ライフサイエンスコーパス: multilineage

1 c colonies but also engraft and reconstitute multilineage adult blood.

2 ell can promote prolonged and high levels of multilineage allogeneic chimerism and robust tolerance t

3 This study revealed reduced myeloid multilineage and committed erythroid progenitors in HIF-

4 se to markedly reduced numbers of definitive multilineage and lineage-committed hematopoietic progeni

5 initive hematopoietic stem cells, capable of multilineage and long-term reconstitution when transplan

6 Without hematopoietic stress, multilineage and myelo-erythroid bone marrow progenitor

7 lso reflect the likelihood that, in PBC, the multilineage antimitochondrial response is a pathogenic

8 nd regional lymph node than in blood, so the multilineage antimitochondrial response may be required

9 The results in other multilineage autoimmune cytopenia cohorts were encouragi

10 es in a majority of children with refractory multilineage autoimmune cytopenias.

11 al line ) SC from the same patients produced multilineage BCR/ABL1(-) engraftment.

12 nly hematopoietic cells capable of lifelong, multilineage blood cell production, understanding the st

13 of hematopoietic stem cells, but its role in multilineage blood development remains unclear.

14 unctional HSCs, which are fully competent in multilineage blood reconstitution upon transplantation.

15 ain transplantable HSCs capable of long-term multilineage blood reconstitution.

16 Conditional deletion of BAF53a resulted in multilineage BM failure, aplastic anemia, and rapid leth

17 ng GFP(+) BM cells showed long-term, serial, multilineage BM reconstitution, fulfilling the functiona

18 of E2F1 in the formation and maintenance of multilineage brain tumors, irrefutably establishing E2F1

19 erythroid colonies in vitro while retaining multilineage capacity, capable of generating MCs and oth

20 transfer to long-lived progenitor cells with multilineage capacity.

21 merization produced divisions of clonogenic, multilineage CD34(+) cells able to engraft immunodeficie

22 ed from pneumococcal surface adhesin A, is a multilineage cell activator in vitro.

23 regulators such as GATA2, ERG, and RUNX1 in multilineage cells and the lineage-specific master regul

24 itors (PPEPs)] has the potential to generate multilineage cells during normal development in vivo.

25 Here we report that stable multilineage chimerism and engraftment can be establishe

26 ychromatic flow cytometry was used to assess multilineage chimerism and lymphocyte recovery posttrans

27 Pigs with functioning spleen grafts had multilineage chimerism in blood, thymus and bone marrow

28 animals evaluated beyond 100 days maintained multilineage chimerism in the peripheral blood and lymph

29 A transient, low-to-moderate degrees of multilineage chimerism was observed after DBM infusion.

30 Fifteen patients developed multilineage chimerism without graft-versus-host disease

31 All 11 SpTx recipients developed multilineage chimerism, but chimerism was rapidly lost i

32 Multilineage chimerism, clonal deletion, and lymphocyte

33 mg/kg with CD154 blockade regularly induced multilineage chimerism.

34 genic recipients maintain stable, long-term, multilineage chimerism.

35 eatment with eltrombopag was associated with multilineage clinical responses in some patients with re

36 oliferative neoplasms (MPN) characterized by multilineage clonal hematopoiesis.

37 f-renew, and their ability to give rise to a multilineage clone of differentiating and maturing blood

38 at 1 month but were supplanted over time by multilineage clones, initially myeloid restricted, then

39 transplantable, donor-derived, macroscopic, multilineage colonies detectable on the spleen surface 1

40 eural crest-derived cells capable of forming multilineage colonies in culture, and neurons and glia u

41 netically manipulated, and are competent for multilineage colonisation of chimaeras.

42 ematopoietic cells, accompanied by increased multilineage colony-forming potential in colony-forming

43 able for up to 1 year in vitro, and remained multilineage competent throughout.

44 Dox withdrawal in combination with multilineage cytokines restored GATA1 expression, result

45 SC accompanied by development of progressive multilineage cytopenias and cytological dysplasia.

46 ic deletion of Asxl1 results in progressive, multilineage cytopenias and dysplasia in the context of

47 Patients with autoimmune multilineage cytopenias are often refractory to standard

48 Patients often present with chronic multilineage cytopenias due to autoimmune peripheral des

49 We also treated 12 patients with multilineage cytopenias secondary to common variable imm

50 onset chronic lymphadenopathy, splenomegaly, multilineage cytopenias, and an increased risk of B-cell

51 denopathy, hepatosplenomegaly, and recurring multilineage cytopenias.

