ライフサイエンスコーパス: multicellular organism

1 new units of biological organization (e.g., multicellular organisms).

2 roup of unicellular amoebae to an integrated multicellular organism.

3 overcome cell damage and to transition to a multicellular organism.

4 specific histone methyltransferase within a multicellular organism.

5 and GATOR2 complexes within the context of a multicellular organism.

6 of a cell accumulate over the lifetime of a multicellular organism.

7 g an unprecedented genetic resource for this multicellular organism.

8 ablish the first series of Top2 alleles in a multicellular organism.

9 uring metabolic stress to the advantage of a multicellular organism.

10 inventory of haploinsufficient genes of any multicellular organism.

11 on the architecture of a complex tissue in a multicellular organism.

12 ion of seh1 function within the context of a multicellular organism.

13 the functional complexity found in a living multicellular organism.

14 one of best-described transcriptomes of any multicellular organism.

15 ideally involve all cell types present in a multicellular organism.

16 ents present in multiple cell types within a multicellular organism.

17 or small RNA regulatory circuit studies in a multicellular organism.

18 to the correct assembly of tissues within a multicellular organism.

19 stinguish between the numerous cell types of multicellular organism.

20 ng this powerful optogenetic system in other multicellular organisms.

21 ranslation has yet to be determined in other multicellular organisms.

22 as been demonstrated in both unicellular and multicellular organisms.

23 function of complex miRNA families in higher multicellular organisms.

24 key mediators of heritable gene silencing in multicellular organisms.

25 re with its extraordinary diversity of large multicellular organisms.

26 ing mechanisms required for the evolution of multicellular organisms.

27 tional consequences, in both unicellular and multicellular organisms.

28 lications for the development and disease of multicellular organisms.

29 , leading to severe developmental defects in multicellular organisms.

30 ve a riok-3 gene, which is unprecedented for multicellular organisms.

31 nitoring the orientation of cell division in multicellular organisms.

32 tion is part of the developmental process of multicellular organisms.

33 al stimuli are essential for the survival of multicellular organisms.

34 ional heterogeneity are integral features of multicellular organisms.

35 st-translational modification of proteins in multicellular organisms.

36 ia formed eukaryotic cells, and cells formed multicellular organisms.

37 e double bind that makes aging inevitable in multicellular organisms.

38 developmental and physiological processes in multicellular organisms.

39 have been described in other microbes and in multicellular organisms.

40 isions are fundamental to the development of multicellular organisms.

41 pment, growth and tumor-free survival in all multicellular organisms.

42 surroundings is critical to the survival of multicellular organisms.

43 pment and maintenance of tissue structure in multicellular organisms.

44 e modifications remains poorly understood in multicellular organisms.

45 ectly led to the emergence of eukaryotic and multicellular organisms.

46 of reproductive division of labor within our multicellular organisms.

47 rcellular bridges are a conserved feature of multicellular organisms.

48 established model of dead cell clearance in multicellular organisms.

49 enance of specific cell types and tissues in multicellular organisms.

50 rocess that occurs during the development of multicellular organisms.

51 cycle has been conserved from single cell to multicellular organisms.

52 ositions is essential for the development of multicellular organisms.

53 targets, is a common developmental motif in multicellular organisms.

54 e (PM) is crucial for essential functions in multicellular organisms.

55 riptionally regulate gene expression in many multicellular organisms.

56 is an inseparable process of development in multicellular organisms.

57 proteins and assemble signaling complexes in multicellular organisms.

58 on of signaling circuits in intact cells and multicellular organisms.

59 roductive division of labor is a hallmark of multicellular organisms.

60 lular products as cell-specific scaffolds in multicellular organisms.

61 e implementation of this technology in other multicellular organisms.

62 in many different tissues and many uni- and multicellular organisms.

63 e conception, development, and physiology of multicellular organisms.

64 e (NO) is an important signaling molecule in multicellular organisms.

65 es are innate immune regulators found in all multicellular organisms.

66 sm operating during embryonic development of multicellular organisms.

67 functions and orchestrate the development of multicellular organisms.

68 important for the growth and development of multicellular organisms.

