ライフサイエンスコーパス: multifunctional enzyme

1 Human tissue transglutaminase (hTG2) is a multifunctional enzyme.

2 somerase (hPDI), is an essential four-domain multifunctional enzyme.

3 tion may be an important determinant of this multifunctional enzyme.

4 nal events is proposed to help regulate this multifunctional enzyme.

5 n that has been excised from the full-length multifunctional enzyme.

6 mine transaminase K (hKAT-I) is an important multifunctional enzyme.

7 n the SCP-2-like domain from the peroxisomal multifunctional enzyme.

8 the structure/function correlations of this multifunctional enzyme.

9 to function as a scaffold protein for three multifunctional enzymes.

10 nd the fact that some of the potent MMPs are multifunctional enzymes.

11 Metabolite channeling is a common feature of multifunctional enzymes.

12 e-diphosphate-kinases (NDKs) are leaderless, multifunctional enzymes.

13 s characterization of activities mediated by multifunctional enzymes.

14 te- and stereo-selectivity of this family of multifunctional enzymes.

15 illustrate the limits to modularity of these multifunctional enzymes.

16 hondria, whereas peroxisomes contain ECI and multifunctional enzyme 1 (MFE1).

17 the NH2-terminal domain of the multidomain, multifunctional enzyme, 10-formyltetrahydrofolate dehydr

18 A novel target is the multifunctional enzyme acetyl-CoA carboxylase (ACC), whi

19 n debranching enzyme (gene symbol, AGL) is a multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-

20 This multifunctional enzyme also has inositol 3,4,5,6-tetraki

21 like all members of the cyclase family, is a multifunctional enzyme and catalyzes NAD(+) glycohydrola

22 ostulate the domain organization of a set of multifunctional enzymes and a cluster of genes (pps) tha

23 vitro assays indicate that LAP5 and LAP6 are multifunctional enzymes and may play a role in both the

24 he human SCHAD gene product, a single-domain multifunctional enzyme, appears to function in two diffe

25 The multifunctional enzyme apurinic endonuclease 1/redox enh

26 t the comparatively weak activities of these multifunctional enzymes are each physiologically relevan

27 These large multifunctional enzymes are organized into "modules", wh

28 in modifier, and transglutaminase 2 (TG2), a multifunctional enzyme, are known to be activated during

29 rovide specificity in the activation of this multifunctional enzyme by distinct cellular stimuli and

30 l phosphate synthetase (CPS II), part of the multifunctional enzyme CAD.

31 ny polyketides are synthesized by a class of multifunctional enzymes called type I modular polyketide

32 Alternative targeting of bifunctional or multifunctional enzymes can exploit eukaryotic subcellul

33 tive enzymes, broad-specificity enzymes, and multifunctional enzymes can often substitute for a missi

34 tissues are primarily controlled by CD38, a multifunctional enzyme capable of both synthesizing and

35 CD38 is a multifunctional enzyme capable of generating metabolites

36 Biotin-dependent multifunctional enzymes carry out metabolically importan

37 dent enzymes and presents a new paradigm for multifunctional enzyme catalysis.

38 1 or sterol 27-hydroxylase) is a ubiquitous, multifunctional enzyme catalyzing regio- and stereospeci

39 among which fatty acid synthase (FASN), the multifunctional enzyme catalyzing the de novo synthesis

40 nctions not only as a receptor but also as a multifunctional enzyme,catalyzing the synthesis of and h

41 decreased levels of the apoptosis-associated multifunctional enzyme CD38.

42 Its synthesis is catalyzed by multifunctional enzymes, CD38 and ADP-ribosyl cyclase (c

43 ridoxal 5'-phosphate (PLP) is a fundamental, multifunctional enzyme cofactor used to catalyze a wide

44 xyerythronolide B synthase (DEBS), are large multifunctional enzyme complexes that are organized into

45 LigD is a multifunctional enzyme composed of a ligase domain fused

46 LigD is a multifunctional enzyme composed of a ligase domain fused

47 ACC is a multifunctional enzyme composed of three separate protei

48 alyzed by individual monofunctional enzymes, multifunctional enzymes comprising several domains, or e

49 The Escherichia coli form is a multifunctional enzyme consisting of three separate prot

50 ulin-dependent protein kinase II (CaMKII), a multifunctional enzyme critically involved in synaptic p

51 report a chemosynthetic route relying on the multifunctional enzyme CrpD-M2 that incorporates a 2-hyd

52 encing (RISC) complex requires the essential multifunctional enzyme Dicer.

53 trates the evolutionary conservation of this multifunctional enzyme family.

54 , an insulin-dependent process driven by the multifunctional enzyme fatty-acid synthase (FAS), mainta

55 Dehaloperoxidase (DHP A), a unique multifunctional enzyme, from the marine annelid Amphitri

56 ew tools for manipulating and studying these multifunctional enzymes have been developed.