52 ostic evaluation of children with refractory multilineage cytopenias.

53 rogation of hematopoiesis as demonstrated by multilineage defects in lymphocyte, granulocyte, erythro

54 d whether HSC gene therapy could correct the multilineage defects seen in SAP(-/-) mice.

55 ential, but exhibited a fivefold decrease in multilineage definitive hematopoietic potential.

56 lator of HSC self-renewal, mobilization, and multilineage development and executes these actions via

57 cells with diverse angiogenic functions and multilineage developmental features of mesenchymal stem

58 the numbers of haematopoietic stem cells and multilineage-differentiated cells are reduced in iqcg-de

59 tes the ability to effectively differentiate multilineage-differentiating stress-enduring cells into

60 Multilineage-differentiating stress-enduring cells were

61 absence of CHIR99021 and valproic acid, and multilineage differentiation ability is preserved.

62 nd exhibited clonogenic capacity, as well as multilineage differentiation ability.

63 oblast cells, which possess the capacity for multilineage differentiation and are responsible for pla

64 ncer tissues is largely explained by in vivo multilineage differentiation and not only by clonal gene

65 ing holds promise for combining the accurate multilineage differentiation and physiology of in vivo s

66 These cells have potential for multilineage differentiation and provide a resource for

67 Thus, HSC maintenance and multilineage differentiation are distinct cell lineage d

68 graft experiment indicated that renewal and multilineage differentiation are normal in the absence o

69 different gene-expression programs linked to multilineage differentiation are strongly associated wit

70 SC) fate decisions between proliferation and multilineage differentiation are unclear.

71 and retain the capacity for self-renewal and multilineage differentiation as long as they reside in t

72 a single-cell sorting approach and in vitro multilineage differentiation assays, here we show that i

73 s colonize embryonic germ layers and exhibit multilineage differentiation both in fetal and adult chi

74 r results reveal that Mbd3/NuRD can regulate multilineage differentiation by constraining the activat

75 ll surface extracellular matrix receptors in multilineage differentiation by these multipotent human

76 feration, resistance to oxidative stress and multilineage differentiation capacities compared with ag

77 rthermore, these cells showed clonogenic and multilineage differentiation capacities.

78 expression and significantly improved their multilineage differentiation capacities.

79 Their propensity for multilineage differentiation carries, however, the liabi

80 ation, indicating that competence to undergo multilineage differentiation depends upon JAK/STAT.

81 onment to fulfill long-term self-renewal and multilineage differentiation functions, an event that is

82 ) complex is required for maintenance of and multilineage differentiation in the early hematopoietic

83 and genetic manipulation of cells capable of multilineage differentiation in vitro and in vivo to exa

84 sFRP2-MSCs maintained their ability for multilineage differentiation in vitro and, when implante

85 nated control of stem cell proliferation and multilineage differentiation is essential to ensure a st

86 s neurofibromin-regulated NSC proliferation, multilineage differentiation is MEK-dependent.

87 intrinsically required for self-renewal and multilineage differentiation of adult HSCs.

88 dinal stem cell features of self-renewal and multilineage differentiation of ESC-derived hematopoieti

89 aftment in the bone marrow of the hosts, and multilineage differentiation of hematopoietic cells was

90 o culture without altering proliferation and multilineage differentiation of HSC and progeny.

91 hat supports robust expansion and subsequent multilineage differentiation of human pluripotent stem c

92 lls (MSCs) from hESCs (hESCd-MSCs) that have multilineage differentiation potential and are capable o

93 ed regeneration therapies by virtue of their multilineage differentiation potential and immunogenicit

94 quire long-term self-renewing capacities and multilineage differentiation potential during physiologi

95 proliferating progenitor cells, and possess multilineage differentiation potential generating functi

96 cells exhibited long-term proliferation and multilineage differentiation potential in vitro.

97 a non-self-renewing progenitor with limited multilineage differentiation potential termed the erythr

98 ionally heterogeneous, and displays distinct multilineage differentiation potential, cell cycle profi

99 id not adversely impact either clonogenic or multilineage differentiation potential, indicating a sel

100 ignated induced-HSCs (iHSCs), possess clonal multilineage differentiation potential, reconstitute ste

101 gy, typical hMSC marker profile and in vitro multilineage differentiation potential.

