ライフサイエンスコーパス: multimeric

1 Multimeric AAA ATPases represent a structurally homologo

2 Jun is a highly conserved member of the multimeric activator protein 1 transcription factor comp

3 , Dronc, in fruit flies, is facilitated by a multimeric adaptor complex known as the apoptosome.

4 ll pDCs are intrinsically more responsive to multimeric agonist of TLR9 and constitutively secrete ty

5 a-synuclein that ranges from a physiological multimeric, alpha-helical, and membrane-bound species th

6 integrity markers, and soluble monomeric and multimeric amyloid-beta and tau species were measured.

7 d 807 causes the C region to form aberrantly multimeric and aggregated complexes with an unstable sec

8 The overall organization reflects a multimeric and bipolar organization, with molecules of M

9 At high concentrations, the proteins are multimeric and dynamically interact with RNA in an RNA l

10 ion, gel filtration chromatography separated multimeric and monomeric forms of wild type and mutant h

11 The Nipah virus phosphoprotein (P) is multimeric and tethers the viral polymerase to the nucle

12 Tie2 is regulated directly by the multimeric angiopoietin (Ang) ligands, with Ang1 being i

13 2 and CD20 positive cancer cells, as well as multimeric antibody fragments with enhanced activity.

14 eted cross-linking indicates that it forms a multimeric array.

15 ncies among multiple donors and acceptors in multimeric arrays has waited for further testing.

16 etermine the characteristics of the distinct multimeric assemblies - a flexuous, helical rod or a loo

17 Structural comparisons between known S100 multimeric assemblies together with analysis of calcium-

18 In multimeric assemblies, the controllable motors walk proc

19 stallin ('alphaB'), forms large polydisperse multimeric assemblies.

20 as under nonreducing conditions it presented multimeric assembly forms.

21 ts are several enzymes for which the correct multimeric assembly is crucial to their activity, such a

22 its cognate effector, SopB, implying a novel multimeric association for chaperone/effector complexes

23 nked glycan has a similarly critical role in multimeric, avidly binding Fcs, is unknown.

24 PFO forms a multimeric barrel with many TM segments.

25 levels of complexity in the engagement of a multimeric bEBP with a basal transcription complex via s

26 adhesin molecules to form arrays of ordered multimeric binding sites.

27 s thread-like shape exposes its monomers for multimeric binding to platelets and subendothelium and l

28 Proteolysis of the multimeric blood coagulation protein von Willebrand Fact

29 Physiological concentrations of multimeric but not monomeric cochlin reduce TREK-1 curre

30 ic state as being monomeric, dimeric, and/or multimeric, but the native cellular stoichiometry has re

31 In multimeric cell-surface receptors, the conformational ch

32 c region in CESA oligomerization to form the multimeric cellulose-synthesis complexes that are charac

33 TRPM1 likely forms a multimeric channel complex, although almost nothing is k

34 Secretins form multimeric channels across the outer membrane of Gram-ne

35 gative mutations in other disease-associated multimeric channels, we developed a generalizable comput

36 ntly influence subunit stoichiometry to form multimeric channels.

37 lized regulatory mechanism for other related multimeric channels.

38 iral reverse genetic system and introduced a multimeric clone into the laboratory model plant Nicotia

39 recise excision of the viral genome from the multimeric clones in inoculated leaves.

40 Agroinoculation of multimeric clones of the genomic DNA of three ToLDeV gen

41 Pourbaix diagrams with full consideration of multimeric cluster speciation from computations.

42 APLP1 oligomerization and forced APLP1 into multimeric clusters at the plasma membrane consistent wi

43 metastable but also thermodynamically stable multimeric clusters in aqueous solutions.