69 most diverse group of signaling molecules in multicellular organisms.

70 been a central challenge in the evolution of multicellular organisms.

71 llular diversity required for development in multicellular organisms.

72 that control patterns of gene expression in multicellular organisms.

73 ial for differentiation and tissue growth in multicellular organisms.

74 served transmembrane proteins present in all multicellular organisms.

75 signature features of tetraspanins in other multicellular organisms.

76 /3 in Clathrin-Mediated Endocytosis (CME) in multicellular organisms.

77 ssential for maintaining tissue integrity in multicellular organisms.

78 volved in the development and homeostasis of multicellular organisms.

79 for the development, growth and survival of multicellular organisms.

80 coordination of cell-fate decision making in multicellular organisms.

81 o gaining an understanding of the biology of multicellular organisms.

82 tential of germ and stem cell populations of multicellular organisms.

83 as cancers, and the development of organs in multicellular organisms.

84 ys a vital role in cellular communication in multicellular organisms.

85 on rate are poorly understood, especially in multicellular organisms.

86 intain cell states throughout development in multicellular organisms.

87 ellular proteomes and the whole proteomes of multicellular organisms.

88 for maintaining gene expression patterns in multicellular organisms.

89 similar to those that apoptosis provides to multicellular organisms.

90 eleton that underlies chirality in cells and multicellular organisms.

91 es form ducts (tubes) and acini (spheres) in multicellular organisms.

92 a central role in development and disease of multicellular organisms.

93 chieve cell-type-specific gene expression in multicellular organisms.

94 that mediates leukocyte wound attraction in multicellular organisms.

95 , but remain technically challenging in live multicellular organisms.

96 cell-surface adhesion receptors essential in multicellular organisms.

97 gical changes taking place within developing multicellular organisms.

98 govern a multitude of signalling pathways in multicellular organisms.

99 ubcellular resolutions in tissue samples and multicellular organisms.

100 sms require a smaller degree of control than multicellular organisms.

101 precise subcellular location of proteins in multicellular organisms.

102 ral role in developmental gene regulation in multicellular organisms.

103 the spreading of morphogens and vesicles in multicellular organisms.

104 epithelial cells is a fundamental process in multicellular organisms.

105 CE occurs during the development of most multicellular organisms.

106 Cell death is a vital process for multicellular organisms.

107 rotein-protein interaction in live cells and multicellular organisms.

108 central to the growth and development of all multicellular organisms.

109 e produced as a first line of defense by all multicellular organisms.

110 ntiation is essential for the development of multicellular organisms.

111 acilitate studies of biological processes in multicellular organisms.

112 in studying single molecules or complexes in multicellular organisms.

113 which is essential for proper development of multicellular organisms.

114 From microbial biofilm communities to multicellular organisms, 3D macroscopic structures devel

115 ted with greater developmental complexity in multicellular organisms, a pattern taken to an extreme i

116 In multicellular organisms, a stringent control of the tran

117 Oxygen is vital for the existence of all multicellular organisms, acting as a signalling molecule

118 ns serve pivotal roles in the development of multicellular organisms, acting as structural matrix, ex

119 Both microbes and multicellular organisms actively regulate their cell fat

120 transcriptional programs required to protect multicellular organisms against infections and to fortif

121 en cells is necessary for development of any multicellular organism and depends on the recognition of

122 es, but their effects on transcriptomes of a multicellular organism and on transcriptomic divergence

123 Cell types are the basic building blocks of multicellular organisms and are extensively diversified

124 Cell-cell contacts are fundamental to multicellular organisms and are subject to exquisite lev

125 viruses that integrate into the germline of multicellular organisms and are thereafter inherited lik

126 In multicellular organisms and complex ecosystems, cells mi

127 nt functional role emerged with the earliest multicellular organisms and has been maintained to varyi

128 net would be consistent with the presence of multicellular organisms and high levels of O2 on Earth-l

129 ow this gives rise to rhythmic physiology in multicellular organisms and how environmental signals en

130 ing of CENP-A assembly in somatic tissues in multicellular organisms and in meiosis, the specialized

131 cated biological systems, including genomes, multicellular organisms and societies, which took millio

