ライフサイエンスコーパス: multigenic

1 to cause the defect, indicating that AVSD is multigenic.

2 ice indicated that the percent mortality was multigenic.

3 is not fully understood and is likely to be multigenic.

4 f genes across the genome, allowing complex, multigenic adaptations to evolve.

5 vian influenza viruses (AIVs) are considered multigenic, although the best characterized virulence fa

6 is is the first comprehensive study to use a multigenic analysis for bladder cancer, and the data sug

7 This type of multigenic analysis in human tumors may serve to substan

8 Asexual transmission appears to be multigenic and although the specific genes mediating thi

9 The effects of Zfp335(bloto) are multigenic and cannot be attributed to altered thymic se

10 The multigenic and complex etiology of ARD in humans is refl

11 , such as identifying the molecular basis of multigenic and complex traits.

12 g1-mediated resistance response appear to be multigenic and complex, as judged by transcript abundanc

13 gest that OA severity and progression have a multigenic and feature-specific nature.

14 left heart syndrome (HLHS), a severe CHD, is multigenic and genetically heterogeneous.

15 Here we show that the QTL is multigenic and includes alternative alleles of srx-44, a

16 pproximately 1 log (P = 0.017), and both the multigenic and Tat/Env groups reduced chronic viremia by

17 the hypothesis that the virulence of NDV is multigenic and that the cleavability of F protein alone

18 in man is a challenge as the cause is often multigenic and the phenotype is modulated by environment

19 E clinical phenotype is genetically complex, multigenic, and heterogeneous.

20 ty of avian influenza viruses in mammals are multigenic, and overcoming them requires adaptations in

21 -moderate hypertriglyceridaemia is typically multigenic, and results from the cumulative burden of co

22 These data demonstrate how multigenic animal models that reference cancer genomes c

23 629 unaffected white controls, we applied a multigenic approach to examine the associations with bla

24 udy, we demonstrate that within the complex, multigenic architecture of tuberculosis susceptibility,

25 Lupus, a multigenic autoimmune condition in which a breakdown of

26 Fanconi anemia (FA) is a multigenic autosomal recessive cancer susceptibility syn

27 the strain distribution pattern suggested a multigenic basis of disease resistance.

28 blished vl as a mouse model for studying the multigenic basis of NTDs and cataracts.

29 ained elusive and most models have posited a multigenic basis of resistance.

30 s, and gene repression in lamina-interacting multigenic chromatin domains were analyzed in Drosophila

31 se gene cluster of spinach chloroplasts is a multigenic cluster that encodes the small ribosomal subu

32 uman cancer, often as emergent properties of multigenic combinations.

33 The large (220 kbp) multigenic complex R-r is paramutable: its level of expr

34 nce a phenotype; and several examples of how multigenic conditions, both complex disorders and duplic

35 Hirschsprung disease (HSCR) is a multigenic, congenital disorder that affects 1 in 5,000

36 quantitative traits and contribute to their multigenic control in a semidominant fashion.

37 genetic interactions suggest a model for the multigenic control of anterior digit patterning during v

38 epistatic analyses, seeking to decipher the multigenic control of circadian pacemaking.

39 rentiating maize and teosinte are each under multigenic control, although for some traits, such as th

40 inbred strains, and susceptibility is under multigenic control.

41 tumor induction in mice by pristane is under multigenic control.

42 ons contribute to the pathogenicity of rare, multigenic copy-number variants (CNVs) that have been ob

43 itating population genetic analysis of large multigenic datasets.

44 as helped identify a rich array of mono- and multigenic defects in humans and animal models that conn

45 ed to LDL size, supporting the hypothesis of multigenic determination of LDL size heterogeneity.

46 The mammalian beta-globin locus is a multigenic, developmentally regulated, tissue-specific l

47 We propose that PNTM infection is a multigenic disease in which combinations of variants acr

48 Our results indicate that cord1 is a multigenic disease in which mutations in neither RPGRIP1

49 Cancer is a multigenic disease resulting from both germline suscepti

50 ET mutations and disease severity even for a multigenic disease such as Hirschsprung disease.

51 l anemia is not a monogenic disease; it is a multigenic disease.