102 including the capacity for self-renewal and multilineage differentiation potential.

103 some adipose-derived stem cells (ADSCs) have multilineage differentiation potential.

104 progenitors generated uncommitted cells with multilineage differentiation potential.

105 vitro CD34(+) cell derived SG-MSCs revealed multilineage differentiation potential.

106 s cellular heterogeneity truly recapitulates multilineage differentiation processes of normal tissues

107 Moreover, whereas MEK-regulated multilineage differentiation requires Smad3-induced Jagg

108 nd contains tissue-derived MSCs that exhibit multilineage differentiation similar to bone marrow-deri

109 ols neural stem cell (NSC) proliferation and multilineage differentiation through the selective use o

110 hermore, this population demonstrates robust multilineage differentiation using standard in vivo and

111 Multilineage differentiation within clones was demonstra

112 are uniquely able to self-renew, to undergo multilineage differentiation, and to persist throughout

113 the competence of daughter cells to undergo multilineage differentiation, ensuring a robust cellular

114 nt of cell therapies and tissue engineering: multilineage differentiation, immunomodulation, and prod

115 long with the properties of self-renewal and multilineage differentiation, pancreatic CSCs display up

116 GPx2 overexpression stimulated multilineage differentiation, proliferation, and tumor g

117 rther explore the role of alpha2 integrin in multilineage differentiation, we established multipotent

118 roid mice are defective in proliferation and multilineage differentiation.

119 of individual RGLs for both self-renewal and multilineage differentiation.

120 sphere-like organoids with proliferation and multilineage differentiation.

121 d HCECs that are capable of self-renewal and multilineage differentiation.

122 al characteristics revealed-self-renewal and multilineage differentiation.

123 m cells with a capacity for self-renewal and multilineage differentiation.

124 al cell types, but inflammation prevents the multilineage differentiation.

125 es have the potential to improve iPSC-driven multilineage differentiation.

126 ructure, pluripotency-marker expression, and multilineage differentiation.

127 their ability to proliferate and to undergo multilineage differentiation.

128 reatment translates into increased long-term multilineage donor cell engraftment.

129 of alloengraftment remained enigmatic until multilineage donor leukocyte microchimerism was discover

130 the classification of CEBPA-mutated AML with multilineage dysplasia (MLD; >/= 50% dysplastic cells in

131 n DNA methylation genes were associated with multilineage dysplasia (P = .015) but had no effect on c

132 RS (RARS), 43 with refractory cytopenia with multilineage dysplasia (RCMD)-RS, 11 with refractory ane

133 n complex were independently associated with multilineage dysplasia and identified a distinct subset

134 subtypes, such as refractory cytopenia with multilineage dysplasia and ring sideroblasts (RCMD-RS).

135 Four patients had refractory cytopenia with multilineage dysplasia and ringed sideroblasts (RCMD-RS)

136 ineage dysplasia, others have suggested that multilineage dysplasia correlates with unfavorable cytog

137 t SF3B1 and inversely with hemoglobin level, multilineage dysplasia, and high-risk karyotype; but did

138 ory anemia, n = 1; refractory cytopenia with multilineage dysplasia, n = 1) had no UPD4q24.

139 leukemia (AML), including the importance of multilineage dysplasia, others have suggested that multi

140 These genome-edited HSPCs support multilineage engraftment and generate progeny capable of

141 Long-term multilineage engraftment and persistent VCN and vector e

142 mitted greater expansion of cells capable of multilineage engraftment and serial transplantation, hal

143 Primary and secondary recipients showed multilineage engraftment at 3 months after transplantati

144 ematopoietic cells with robust and sustained multilineage engraftment has not been achieved.

145 these findings, we achieved stable long-term multilineage engraftment in 21 of 24 surviving recipient

146 They were also able to give rise to multilineage engraftment in both secondary recipients an

147 cobblestone area-forming cell potential, and multilineage engraftment in NOD/SCID/IL2R-gamma(null) mi

148 tudy demonstrated clear safety with durable, multilineage engraftment of dmPGE2-treated UCB units.