132 mportant consequences for the development of multicellular organisms and the fitness of bacterial col

133 ere is a substantial lack of such studies in multicellular organisms and their complex phenotypes suc

134 ng pathway is involved in the development of multicellular organisms and, when deregulated, can contr

135 or the correct development and physiology of multicellular organisms and, when misregulated, may lead

136 n accumulation and somatic cell mosaicism in multicellular organisms, and is also implicated as an un

137 he central requirements for the existence of multicellular organisms, and is maintained by complex fe

138 transport is essential for the growth of all multicellular organisms, and its dysregulation is implic

139 , growth, reproduction, and longevity of all multicellular organisms, and its regulation has been the

140 re important for bacterial interactions with multicellular organisms, and some are virulence factors

141 and the evolution of a dedicated germline in multicellular organisms are critical landmarks in eukary

142 Methods for in vivo visualizing ribosomes in multicellular organisms are desirable in mechanistic inv

143 Multicellular organisms are equipped with cellular mecha

144 Morphometric studies in multicellular organisms are generally performed manually

145 Intercellular contacts in multicellular organisms are maintained by membrane recep

146 Early multicellular organisms are mostly extinct and the origi

147 However, effects of ozonated-OSPW on multicellular organisms are unknown.

148 icellular organism, or of a cell type from a multicellular organism, as the collection of cellular co

149 Soluble sugars serve five main purposes in multicellular organisms: as sources of carbon skeletons,

150 recedented insights on metabolic outcomes in multicellular organisms at single-cell resolution.

151 In multicellular organisms, autophagy is induced as an inna

152 ng of normal, aqueous physiology: how does a multicellular organism avoid lethal cellular collapse in

153 volutionary transition from single-celled to multicellular organisms, because it leads to reduced con

154 are inevitable, the genome of each cell in a multicellular organism becomes unique and therefore enco

155 in to define specific activities for Maf1 in multicellular organisms beyond the regulation of RNA pol

156 ary dramatically across species and within a multicellular organism, but the nature of scaling events

157 ies are built on models of selection between multicellular organisms, but a full understanding of agi

158 differentiation of epithelial cell layers in multicellular organisms by regulating cell junction- and

159 e creation of mutant viruses directly in the multicellular organism C. elegans without the use of cel

160 Multicellular organisms can generate and maintain homoge

161 While most cells in multicellular organisms carry the same genetic informati

162 In multicellular organisms, cell-cell junctions are involve

163 In multicellular organisms, cellular differences in gene ac

164 Multicellular organisms consist of cells of many differe

165 narily, the SLED domain emerges in the first multicellular organisms, consistent with the role of Scm

166 Multicellular organisms contain a large number of differ

167 neering the whole-genome networks of complex multicellular organisms continues to remain a challenge.

168 Selective uptake in multicellular organisms critically requires epithelia wi

169 ange of the Ediacara Biota, fossils of these multicellular organisms demonstrate the advent of mobili

170 However, the fitness of a multicellular organism depends not just on how functiona

171 Successful development of a multicellular organism depends on the finely tuned orche

172 The development of multicellular organisms depends on correct establishment

173 Most complex multicellular organisms develop clonally from a single c

174 tion and cellular specification required for multicellular organism development.

175 In multicellular organisms, developmental changes to replic

176 iving RNA to bacteria, yeast and the complex multicellular organism Drosophila melanogaster.

177 tigated E4orf4-induced cell death in a whole multicellular organism, Drosophila melanogaster.

178 Multicellular organisms employ a wide range of sensors t

179 Multicellular organisms encounter environmental conditio

180 In complex multicellular organisms, epithelia lining body cavities

181 rom single-celled yeasts to the most complex multicellular organisms (exceptions include the chromati

182 individual cells is intrisically stochastic, multicellular organisms exhibit highly regulated respons

183 Multicellular organisms fight bacterial and fungal infec

184 time determine what is necessary to build a multicellular organism from a single cell.