52 ages of polypharmacology in the treatment of multigenic diseases and infections, and opportunities fo

53 e same deleterious variants, and for common, multigenic diseases using as few as 150 cases.

54 apy and in identifying genes responsible for multigenic diseases.

55 of the IGEs that are inherited are complex, multigenic diseases.

56 elated macular degeneration (AMD), a complex multigenic disorder and the most common cause of vision

57 Cancer is a progressive multigenic disorder characterized by defined changes in

58 Hypertension is a multigenic disorder in which abnormal counterregulation

59 hy, and that myotonic dystrophy represents a multigenic disorder.

60 For most multigenic disorders, clinical manifestation (penetrance

61 ironment interactions that influence complex multigenic disorders.

62 in disease pathogenesis for common, complex multigenic disorders.

63 me-wide scans that exploit LD to map common, multigenic disorders.

64 ase models may impact the treatment of human multigenic disorders.

65 simplify the preparation and manipulation of multigenic DNA polymorphism datasets.

66 ed in decreased compactness of the repressed multigenic domain associated with its detachment from th

67 omatin compaction, and gene silencing in the multigenic domain, and an auxiliary role for HDAC3 that

68 l ancestries, and a disentangled complex HLA multigenic effect.

69 More common forms may also result from multigenic effects or post-zygotic mutations.

70 Mutations from seven HLHS mouse lines showed multigenic enrichment in ten human chromosome regions li

71 Furthermore, these results support a multigenic etiology for prostate cancer.

72 SGs conserved across vertebrates, as well as multigenic families diversified independently in each ta

73 Thus, multigenic families encoding diversified V regions exist

74 Plasmodium falciparum possesses two multigenic families, var and rif, the products of which

75 The large multigenic family of nuclear encoded chloroplastic prote

76 onstrate that Bc28.1, a major member of this multigenic family, is expressed at high levels at the su

77 Two such are the use of multigenic feedback loops to ensure the progressivity of

78 s against Gag induced in mice immunized with multigenic gagpol plasmids were similar to those observe

79 r reduction in the Tat/Env group than in the multigenic group (P = 0.014) was correlated with Tat and

80 However, the multigenic group blunted acute viremia by approximately

81 enhance chronic viremia control, we tested a multigenic group: Ad-HIV tat, -HIV env, -SIV gag, and -S

82 duced pathology is affected by a complex and multigenic host component.

83 of individual gene loci to investigation of multigenic human traits, and it establishes an approach

84 chizophrenia risk in 22q11.2DS, supporting a multigenic hypothesis for schizophrenia.

85 ese diseases has led to their designation as multigenic--implying that the expression levels and alle

86 of these resources by lipolysis is similarly multigenic in determination and regulation.

87 Multigenic influences are major contributors to human ge

88 or haploinsufficiency, with implications for multigenic inheritance of CHDs.

89 the pedicellate spikelet, the data indicate multigenic inheritance with no single locus having a dra

90 A new study focuses attention on multigenic interactions influencing the risk of autism s

91 lts support the concept of an AP-1-regulated multigenic invasion program in which proteins encoded by

92 rate that the EILV host range restriction is multigenic, involving at least one gene from both nonstr

93 ve trait loci have been mapped in mice, but "multigenic" is an insufficient term for the thousands of

94 Moreover, we find unexpected concomitant multigenic lesions involving Cdkn2a loss and other cance

95 understanding how so many variants of these multigenic loci could have evolved through duplication a

96 , they enable the analysis of large genes or multigenic loci in vivo.

97 A multigenic locus at 3p13-14, spanning FOXP1 to SHQ1, is

98 restricted transcriptional regulation from a multigenic locus.

99 stage-specific expression of genes from this multigenic locus.

