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   1 nd was necessary for the evolution of animal multicellularity.                                       
     2  in basic processes associated with metazoan multicellularity.                                       
     3 pmental changes relevant to the evolution of multicellularity.                                       
     4 not cause potassium leakage failed to induce multicellularity.                                       
     5 ve played roles in the evolution of metazoan multicellularity.                                       
     6 rst the eukaryotic cell and later eukaryotic multicellularity.                                       
     7  ecological context during the transition to multicellularity.                                       
     8 ng the evolution of cell differentiation and multicellularity.                                       
     9 y have contributed to the advent of metazoan multicellularity.                                       
    10 tural novelties in Eukarya perhaps linked to multicellularity.                                       
    11 rons and ectopic expression at the origin of multicellularity.                                       
    12 for a long time was considered a hallmark of multicellularity.                                       
    13 ehavior during the earliest experiments with multicellularity.                                       
    14 Xdh gene in eukaryotes, before the origin of multicellularity.                                       
    15 ts that they are associated with the rise of multicellularity.                                       
    16 one of the early steps in the development of multicellularity.                                       
    17 ultrastructure when examining the origins of multicellularity.                                       
    18 erefore be an early step in the evolution of multicellularity.                                       
    19 e worm may have contributed to the advent of multicellularity.                                       
    20  during the initial step in the evolution of multicellularity.                                       
    21 s to have had an impact during the origin of multicellularity.                                       
    22 ther mechanistic studies on the emergence of multicellularity.                                       
    23 ms for understanding the evolution of animal multicellularity.                                       
    24 ping clusters may often be the first step to multicellularity.                                       
    25  not necessarily alongside, the emergence of multicellularity.                                       
    26 e challenges in how to organize and maintain multicellularity.                                       
    27 ulatory systems and the evolution of complex multicellularity.                                       
    28 organism, and this acts as a gating step for multicellularity.                                       
    29 ts, and rarer metazoan innovations linked to multicellularity.                                       
    30 key factor underlying the diverse origins of multicellularity.                                       
    31 l roles in the generation and maintenance of multicellularity.                                       
    32 ich evolved in tandem with the transition to multicellularity.                                       
    33 pression is essential for the maintenance of multicellularity.                                       
    34 oviding a necessary step in the evolution of multicellularity.                                       
    35 ic mechanisms, facilitated the transition to multicellularity.                                       
    36 y during the transition from single cells to multicellularity.                                       
    37 teria are a beautiful example of prokaryotic multicellularity.                                       
    38 select for the evolution of undifferentiated multicellularity.                                       
    39  PCD in microbes, including the evolution of multicellularity.                                       
    40 s was already in place at the dawn of animal multicellularity.                                       
    41 aiming to better understand genomic basis of multicellularity.                                       
    42 atterns as genomic and evolutionary basis of multicellularity.                                       
    43 cine algae coevolved with the acquisition of multicellularity.                                       
    44 ve demarcated the genetic toolkit for animal multicellularity, a select set of a few hundred genes fr
    45 emical, and mechanistic basis of prokaryotic multicellularity, a topic that has garnered considerable
    46 ment, expression pattern diversification and multicellularity, aiming to better understand genomic ba
    47    Coming together amplifies the benefits of multicellularity and allows social clusters to collectiv
  
    49 entally responsive molecular determinants of multicellularity and contribute to the natural morpholog
  
  
  
  
    54 and facilitating evolutionary transitions to multicellularity and germ-soma differentiation in the vo
    55 he major evolutionary transition to obligate multicellularity and had more cell types, a higher likel
    56 al control mechanism governing the switch to multicellularity and raises the possibility that YlbF, Y
    57  cadherins, which are essential for metazoan multicellularity and restricted to metazoans and their c
    58 at differ only in the presence or absence of multicellularity and somatic differentiation, permitting
    59 ion of orthologs of genes known to establish multicellularity and tissue architecture in metazoans.  
    60 to the understanding of natural evolution of multicellularity and to manipulating cell sedimentation 
    61 ordinated expression of strongly interacting multicellularity and unicellularity processes was lost i
    62 complex RNA-silencing systems evolved before multicellularity and were a feature of primitive eukaryo
    63 ation, the evolution of the eukaryotic cell, multicellularity, and the origin of human groups with la
    64 s, the Palmophyllales, with a unique form of multicellularity, and typically found in deep water.    
  