149 Long-term multilineage engraftment of Klf7(-/-) cells was comparab

150 red blood cells, and platelets), indicating multilineage engraftment of transduced cells.

151 how that fluid shear stress endows long-term multilineage engraftment potential upon early hematopoie

152 matopoietic stem cells capable of long-term, multilineage engraftment still remains a significant cha

153 overt neuronal and glial differentiation of multilineage ENS progenitor cells (EPCs), without interf

154 a role for this factor in the maintenance of multilineage ENS progenitors.

155 3 have a crucial role in the maintenance of multilineage enteric nervous system progenitors.

156 s expressing stem cell markers and retaining multilineage epithelial differentiation capability.

157 to human NPMc+ AML, where the observed NPMc+ multilineage expression pattern implies transformation o

158 hat Gimap5-deficient mice showed progressive multilineage failure of bone marrow and hematopoiesis.

159 , which successfully engraft and expand in a multilineage fashion in secondary transplantation recipi

160 developed GFP-positive CFU-Cs and propagated multilineage GFP-positive leukocytes when adoptively tra

161 ed expression of KLF7, although resulting in multilineage growth suppression that extended to hematop

162 Multilineage hematopoiesis from anti-HIV lentiviral vect

163 r of SCID-repopulating cells and established multilineage hematopoiesis in primary and secondary immu

164 ent that could radioprotect and reconstitute multilineage hematopoiesis in secondary and tertiary rec

165 d resulted in the concomitant suppression of multilineage hematopoiesis in vitro.

166 In contrast, we observed multilineage hematopoiesis up to 68 weeks after primary

167 efficiently self-renew and sustain long-term multilineage hematopoiesis upon serial transplantation.

168 the major contributor to the maintenance of multilineage hematopoiesis, both in the steady state and

169 Cs during cytokinesis and thus essential for multilineage hematopoiesis.

170 phoid tissue that demonstrate high levels of multilineage hematopoiesis.

171 ss" phase and develop to fertile adults with multilineage hematopoiesis.

172 al to HSC can result in a profound effect on multilineage hematopoiesis.

173 ulture-initiating cell potential and sustain multilineage hematopoietic cell engraftment when transpl

174 We now report on transient multilineage hematopoietic chimerism and lymphocyte reco

175 ch deficient emi1 gene expression results in multilineage hematopoietic defects and widespread develo

176 CD41-knockout (KO) mice displayed multilineage hematopoietic defects coupled with decrease

177 granulocyte lineage commitment to facilitate multilineage hematopoietic differentiation and thus iden

178 erized by exocrine pancreatic insufficiency, multilineage hematopoietic dysfunction, and metaphyseal

179 >40-80 population doublings, are capable of multilineage hematopoietic engraftment of immunodeficien

180 ormation, and, together with HoxB4, enhances multilineage hematopoietic engraftment of lethally irrad

181 model, we show that RhoA deficiency causes a multilineage hematopoietic failure that is associated wi

182 This multilineage hematopoietic failure was rescued by recons

183 strate, on a clonal level, that they exhibit multilineage hematopoietic potential.

184 induced runx1 gene expression and increased multilineage hematopoietic precursor cells approximately

185 During developmental hematopoiesis, multilineage hematopoietic progenitors are thought to de

186 sess >/=9-week repopulation ability and show multilineage hematopoietic reconstitution in vivo.

187 ting target for promoting HSPC expansion and multilineage hematopoietic recovery after transplant.

188 potentially superior, approaches to promote multilineage hematopoietic recovery by blocking the TGFb

189 hereas the CD34(+) fraction contained normal multilineage hematopoietic repopulating cells.

190 odeficient mice provide long-term high level multilineage hematopoietic repopulation.

191 g and transcriptional circuits that regulate multilineage hematopoietic specification.

192 During embryonic development, multilineage HSCs/progenitor cells are derived from spec

193 mouse strain, we have established long-term multilineage human grafts and demonstrated their seriall

194 an immune system have a capacity for de novo multilineage human hematopoiesis and generate T cells, B

195 mmac(-/-) mice results in the development of multilineage human hematopoietic cells.