57 arge majority of histidine kinases (HKs) are multifunctional enzymes having autokinase, phosphotransf

58 Class II genes (AtTPS5-AtTPS11) encode multifunctional enzymes having synthase and phosphatase

59 Phospholipase Cepsilon (PLCepsilon) is a multifunctional enzyme implicated in cardiovascular, pan

60 est structural relatives of CblD are CblC, a multifunctional enzyme important for cobalamin trafficki

61 EJ are the most mechanistically flexible and multifunctional enzymes in each of their classes.

62 1/redox effector factor 1 (APE1/Ref-1) is a multifunctional enzyme involved in DNA repair and activa

63 CD38 is a multifunctional enzyme involved in metabolizing two Ca(2

64 Tissue transglutaminase (TG2) is a multifunctional enzyme involved in protein cross-linking

65 nd drrA, which constitute an operon encoding multifunctional enzymes involved in the biosynthesis of

66 arides to soluble sugars, many organisms use multifunctional enzyme mixtures consisting of glycoside

67 The multifunctional enzyme NSP2, an octamer with RNA binding

68 r signals that determine the turnover of the multifunctional enzyme nucleoside diphosphate kinase A (

69 cyte antigen and recently also found to be a multifunctional enzyme participating in the synthesis an

70 Non-structural protein 3 (NS3) is a multifunctional enzyme possessing serine protease, NTPas

71 TDP2 is a multifunctional enzyme previously known for its role in

72 HIV-1 reverse transcriptase (HIV-1 RT) is a multifunctional enzyme responsible for converting viral

73 lly pine (Pinus taeda) xylem cDNA encoding a multifunctional enzyme, SAM:hydroxycinnamic Acids/hydrox

74 e little-considered role of some proteins as multifunctional enzymes - substitutes for 'missing' gene

75 we discuss several of nature's most notable multifunctional enzyme systems including the AROM comple

76 n (Pik) polyketide synthase (PKS) are unique multifunctional enzyme systems that are responsible for

77 new model for molecular dissection of these multifunctional enzyme systems.

78 Here, we provide evidence that CYP76C1 is a multifunctional enzyme that catalyzes a cascade of oxida

79 human immunodeficiency virus-1 (HIV-1) is a multifunctional enzyme that catalyzes the conversion of

80 homocysteine nucleosidase (MTAN) enzyme is a multifunctional enzyme that catalyzes the hydrolysis of

81 Aldose reductase (AR) is a multifunctional enzyme that catalyzes the reduction of g

82 A single gene (mas) encodes the multifunctional enzyme that catalyzes the synthesis of v

83 I) is one of the glycolytic enzymes and is a multifunctional enzyme that functions in glucose metabol

84 ehyde-3-phosphate dehydrogenase (GAPDH) is a multifunctional enzyme that has been associated with neu

85 Transglutaminase 2 (TG2) is a multifunctional enzyme that has been implicated in the p

86 in-dependent protein kinase II (CaMKII) is a multifunctional enzyme that is postulated to be the down

87 in-dependent protein kinase II (CaMKII) is a multifunctional enzyme that is very critical for synapti

88 YfcX is shown to be a multifunctional enzyme that minimally encodes hydratase

89 RecBCD is a multifunctional enzyme that possesses both helicase and

90 We conclude that HydG is a multifunctional enzyme that produces DHG, CN(-), and CO

91 Aldose reductase (AR) is a multifunctional enzyme that reduces aldehydes.

92 n fatty acid synthase is a large homodimeric multifunctional enzyme that synthesizes palmitic acid.

93 Type I polyketide synthases (PKSs) are multifunctional enzymes that are organized into modules,

94 Modular polyketide synthases are giant multifunctional enzymes that catalyse the condensation o

95 Modular polyketide synthases are large multifunctional enzymes that direct the biosynthetic pro

96 They are key, multifunctional enzymes that have been linked to three h

97 Thiol isomerases are multifunctional enzymes that influence protein structure

98 ng iterative polyketide synthases are large, multifunctional enzymes that make important metabolites

99 Hepadnavirus polymerases are multifunctional enzymes that play critical roles during

100 thione S-transferases (GSTs) are a family of multifunctional enzymes that play critical roles in the

101 ative polyketide synthases (PKSs) are large, multifunctional enzymes that resemble eukaryotic fatty a

102 e I polyketide synthases (PKSs) are complex, multifunctional enzymes that synthesize structurally div

103 3 provides a platform for generating bespoke multifunctional enzymes that target industrially signifi

104 ic gramicidin S is accomplished by two large multifunctional enzymes, the peptide synthetases 1 and 2

105 The multifunctional enzyme transglutaminase 2 (TG2) is the t

106 Previous studies have established that multifunctional enzymes use methylmalonyl coenzyme A (Co

107 ber of a newly defined family of prokaryotic multifunctional enzymes, which includes the Escherichia

108 The Dna2 protein is a multifunctional enzyme with 5'-3' DNA helicase, DNA-depe

109 al NS3 protein of the hepatitis C virus is a multifunctional enzyme with an N-terminal serine proteas

110 onuclease of human cells, Ape1 protein, is a multifunctional enzyme with critical roles in base excis

111 Protein phosphatase 1 (PP1) is a multifunctional enzyme with diverse roles in the nervous

112 The P gene product is believed to be a multifunctional enzyme with DNA-dependent DNA polymerase

113 that it encodes LH3, a myotomally expressed multifunctional enzyme with lysyl hydroxylase and glycos

114 rus (HCV) nonstructural protein 3 (NS3) is a multifunctional enzyme with serine protease and DEXH/D-b

115 V) nonstructural 3 protein (NS3) is a 70-kDa multifunctional enzyme with three known catalytic activi

116 Tissue transglutaminase (tTG) is a multifunctional enzyme with transglutaminase crosslinkin

117 Bacterial chondroitin polymerase K4CP is a multifunctional enzyme with two active sites.