185 Cellular senescence both protects multicellular organisms from cancer and contributes to t

186 ry form of cell death that not only protects multicellular organisms from invading pathogenic bacteri

187 The immune system has evolved to protect multicellular organisms from the attack of a variety of

188 In sexually reproducing multicellular organisms, genetic information is propagat

189 In multicellular organisms, germ cells carry the hereditary

190 In multicellular organisms gradient sensing plays an import

191 o wound healing and embryonic development in multicellular organisms, groups of living cells must oft

192 As multicellular organisms grow, positional information is

193 embryonic and post-embryonic development of multicellular organisms has generated a universal view o

194 onsive transcription factor (TF) networks in multicellular organisms have been limited.

195 Cells in multicellular organisms have distinct identities charact

196 Many multicellular organisms have evolved strategies to cope

197 ediated antiviral defense, establishing that multicellular organisms have evolved to use portions of

198 However, metabolomics studies on multicellular organisms have thus far been performed pri

199 In most multicellular organisms, homeostasis is contingent upon

200 oding RNAs (lincRNAs) have been described in multicellular organisms, however the origins and functio

201 Applications of optogenetics in multicellular organisms, however, have not been widely r

202 The performance of these methods in multicellular organisms, however, is degraded by sample-

203 bolic homeostasis is key for the survival of multicellular organisms in changing environmental condit

204 Heterocyst-forming cyanobacteria are multicellular organisms in which growth requires the act

205 ates intra- and extra-cellular activities in multicellular organisms, in human corneal fibroblast cul

206 arious types have been identified in diverse multicellular organisms, in which they display profound

207 lation is critical to the development of all multicellular organisms; in plants, stem cell niches res

208 semble into groups, such as endosymbionts or multicellular organisms; in turn, multicellular organism

209 Development in multicellular organisms includes both small incremental

210 ton in single cells in culture, tissues, and multicellular organisms including various neurodevelopme

211 onary features with other photosynthetic and multicellular organisms, including a carbohydrate-rich c

212 The development of multicellular organisms involves cells to decide their f

213 Loss of complex I in a multicellular organism is unprecedented.

214 e reconstruction of cell lineages in complex multicellular organisms is a central goal of development

215 Programmed cell death (PCD) in multicellular organisms is a vital process in growth, de

216 this increased complexity, cell fate within multicellular organisms is also influenced by metabolism

217 through large-scale integrative analyses for multicellular organisms is challenging because most samp

218 The biology of multicellular organisms is coordinated across multiple s

219 in which cells each gene is expressed across multicellular organisms is critical in understanding bot

220 The process of phagocytosis in multicellular organisms is required for homeostasis, cle

221 Tissue patterning in multicellular organisms is the output of precise spatio-

222 A fundamental characteristic of multicellular organisms is the specialization of functio

223 o understand complex regulatory processes in multicellular organisms, it is critical to be able to qu

224 ar oxygen underpins the energy metabolism of multicellular organisms, liberating free energy needed t

225 Hundreds of different species colonize multicellular organisms making them "metaorganisms".

226 ppears to occur via protein sequestration in multicellular organisms, mammals, and Drosophila, in con

227 As regulators of gene expression in multicellular organisms, microRNAs (miRNAs) are crucial

228 During development, multicellular organisms must accurately control both tem

229 Like all multicellular organisms, myxobacteria face challenges in

230 Histocompatibility is the basis by which multicellular organisms of the same species distinguish

231 hanical cues generated during development of multicellular organisms on formation and dissolution of

232 is critical for biological investigation in multicellular organisms or tissues.

233 To form and maintain organized tissues, multicellular organisms orient their mitotic spindles re

234 Many innovations among multicellular organisms originated in the sea during or

235 In multicellular organisms, Polycomb Repressive Complex 1 (

236 Development of multicellular organisms proceeds via the correct interpr

237 Many multicellular organisms produce two cell lineages: germ

238 In multicellular organisms, proteins of the extracellular m

239 m-sensitive regulators of gene expression in multicellular organisms ranging from plants to humans.

240 Effective antiviral protection in multicellular organisms relies on both cell-autonomous a

241 Patterning of body parts in multicellular organisms relies on the interpretation of

242 The development of multicellular organisms relies on the precise regulation

243 Multicellular organisms rely on cell adhesion molecules

244 intracellular signaling in intact cells and multicellular organisms remain limited.