100 Mphi from the two principal mouse models of multigenic lupus provides insight into how excessive hum

101 lation in the two principal animal models of multigenic lupus, and suggest that the study of Mphi (an

102 congenital amaurosis through a recessive or multigenic mechanism.

103 f "complex traits" can be understood using a multigenic model of candidate genes.

104 vide a potential mechanistic basis for a new multigenic model of HPE.

105 A multigenic model of prostate cancer susceptibility has b

106 re, Tcf4 haplodeficiency in the B6.Sle1.Sle3 multigenic model of SLE nearly abolished key disease man

107 Here we tested the ability of this multigenic model to predict stroke risk in a large popul

108 Here we use Drosophila to generate 32 multigenic models of colon cancer using patient data fro

109 Multigenic models such as ras p53 pten apc exhibit emerg

110 inflammatory molecules may be used to create multigenic models that predict stroke risk in subjects w

111 ctional dissection of susceptibility loci in multigenic mouse models of lupus has provided insight in

112 d PRKDC) immunodeficient rabbits, as well as multigenic mutant immunodeficient rabbits have been prod

113 Unexpectedly, given the multigenic nature and partial functional redundancy obse

114 The highly multigenic nature of dosage-sensitive modulation of both

115 The complex, multigenic nature of HLA class II-associated IDDM suscep

116 these AIDS restriction genes illustrates the multigenic nature of host factors limiting AIDS disease

117 The multigenic nature of human tumours presents a fundamenta

118 present known limitations given the complex, multigenic nature of many diseases or traits.

119 extent of natural genetic variation, 2) the multigenic nature of natural variation, 3) the impact of

120 The results demonstrate the multigenic nature of susceptibility to urinary tract inf

121 ssociated with resistance, demonstrating the multigenic nature of this phenotype.

122 ties has been challenging due in part to its multigenic nature.

123 irschsprung disease (HSCR, MIM #142623) is a multigenic neurocristopathy (neural crest disorder) char

124 Hirschsprung disease (HSCR) is a multigenic neurocristopathy clinically recognized by aga

125 Alzheimer's disease (AD) is a multigenic neurodegenerative disorder characterized by d

126 immunodeficiency virus (SIV) Gag and Pol as multigenic, nonintegrating vectors, but rBCG-expressing

127 eral candidate genes, including tubby (tub), multigenic obesity 1 (Mob1), adult obesity and diabetes

128 ns with CAST alleles encompassing 67-162 Mb (multigenic obesity 6 [MOB6]) and 84-180 Mb (MOB5) from m

129 the s(1Acrg) phenotype is either complex and multigenic or due to the loss of another gene within the

130 chromosomal interactions results in weak and multigenic OR expression, suggesting that the rare coinc

131 , this investigation provides candidates for multigenic orchestration of the incompatibility response

132 ated with human autoimmune disease suggest a multigenic origin of susceptibility; however, how these

133 4 logs, respectively, compared to controls (multigenic, P = 0.0003; Tat/Env, P < 0.0001).

134 A multigenic pathway-based approach may identify gene-gene

135 ur study confirms the importance of taking a multigenic pathway-based approach to risk assessment.

136 ancer, confirming the importance of taking a multigenic pathway-based approach to risk assessment.

137 Several interesting studies using a multigenic pathway-based genotyping approach and novel s

138 itical genes has proven difficult due to the multigenic pattern of inheritance and strong role of cur

139 support the hypothesis that "curlicue" is a multigenic phenomenon.

140 y to complex autoimmune diseases (AIDs) is a multigenic phenotype affected by a variety of genetic an

141 e to evolutionary engineering approaches for multigenic phenotypes is the ability to simultaneously m

142 cted to undertake the development of complex multigenic phenotypes, such as aerotolerance, solvent to

143 iation analysis, we demonstrate that complex multigenic phenotypes, such as food intake, can be assoc

144 skin disease of unknown cause determined by multigenic predisposition, environmental factors, and ab

145 mary candidate regulating the opening of the multigenic PRM1 --> PRM2 --> TNP2 human protamine domain

146 lection for strains defective in two defined multigenic processes (twitching motility and prototrophi

147 rly, the effects of environmental factors or multigenic processes such as ageing or disease cannot be

148 From these observations we propose that a multigenic program for sensitivity to apoptosis involves

149 Multigenic programs controlling susceptibility to apopto

150 breast cancer cells includes alternations of multigenic programs that permit tumor cells to metastasi

151 structures occurs through the activation of multigenic programs.