  
  
    68  of living myocardium that retain the native multicellularity, architecture and physiology of the hea
  
    70 lular relatives indicate that transitions to multicellularity are typically associated with increases
  
    72 d of modular domains have evolved along with multicellularity as a method to facilitate increasing in
    73 ns must be key players in the development of multicellularity because they are well positioned to for
    74 nscription factors are key players in animal multicellularity, being members of the T-box family that
  
    76  Integrin-mediated adhesion is as ancient as multicellularity, but it was not always as complex as it
    77 tions have been identified in the context of multicellularity, but they have been treated very simila
    78 gg, the social amoeba Dictyostelium achieves multicellularity by the aggregation of approximately 10(
  
  
    81 ife histories, including social behavior and multicellularity, can only be understood in the appropri
  
  
    84 lar, soma-producing strains, suggesting that multicellularity confers evolutionary stability to somat
  
  
    87 nities do not satisfy the strict criteria of multicellularity developed by multi-level selection theo
  
    89 and possible interplay between the origin of multicellularity, diversification of cyanobacteria, and 
  
  
  
  
  
    95  genes and their corresponding tRNAs, and in multicellularity genes and their tRNAs, suggesting the e
  
    97 ot in laboratory strains, an indication that multicellularity has been lost during domestication of B
    98 iridiplantae comprise unicellular algae, and multicellularity has evolved independently in the two cl
  
  
  
  
  
   104 mergence of BMs coincided with the origin of multicellularity in animals, suggesting that they were e
  
  
  
   108 osetta as a model system for studying simple multicellularity in choanoflagellates and provide an exp
  
  
  
   112 en suggested that they evolved together with multicellularity in separate plant and animal lineages. 
   113 h a comparative study, comparing the form of multicellularity in species where groups are clonal (r =
   114 (+)], governs the acquisition of facultative multicellularity in the budding yeast Saccharomyces cere
  
   116 Among the best-studied ETIs is the origin of multicellularity in the green alga Volvox, a model syste
   117 ystem for understanding the genetic basis of multicellularity including the initial formation of coop
  
  
  
   121 llularity overlaps with the GOE, and whether multicellularity is associated with significant shifts i
  
  
  
  
  
  
   128 s, the organizational principles of metazoan multicellularity may be more ancient than previously rec
  
   130 elated to halogen metabolism, oxylipins, and multicellularity (microRNA processing and transcription 
  
   132 n ccs52A1 mutations dramatically enhance the multicellularity of sim mutants trichomes in double muta
   133 s harbor features important in sexuality and multicellularity once believed to have originated in met
   134 ransitions can be recursive (e.g., plastids, multicellularity) or limited (transitions that share the
  
   136 peration and competition for the benefits of multicellularity promote the stable coexistence of unice
   137 ll biology, we reason that the transition to multicellularity required modification of pre-existing m
  
  
  
   141 omonas reinhardtii to conditions that favour multicellularity, resulting in the evolution of a multic
  
   143 may constitute a barrier to the evolution of multicellularity since cell differentiation requires sen
   144 ty that likely relate to the requirements of multicellularity such as the need to establish faithful 
   145 tonomous timing allows a trial commitment to multicellularity that external signals could extend.    
  
   147 early and formative step in the evolution of multicellularity, the evolution of cell cycle regulation
  
  
   150  mechanisms evolved during the transition to multicellularity to control fundamental cellular process
  
  
   153  in normal tissues, the evolution of complex multicellularity was not accompanied by reductions in mu
  
  
  
   157 hanisms underlying the evolution of metazoan multicellularity, we sequenced and analysed the genome o
   158 , reproductive division of labor, and clonal multicellularity while maintaining sufficient generality
  
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