ライフサイエンスコーパス: multidrug resistance protein

1 resistance proteins, P-glycoprotein and MRP (multidrug resistance protein).

2 23/R resistant cell line which overexpresses multidrug resistance protein.

3 ne that do not overexpress P-glycoprotein or multidrug resistance protein.

4 e transporters such as P glycoprotein or the multidrug resistance protein.

5 hout overexpression of P-glycoprotein or the multidrug resistance protein.

6 (MOAT), the liver-specific homologue of the multidrug resistance protein.

7 ansporter protein with homology to mammalian multidrug resistance proteins.

8 the expression of anti-apoptotic factors and multidrug resistance proteins.

9 f the intestinal barrier, such as mucins and multidrug resistance proteins.

10 efflux pumps such as P-glycoprotein (ABCB1), multidrug resistance protein 1 (ABCC1), and breast cance

11 Upregulation of the multidrug resistance protein 1 (LeMDR1) in the protozoan

12 led to increased expression and activity of multidrug resistance protein 1 (MDR-1), a membrane trans

13 The overexpression of multidrug resistance protein 1 (MDR1) and multidrug resi

14 ociated proteins caveolin-1, syntaxin-6, and multidrug resistance protein 1 (MDR1) in brain endotheli

15 Discovery of the multidrug resistance protein 1 (MDR1), an ATP-binding ca

16 Multidrug resistance protein 1 (MRP1) actively transport

17 To examine the role of multidrug resistance protein 1 (MRP1) and glutathione S-

18 ions, and the role of P-glycoprotein (P-gp), multidrug resistance protein 1 (mrp1) and organic anion

19 histochemical expression of bronchopulmonary multidrug resistance protein 1 (MRP1) and permeability g

20 The multidrug resistance protein 1 (MRP1) contributes cellul

21 The multidrug resistance protein 1 (MRP1) encoded by ABCC1 w

22 of multidrug resistance protein 1 (MDR1) and multidrug resistance protein 1 (MRP1) gene products is a

23 Human multidrug resistance protein 1 (MRP1) is a member of the

24 eans to overcome resistance by silencing the multidrug resistance protein 1 (MRP1), before chemothera

25 The multidrug resistance protein 1 (MRP1), P-glycoprotein, a

26 reports, no consistent relationship between multidrug resistance protein 1 (MRP1, ABCC1) expression

27 ned against P-glycoprotein (P-gp, ABCB1) and multidrug resistance protein 1 (MRP1, ABCC1) to confirm

28 The polytopic 5-domain multidrug resistance protein 1 (MRP1/ABCC1) extrudes a v

29 The ATP-binding cassette (ABC) transporter multidrug resistance protein 1 (MRP1/ABCC1) is responsib

30 uman ATP-binding cassette (ABC) transporter, multidrug resistance protein 1 (MRP1/ABCC1), confers res

31 not for the MDR1 P-glycoprotein (ABCB1/Pgp), multidrug resistance protein 1 (MRP1/ABCC1), or multidru

32 iron release from cells via the transporter multidrug resistance protein 1 (MRP1/ABCC1).

33 her conferred by the classic P-glycoprotein (multidrug resistance protein 1) or by other mechanisms,

34 ne domains but some, including SUR and MRP1 (multidrug resistance protein 1), contain an extra N-term

35 Low or no induction of multidrug resistance protein 1, multidrug resistance-rel

36 l-time PCR to measure the mRNA expression of multidrug resistance protein 1, multidrug resistance-rel

37 mium resistance by serving as a cofactor for multidrug resistance protein 1/GS-X pump-mediated cadmiu

38 ers breast cancer resistance protein (BCRP), multidrug-resistance protein 1 (MDR1), and multidrug-res

39 ciated protein 2, bile salt export pump, and multidrug-resistance protein 1) dissociated from their n

40 lar cAMP or inhibit non-CFTR Cl(-) channels, multidrug resistance protein-1 (MDR-1), ATP-sensitive K(

41 Interestingly, multidrug resistance protein-1 (MRP-1) expression, but n

42 und that human endothelial cells express the multidrug resistance protein-1 (MRP1) and use this as th

43 thiol/disulfide balance, greater extents of multidrug resistance protein-1 (MRP1) expression, and gr

44 calcein, a membrane-impermeant substrate of multidrug resistance protein-1 (MRP1), into HEK-MRP1 cel

45 4) is transferred to its export carrier, the multidrug resistance protein-1.

46 toplasmic side of the membrane for export by multidrug resistance protein-1.

47 P-glycoprotein (P-gp) and multidrug-resistance protein-1 (MRP-1) are adenosine tri

48 s classified as ABCC2 or Leishmania donovani multidrug resistance protein 2 (LdMRP2).

49 transport protein 1a and 1b (Oatp1a/1b) and multidrug resistance protein 2 (Mrp2) was investigated b

50 Multidrug resistance protein 2 (MRP2), a marker selectiv

51 In contrast, levels of RNA coding for multidrug resistance protein 2 (MRP2), which transports

52 tidrug resistance protein 1 (MRP1/ABCC1), or multidrug resistance protein 2 (MRP2/ABCC2).