152 Tick salivary proteins cluster in multigenic protein families, and individual family membe

153 stance and development of type 2 diabetes is multigenic rather than monogenic in origin.

154 Fanconi anemia (FA) is a multigenic recessive disease resulting in bone marrow fa

155 Our findings highlight the multigenic regulation of the size of the pDC compartment

156 ong-range chromatin interactions that enable multigenic regulation.

157 After a multigenic replicating Ad-SIV immunization, all groups r

158 Quantitative or multigenic resistance has also more recently been resear

159 Multigenic resistance to dauer formation has also arisen

160 at high density have independently acquired multigenic resistance to pheromone-induced dauer formati

161 nstrates the need for finding germplasm with multigenic resistance to the aphid.

162 al machinery can indeed detect and translate multigenic sequences that are not of chloroplast origin.

163 us macaques per group were primed twice with multigenic SIV plasmid DNA with or without interleukin-1

164 cRNA and underscores that LOI phenotypes are multigenic so that complex interactions will contribute

165 rice (Oryza sativa L.), the haplotype at the multigenic SUBMERGENCE1 (SUB1) locus determines whether

166 ic such as Timothy syndrome (TS); others are multigenic such as the microdeletion and microduplicatio

167 To understand how a multigenic system evolved to adapt to the changing envir

168 es of dormancy genes observed in this simple multigenic system presumably have selective advantages i

169 often been described as a complex and likely multigenic trait for which complex gene interactions com

170 for and accurately assessing such a complex, multigenic trait in a natural product such as a fruit.

171 sted that RNA-mediated virus resistance is a multigenic trait in line 2RC-6.13; three or more transge

172 Here we show that patch-leaving is a multigenic trait regulated in part by naturally occurrin

173 Fasting plasma glucose is a multigenic trait related to both diabetes and obesity.

174 Obesity is a multigenic trait that has a substantial genetic componen

175 nation of Medicago truncatula seedlings is a multigenic trait that is responsive to exogenous nitrate

176 Obesity is a highly prevalent, multigenic trait that predicts increased morbidity and m

177 roid disorder that is inherited as a complex multigenic trait.

178 continuous phenotypic pattern, suggesting a multigenic trait.

179 ene disorder with reduced penetrance or as a multigenic trait.

180 suggested that the NZB apoptosis defect is a multigenic trait.

181 Fetal hemoglobin (HbF) is regulated as a multigenic trait.

182 The virulence of influenza virus is a multigenic trait.

183 ity gene has been identified for this highly multigenic trait.

184 traits have a complex genetic basis, but few multigenic traits are understood at a molecular level.

185 ation of oocytes, and teratoma formation are multigenic traits involving a modest number of permissiv

186 dentifying candidate genes encoding QTLs for multigenic traits.

187 ility supports our hypothesis that these are multigenic traits.

188 ough of a single stop codon, but instead are multigenic traits.

189 genome and combinatorially optimize complex (multigenic) traits using multiplex recombineering.

190 rid selection assays showed that some of the multigenic transcription units of the mitochondrial geno

191 its replication origins to the boundaries of multigenic transcription units.

192 which has demonstrated the ability to elicit multigenic transcriptional changes that have improved ph

193 ut sequencing promise to accelerate our full multigenic understanding of this disease, contributing t

194 important implications in the development of multigenic vaccine candidates for this common infection.

195 We used subtle, naturally occurring, multigenic variation of cardiovascular (CV) properties i

196 analysis of both rare single-gene and common multigenic vascular disorders.