ライフサイエンスコーパス: multigene

1 pendent populations has been used to develop multigene algorithms for estimating recurrence risk and

2 rouracil (FU) and leucovorin (LV) to develop multigene algorithms to quantify the risk of recurrence

3 Coordinate regulation of a multigene alpha-KG synthesis and transport pathway resul

4 Products of the multigene alpha-zein families and the single-gene gamma-

5 An associated multigene analysis enabled us to infer the nature of sel

6 molecules, plant transformation with linked multigenes and plant artificial chromosomes.

7 that marker status to other treatments (eg, multigene assay and breast cancer).

8 of the MR radiomics features relative to the multigene assay classifications.

9 [RS]) categories of a commercially available multigene assay influences the power of randomized trial

10 P < .0001) between radiomics signatures and multigene assay recurrence scores.

11 netic resonance (MR) imaging phenotypes with multigene assays of MammaPrint, Oncotype DX, and PAM50 t

12 This first multigene association genetic study in forest trees has

13 on a recent large dataset, multispecies, and multigene-based alignment.

14 Germline testing with multigene cancer panels should be considered for all you

15 to have occurred by tandem duplication of a multigene cassette that was not found in the mixed-strai

16 t baculovirus carrying a vector containing a multigene cassette was created to coexpress in insect ce

17 efficient assembly of bacterial marker free multigene cassettes containing up to six complementary D

18 d to it, with alcohol dependence indicates a multigene causality for this complex disorder.

19 To determine if a multigene classifier is associated with indolent behavio

20 lecular classification system and prognostic multigene classifiers based on microarrays or derivative

21 The human Growth Hormone (hGH) multigene cluster contains five gene paralogs.

22 to tissue-specific gene regulation within a multigene cluster.

23 Analogous multigene clusters also encode the immunodominant outer

24 Multigene clusters collectively upregulate in single aph

25 xpressed genes and DNA vaccines based on the multigene clusters have been shown to induce protective

26 Recent studies of several multigene clusters have shown that gene activation by a

27 ), controlled by a single highly polymorphic multigene complex termed the S-locus.

28 y on the actions of the LCR, but also on the multigene composition of the cluster itself.

29 ntal specificity is dependent on the overall multigene configuration of the cluster whereas the dista

30 stably transformed, respectively, by several multigene constructs, and the expression of the transfor

31 and we show that it can be used to assemble multigene constructs.

32 Here, we use taxon-rich multigene data combined with diverse fossils and a relax

33 Here we estimate divergence times using a multigene data set with multiple fossil calibrations and

34 defects at the neuromuscular junction in the multigene deficiency strain were the likely basis of its

35 We previously reported that mice carrying a multigene deletion (Df1) that models 22q11DS have reduce

36 utions, an intragenic deletion, and a 4.7-Mb multigene deletion involved the DNA-binding domain of IK

37 nfectious cycle, we screened a S Typhimurium multigene deletion library in Caco-2 C2Bbe1 and HeLa epi

38 uman homologue is a component of two related multigene deletion syndromes in humans.

39 Multigene delivery and subsequent cellular expression is

40 Autism is currently considered a multigene disorder with epigenetic influences.

41 exes via coexpression of their subunits from multigene DNA constructs.

42 eotides a completely de-novo-designed, 58-kb multigene DNA.

43 etween teleosts and tetrapods and suggests a multigene duplication event.

44 nological advances in data mining, modeling, multigene engineering and genome editing are now taking

45 xample to establish principles of successful multigene engineering by stable transformation of the ch

46 ates fully exchangeable genetic elements for multigene engineering, the GB2.0 toolkit offers an everg

47 perimenter's choice of the best strategy for multigene engineering.

48 y protocols for GB2.0 part domestication and multigene engineering.

49 The multigene ethylene receptor family has been shown to neg

50 nough to allow the manual generation of many multigene expression constructs in parallel.

51 approach is challenging and inefficient for multigene expression due to increased labour for cloning

52 al oncogene effects to weak but quantifiable multigene expression effects.

53 system expediting highly efficient transient multigene expression from a variety of promoters.

54 Multigene expression is required for metabolic engineeri

55 Two measures of information based on multigene expression profiles are considered for a backw

56 By considering multigene expression profiles, we are able to utilize in

57 Using this approach, we demonstrated multigene expression profiling of individual CTCs from n

58 f 14 (TRIM14) as a component of a prognostic multigene expression signature for NSCLC.

59 nd comparable to those of microarray-derived multigene expression signatures.

60 d, also by a one-step cloning, into a binary multigene expression vector for transient or stable coex

61 ast cancers are imperfect when compared with multigene expression-based assays.

