ライフサイエンスコーパス: multifaceted

1 Finally, MFP inhibition is multifaceted.

2 single mechanism or process, but instead is multifaceted.

3 rse of the disease, and imaging findings are multifaceted.

4 a cluster-randomized, controlled trial of a multifaceted 1.5-year intervention at 32 hospitals in Qu

5 Given its multifaceted ability to target monomeric and aggregated

6 y face and to underscore urgent large-scale, multifaceted actions needed to maintain them.

7 In summary, our work pinpoints a multifaceted activity of Tob1 in both homeostasis and di

8 These data reveal the remarkable multifaceted activity of TRIM56, which has developed mul

9 history in the treatment of cancer, but its multifaceted activity pattern and complex side effects p

10 a result of the limited understanding of its multifaceted aetiology.

11 A multifaceted analysis of stimulated emission depletion i

12 different types of information available by multifaceted analysis starting from raw paired-end RNA-s

13 Multifaceted and complex mechanisms control platelet pro

14 This complexity is readily reflected by the multifaceted and contextual involvement of complement-dr

15 terial, several complaints in the US alleged multifaceted and covert marketing activities.

16 We reviewed our multifaceted and evolving international collaboration an

17 CRPC is a complex, multifaceted and heterogeneous malady with limited stand

18 nismal function and integrity and requires a multifaceted and highly ordered sequence of events.

19 Mitochondria are multifaceted and indispensable organelles required for c

20 lar mechanisms that dictate CNS function are multifaceted and it is unclear how irradiation induces p

21 ed effectiveness of CGRP as a vasodilator is multifaceted and may adversely affect splanchnic perfusi

22 Disease management is multifaceted and multidisciplinary, and is focused on th

23 INTERPRETATION: A multifaceted and multilevel educational intervention, ai

24 Overall, our data uncover the multifaceted and opposing roles of M-CSFR and GM-CSFR si

25 is bacille Calmette-Guerin (BCG) vaccine are multifaceted and poorly understood.

26 ctivation as an ex vivo challenge makes it a multifaceted and promising tool for the allergist.

27 line availability or active promotion with a multifaceted and repeated intervention comprising remind

28 stem is pro-arrhythmic or anti-arrhythmic is multifaceted and varies for different types of arrhythmi

29 s likely to be achieved through longer-term, multifaceted, and collaborative approaches, with support

30 t, and it identifies accessory protein 3a as multifaceted antagonist of the avian IFN system.

31 CTFS-ForestGEO sites are experiencing multifaceted anthropogenic global change pressures inclu

32 e assistance of N in eukaryotic hosts having multifaceted antiviral defense, we demonstrate its inter

33 tion and to survive in infected hosts with a multifaceted antiviral defense.

34 due to their ability to stimulate potent and multifaceted antiviral immune responses.

35 term, robust culture system will depend on a multifaceted approach combining the ideal cell type and

36 has, therefore, emerged as an innovative and multifaceted approach for the development of new antineo

37 This work demonstrates the utility of a multifaceted approach for the study of isobaric species

38 , key stakeholders need to rapidly embrace a multifaceted approach including a reduction in the cost

39 A multifaceted approach is imperative to control and preve

40 However, a multifaceted approach that engages policymakers, educato

41 tarium to combat CRE is extremely limited, a multifaceted approach that includes antimicrobial stewar

42 he diagnosis of histoplasmosis is based on a multifaceted approach that includes clinical, radiograph

43 A multifaceted approach that includes stronger activators

44 a diagnosis of CCA, providers should apply a multifaceted approach that involves biliary cytology, FI

45 habitat groups underscore the relevance of a multifaceted approach to measuring biodiversity change.

46 expression could be applicable as part of a multifaceted approach to optimize the production of HSPC

47 Using a multifaceted approach we systematically characterize FR

48 To identify new AF-related genes, we used a multifaceted approach, combining large-scale genotyping

49 Improving outcomes will depend on a multifaceted approach, including correction of modifiabl

50 ng from an IQ-oriented diagnosis system to a multifaceted approach, introducing more flexibility and

51 Determination of commutability may require a multifaceted approach; the lack of commutability seen wh

52 iscuss their potential ramifications for the multifaceted approaches of zoology and botany.