196 f CD34(+) cells from the same donor achieves multilineage human lymphohematopoietic reconstitution, i

197 helming female predominance, production of a multilineage immune response to mitochondrial autoantige

198 First, the multilineage immune response, including AMAs, is directe

199 Our multilineage immunohistochemical analyses of early embry

200 hanisms of immune regulation; and subsequent multilineage immunopathology impacts upon uniquely susce

201 C) for immune cell subsets revealed a marked multilineage increase in infiltrates, consisting predomi

202 Multilineage involvement of bone marrow (BM) hematopoies

203 The multilineage involvement of the BCR-ABL1-positive clone

204 BM mast cells (64% vs 0%; P = .01) vs other multilineage ISM cases.

205 All MSC-mutated patients had multilineage KIT mutation (100% vs 30%, P = .0001) and t

206 ervations such as cellular reprogramming and multilineage locus priming.

207 ones, and marrow from ossicles reconstituted multilineage long-term hematopoiesis in lethally irradia

208 yeloid-B clones, and then stable myeloid-B-T multilineage, long-term repopulating clones.

209 h minimal conditioning led to stable, mixed, multilineage lymphoid and myeloid macrochimerism, deleti

210 With multilineage mesodermal potential and possible ectoderma

211 Transient multilineage mixed chimerism was observed in all patient

212 These results characterize the transient multilineage mixed hematopoietic chimerism and recovery

213 isease is characterized by severe anemia and multilineage myeloid dysplasia that are thought to be a

214 ndings establish an intrinsic disturbance of multilineage myeloid hematopoiesis in trisomy 21 at the

215 two types of neuronal progenitors (NPs) from multilineage-negative NSCs.

216 tic stem cells and their progenitors exhibit multilineage patterns of gene expression.

217 with the nonmyeloablative regimen developed multilineage peripheral blood chimerism during the first

218 eural progenitor cells with self-renewal and multilineage potency.

219 ously uncharacterized roles in promoting NSC multilineage potential and modulating early neural fate

220 at adult hippocampal NSCs inherently possess multilineage potential but that Drosha functions as a mo

221 A9, ERG, and RORA conferred self-renewal and multilineage potential in vitro and maintained primitive

222 itial cells, have also been shown to exhibit multilineage potential in vitro.

223 The persistence of fetal stem cells with multilineage potential in women who have been pregnant,

224 Priming and resolution of multilineage potential is dependent on the activity of t

225 c transplantation experiments to assess true multilineage potential of engrafted cells.

226 Recent studies show that the fate and multilineage potential of epithelial stem cells can chan

227 Although the multilineage potential of human adipose-derived adult st

228 transcriptional regulators necessary for HSC multilineage potential to be maintained.

229 t do conform to classical definitions retain multilineage potential, but surprisingly, cannot make B

230 by resistance to chemotherapy, self-renewal, multilineage potential, increased colony formation, and

231 ategies have generated progenitor cells with multilineage potential, to date, therapy-grade engineere

232 progenitor cells in the gastric antrum have multilineage potential.

233 and investigated whether these cells possess multilineage potential.

234 re subpopulation of gastric progenitors with multilineage potential.

235 cted to in vitro assays to investigate their multilineage potential.

236 poietic cells that lack robust and sustained multilineage potential.

237 one genome editing with CRISPR/Cas9 retained multilineage potential.

238 icle bulge are self-renewing stem cells with multilineage potential.

239 ntain long-term growth of genomically stable multilineage pre-stasis HMEC populations can greatly enh

240 hese regulatory genes were also monitored in multilineage precursors as they entered T-cell or non-T-

241 e cell types representing a progression from multilineage precursors to differentiated erythroblasts

242 on by downregulating C/EBP alpha and PU.1 in multilineage precursors.

243 genome-wide analyses support the concept of multilineage priming and will increasingly refine the ne

244 Thus, in hematopoietic progenitors, multilineage priming of enhancer elements precedes commi

245 Although this multilineage priming was resolved upon subsequent lineag

246 th regulators, explaining the phenomenon of "multilineage priming".

247 development of LTi cells did not go through multilineage priming.

248 initial organogenesis involves a process of multilineage priming.

249 indicate lineage potentials consistent with multilineage progenitor (MLP), common lymphoid progenito

250 a myelomonocytic morphology while retaining multilineage progenitor activity and engraftment in NOD/

251 These data support a luminal multilineage progenitor cell model for prostate tissue a

252 O-coupled regulatory pathway exists in human multilineage progenitor cells (MLPC) prepared from umbil

253 xpressing primitive HSPCs capable of forming multilineage progenitor colonies (colony-forming units [

254 ) myeloid precursors derived from hPSCs into multilineage progenitors that can be expanded in vitro a

255 In multilineage progenitors, the likely target genes are en

256 tenin active cells and inhibits expansion of multilineage progenitors.