53 vity of two other major efflux transporters, multidrug resistance protein 2 and breast cancer resista

54 cles ranging from 100 to 160 nm and that the multidrug resistance protein 2 and the bile salt export

55 apical membrane to subapical puncta, whereas multidrug resistance protein 2 distributions were not ch

56 10 (apicoplast ribosomal protein S10), mdr2 (multidrug resistance protein 2) and crt (chloroquine res

57 ferase and the biliary phospholipid floppase multidrug-resistance protein 2 (Mdr2/Abcb4), resulting i

58 sporters RLIP76 (Ral-binding protein) or the multidrug resistance protein-2.

59 information on the interaction of drugs with multidrug resistance protein 3 (MDR3) exists and its rol

60 ansporters, bile salt export pump (BSEP) and multidrug resistance protein 3 (MDR3).

61 The human multidrug resistance protein 3 (MDR3/ABCB4) belongs to t

62 hydroxysteroid sulfotransferase enzyme 2A1, multidrug resistance protein 3, and apical sodium-depend

63 Human multidrug resistance protein 4 (MRP4) has recently been

64 Here, we report that the multidrug resistance protein 4 (MRP4), a cAMP transporte

65 drugs are either substrates or inhibitors of multidrug resistance protein 4 (MRP4), such as the anti-

66 In this study, we used multidrug resistance protein 4 (MRP4)-expressing cell li

67 The physiological role of multidrug resistance protein 4 (Mrp4, Abcc4) in the test

68 In this study, we evaluated the role of multidrug resistance protein 4 (MRP4, or ABCC4), a nucle

69 Multidrug resistance protein 4 (MRP4/ABCC4), transports

70 Multidrug resistance protein 4 (MRP4; ABCC4) is a member

71 signaling cascade (phospholipase A2, COX-2, multidrug resistance protein 4, and G-protein-coupled pr

72 g that the ATP-binding cassette transporter, multidrug resistance protein 4, is able to efflux nucleo

73 We hypothesized that multidrug resistance protein 4/ATP binding cassette tran

74 We show that multidrug-resistance protein 4 (Mrp4) is abundant in mye

75 Mutations in human multidrug resistance protein 6 (MRP6, ABCC6), a member o

76 o referred to as "MRP6" or "eMOAT") encoding multidrug-resistance protein 6 (MRP6), a putative transm

77 ding overexpression of P-glycoprotein (Pgp), multidrug resistance protein 7 (MRP7), and the betaIII i

78 sette transporter 10 (ABCC10), also known as multidrug resistance protein 7 (MRP7), is able to confer

79 Human multidrug resistance protein 7 (MRP7, ABCC10) is a recen

80 ucture of heterodimeric Thermus thermophilus multidrug resistance proteins A and B (TmrAB), which not

81 Pase beta (flippase), the hematopoietic cell multidrug resistance protein ABC transporter (floppase),

82 Jurkat cells express several members of the multidrug resistance protein (ABCC/MRP), and the organic

83 We have previously established that the multidrug resistance protein Abcg2 is the molecular dete

84 tivation of TGFbeta, and upregulation of the multidrug resistance protein ABCG2.

85 These factors likely include multidrug resistance proteins, aberrant signal transduct

86 on antiparallel homo- or heterodimeric small multidrug resistance proteins and examine whether the in

87 n-regulation of miRNA downstream targets and multidrug resistance proteins and extent of apoptosis we

88 nce regulator (CFTR), the P-glycoprotein (or multidrug-resistance protein) and the heterodimeric tran

89 nd chloride transport, interference with the multidrug resistance protein, and enhancement of prostac

90 c scramblases or proteins from the family of multidrug resistance proteins, and cofactors such as pho

91 teins, several plasma membrane (PM) ATPases, multidrug resistance proteins, and proteins of the stoma

92 P-Glycoprotein (Pgp) (also known as multidrug-resistance protein) contains two nucleotide bi

93 Its protein sequence places it in the multidrug resistance protein/cystic fibrosis transmembra

94 lines that overexpress P-glycoprotein or the multidrug resistance protein do not have higher levels o

95 ansfected with combinations of gamma-GCS and multidrug resistance protein exhibited enhanced resistan

96 Unlike previously characterized multidrug resistance protein family members, ABCG2 is al

97 educed folates are not identical to those of multidrug resistance protein family members.

98 EmrE is part of a multidrug resistance protein family that is highly conse

99 te (ABC) transporter homologous to mammalian multidrug resistance proteins, functions in the formatio

100 The mrp (multidrug resistance protein) gene has been associated w

101 The MRP (multidrug resistance protein) gene, a member of the ubiq

102 Mutation and/or overexpression of one of the multidrug resistance protein homologues found in this ma

103 sment of the affinity of drug candidates for multidrug resistance proteins is central to predict in v

104 empts in several clinical studies to reverse multidrug resistance protein (MDR) by using MDR modulato

105 staining pattern of the SP cells is due to a multidrug resistance protein (mdr) or mdr-like mediated

106 The efflux of antimony through multidrug resistance protein (MDR)-1 is the key factor i

107 extrusion of chemotherapeutic agents by the multidrug resistance protein MDR1 (p-glycoprotein).