53 Here, we make multifaceted approaches to characterize F77 antigen, inc

54 ling inhibition by NO2-OA in TNBC cells were multifaceted, as NO2-OA (a) inhibited the inhibitor of N

55 ul understanding of demographic responses to multifaceted aspects of global changes, such as climate

56 Impulsivity, a multifaceted behavioral hallmark of attention-deficit/hy

57 tri-n-octylphosphine, in these reactions, is multifaceted: besides acting as selective solvating liga

58 strate that both the ASC and pyrin PYDs have multifaceted binding modes, involving three sites on pyr

59 The multifaceted biointerfacing enabled by the platelet memb

60 and binding partners, point to the protein's multifaceted biological functions.

61 This paper synthesizes ideas stressing the multifaceted biological relevance of phytoplankton chytr

62 We sought to determine whether a multifaceted BP control program that uses a web-based he

63 Carrageenan catabolism relies on a multifaceted carrageenan-induced regulon, including a no

64 Injury or disease to the CNS results in multifaceted cellular and molecular responses.

65 Our data suggest that DDX3X initiates a multifaceted cellular program involving dynamic associat

66 Our data demonstrate that DDX3X initiates a multifaceted cellular program involving dynamic associat

67 The multifaceted character of 5f electrons in actinide mater

68 dical materials can be synthesized that have multifaceted chemical, biological and physical character

69 Multifaceted chikungunya surveillance in Puerto Rico res

70 A multifaceted, collaborative change intervention aimed at

71 ive areas for continuing research into these multifaceted complexities.

72 and sophisticated ability to counteract the multifaceted components of human innate defense.

73 Down syndrome (DS), trisomy 21, is a multifaceted condition marked by intellectual disability

74 is is the first study to explore coping as a multifaceted construct and its relationship with family

75 nal symptom despite research demonstrating a multifaceted construct.

76 These data illustrate the surprisingly multifaceted contribution of AS1-AS2 to leaf development

77 Characterizing the multifaceted contribution of genetic and epigenetic fact

78 Thus, LCs make multifaceted contributions to cutaneous carcinogenesis,

79 This knowledge will allow generation of multifaceted control strategies, including cultural, phy

80 soils, was used as an exemplar nonmodel and multifaceted crop response well-disposed to the study of

81 IL-32 is a multifaceted cytokine with a role in infections, autoimm

82 ts indicate that RBC-targeted scFv/TM exerts multifaceted cytoprotective effects and may find utility

83 In summary, the multifaceted data support a rosette CSC with 18 CESAs th

84 We compiled a multifaceted dataset to quantify coastal trends and exam

85 -1-driven pore-induced cell death triggers a multifaceted defense against intracellular bacteria faci

86 Yet, muscular exercise makes unique and multifaceted demands on the respiratory system.

87 The multifaceted design strategies and the orthogonal protoc

88 that regulate these processes, we applied a multifaceted discovery platform and found that Daam2-PIP

89 Alzheimer's disease is a multifaceted disease.

90 eurofibromatosis type 1 (NF1), a single-gene multifaceted disorder with comparatively high co-occurre

91 onstant attack from genotoxins and rely on a multifaceted DNA damage response (DDR) network to mainta

92 Instead, ParA-AMPPNP dimerization creates a multifaceted DNA-binding surface, allowing it to prefere

93 in is an apical kinase that orchestrates the multifaceted DNA-damage response.