44 s demonstrate that high shear stress-induced multimeric cochlin produces a qualitatively different in

45 omeodomain (HD) transcription factors form a multimeric complex and assign neuronal subtype identitie

46 containing the WDXNWD motif dissociates the multimeric complex and reduces but does not fully abolis

47 Formation of a multimeric complex between C4-S and pro-CatK has been sp

48 A recent study has identified a new multimeric complex called retriever that is essential fo

49 is study, we demonstrate that CTLA-4 forms a multimeric complex comprised of TRIM and related LAX tha

50 The resulting multimeric complex consisting of DiRas3, C-RAF, and acti

51 phaSuFc complex, also known as ALT-803, is a multimeric complex constructed by fusing IL-15N72D.IL-15

52 ge assembly of splicing regulators (LASR), a multimeric complex containing the proteins hnRNP M, hnRN

53 ed at opposite sides of the protein allowing multimeric complex formation previously shown in ASC PYD

54 PRMT5 acts as part of a multimeric complex in concert with a variety of partner

55 DM1 and DM2d each resides in a multimeric complex in the absence of signaling, with the

56 erent proteins (Gemins 2-8, Unrip) to form a multimeric complex involved in the assembly of small nuc

57 units and their positions within the overall multimeric complex is key to understanding the molecular

58 f the viral Rev adapter protein that forms a multimeric complex on these mRNAs prior to recruiting hC

59 rimental evidence for secretion of an intact multimeric complex requiring a signal formed by both mem

60 e.g., tubulin and actin) as a membrane-bound multimeric complex that favors p35 binding to Cdk5 and c

61 We conclude that Raa7 is a component of a multimeric complex that is required for trans-splicing o

62 s, we could demonstrate that AtALMT9 forms a multimeric complex that is supposedly composed of four s

63 The Sec61 protein translocon is a multimeric complex that transports proteins across lipid

64 glycan that can organize co-receptors into a multimeric complex to transduce intracellular signals.

65 Our results suggest the formation of a multimeric complex, dependent on a conserved cysteine at

66 tional criteria, for example membership of a multimeric complex, participation in a metabolic or sign

67 t, Bax activation promotes the assembly of a multimeric complex, which then catalyzes the second reac

68 also affect stability and disassembly of the multimeric complex.

69 re dependent on the interactions of Hand2 in multimeric complexes and are independent of direct DNA b

70 in the WDXNWD motif abolish the formation of multimeric complexes and markedly reduce phosphatase act

71 binding proteins that form ordered, rod-like multimeric complexes and polymerize into filaments, but

72 these mutated proteins assembled into large multimeric complexes and, compared to CFHR5, bound damag

73 l characterized Arps are components of large multimeric complexes associated with chromatin or the cy

74 that via homophilic interactions ORF3 forms multimeric complexes associated with intracellular endop

75 Typically, these membrane proteins are multimeric complexes associating several homologous subu

76 iffusing molecules, are often organized into multimeric complexes forming clusters on the cell and or

77 we were able to demonstrate the formation of multimeric complexes in live cells.

78 contributes to the assembly and function of multimeric complexes is an important question with impli

79 t the surface of the cell membrane by large, multimeric complexes of synthase proteins.

80 lific class of ubiquitin ligase enzymes, are multimeric complexes that regulate a wide range of cellu

81 e constructs can then be self-assembled into multimeric complexes with defined composition, valency,

82 N-terminal half of adenovirus e1a assembles multimeric complexes with host proteins that repress inn

83 homeodomain transcription factor that forms multimeric complexes with TALE and HOX proteins to regul

84 itions in ORF3 critical for its formation of multimeric complexes, ion channel activity, and, ultimat

85 f PGAM5, in which the assembly of PGAM5 into multimeric complexes, mediated by the WDXNWD motif, resu

86 is required for assembly of PGAM5 into large multimeric complexes.

87 tanding the assembly of other TPR-containing multimeric complexes.

88 not other regions, are in close proximity in multimeric complexes.

89 copurifying with Cdk5/p35 in membrane-bound multimeric complexes.

90 o the structure determination of subunits of multimeric complexes.

91 discrete yes/no output similar to that of a multimeric cooperative enzyme with a Hill coefficient ab

92 he binding constants of a ligand to a highly multimeric cooperative system, and thereby infer its all

93 Hemocyanins are multimeric copper-containing hemolymph proteins involved

94 in its integral capacity as a scaffold for a multimeric core complex.

95 is and survival; it is composed of 12 mostly multimeric core proteins, which build a sophisticated se

96 ssary for ubiquitin ligation activity of the multimeric cullin ring ubiquitin ligases (CRLs).

97 omoting complex/cyclosome (APC/C) is a large multimeric cullin-RING E3 ubiquitin ligase that orchestr

98 The APC/C is an unusually large multimeric cullin-RING ligase.

99 Inflammasomes, multimeric cytosolic sensors of infection, are required

100 We expect that this enhanced multimeric de novo peptide design framework will find fu

101 proteins within the 26 S proteasome, a large multimeric degradation machine.

