micro-funnel can be implanted into live multicellular tumor spheroids to accumulate the extracel

297 nd potent at sub-micromolar doses towards 3D multicellular tumor spheroids with 2-photon red light.

298 antly colocalize in pancreatic cancer cells, multicellular tumor spheroids, and cancerous patient tis

299 e of cell contractility and tissue stress to multicellular vertex formation and resolution, respectiv

300 lobally, or specifically in the cells around multicellular vertices, disrupted the rate and direction