ライフサイエンスコーパス: multimerization

1 instead results from oxidation-mediated PML multimerization.

2 MLV Gag via the basic cluster of MA and Gag multimerization.

3 argeted glycans, we tested the use of lectin multimerization.

4 s a potential mechanism for GAG-dependent Hh multimerization.

5 oup of membrane proteins is only formed upon multimerization.

6 ytoskeleton is required for zinc-induced cis multimerization.

7 y that could be detected only through lectin multimerization.

8 sis, we examined the domains involved in HuR multimerization.

9 These interactions promote CA domain multimerization.

10 tion at Asn-563 is essential for controlling multimerization.

11 )(6)(0) in the D2 domain as critical for VWF multimerization.

12 s (pK(a) ~6.0) mediates the pH dependence of multimerization.

13 , reverse transcription, integration, and IN multimerization.

14 positively charged NC domains of Gag3 limit multimerization.

15 uctural changes of the TCR allowing improved multimerization.

16 is segment is known to be involved in capsid multimerization.

17 hile the hydrophobic residues function in IN multimerization.

18 on, underlining the functional importance of multimerization.

19 tial for the oxidoreductase mechanism of VWF multimerization.

20 slational modification, and sites of complex multimerization.

21 on the role of the cholesterol moiety in Shh multimerization.

22 nuclear localization as a measure of in vivo multimerization.

23 ts transcriptional activity through impaired multimerization.

24 HuR domains involved in cancer cell-specific multimerization.

25 feration largely paralleled their effects on multimerization.

26 osphorylation, consistent with phospholemman multimerization.

27 olecular factors influencing alpha-synuclein multimerization.

28 zipper dimerization motif that promotes Gag multimerization.

29 ropriate receptor self-association and/or HA multimerization.

30 , and these substitutions also diminished IN multimerization.

31 ions were identified, which impaired protein multimerization.

32 iation that affects HP protein structure and multimerization.

33 HIV-1 Gag to the VCCs requires NC-dependent multimerization.

34 e inhibitor interface blocked ALLINI-induced multimerization.

35 , preference for membrane order, and protein multimerization.

36 contacting acidic lipids or by promoting Gag multimerization.

37 losterically but, rather, by stimulating its multimerization.

38 hich structural determinants underlie native multimerization.

39 ish LPL binding lead to protein dimerization/multimerization.

40 ng of the disintegrin domain, prevents ADAM8 multimerization.

41 micronemia, also led to protein dimerization/multimerization.

42 ma1R ligands had distinct effects on sigma1R multimerization.

43 tention or degradation of VWF, (2) defective multimerization, (3) loss of regulated storage, and (4)

44 e and strongly impair nucleotide binding and multimerization ability.

45 Localization of multimerization activity to the C terminus led to the di

46 rting this, alpha-syn mutations that disrupt multimerization also fail to restrict synaptic vesicle m

47 Reduced activity of AtxA H199A, lack of multimerization and activity of AtxAH379D variants, and

48 palmitoylation of HCMV gB and its role in gB multimerization and activity.

49 se susceptibility, release by osmotic shock, multimerization and affinity for metal cofactors.

50 For biological function, ADAM8 requires multimerization and associates with beta1 integrin on th

51 protein was shown to be involved in protein multimerization and binding to single and double strande

52 extensions that have been linked to protein multimerization and cellular localization.

53 As multimerization and clustering is a prerequisite for TNF

54 inct Cys-->Ser substitutions were tested for multimerization and cross-linking.

55 ce of the prefactor that arises from protein multimerization and DNA binding.

56 Finally, although multimerization and enzymatic activity are necessary for

57 t; removal of this linker impairs both Cox15 multimerization and enzymatic activity.

58 These results indicate that the multimerization and IN binding properties of INI1 are ne

59 Although ALLINIs promote aberrant IN multimerization and inhibit IN interaction with its cell

60 sm of action by allosterically modulating IN multimerization and interfering with IN-lens epithelium-

61 GP(Y/F) residues may play roles in promoting multimerization and intermolecular strand joining.

62 al repressor domain (RD) that controls RIG-I multimerization and IPS-1 interaction.

63 actively participates in the process of VWF multimerization and is essential for trafficking of VWF

64 significant correlation between adiponectin multimerization and its insulin-sensitizing effects has

65 omain and hydrophobic groove did not inhibit multimerization and mitochondrial damage, indicating tha

66 ting Bax and Bcl-X(L), thereby promoting Bax multimerization and mitochondrial translocation.

67 We propose that Rev multimerization and NES masking regulates Rev's traffick

68 on of storage granules, and was defective in multimerization and platelet binding.

69 -abolishing alphaS variant but also restored multimerization and prevented the aberrant vesicle inter

70 ing and beta-structure formation inhibits FN multimerization and prevents physiological cell-based FN

71 ptide (VWFpp) and mature VWF aids N-terminal multimerization and protein compartmentalization in stor

72 ut are instead due in part to differences in multimerization and receptor-ligand stoichiometry confer

73 t a high degree of plasticity for functional multimerization and reveal a critical role of the C-term

74 its robust inhibition of virus-induced RIG-I multimerization and RIG-I-MAVS signaling complex formati

75 NC is also critical for Gag multimerization and RNA binding.

76 nteractive protein that promotes adiponectin multimerization and stability in obesity-induced endopla

77 hanisms by which obesity impairs adiponectin multimerization and stability, and 2) to determine the p

78 nd D3 domains that are known to regulate VWF multimerization and storage.