102 The cyclic, multimeric derivatives exhibited slightly higher relaxiv

103 overcome these challenges with high-affinity multimeric designs.

104 KIR3DL2Fc pulled down multimeric, dimeric, and monomeric FHC from HLA-B27-expr

105 Multimeric discriminant functions combined with individu

106 ally engineered, to be used as platforms for multimeric display of foreign antigens.

107 biquitin chain assembly complex (LUBAC) is a multimeric E3 ligase that catalyses M1 or linear ubiquit

108 though the production of isolated domains of multimeric ectodomain proteins has proven difficult, we

109 r co-fractionation from lens extracts as one multimeric entity, alpha-crystallin.

110 To study the assembly of this multimeric enzyme complex consisting of membrane-integra

111 Mitochondrial complex I is the largest multimeric enzyme of the respiratory chain.

112 air cytochrome C oxidase (COX) function, the multimeric enzyme that executes the last step in aerobic

113 ther, the trend exists in both monomeric and multimeric enzymes and irrespective of enzyme size and/o

114 Our study establishes the principle that multimeric enzymes can exploit this cooperativity withou

115 ive approach to identify allosteric sites of multimeric enzymes in general.

116 While the mechanism underlying regulation of multimeric enzymes is generally well understood and prop

117 lfide bridging is commonly used to stabilize multimeric enzymes.

118 Here we show that the multimeric ER proteins erlins-1 and -2 are additional SR

119 metry of multimer assembly, producing unique multimeric Fab structures.

120 We have purified a multimeric [FeFe]-hydrogenase from A. woodii containing

121 resulted in the formation of unusually large multimeric FHR complexes that exhibited increased avidit

122 rmediates and assemble into their functional multimeric folds only upon reaching the spirochetal surf

123 atural hosts, Neurospora crassa, exists in a multimeric form and has the ability to polymerize NTPs a

124 NA by allosterically stabilizing an inactive multimeric form of integrase.

125 d to increased levels of an overoxidized and multimeric form of Prdx-1 with activity as a molecular c

126 in cytosol to a physiologically functional, multimeric form upon membrane binding, and show that onl

127 its antiviral activity in a monomeric and/or multimeric form.

128 e plasma of patients revealed a reduction of multimeric forms and a reduced ability to bind the natur

129 nding to an isolated M-CAT-like DNA element, multimeric forms are deficient for cooperative binding t

130 Using this mechanistic insight, we designed multimeric forms of anti-CD40 mAb with intrinsic Fcgamma

131 ed neurons, contain dithiothreitol-sensitive multimeric forms of cofilin, predominantly dimer.

132 caused a reduction in antibody reactivity to multimeric forms of parvalbumins for most bony fish, a c

133 hosphorylated, conformationally altered, and multimeric forms of tau lead to a disruption of MT stabi

134 ried out to ascertain which of the potential multimeric forms of the transmembrane peptaibol channel,

135 plasma metalloproteinase that cleaves large multimeric forms of von Willebrand factor (VWF) to small

136 aracter, making it prone to aggregation into multimeric forms.

137 nscribed, generating genomic and antigenomic multimeric forms.

138 ure consisting of both monomeric circles and multimeric forms.

139 Multimeric fragment crystallizable (Fc) regions and Fc-f

140 gle x-ray scattering in contrast to reported multimeric fucosidases.

141 The multimeric function, which consisted of the Zernike fitt

142 tion of potassium current was also seen with multimeric G85R SOD1YFP of approximately 300 kDa or >300

143 e mutations in GBMs to be recruitment of the multimeric GA-binding protein (GABP) transcription facto

144 f Gal80 in light of the evidence pointing to multimeric Gal80 as the form required to inhibit Gal4.

145 from the cartilage surface, and addition of multimeric galectin-3 enhances cartilage lubrication.

146 aracterization of the primary structure of a multimeric glycoprotein in a single analysis by capillar

147 von Willebrand factor (VWF) is a large multimeric glycoprotein that mediates the attachment of

148 The large multimeric glycoprotein von Willebrand Factor (VWF) play

149 The large multimeric glyocoprotein von Willebrand factor (VWF) is

150 The TRAPP complexes are multimeric guanine exchange factors (GEFs) for the Rab G

151 , a general prerequisite for the assembly of multimeric H(+)-translocating enzymes.