62 A cargo capacity, thus impeding unrestricted multigene expression.

63 id transfer proteins (nsLTPs) are encoded by multigene families and possess physiological functions t

64 s an inherent property of highly polymorphic multigene families and that it cannot be taken as eviden

65 ral differences between divergent members of multigene families are functionally important.

66 Major repeat sequences and multigene families are largely free of DNA methylation.

67 Several multigene families encode RNA binding proteins (RNABPs)

68 Multigene families encoding class XI myosins are conserv

69 These findings suggest that novel multigene families encoding diversified immune receptors

70 ls large-scale duplication and divergence of multigene families encoding molecules that effect innate

71 ocyte Membrane Protein 1 (PfEMP1), two other multigene families encoding STEVOR and RIFIN are express

72 able expression of individual members of the multigene families encoding these genes also occurs duri

73 eplication-dependent histones are encoded by multigene families found in several large clusters in th

74 Our phylogenetic analyses of 11 multigene families from five species belonging to distin

75 In mammals, small multigene families generate spliceosomal U snRNAs that a

76 es encoding PP2A subunits have expanded into multigene families in both flowering plants and mammals,

77 specific opportunities to target members of multigene families in crops.

78 ying genetic variation in homologous loci or multigene families in general.

79 unctional characterization of members of the multigene families in this model insect.

80 mb repressive complexes (PRC) are encoded by multigene families in vertebrates.

81 nctional dissection of different isoforms of multigene families involved in beta-oxidation.

82 est that representatives of the FcR and FCRL multigene families may have independently evolved to eng

83 Flowering plants have evolved multigene families of the class XI myosin motors, the fu

84 sis of homologous gene sequences either from multigene families or from different species with a spec

85 Plasmodium multigene families play a central role in the pathogenes

86 the extent of lateral transfer in bacterial multigene families should be re-examined in the light of

87 anisms that cause the concerted evolution of multigene families such as rDNA.

88 s linked to the variant expression of clonal multigene families such as the var genes.

89 s in TUBA1A and TUBB2B, each a member of the multigene families that encode alpha- and beta-tubulins,

90 Intriguingly, actinoporins appear as multigene families that give rise to many protein isofor

91 he organization of most virulence-associated multigene families, including the hypervariable var gene

92 sed in a given culture condition in expanded multigene families, suggesting that family expansi on co

93 any metazoan splicing factors are members of multigene families, with each member having different fu

94 rs performed the best at aligning genes from multigene families-perhaps the most challenging test for

95 everal E3s have expanded in their genomes as multigene families.

96 ed by at least four evolutionarily unrelated multigene families.

97 ter GA biosynthetic stages being governed by multigene families.

98 lenging when the target genes are members of multigene families.

99 d to gene-rich regions that harbor clustered multigene families.

100 roles of the different members of these OMP multigene families.

101 to characterize a large number of eukaryotic multigene families.

102 ins of gap junctions are the products of two multigene families.

103 origination, diversification and loss within multigene families.

104 he japonica genome, 38 (76%) fell into eight multigene families.

105 ry receptor (Or) and gustatory receptor (Gr) multigene families.

106 ch step is executed by components encoded by multigene families.

107 mes, many of which are encoded by members of multigene families.

108 e evolution and expression dynamics of these multigene families.

109 nce diversity, such as that seen in variable multigene families.

110 ants, the CslA genes are members of extended multigene families; however, it is not known whether all

111 ain Georgia (ASFV-G) lacking only six of the multigene family 360 (MGF360) and MGF505 genes (ASFV-G-D

112 Multigene family 360 (MGF360) and MGF505 represent a gro

113 sine, (2) determination of when members of a multigene family acquire distinct activities, (3) applic

114 shock protein 70s (Hsp70s) are encoded by a multigene family and are located in different cellular c

115 s a member of the ATP-binding cassette (ABC) multigene family and is composed of two nucleotide bindi

116 The members of this multigene family are found in all cellular organisms, mo

117 hown that subfamily 1 receptors encoded by a multigene family are present in all charophytes examined

118 Phylogenetic analysis revealed multigene family associations and faster evolution of ea

119 Like PRF and SPF, PMF is produced by a multigene family characterized by gene duplication and h

120 ity-related factor prediction, orthology and multigene family classification, transcriptome analyses,

121 Phylogenetic analyses assigned the vap multigene family complement from pVAPN, pVAPA, and pVAPB

122 bidopsis ENOD-like proteins are encoded by a multigene family composed of several types of structural