245 l resolution in cellular environments and in multicellular organisms remains challenging.

246 rtion, but the physiological significance in multicellular organisms remains to be resolved.

247 e of cell-size control in the development of multicellular organisms remains unclear.

248 The evolution of multicellular organisms represents one of approximately

249 Growth of a complex multicellular organism requires coordinated changes in d

250 Understanding cell type identity in a multicellular organism requires the integration of gene

251 The proper development of multicellular organisms requires precise regulation and

252 The complexity of multicellular organisms requires precise spatiotemporal

253 The homeostasis of multicellular organisms requires terminally differentiat

254 The development of multicellular organisms requires the precisely coordinat

255 In multicellular organisms, Rho-guanine nucleotide exchange

256 n plants has identified the first protein in multicellular organisms shown by gene disruption to be e

257 fundamental for the organization of cells in multicellular organisms since it has a key role in sever

258 In multicellular organisms, single-fluorophore imaging is o

259 cal and forensic studies of humans and other multicellular organisms.Single-cell genomics can be used

260 In multicellular organisms, some cells specialize in provid

261 mbionts or multicellular organisms; in turn, multicellular organisms sometimes assemble into yet othe

262 In multicellular organisms, specialized functions are deleg

263 All multicellular organisms studied to date have three right

264 enriched in many of the functions unique to multicellular organisms such as cell-cell adhesion, sign

265 onal interactions among genes, especially in multicellular organisms such as Drosophila, often requir

266 ect to this form of regulation in tissues of multicellular organisms such as plants and humans, in th

267 This study in a multicellular organism supports an essential role for br

268 In multicellular organisms, temporal and spatial regulation

269 is work demonstrates for the first time in a multicellular organism that the ability of a formin to a

270 We analyze the lineages of multicellular organisms that successfully differentiate

271 For multicellular organisms, the ability to respond to exter

272 However, in complex multicellular organisms, the core molecular machinery of

273 In all multicellular organisms, the links between patterning ge

274 ncy would be a selection pressure in complex multicellular organisms, the overall level of selective

275 In multicellular organisms, the PN is regulated at the cell

276 Although widespread among multicellular organisms, there are relatively few docume

277 Although these issues are universal to all multicellular organisms, they can be effectively tackled

278 In multicellular organisms, tissue integrity and organ size

279 tation of these same quantitative methods in multicellular organisms to ask how transcriptional regul

280 enables nature to build complex forms, from multicellular organisms to complex animal structures suc

281 highlights the dynamic biologic response of multicellular organisms to deguelin perturbation.

282 unctional specialization of kindlins allowed multicellular organisms to develop additional tissue-spe

283 iological processes, from the development of multicellular organisms to information processing in the

284 thway, from germ-line surveillance in simple multicellular organisms to its pluripotential role in hu

285 In multicellular organisms, transcription regulation is one

286 importance in chromosome segregation and, in multicellular organisms, transcription regulation.

287 All multicellular organisms undergo a decline in tissue and

288 ee-dimensional (3D) super-resolution in live multicellular organisms using structured illumination mi

289 The evolution of multicellular organisms was made possible by the evoluti

290 , by considering the geometry of a primitive multicellular organism we can gain insight into the init

291 te question of "why" this process evolved in multicellular organisms, we hope to uncover proximate ex

292 a Dictyostelium discoideum integrates into a multicellular organism when individual starving cells ag

293 In contrast to multicellular organisms, where GnTII activity is essenti

294 In contrast to multicellular organisms, where the GnTI reaction is esse

295 is known about the somatic mutation rate in multicellular organisms, which remains very difficult to

296 enerations, represent the first example of a multicellular organism with canonical telomeres that can

297 ing endocytosis in Caenorhabditis elegans, a multicellular organism with polarized epithelia.

298 enefit from direct imaging of the developing multicellular organism with single-cell resolution.

299 the pathogenic roles of genetic mosaicism in multicellular organisms, with a focus on cancer.

300 thick monolayers are the simplest tissues in multicellular organisms, yet they fulfill critical roles