257 lly; however, we identified defects in their multilineage reconstituting capacity.

258 istatin enriches for long-term hematopoietic multilineage reconstituting cells by 5-fold or more as a

259 assays, Tet2-deficient HSCs were capable of multilineage reconstitution and possessed a competitive

260 matopoietic stem cell (HSC) self-renewal and multilineage reconstitution are controlled by positive a

261 ation; however, transplantation efficacy and multilineage reconstitution can be limited by inadequate

262 ains HSPCs that possess short- and long-term multilineage reconstitution capacity.

263 ion induced both defects in self-renewal and multilineage reconstitution in cyclin E knock-in HSCs wi

264 (-)Mac-1(+) fetal liver cells gave long-term multilineage reconstitution in irradiated mice, 1 (18%)

265 from 5-fluorouracil treatment and diminished multilineage reconstitution in lethally irradiated bone

266 rogenetic) derived cells conveyed long-term, multilineage reconstitution of hematopoiesis in recipien

267 -catulin-GFP(+)c-kit(+) cells give long-term multilineage reconstitution of irradiated mice, indicati

268 n vivo (as shown by the successful long-term multilineage reconstitution of primary neonates and seco

269 tituting adult progenitors to give long-term multilineage reconstitution that resembled fetal hematop

270 hich endows them with the ability to mediate multilineage reconstitution that resembles fetal lymphop

271 etic stem cell (HSC) that supports long-term multilineage reconstitution upon transplantation into ad

272 M cells yields HSC enrichments and long-term multilineage reconstitution when transferred to lethally

273 l products are capable of stable, polyclonal multilineage reconstitution with follow-up of more than

274 mpete with BM from wild-type mice to provide multilineage reconstitution, indicating that there is an

275 of HSCs and early HPCs that are defective in multilineage reconstitution, suggesting a differentiatio

276 ained upon serial transplantation, with full multilineage reconstitution.

277 both populations can contribute to long-term multilineage reconstitution.

278 (-)Mac-1(+) fetal liver cells gave long-term multilineage reconstitution.

279 with 1 in 3 to 1 in 7 cells giving long-term multilineage reconstitution.

280 try demonstrate that damaged lobes underwent multilineage regeneration, reforming a lobe often indist

281 ncluding self-renewal capacity and long-term multilineage repopulation ability.

282 nome-edited HSPCs engraft, and contribute to multilineage repopulation after autologous transplantati

283 The SALL4 expanded HSCs/HPCs retain multilineage repopulation and long-term engraftment acti

284 posed to EPCR-negative cells, exhibit robust multilineage repopulation and serial reconstitution abil

285 geted integration in human HSCs by long-term multilineage repopulation of transplanted mice.

286 Gene-modified cells achieved multilineage repopulation, and we identified the same ge

287 marrow cells resulted in defective long-term multilineage repopulation.

288 biliary cirrhosis (PBC), patients develop a multilineage response to a highly restricted peptide of

289 to immunosuppressive therapy, with frequent multilineage responses and maintenance of normalized hem

290 in the youngest subject (age 10 years), and multilineage retroviral marking occurred in all 3 childr

291 port efficient and stable MGMTP140K-mediated multilineage selection in both macaque and baboon nonhum

292 ork for modeling complex processes involving multilineage specifications.

293 ge colony-stimulating factor (GMCSF) induced multilineage, STAT5-dependent differentiation, including

294 y enhanced by the rigorous dissection of the multilineage T and B cell response against the immunodom

295 PGCs are also the cell of origin of multilineage teratocarcinomas.

296 complex process resulting in an integrated, multilineage tissue with developmental corruption in ear

297 Multilineage transcriptional priming is quickly resolved

298 1, Hlf, Lmo2, Prdm5, Pbx1, and Zfp37 imparts multilineage transplantation potential onto otherwise co

299 em cell function, tumor-initiating cells and multilineage tumor development.

300 We show that transgenic mice developed multilineage tumors, including metastatic SCCs.