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1 to amplify a species-specific region of the multicopy 18S rRNA gene, and SYBR Green was used for det
2 dependent lines of transgenic mice bearing a multicopy 413-kbp-linked Gata2 BAC transgene (bearing se
3 tation of maize carrying a tandemly repeated multicopy allele of pericarp color1 (p1) was examined us
6 y by combining FISH with immunofluorescence; multicopy and repetitive element expression can also be
8 RNA gene (SL RNA) repeat is present in large multicopy arrays and has been used as a marker for the d
12 ates independent of copy number variation in multicopy ChrY gene families that influence susceptibili
14 ify novel mutator effects resulting from the multicopy cloning (MCC) of specific genes and therefore
17 range from 28 to 348 bp, and the lengths of multicopy CREE appear mainly in the ranges of 154 to 156
18 ies demonstrated that deletion of the entire multicopy cysteine protease B (CPB) gene array in L. mex
19 ive to QseBC was mapped, and single-copy and multicopy deletion analyses were performed to determine
21 yed octapeptides and avidity effect of their multicopy display on the phage scaffold, good biocompati
23 -Asp-pThr-Asp motifs, recently identified as multicopy docking sites within Mdc1, are evolutionarily
24 s tended to be differentially expressed, and multicopy duplicate genes were likely to diverge express
26 t to (i) complementation; (ii) dominance and multicopy effects; (iii) interaction with wild-type FliH
29 of the null mutant with the LmGT4 gene on a multicopy episomal expression vector also reverted these
30 atent, with the viral genome persisting as a multicopy episome and expressing only a small subset of
33 asmids to persist in dividing human cells as multicopy episomes that attach to chromosomes during mit
34 virus (EBV) establishes latent infections as multicopy episomes with complex patterns of viral gene t
38 ster carrier Nfu and partially suppressed by multicopy expression of either sufA or nfu, suggesting f
39 This inhibition can be suppressed by the multicopy expression of mex67 suggesting that Mex67p can
43 boratory conditions, but could be induced by multicopy expression of sypG, which encodes a response r
44 biofilm formation and a hyperswarmer, while multicopy expression of this gene promotes sessility.
50 ated Bcl-X(L) transgenic mice that contain a multicopy Flag-tagged mouse Bcl-x(Flag) transgene driven
57 asite Plasmodium falciparum contains several multicopy gene families, including var, rifin, stevor an
64 nia in immunosuppressed patients, contains a multicopy gene family that encodes the major surface gly
67 ntagonists in this conflict are the X-linked multicopy gene Xmr and its multicopy MSYq-linked relativ
70 entical X chromosome and CNV in Y chromosome multicopy genes exhibit sperm head abnormalities and fem
71 genome stability and organelle function and multicopy genes in signaling, transport, and metabolism.
72 test the hypothesis that CNV in Y chromosome multicopy genes influences the paternal parent-of-origin
74 an and mouse sex chromosomes are enriched in multicopy genes required for postmeiotic differentiation
80 coli, genes encoding Vgr are associated with multicopy genetic elements designated Rhs (rearrangement
84 ously published M. tuberculosis strains with multicopy inhA or kasAB plasmids, were tested for their
85 rtussis, and B. holmesii was developed using multicopy insertion sequences (ISs) in combination with
87 lating cells, which may obviate the need for multicopy integration to achieve high-level expression a
88 t host and thus bypasses the requirement for multicopy Kan(r); faa and ssrA mutants are additive in t
89 NA (tmRNA) (encoded by ssrA), coupled with a multicopy kanamycin resistance determinant, suppressed b
90 nii, in which the homologous PRT-1 genes are multicopy, kex1 is a single-copy gene encoding a protein
92 ocumented, are also unusual in their lack of multicopy LINE-like and gypsy-like retrotransposons, gro
94 point of view, our results suggest that the multicopy MD simulation approach is very useful when stu
99 Synonymous substitution rate analyses of the multicopy MSY genes indicated that two major periods of
100 are the X-linked multicopy gene Xmr and its multicopy MSYq-linked relative Sly, which are upregulate
101 regulatory mechanism controlling dispersed, multicopy MuDR/Mu elements responsible for Mutator activ
106 ry components of the ribosome are encoded by multicopy nuclear ribosomal RNA (rRNA) genes: 28/26S, 18
109 e hyperfimbriated phenotype conferred by the multicopy oxyR plasmid was absent in a type I fimbrial m
111 ion and small RNA targeting, relating to the multicopy paralogous genes generated from whole genome t
112 hed at centromeres, TET/JBP transposons, and multicopy paralogous genes that are not expressed, but r
113 n in plants is often associated with complex multicopy patterns of transgene integration at the same
116 Second, in medium that lacked thymidine, multicopy phtC(+) or phtD(+) alleles enhanced the surviv
118 treated with dihydroartemisinin-piperaquine, multicopy plasmepsin 2 in the sample collected before tr
120 l and temporal increase of the proportion of multicopy plasmepsin 2 parasites was highly correlated w
123 mutation in acrR or acrAB expression from a multicopy plasmid also suppressed the TolCP246R,S350C de
125 onsequences of overexpression of tnaC from a multicopy plasmid and observed that under inducing condi
126 the C-terminal 53 amino acids of MutS) on a multicopy plasmid are proficient for mutation avoidance.