123 RIFIN proteins are products of a polymorphic multigene family comprising approximately 150-200 genes

124 rabidopsis thaliana, AUX1 belongs to a small multigene family comprising four highly conserved genes

125 lin 3-oxidase in Arabidopsis is encoded by a multigene family consisting of at least four members, de

126 TbPT0 belongs to a clustered multigene family consisting of five members, whose expre

127 In angiosperms, CAD is encoded by a multigene family consisting of members thought to have d

128 erefore, the Sperm dynein intermediate chain multigene family contributes to the differential reprodu

129 hicken Ig-like receptors (CHIRs) represent a multigene family encoded by the leukocyte receptor compl

130 In Arabidopsis, a multigene family encodes six SUS (SUS1-6) isoforms.

131 A heretofore-unrecognized multigene family encoding diverse immunoglobulin (Ig) do

132 analysis of the Chlamydiaceae has revealed a multigene family encoding large, putatively autotranspor

133 e recruitment is a common phenomenon in tRNA multigene family evolution and should be taken into cons

134 The birth-and-death model of multigene family evolution describes patterns of gene or

135 rsed repeat (pir) genes comprise the largest multigene family in many Plasmodium spp.

136 ent of microtubules, alpha-tubulin is also a multigene family in many species.

137 s related-10 (PR-10) proteins are present as multigene family in most of the higher plants.

138 nt a detailed molecular analysis of the PpcK multigene family in nodulated soybeans.

139 g our understanding of the evolution of this multigene family in nonmodel avian groups.

140 remarkable Laverania-specific expansion of a multigene family involved in erythrocyte remodelling, an

141 The MASP multigene family is specific to T. cruzi, accounting for

142 known as PfEMP1 and encoded by the multicopy multigene family known as the var genes.

143 er protection in a mouse model and to be the multigene family member primarily expressed in mammalian

144 Rhodococcus sp. NS1 and harbors six new vap multigene family members (vapN to vapS) in a vap pathoge

145 To date, certain members of this multigene family occur only in mycobacteria that cause d

146 dorant-binding proteins (OBPs), encoded by a multigene family of 51 genes.

147 ences patterned after conserved regions in a multigene family of 56 subtilisin-related proteolytic en

148 APOBEC3 proteins comprise a multigene family of antiviral cytidine deaminases that a

149 Proteins expressed from the map1 multigene family of Ehrlichia ruminantium are strongly r

150 rabidopsis thaliana) aldehyde oxidases are a multigene family of four oxidases (AAO1-AAO4) that oxidi

151 In plants, a large multigene family of glycosyltransferases is involved in

152 the context of functional redundancy of the multigene family of GTs in Arabidopsis.

153 E. chaffeensis has a multigene family of major outer membrane proteins with p

154 different protein cargoes including the MASP multigene family of proteins MASPs are specific to this

155 Glutathione transferases are a multigene family of proteins that catalyze the conjugati

156 Connexins comprise a multigene family of transmembrane proteins that form gap

157 nition may be mediated by a complex germline multigene family of V structures resembling those that a

158 A multigene family produces tubulin isotypes that are expr

159 Our work suggests that the wtf multigene family proliferated due to meiotic drive and h

160 Claudin-8 (CLDN8), a multigene family protein that constitutes the backbone o

161 of these chromosomally proximal members of a multigene family provides a mechanism for both immune ev

162 squito D7 salivary proteins are encoded by a multigene family related to the arthropod odorant-bindin

163 We deleted all the members of this multigene family resident on the X chromosome of D. mela

164 te immune type receptors (LITRs) represent a multigene family that encodes Ig superfamily proteins th

165 erged in primitive land plants and founded a multigene family that is conserved in all flowering plan

166 so called psoriasin, is a member of the S100 multigene family that is encoded in the epidermal differ

167 RL representatives are members of an ancient multigene family that share a common ancestor with the c

168 er, we report for the first time a bacterial multigene family that undergoes birth-and-death evolutio

169 InlF, a member of the internalin multigene family with no known function, was identified

170 protein expression from many members of the multigene family, despite primary high-level expression

171 IV, a secreted protein and member of the Reg multigene family, is up-regulated in malignancies of the

172 birth-and-death evolution within a bacterial multigene family, our results indicate that the extent o

173 However, Naip5 is a member of a small multigene family, raising the possibility of redundancy

174 Ets1 is a member of a multigene family, several members of which are expressed

175 One such multigene family, the acyl-CoA desaturases, is composed

176 Encoded by a multigene family, ubiquitin is expressed in the form of

177 ibed, and identify a novel branch of the ves multigene family, ves1beta.