94 However, to address the multifaceted drug delivery challenges ahead and further

95 Further, we demonstrate the multifaceted dynamics of lymphangiogenesis and valvuloge

96 A multidisciplinary team conducted a multifaceted educational intervention in our tertiary-ca

97 We assessed the impact of a multifaceted educational intervention, versus usual care

98 , which are translational repressors, have a multifaceted effect on the reprogramming of mouse embryo

99 This study highlights the multifaceted effects of environmental change and fishing

100 This study unravels multifaceted effects of licensing on NK cell populations

101 ts suggest that variable LOS structures have multifaceted effects on homeostatic innate immune respon

102 hese findings reveal that BCL6 has broad and multifaceted effects on Tfh biology and provide insight

103 Despite a large and multifaceted effort to understand the vast landscape of

104 l lung fibrosis initiative that unites these multifaceted efforts into a single virtual umbrella stru

105 lective cytotoxicity of HO-3867 seemed to be multifaceted, eliciting differential activation of the A

106 vels of protein-disulfide isomerase (PDI), a multifaceted endoplasmic reticulum resident chaperone, h

107 hat the self-assembly of small molecules, as multifaceted entities and processes to interact with mul

108 None of them, however, considered multifaceted environmental drivers and the coupled analy

109 A multifaceted ERAS program designed with a particular foc

110 forks, represents a conserved feature of the multifaceted eukaryotic DNA damage response.

111 her combinatorial mechanisms can explain its multifaceted existence.

112 Here, we report a multifaceted experimental and computational study of hal

113 A multifaceted experimental approach that included structu

114 Nature supports multifaceted forms of life.

115 de, the hexaphyrin skeleton has emerged as a multifaceted frame exhibiting strong interplay between t

116 upled with strong silane activation, effects multifaceted frustrated-Lewis-pair-type catalysis.

117 Hence, we propose that the multifaceted functional properties exhibited by methaqua

118 the cephalopod protein reflectin demonstrate multifaceted functionality as infrared camouflage coatin

119 , these findings indicate that REM sleep has multifaceted functions in brain development, learning an

120 R)-targeted HSP40 co-chaperone that performs multifaceted functions involved in coordinating ER and e

121 This article summarizes how these multifaceted functions of exosomes may promote developme

122 In this review, we discuss the multifaceted functions of long noncoding RNAs and highli

123 T1 in melanoma progression, underscoring the multifaceted functions that immunomodulatory factors may

124 In this Primer, I summarise how this multifaceted gene functions in various mammalian tissues

125 Recent studies underscore the multifaceted, genetically heterogeneous nature of TKI re

126 review summarizes the evidence supporting a multifaceted hypothesis of the natural history of athero

127 he perception and experience of the complex, multifaceted identities that both complicate and enrich

128 Narcolepsy patients displayed multifaceted immune activation in CD4(+) and CD8(+) T ce

129 uated influenza vaccines (LAIVs) stimulate a multifaceted immune response including cellular immunity

130 These studies demonstrate that Chi3l1 is a multifaceted immune stimulator of tumor progression and

131 f colonized patients combined with effective multifaceted infection control practices can reduce the

132 ed by Bp and Bm.Melioidosis and glanders are multifaceted infections caused by gram-negative bacteria

133 rs (GPCRs) is an important component of this multifaceted inflammatory cascade.

134 These results demonstrate the multifaceted influence of age on both fitness and sexual

135 In keeping with the multifaceted influence of sleep on health and well-being

136 ntrol of the parasite population by a potent multifaceted innate immune response that engages residen

137 These multifaceted interactions achieve dominance over neural

138 and (3) improvements in our knowledge of the multifaceted interactions between disease agents and ins

139 Phe accumulation had multifaceted intercompartmental effects on aromatic amin

140 feasibility, effectiveness, and safety of a multifaceted intervention designed to increase the use o

141 A multifaceted intervention improved compliance with a ped

142 Pakistan, and Zambia) to standard care or a multifaceted intervention including components to improv

143 We evaluated the effect of a sequential multifaceted intervention on decreasing albumin use in I

144 ether the Matrika social franchising model-a multifaceted intervention that established a network of

145 We organized a multifaceted intervention to improve adherence with evid

146 A multifaceted intervention was associated with improved c

147 uality improvement initiative was based on a multifaceted intervention.

148 single intervention may be an alternative to multifaceted interventions currently recommended to impr

149 in D supplementation, exercise regimens, and multifaceted interventions incorporating several approac

150 , home modification to reduce fall risk, and multifaceted interventions to prevent falls in all age g

151 improvement in asthma health outcomes using multifaceted interventions.

152 -18Ralpha and exploited IL-1R8 to activate a multifaceted intracellular anti-inflammatory program.