152 een immunized with a multicomponent vaccine (multimeric HIV-1 gp160, HIV-1 Tat, and SIV Gag-Pol parti

153 Apparently, the multimeric hydrogenase of A. woodii is a soluble energy-

154 l tendency of each clone to form dimeric and multimeric immune complexes.

155 cellular FcgammaRs occurring in the form of multimeric immune complexes.

156 They are multimeric in structure and comprised of an alpha subuni

157 Upon activation, NLRP3 assembles a multimeric inflammasome complex comprising the adaptor A

158 inflammation, mediates cell adhesion through multimeric interactions with the linear extracellular gl

159 activity or structure-specific disruption of multimeric interactions.

160 based single-molecule FRET measurements of a multimeric ion channel in a lipid bilayer have allowed u

161 ondrial Ca(2+) uniporter complex (MCUC) is a multimeric ion channel which, by tuning Ca(2+) influx in

162 Together, these results suggest that multimeric KhpA/B may function as a pleiotropic RNA chap

163 The function of this multimeric LASR complex has implications for deciphering

164 These findings indicate that multimeric ligands can significantly enhance conotoxin p

165 he characterization of industrial grade MDA, multimeric MDA species, and methylene diphenyl diisocyan

166 orulating Bacillus subtilis cells assemble a multimeric membrane complex connecting the mother cell a

167 ive approach to extract the stoichiometry of multimeric membrane proteins in their native cellular en

168 ly at the presynaptic plasma membrane in its multimeric membrane-bound state, but not in its monomeri

169 e binding and oligomerization to form large, multimeric membrane-embedded complexes.

170 e proteolysis by gamma-secretase, which is a multimeric membrane-embedded protease comprised of prese

171 A multimeric model of the pore is presented based on these

172 symmetry aspects affecting the reactions of multimeric molecular structures.

173 d structures and that may be used to develop multimeric, multimodal molecular imaging agents to probe

174 rmal growth factor (EGF)-like molecule) is a multimeric, multimodular extracellular glycoprotein with

175 We have investigated the multimeric nature of Spd1 using size-exclusion chromatog

176 ibe the synthesis and in vivo testing of two multimeric NIR-MR contrast agents that contain three Gd(

177 Multimeric oxo-hydroxo Al clusters function as models fo

178 -based DNA translocation motors consist of a multimeric packaging terminase docked onto a unique proc

179 most often in variants with a nearly normal multimeric pattern (type 2M).

180 ate that variations in von Willebrand factor multimeric pattern are highly dynamic, occurring within

181 Importantly, administration of soluble multimeric PD-L2 to mice with lethal malaria was suffici

182 Von Willebrand factor (VWF) is a large, multimeric plasma glycoprotein that critically mediates

183 Von Willebrand factor (VWF) is a multimeric plasma glycoprotein that is activated for hem

184 tween Stx and von Willebrand Factor (VWF), a multimeric plasma glycoprotein that mediates platelet ad

185 von Willebrand factor (VWF) is a multimeric plasma protein that mediates platelet adhesio

186 r activity 44 IU/dL; factor VIII 99%; normal multimeric plasma vWF pattern) was referred to our insti

187 ty using both a VWF A2 peptide substrate and multimeric plasma VWF.

188 in a substrate peptide, but required urea in multimeric plasma VWF.

189 low affinity, which necessitates the use of multimeric pMHC complexes to label T lymphocytes stably.

190 s the synthesis and biological evaluation of multimeric polyamine derivatives as efficient PTS ligand

191 r membrane secretins are suggested to form a multimeric pore for the uptake of external DNA.

192 e in NT4 peptides led to identification of a multimeric positively charged motif, which mediates inte

193 recursor proteins or cooperatively transport multimeric precursors.

194 presenilin components of gamma-secretase, a multimeric protease.