127 nhibited by an oversupply of DnaA and that a multicopy plasmid carrying rcbA neutralizes this inhibit
128 eplication and distribution of the bacterial multicopy plasmid ColE1 in a population of exponentially
134 igen gene promoter or in a strain carrying a multicopy plasmid containing the entire B. cereus plc-sp
135 in place of WT ftsA or with ftsA* alone on a multicopy plasmid divide mostly normally, whether they a
136 hromosomal DeltaacrB mutant transformed with multicopy plasmid encoding MdtM suggested a functional s
138 outer membrane phospholipase gene pldA on a multicopy plasmid in a vpsC or vacJ mutant restored its
142 type strain, while expression of YggX from a multicopy plasmid increased the aconitase levels above t
143 NAIII in trans to the MW2 arlRS mutant via a multicopy plasmid induced autolysis in this MRSA strain.
145 We demonstrate that DksA expression from a multicopy plasmid is necessary and sufficient for suppre
146 f the CCU/CCA/CCG-decoding tRNA(Pr)(o)3 on a multicopy plasmid leads to suppression of several +1 fra
149 expressed either from the trc promoter on a multicopy plasmid or from the endogenous dsbA promoter b
151 e its role further, comW was cloned into the multicopy plasmid pMSP3535, under the control of a nisin
152 When induced for expression, baeR cloned in multicopy plasmid pTrc99A significantly increased the re
153 d over-expression of the DinG protein from a multicopy plasmid result in a slight reduction of UV res
156 partitioning locus STB of the 2mum circle--a multicopy plasmid that resides in the yeast nucleus and
157 ains containing the B. cereus plcR gene on a multicopy plasmid under control of the strong B. anthrac
158 fragments between 3 and 5 kbp in length on a multicopy plasmid vector that was transformed into E. co
159 ontaining the intact groES-groEL operon on a multicopy plasmid was generated and used to demonstrate
160 some of the TBP mutations is suppressed by a multicopy plasmid with SNR6 or by an spt3 mutation.
162 ntify the genes which, when expressed from a multicopy plasmid, can restore the growth defect of the
164 tein was expressed in the hetF mutant from a multicopy plasmid, HetR-GFP accumulated nonspecifically
165 erhelicase mutant, and when expressed from a multicopy plasmid, it results in UV sensitivity (UV(s)),
166 When each of the genes was expressed from a multicopy plasmid, M. smegmatis exported comparable prop
168 1 gene and/or the mobN1 gene was cloned on a multicopy plasmid, production of the protein was constit
169 product, when either mutated or cloned on a multicopy plasmid, seems to be capable of compensating f
180 lly constitutive not only when produced from multicopy plasmids but also at a single-copy gene dosage
185 While the expression of these proteins on multicopy plasmids did not improve production over the b
189 mltG was initially isolated in a screen for multicopy plasmids generating a lethal phenotype in cell
191 harvesting complex components expressed from multicopy plasmids in strains in which the corresponding
192 o- to four-times-higher values obtained from multicopy plasmids in stringent cells and eight-times-hi
196 lso monitored the effects of the presence of multicopy plasmids on the position of DNA polymerase usi
198 strong inducer dependence when produced from multicopy plasmids, B. bronchiseptica B013N alcR partial
202 n: a novel thrombin inhibitor derived from a multicopy precursor in the salivary glands of the ixodid
203 to test E. coli strains, both in the form of multicopy recombinant plasmids and as lysogenized propha
206 lines of evidence that a eutherian-specific multicopy retrogene, DUX4, encodes a transcription facto
207 ared origin of the two resistance-conferring multicopy Rhg1 groups and subsequent independent evoluti
208 find that SCN resistance is associated with multicopy Rhg1 haplotypes that form two distinct groups.