178 The Sperm dynein intermediate chain multigene family, which encodes a Sperm dynein intermedi

179 These studies show that multigene family-specific antibodies can be applied to t

180 mylase (BAM) activity, which is encoded by a multigene family.

181 luding Arabidopsis and rice, contains a CAF1 multigene family.

182 f the surface-associated interspersed (surf) multigene family.

183 use of the difficulty in deleting this large multigene family.

184 rved in the Diptera and may be a member of a multigene family.

185 a heteromer of MSP1a and MSP1b, encoded by a multigene family.

186 ot is the COBRA (COB) gene that belongs to a multigene family.

187 specifically altering a single gene within a multigene family.

188 the prototypic member of a novel B7-related multigene family.

189 to reflect functional specification of this multigene family.

190 It is highly conserved and encoded by a multigene family.

191 usly, we identified the conserved obstructor multigene-family, which encodes chitin-binding proteins.

192 of all single open reading frames and larger multigene fragments within a genomic library that alter

193 his review describes the state of the art in multigene genetic engineering of plants.

194 nce of germline variants in other genes from multigene hereditary cancer testing panels is not well d

195 lly expressed gene), (2) periostin, or (3) a multigene IL-13 in vitro signature (IVS).

196 B and T lymphocyte systems and a polymorphic multigene immune complex, but little is known about the

197 nd, potentially, other genes residing within multigene loci.

198 istone-modifying enzymes coexist on the same multigene locus and play a crucial role in the precise c

199 e of mammals, particularly in that the large multigene locus seen in mammals is absent.

200 ase-like protein gene, W1-COE, within the W1 multigene locus.

201 tightly controlled expression from a complex multigene locus.

202 The molecular multigene marker here identified is associated with risk

203 Several multigene markers that predict relapse more accurately t

204 ypically resides in a noncoding section of a multigene messenger RNA in extremophilic Gram-positive e

205 gramming cellular phenotypes and controlling multigene metabolic pathway expression.

206 tion data sets identified and confirmed four multigene models (BI, ICE, BICE, and BITE, with each let

207 ng in fibroblast cells including single- and multigene modifications, chromosome rearrangements, and

208 s Analysis Phylogenetics), to assemble these multigene/multi species matrices and to evaluate the sig

209 In cohort 1, MT for a multigene mutation panel was performed for nonbenign cyt

210 These results help us understand the multigene nature of actinoporins and may be extended to

211 scle samples to elucidate the involvement of multigene neighborhoods in the regulation of MRF genes.

212 With the increasing use of multigene next-generation sequencing panels in hereditar

213 ff for mutational load can be identified via multigene NGS tumor profiling, which provides a highly a

214 onal studies revealed that atlA is part of a multigene operon under the control of at least three pro

215 on of both coding and noncoding RNAs, act on multigene operons and can be predictably tethered into h

216 lements, and riboregulators into single- and multigene operons with predictable functions in bacteria

217 ables reliable and predictable regulation of multigene operons.

218 cycling occurs, including microRNA loci and multigene operons.

219 tions, genetic counseling and testing with a multigene panel could be considered for all patients wit

220 s, next-generation sequence analysis using a multigene panel detected actionable germline variants in

221 ophic cardiomyopathy genetic testing (either multigene panel or familial variant test) were recruited

222 Subsequently, multigene panel testing (105 or 177 IRD-associated genes

223 implications of somatic mutation profiling, multigene panel testing for cancer susceptibility, quali

224 In a clinically representative cohort, multigene panel testing for HBOC risk assessment yielded

225 Multigene panel testing identified 114 probands with Lyn

226 n individuals with suspected Lynch syndrome, multigene panel testing identified high-penetrance mutat

227 We carried out multigene panel testing on all participants, then determ

228 Multigene panel testing pointed to a molecular diagnosis

229 (MMR) mutation carriers ascertained through multigene panel testing, evaluate their phenotype, and c

230 iewed clinical histories of patients who had multigene panel testing, including the MMR and EPCAM gen

231 P53, and 1 in CHEK2), all identified through multigene panel tests.

232 a research-based next-generation sequencing multigene panel.

233 Multigene panels are commercially available tools for he

234 emental value compared with disease-specific multigene panels that have been the cornerstone of genet

235 predisposition genes with hereditary cancer multigene panels.

236 evolving owing to the recent introduction of multigene panels.

237 ly incorporated into the control of complex, multigene pathways and cellular functions.

238 Recombination," a robust method for building multigene pathways directly in the yeast chromosome.

239 adly accessible methodology for constructing multigene pathways inside of the cell.