195 Meprins are multimeric proteases that are implicated in inflammatory

196 es, we produced at high levels in bacteria a multimeric protein (alpha11-88x8) fusing eight polypepti

197 Multimeric protein assemblies are essential components i

198 PC1 binds a multimeric protein complex consisting of several GTPases

199 The retromer complex is a multimeric protein complex involved in recycling protein

200 N-mtMCM is a multimeric protein complex that consists of 12 monomers,

201 The NLRP3 inflammasome is a multimeric protein complex that is assembled in response

202 1)F(o) complex) is an evolutionary conserved multimeric protein complex that synthesizes the main bul

203 n nuclear receptor that we show engages in a multimeric protein complex to regulate the transcription

204 investigate the gas-phase structures of four multimeric protein complexes during collisional activati

205 The spliceosome machinery is composed of multimeric protein complexes that generate a diverse rep

206 PMTs often function in vivo through forming multimeric protein complexes, dissecting their activitie

207 ature on the stability and structure of four multimeric protein complexes.

208 try with which monomers are arranged in many multimeric protein complexes.

209 potential of glycosaminoglycans to assemble multimeric protein complexes.

210 Von Willebrand Factor (VWF) is a multimeric protein crucial for hemostasis.

211 wever, understanding the cell cycle roles of multimeric protein phosphatases has been limited by the

212 ace, anchored in both bacterial membranes by multimeric protein rings.

213 t chemical and biological studies on natural multimeric protein structures, including fibers, rings,

214 Clathrin is a multimeric protein that has been shown to stabilise K-fi

215 PAH is a multidomain homo-multimeric protein whose conformation and multimerizatio

216 von Willebrand factor (VWF), a multimeric protein with a central role in hemostasis, ha

217 ity to control labeling of subunits within a multimeric protein with acceptor and donor fluorophores,

218 ins are considered to be two subunits of one multimeric protein, alpha-crystallin, within the ocular

219 As a secreted multimeric protein, CTRP11 forms disulfide-linked oligom

220 These results highlight the use of multimeric protein-polymer conjugates for their potentia

221 bind cooperatively to DNA and to form large multimeric protein/DNA fibers.

222 Soluble, recombinant multimeric proteins based on the HIV-1 env gene are curr

223 by its amino acid sequence, but how complex multimeric proteins fold and assemble into functional qu

224 The concerted transition model for multimeric proteins is a simple formulation for analyzin

225 icals, is especially useful for insoluble or multimeric proteins required for oral drug delivery.

226 Ion channels are dynamic multimeric proteins that often undergo multiple unsynchr

227 Cooperativity is a feature many multimeric proteins use to control activity.

228 In cases of multimeric proteins, such allosteric regulation has ofte

229 for producing individual domains of complex multimeric proteins.

230 the allosteric transitions of multidomain or multimeric proteins.

231 ting distances up to 170 A to be accessed in multimeric proteins.

232 distance measurements between spin-labels on multimeric protonated proteins using double electron-ele

233 ive, with the large GTPase Dynamin-3 and the multimeric PSD adaptor protein Homer1 as the two main pl

234 Intriguingly, one subfamily retained a multimeric quaternary structure and has small insertions

235 ed 20 different proteins, both monomeric and multimeric, ranging in mass from 2846 Da (melittin) to 1

236 ng of one or more molecules of a ligand to a multimeric receptor makes it more difficult for subseque

237 In a multimeric receptor protein, the binding of a ligand can

238 Negative cooperativity can make a multimeric receptor's response more graded than it would

239 sts that the mutated delta incorporates into multimeric receptors and reduces the overall forward tra

240 reveals that assembly of Pcdh isoforms into multimeric recognition units and the observed tolerance

241 Our experiments demonstrate that multimeric regulatory complexes feature a dynamic interp

242 of function might explain how other complex multimeric restriction enzymes act.

243 The anaphase-promoting complex (APC/C) is a multimeric RING E3 ubiquitin ligase that controls chromo

244 -related genes, in particular, components of multimeric RING E3 ubiquitin ligases including F-Box, SK

245 The pRNA forms a multimeric ring via intermolecular base-pairing interact

246 Multimeric, ring-shaped molecular motors rely on the coo

247 involving dissociation and re-association of multimeric rings has been described.

248 YscJ proteins form large multimeric rings that are the structural scaffolds for t

249 report the quaternary structure of this rare multimeric RNA at 3.5 A resolution, crystallized as tetr

250 structure of polymerase lattices within the multimeric RNA-dependent RNA polymerase complex should f

251 tric rolling circle mechanism to form linear multimeric RNAs.