213 Saccharomyces cerevisiae 2-mum plasmid is a multicopy selfish genome that resides in the nucleus.
214 cular type of error in the reference genome: multicopy sequences which have been incorrectly assemble
227 rowth with pyruvate as the carbon source and multicopy suppression suggest that several other transam
228 ty is typically studied experimentally using multicopy suppression, in which over-expression of a pro
230 Proteus mirabilis, tatA was identified as a multicopy suppressor and restored extracellular signal p
234 Escherichia coli, is known to function as a multicopy suppressor for dnaJ mutations and to bind nons
235 e recently observed that KsgA functions as a multicopy suppressor for the cold-sensitive cell growth
237 RbfA, a 30S ribosome-binding factor, is a multicopy suppressor of a cold-sensitive C23U mutation o
238 complex), which was originally isolated as a multicopy suppressor of a cytochrome b mRNA translation
239 encodes a putative Hsp90 co-chaperone, as a multicopy suppressor of a temperature-sensitive allele (
241 ste 12 (Su(z)12), Extra Sex Combs (ESC), and Multicopy Suppressor of IRA 1 (MSI1), and functions in m
244 The transcription factors Msn2 and Msn4 (multicopy suppressor of SNF1 mutation proteins 2 and 4)
246 We isolated a novel gene, alp16(+), as a multicopy suppressor of temperature-sensitive alp6-719 m
247 des C, C, and A to the 3' end of tRNAs, is a multicopy suppressor of the defect in tRNA nuclear expor
248 isolated the transcription factor MBP1 as a multicopy suppressor of the growth and alpha-factor resp
250 he pleiotropic drug resistance network, as a multicopy suppressor of the mitochondrial import defects
251 e identified a truncated allele of dam1 as a multicopy suppressor of the sensitivity of cdc13-117 (cy
252 NA processing and degradation pathways, is a multicopy suppressor of the synthetic lethality and of t
254 ified the ribosome binding protein Stm1 as a multicopy suppressor of the temperature sensitivity of t
256 ized open reading frame YER074W-A as a novel multicopy suppressor of the thermosensitive yip1-4 strai
264 ial proteins (e.g. MTCO3) were identified as multicopy suppressors of cdc13-1, suggesting the involve
265 gh three independent genome-wide screens for multicopy suppressors of each of the three Vpr activitie
266 We have identified OXA1 and TIM17 as novel multicopy suppressors of mtDNA instability in ilv5 cells
268 otential targets for Cln3/CDK, we identified multicopy suppressors of the temperature sensitivity of
269 dentify functional partners, we screened for multicopy suppressors of the temperature-sensitive ydj1-
270 D23 and DDI1 were identified in a screen for multicopy suppressors of the temperature-sensitivity of
273 re we identify several HAL genes that act as multicopy suppressors of this sensitivity and are connec
274 ia coli porin regulation was discovered from multicopy suppressors that permitted growth of cells exp
277 rDNA) genes in eukaryotes are organized into multicopy tandem arrays and transcribed by RNA polymeras
278 genomes by inserting site-specifically into multicopy target sites, thereby avoiding random disrupti
279 oth the deletion and/or the transposition of multicopy TEs associated with 2b-induced hypomethylation
282 SID-1 is required for efficient silencing of multicopy transgenes, indicating that mobile silencing s
288 te that mutation of Rnu2-8, one of the mouse multicopy U2 snRNA genes, causes ataxia and neurodegener
294 hese B. anthracis Spo0E-like proteins from a multicopy vector consistently resulted in a sporulation-
297 en eis was introduced into M. smegmatis on a multicopy vector, sodium dodecyl sulfate-polyacrylamide
300 oform derived from an internal promoter in a multicopy YAC transgenic line results in a microphthalmi
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