240 ake possible large-scale projects focused on multigene pathways or genome-wide alterations.

241 t they involve loss-of-function mutations in multigene pathways.

242 We demonstrate that insulated multigene PB transposons can stably integrate and faithf

243 We therefore provide the first multigene phylogenetic evidence that Coleochaetales repr

244 cient to place the cell within the ToL using multigene phylogenetics and provided preliminary insight

245 We also constructed a fossil-calibrated, multigene phylogeny to study the evolutionary history an

246 We reconstruct a multigene phylogeny to trace the evolution of colonialit

247 The multigene polymorphism approach holds promise for develo

248 n United States defined at least two sets of multigene polymorphisms to further characterize these va

249 A multigene predictor for distant recurrence-free survival

250 94) and PR expression (ICC = 0.90), and in a multigene predictor of ER pathway activation (ICC = 0.98

251 We developed a multigene predictor of pathologic complete response (pCR

252 apeutic targets, and support the use of this multigene predictor to improve risk stratification for i

253 t control were all highly represented in the multigene predictor.

254 ancer, and discuss prognostic and predictive multigene predictors.

255 ions had the worst outcomes, suggesting that multigene profiling may be useful for therapeutic planni

256 Here, we report a massively parallel, multigene-profiling nanoplatform to compartmentalize and

257 Several multigene protease families have been implicated in canc

258 SEEK provides multigene query searching with iterative metadata-based

259 Here, we introduce 'TEMTAC', a multigene recombineering and delivery system for simulta

260 Mga, or the multigene regulator of the group A streptococcus (GAS) (

261 thymocytes toward a myeloid-like state with multigene regulatory changes, but Notch/Delta signaling

262 xible regulators that modulate expression of multigene regulons to allow cells to adapt to an array o

263 Using multigene reporter and fate-reporter systems, we demonst

264 RhsA is a member of the multigene Rhs family and consists of a complex genetic s

265 A multigene risk scoring model based on 7 landscape genes

266 n of a set of dissimilar genes in a repeated multigene segment.

267 ovide insights into copy number variation of multigene segments, using as the example a disease resis

268 Multigene sequencing identified the spirochaete as a nov

269 al-time polymerase chain reaction (PCR), and multigene sequencing.

270 e aimed to develop and validate a prognostic multigene signature to improve prediction of recurrence

271 A multigene signature, previously reported as predictive f

272 Substantial agreement was also observed for multigene signatures of cancer recurrence (ICC = 0.71) a

273 ate the construction of increasingly complex multigene structures at the DNA level while enabling the

274 d three different complementary data sets: a multigene supermatrix, a genomic structural character ma

275 l topology using protein concatenation and a multigene supertree method based on 3,242 single gene tr

276 in variable systemic performance in designed multigene systems.

277 ped a next-generation sequencing (NGS)-based multigene-targeted panel for SCID and other severe PIDDs

278 Use of multigene targets could integrate both detection and ver

279 e genetic evaluation of inherited PCA in the multigene testing era addressing genetic counseling, tes

280 valuation framework for inherited PCA in the multigene testing era.

281 Multigene testing in this setting is likely to alter nea

282 Multigene testing panels now exist for many cardiovascul

283 Anchoring the coding region rbcL in multigene tiered approach, the combination rbcL + matK +

284 und that resistance to oxidative stress is a multigene trait in these strains.

285 r obstacle when planning the introduction of multigene traits into transgenic plants.

286 Progress in breeding to improve complex multigene traits, such as drought stress tolerance, has

287 ffold RNAs can be used to generate synthetic multigene transcriptional programs in which some genes a

288 Multigene transcriptional signatures from infected lungs

289 sistance genes that can be incorporated into multigene transgenic cassettes to control this devastati

290 ere created by the coordinate induction of a multigene transport system, involving solute carriers (e

291 RecWay assembly of multigene transposon vectors allows for widely applicabl

292 gene, which anchors the telomeric end of the multigene tryptase locus, changed little during primate

293 a novel approach for conducting multisample, multigene, ultradeep bisulfite sequencing analysis of DN

294 with the family pedigree, confirms existing multigene variants and suggests new copy number variants

295 ows for the generation of randomly assembled multigene vector libraries.

296 vectors and adapt our vectors for cloning on multigene vector systems in various binary plasmids.

297 These multigene vectors are integratable, and later excisable,

298 improved the expression of stably integrated multigene vectors by incorporation of insulator elements

299 By the introduction of multigene vectors carrying the human sialylation pathway

300 s to prevent promoter interference seen with multigene vectors.