252 We found that the multimeric rod phosphodiesterase 6 (PDE6), a prenylated

253 of the antigen by combining antigens with a multimeric scaffold.

254 the Fab1 complex requires Vac14/ArPIKfyve, a multimeric scaffolding adaptor protein that coordinates

255 The multimeric scaffolding protein gephyrin forms post-synap

256 Members of a group of multimeric secretion pores that assemble independently o

257 roteins can be versatile building blocks for multimeric, self-assembling structures.

258 y mechanisms of cardiac contractility by the multimeric SERCA/PLN-ensemble and the potential for new

259 ate of number, size, and composition of such multimeric SHE particles in the cell.

260 CM304 increased the proportion of multimeric sigma1Rs, whereas (+)-pentazocine increased m

261 first time that CS is capable of assembling multimeric signaling complexes and modulating neurotroph

262 tion receptor signaling is the assembly of a multimeric signaling platform, termed the inflammasome,

263 The regulation of VWF multimeric size and platelet-tethering function is carri

264 nd form that is composed of an alpha-helical multimeric species that chaperones SNARE-complex assembl

265 assembles at the fork into a distribution of multimeric species, each encompassing a broad distributi

266 useful in the characterization of larger MDA multimeric species, industrial MDA mixtures, and methyle

267 members are large GTPases that assemble into multimeric spirals.

268 of ssDNA in modulating the binding mode of a multimeric SSB protein and consequently, in generating t

269 Multimeric SSBs, such as the human mitochondrial SSB (Hm

270 -TM helix proteins may link raft affinity to multimeric state and thus control the assembly of multim

271 is conformational change does not impact the multimeric state of the protein.

272 bly of the transpososome and arises from the multimeric state of the transposase, mediated by a compe

273 e a unified dataset reporting the amount and multimeric state of VWF secreted from the constitutive,

274 te affected neither exonuclease activity nor multimeric state.

275 our findings provide a mechanism wherein the multimeric states of both Mff and Drp1 regulate their co

276 Here, it is suggested that variation in the multimeric states of proteins can readily arise from sto

277 further insight into the different types of multimeric states that this protein can adopt, we genera

278 th inadequate cleavage by ADAMTS-13 of ULVWF multimeric strings secreted by/anchored to ECs (thrombot

279 and activated on EC-secreted/anchored ULVWF multimeric strings.

280 d to a protein, or surrounding subunits in a multimeric structure or assembly.

281 id not alter VWF secretion by HEK293T cells, multimeric structure, or static collagen binding.

282 human IgG1 (IgG1-Fc) can be engineered into multimeric structures (hexa-Fcs) that bind their cognate

283 us which have been shown to crystallise into multimeric structures have been examined for their scaff

284 lassification algorithms can also be used on multimeric structures obtained using other high-resoluti

285 es of proteins is their common assembly into multimeric structures, usually homomers with even number

286 ing accurate prediction of protein folds and multimeric structures.

287 We used an mAb and/or a multimeric synthetic sulfated sialoglycan ligand recogni

288 n) based on metrics that we have devised for multimeric systems.

289 The first stage uses a simulated multimeric template structure as input into the optimiza

290 meric state and thus control the assembly of multimeric TM complexes in rafts.

291 y of IFN-stimulated gene factor 3 (ISGF3), a multimeric transcriptional activation complex composed o

292 IM domain-binding protein 1 (LDB1) nucleates multimeric transcriptional complexes and establishes pro

293 t depends on the binding and activity of the multimeric ubiquitin ligase, SCF(betaTrCP) (Skp Cullin F

294 cribed here are based on either monomeric or multimeric units harboring RNA aptamers as protein docki

295 ies for the controlled synthesis of extended multimeric units with tunable properties and the potenti

296 The abundance of the multimeric vacuolar ATP-dependent proton pump, V-ATPase,

297 nd provides a scaffold for the assembly of a multimeric viral-cellular NEC.

298 Multimeric von Willebrand factor (VWF) is essential for

299 3-mediated proteolysis of peptidyl VWF73 and multimeric VWF are 3.5 muM and 45 muM, respectively.

300 -fold cleaving a peptide VWF73 substrate and multimeric VWF, respectively.