153 In a multifaceted investigation combining local soft X-ray an

154 This interaction is multifaceted, involving the co-chaperone RAC and two spe

155 verse regulator of DNA replication combining multifaceted kinase-dependent functions with a kinase-in

156 e genetics to address these obstacles with a multifaceted LAV design that combined the codon deoptimi

157 the hematogenous spread of viruses requires multifaceted layers of protection and relies heavily on

158 of etioplasts into mature chloroplasts via a multifaceted, light-driven process comprising multiple,

159 of mutant dopamine transporter demonstrated multifaceted loss of dopamine transporter function.

160 that mTORC1 drives HIF-1alpha synthesis in a multifaceted manner through 4E-BP1/eIF4E, S6K1 and STAT3

161 ve applications for these highly interesting multifaceted materials.

162 ant in vitro system allows us to discern the multifaceted mechanism of FeCl3-induced thrombosis, ther

163 Our results provide novel insights into the multifaceted mechanism of SYS signaling transport and it

164 dependent inactivation (VDI), resulting in a multifaceted mechanism underlying ASD.

165 Our study also suggested a complex multifaceted mechanism underlying physical interaction b

166 rved in DARA-treated patients and the drug's multifaceted mechanisms of action.

167 These multifaceted mechanisms underlie the efficacy of therape

168 0), is presented with the aim of elucidating multifaceted mechanisms underpinning the complex electro

169 ogic systems, whereas extracellular ATP is a multifaceted mediator of several cell functions via its

170 Multifaceted medical therapy reduces the risk of stroke

171 RCR can serve as one component of a multifaceted metric that provides an effective data-driv

172 A growing body of evidence suggests multifaceted mitochondrial dysfunction in mental disorde

173 This work reveals a multifaceted model of lncRNA-mediated transcriptional re

174 ified PI3K/Akt regulation of glycolysis as a multifaceted modulator of single-cell metabolic dynamics

175 these data demonstrate that endophilin is a multifaceted molecule that precisely integrates activiti

176 This is a multifaceted, multistakeholder problem.

177 A multifaceted national effort employed novel strategies t

178 well understood, as it is complicated by the multifaceted nature of bacterial virulence, which has so

179 ssibility are critical for understanding the multifaceted nature of bacterial virulence.

180 Findings highlight the multifaceted nature of both concepts and culture: Indivi

181 As the multifaceted nature of ncRNAs continues to be revealed,

182 Collectively, we established SMCR8 as multifaceted negative autophagy regulator.

183 L-27 has not been defined as a part of these multifaceted neuroendocrine networks.

184 Tau is a multifaceted neuronal protein that stabilizes microtubul

185 A multifaceted NMR analysis now demonstrates that this mut

186 The multifaceted oncogene c-Myc plays important roles in the

187 Overall, our study demonstrates the multifaceted oncogenic function of the protein lysine me

188 egradation and activates telomerase, but the multifaceted oncoprotein has numerous other functions th

189 Blending elements of RA and LCA offers multifaceted opportunities to adapt a given environmenta

190 f inter-chromosomal translocations, offering multifaceted opportunities to study complex structural v

191 Modulation at the level of C3, a multifaceted orchestrator of the complement cascade, ope

192 rmation out of individual pancreas providing multifaceted parameters to study the intrinsic heterogen

193 ity of controlled animal studies to the more multifaceted pattern of human pathophysiology, especiall

194 The possible correlation between the multifaceted phenomenology of aura symptoms and the effe

195 lth of refugee children and adolescents is a multifaceted phenomenon that needs to be understood and

196 Murine double minute-2 protein (Mdm2) is a multifaceted phosphorylated protein that plays a role in

197 Our observations point to GRFs as new multifaceted players in Ribi gene regulation both during

198 A sustained, multifaceted policy intervention involving health and ed

199 The resurgence of pertussis is a multifaceted problem, but the implementation of immuniza

200 ) fishing and seafood supply chain fraud are multifaceted problems that demand multifaceted solutions

201 efficient surface protection to address the multifaceted problems, which is a significant step forwa