108 shows in vitro inhibition of P-glycoprotein [multidrug resistance protein (MDR1); ABCB1], the in vivo

109 A Wistar Hannover rat model lacking the multidrug resistance protein Mdr1a P-glycoprotein (P-gp)

110 Mean multidrug resistance-protein-mediated drug efflux was si

111 hout overexpression of P-glycoprotein or the multidrug resistance protein MRP.

112 We examined the role of multidrug resistance protein (MRP) 1 (ABCC1) in the emer

113 t glutathione S-transferase (GST) P1a-1a and multidrug resistance protein (MRP) 1/2 act in synergy to

114 We have recently determined that human multidrug resistance protein (MRP) 3, which confers resi

115 eviously determined that expression of human multidrug resistance protein (MRP) 8, a recently describ

116 To address whether multidrug resistance protein (MRP) affects GO susceptibi

117 The multidrug resistance protein (MRP) family consists of ni

118 without overexpression of P-glycoprotein or multidrug resistance protein (MRP) family members sugges

119 Human multidrug resistance protein (MRP) was expressed at high

120 Pgp and the multidrug resistance protein (MRP) were not elevated in

121 and primary leukemia-cell samples, including multidrug resistance protein (MRP), breast cancer resist

122 We previously found that the multidrug resistance protein (MRP), MRP1, is overexpress

123 Multidrug resistance protein (MRP)-4 localizes to the gu

124 -overexpressing MCF-7/doxorubicin cells, and multidrug resistance protein (MRP)-expressing MCF-7/etop

125 y of ABC transporter proteins defined by the multidrug resistance protein (MRP).

126 ansmembrane conductance regulator (CFTR) and multidrug resistance protein (MRP).

127 rug transporters P-glycoprotein (Pgp) and/or multidrug resistance protein (MRP).

128 rine and human cell lines overexpressing the multidrug-resistance protein (MRP) showed a marked decre

129 The multidrug resistance protein MRP1 is an ATP-binding cass

130 The multidrug resistance protein MRP1 is an ATP-driven pump

131 Previously, we showed that multidrug resistance proteins MRP1 and MRP3 attenuate cy

132 Multidrug resistance protein (MRP1) utilizes two non-equ

133 nable cell surface localization of the human multidrug resistance protein (MRP1, ABCC1) and to assess

134 The ATP binding cassette protein, multidrug resistance protein (MRP1/ABCC1), transports co

135 ned adenine nucleotide interactions with the multidrug resistance protein, MRP1, a member of a differ

136 identified as the canalicular isoform of the multidrug resistance protein (Mrp2).

137 The multidrug resistance protein MRP4, a member of the ATP-b

138 The role of the multidrug resistance protein MRP4/ABCC4 in vivo remains

139 RECENT FINDINGS: It has been shown that the multidrug-resistance protein MRP4 may play a role in the

140 ritical for firing of action potentials, and multidrug resistance proteins (MRPs) MRP4 and MRP5 contr

141 sporters includes active drug exporters (the multidrug resistance proteins (MRPs)) and a unique ATP-g

142 subfamily includes pumps, the long and short multidrug resistance proteins (MRPs), and an ATP-gated a

143 s that is implicated in the up-regulation of multidrug resistance proteins (MRPs).

144 cs and several other endogenous metabolites, multidrug-resistance proteins (MRPs) extrude the second-

145 , can be reversed by agents that inhibit the multidrug resistance protein on the myeloma cell surface

146 f drug resistance does not appear to require multidrug resistance protein (P-glycoprotein) overexpres

147 and had substantially less interaction with multidrug resistance protein (P-glycoprotein) than curre

148 ng cassette transporter proteins such as the multidrug resistance protein, P-glycoprotein (P-gp).

149 rge superfamily of proteins that include the multidrug resistance proteins, P-glycoprotein and MRP (m

150 P-glycoprotein, also known as multidrug resistance protein, pumps drugs out of cells u

151 rough adherens junction, tight junction, and multidrug resistance protein regulation.

152 One family of these pumps, the small multidrug resistance proteins (SMRs), consists of protei

153 ystic fibrosis conductance regulator and the multidrug resistance protein subfamily of ATP-binding ca

154 Multidrug resistance proteins that belong to the ATP-bin

155 hat overexpression of either P-glycoprotein, multidrug resistance protein type 1, or multidrug resist

156 ein, multidrug resistance protein type 1, or multidrug resistance protein type 2 has little effect on

157 ATPase activity of P-glycoprotein (multidrug-resistance protein) was found to be potently i

158 ynthetase, gamma-glutamyl transpeptidase, or multidrug resistance protein were found.

159 nt human leukemia cells (HL-60-R) expressing multidrug resistance protein when compared with wild-typ