202 e to an independent physician-scientist is a multifaceted process requiring a sustained commitment fr

203 Contact inhibition of locomotion (CIL) is a multifaceted process that causes many cell types to repe

204 Post-MI cardiac remodeling is a multifaceted process that includes activation of fibrobl

205 TLR agonist-induced TAG storage is a multifaceted process that persists long after most early

206 We propose that CO control is a multifaceted process whose different aspects have a vary

207 Decision making is a multifaceted process, consisting of several distinct pha

208 though induction of cardiac hypertrophy is a multifaceted process, inhibition of Shp2 activity throug

209 RANKL is involved in multifaceted processes of immunoregulation and bone reso

210 ccess of real-world PrEP will likely require multifaceted programs addressing barriers to its provisi

211 Together, our results demonstrate a multifaceted protective potential of NRF2 signaling in k

212 mary healthcare centers, we tested whether a multifaceted quality improvement intervention comprising

213 eated in ICUs in Brazil, implementation of a multifaceted quality improvement intervention with daily

214 We describe the effect of a multifaceted quality improvement program designed to dec

215 Implementation of a multifaceted quality improvement program including finan

216 A multifaceted quality improvement program including provi

217 ter randomized controlled trial evaluating a multifaceted quality intervention (education, pathways,

218 ntial generation of several intermediates of multifaceted reactivity, including diazoalkane derivativ

219 viral nonstructural protein facilitates the multifaceted regulation of capsid gene expression.

220 in various plastids expands our view on the multifaceted regulation of carotenogenesis and facilitat

221 calization, turnover, and, most importantly, multifaceted regulation of its function in the heart.

222 are polymodal in their function and exhibit multifaceted regulation with various molecular compounds

223 ariation of APC/C(CDC20)-MCC underlying this multifaceted regulation.

224 ts suggest that the GPR56 ECR has unique and multifaceted regulatory functions, providing novel insig

225 Thus, we identify multifaceted regulatory roles for CTLA-4 in Tfh, Tfr, an

226 ng species that share a zone of contact is a multifaceted relationship affected by climate change [1,

227 l safety surveillance and a key component of multifaceted research surveillance, patient and family r

228 led the S-phase checkpoint, which produces a multifaceted response that preserves genome integrity at

229 Cancer cells undergo a multifaceted rewiring of cellular metabolism to support

230 The Ewing Sarcoma protein (EWS) is a multifaceted RNA binding protein (RBP) with established

231 Coimmunoprecipitation studies revealed a multifaceted role for Bcl-2 in binding proapoptotic part

232 nd FIs in antiviral therapies and point to a multifaceted role for chemokine receptor binding in prom

233 Our study highlights a multifaceted role for Notch signaling in distinct aspect

234 Taken together, these data revealed a multifaceted role for PAR-1 in leukemogenesis, and highl

235 Platelets play a multifaceted role in cancer progression and metastasis.

236 in the treatment of PRC loss because of its multifaceted role in cellular survival.

237 ell-to-cell fusion, while HN169R possesses a multifaceted role in contributing to higher fusion, redu

238 y has identified a new AR coregulator with a multifaceted role in prostate cancer, functioning as an

239 Our data suggest that WC1 gene arrays play a multifaceted role in the gammadelta T cell response to b

240 Among their multifaceted role in the modulation of biological respon

241 Together, our study demonstrates the multifaceted role of CXCR4 in defining BM monocyte heter

242 Our results uncover the multifaceted role of DDX21 in multiple steps of ribosome

243 In this review, we highlight the multifaceted role of mechanics in pattern formation, fro

244 Taken together, our findings highlight the multifaceted role of miR-155 in T cells, in which it pro

245 onal reporter strain provided evidence for a multifaceted role of nostopeptolides, either as an autog

246 Collectively, these data reveal the multifaceted role of PRC2 in hematopoiesis, with diverge

247 The multifaceted role of the gastrointestinal system in Park

248 with previous observations hint at a complex multifaceted role of the natural product within the rhiz

249 PP plays a multifaceted role, slowing the reaction by complexing bo

250 ms to control pDC function in light of their multifaceted roles during immunity, autoimmunity, and ca

251 issue of Neuron, Berg et al. (2015) uncover multifaceted roles for janus kinase and microtubule-inte

252 ging evidence that chromatin regulators have multifaceted roles in cell fate decisions.

253 DP-ribose from the coenzyme NAD(+) and plays multifaceted roles in cellular responses to genotoxic st

254 c immediate hypersensitivity, as well as its multifaceted roles in protective immunity, control of ma

255 sites and mitochondria, consistent with its multifaceted roles in regulating centrosome integrity, d

256 Together, our data reveal that CCR7 plays multifaceted roles in regulating collecting vessel perme

257 Dendritic cells (DCs) and their subsets have multifaceted roles in the early stages of HIV-1 transmis

258 The microbiome plays multifaceted roles in the pathogenesis of inflammatory b

259 s, or therapeutic agents, play important and multifaceted roles in the regulation of malignant diseas

260 He presented the Banting Lecture, "The Multifaceted Roles of Adipose Tissue-Therapeutic Targets

261 clinical studies are necessary to unveil the multifaceted roles of Lcn2 in iron dysregulation during

262 mechanisms were identified that regulate the multifaceted roles of RARs in the salamander limb includ

263 These findings highlight the multifaceted roles of Wnt signaling in the normal develo

264 These results reveal multifaceted roles of YAP in PDAC pathogenesis and under

265 We used a multifaceted screening strategy that integrates bioinfor

266 ying novel biased KOR agonists, we applied a multifaceted screening strategy utilizing both in silico

267 laminated ring (R) neuron axons and mediates multifaceted sensory integration and motor coordination

268 ntroller of innate immunity, now stands as a multifaceted signaling family with a broad range of phys

269 ized mice can provide a means to examine the multifaceted sites of HIV-1 replication including, but n

270 fraud are multifaceted problems that demand multifaceted solutions.

271 These studies have illustrated the multifaceted somatic functions of the pathway not only i

272 that provide additional levels of processing multifaceted sound stimuli.

273 ization reactions carried out exclusively by multifaceted sRNAs that are both targets of and triggers

274 cies for improving the food environment need multifaceted strategies to invoke clinically meaningful

275 S:4 is very remarkable, owing to the unique, multifaceted structural features that have been combined

276 The immune system is multifaceted, structured by diverse components that inte

277 urrent threats to freshwater ecosystems, yet multifaceted studies on the potential impacts of climate

278 This multifaceted study generates a powerful resource and inf

279 In this work, first a multifaceted study of the influence of various factors o

280 This multifaceted study provides new insights in common and s

281 Comprehensive, multifaceted suicide prevention programs, including gate

282 As the first report of multifaceted supramolecular assemblies of cholesterol co

283 red after L-DOPA treatment but also disclose multifaceted synaptic adaptations occurring in response

284 The multifaceted synaptic connections provide spinal network

285 PDX1 is remarkable given its multifaceted synthetic ability to carry out isomerizatio

286 is review is to develop the concept that the multifaceted therapeutic effects of low-dose aspirin may

287 Among the latter especially lipocalins are multifaceted: they may have an immunomodulatory function

288 ral relevant metabolic pathways suggesting a multifaceted toxicity of BMAA including: (1) localized p

289 Bacterial virulence is a multifaceted trait where the interactions between pathog

290 er expands our understanding of this complex multifaceted transcription factor.

291 and attempts to place ivabradine within the multifaceted treatment scheme currently used for patient

292 e described in this paper to demonstrate its multifaceted usability.

293 extural properties which are vital for their multifaceted use.

294 Implementation of a multifaceted value-driven outcomes tool to identify high

295 esults underscore the need for extensive and multifaceted variation to assess and minimize steric and

296 We provide a multifaceted view on cerebral correlates of sleep loss a

297 that AMPylation of Rho GTPases by VopS is a multifaceted virulence mechanism that counters several h

298 e framework presented herein articulates the multifaceted ways in which epidemiologic methods make su

299 fluencing neuronal and synaptic functions in multifaceted ways.

300 We identified multifaceted yield-limiting factors involving agronomic,