79 naptic transmission can be regulated by Syt1 multimerization and that both C2 domains of Syt1 are uni

80 on to the previously demonstrated N-terminal multimerization and the first two PDZ (PSD-95, Dlg1, zon

81 Various mechanisms exist to counter multimerization and thus ensure stable maintenance.

82 emia subtype M4Eo, contains domains for self-multimerization and transcriptional repression, both of

83 The compounds promote virion IN multimerization and, reminiscent of class II IN mutation

84 ion regulates TGFbeta receptor organization, multimerization, and function, providing new insight int

85 unavailable owing to its large size, complex multimerization, and functional differences of the multi

86 idues important for inducer binding, protein multimerization, and interaction with RNA polymerase at

87 tive rates of translational repression, mRNP multimerization, and mRNA decay.

88 to its function, the extent of VWF release, multimerization, and polarity of the 3 secretory pathway

89 n genesis, coincident with membrane binding, multimerization, and proteolytic maturation.

90 on downstream of residue 136 is required for multimerization, and the region downstream of residue 20

91 g DNA, PRDM9's zinc fingers also mediate its multimerization, and we show that a pair of highly diver

92 Although multimerization appears necessary for localization to ea

93 that domains within Gag known to mediate Gag multimerization are also required.

94 Although IN binding and multimerization are required for INI1-mediated inhibitio

95 ations that are predicted to impair receptor multimerization are rescued by overexpression of TSPAN12

96 s provide structural clues for exploiting IN multimerization as a new, attractive therapeutic target

97 ts into the physiological relevance of GLUT1 multimerization as well as a new variant of BRET assay t

98 g (as revealed by mobility shift assays) and multimerization (as revealed by gel filtration, dynamic

99 In this study, a Gag-Gag multimerization assay measuring fluorescence resonance e

100 unoblot, RNA protection, cDNA synthesis, and multimerization assays.

101 zed the defect in DDX6-depleted cells to Gag multimerization at the plasma membrane.

102 maturation by inducing hyper- or aberrant IN multimerization but are largely ineffective during the e

103 Upon netrin-1 stimulation TRIM9 promotes DCC multimerization, but TRIM9-dependent ubiquitination of D

104 Disruption of HDAg multimerization by site-directed mutagenesis was found t

105 sing single-molecule analysis, and show that multimerization can be blocked by mutations in a specifi

106 opisthorchiasis and CagA and CagA with CagA multimerization (CM) sequence-positive H. pylori.

107 of FP11-tag as a labelling tool as well as a multimerization-control tool for both imaging and non-im

108 a suggest that NS5A-NS5A dimerization and/or multimerization could represent a novel target for the d

109 We now demonstrate that a multimerization-defective APO3G variant (APO3G C97A) is

110 molecular weight IN-INI1 complexes, and the multimerization-defective mutant was unable to form thes

111 Multimerization-defective mutants are also defective for

112 ity to tolerate a SNES was both position and multimerization dependent, an observation consistent wit

113 rear-end protrusion known as the uropod in a multimerization-dependent manner.

114 membrane binding and targeting and suggest a multimerization-dependent mechanism for Gag trafficking

115 N function in vivo as overexpression of this multimerization domain caused increased sensitivity to c

116 the yeast two-hybrid system to determine the multimerization domain of ELAV.

117 the ALL-associated PAX5 fused to ETV6 or the multimerization domain of ETV6 SAM results in stable chr

118 We present the crystal structure of the multimerization domain of Nipah virus P: a long, paralle

119 ests this Nab3 'tail' forms an alpha-helical multimerization domain that helps assemble it onto an RN

120 at the Rpt1 and Rpt2 motifs form the minimal multimerization domain.

121 LR, or replacement of the LR by heterologous multimerization domains from the GCN4 or p53 proteins, d

122 Silencing of immunogenic multimerization domains with glycans might be relevant f

123 itial steps including proprotein processing, multimerization driven by the C terminus, and the head-t

124 mechanism of action by inducing aberrant IN multimerization during virion morphogenesis and by compe

125 Mutant HDAg proteins defective for multimerization exhibited neither the 300-nt RNA size re

126 4-ORF3 mutant, which is defective in protein multimerization, exhibited severely decreased activity,

127 Our results support a model in which Atg9 multimerization facilitates membrane flow to the PAS for

128 the predicted dimensions on the DNA, with CI multimerization favoured by DNA binding.

129 of human APO3G and studied the role of APO3G multimerization for catalytic activity, virus encapsidat

130 t of retroviral gag capsid domains and whose multimerization has been proposed as a model for retrovi

131 overexpression of XBP1s promotes adiponectin multimerization in adipocytes, thereby regulating system

132 localization of PopZ largely relies on PopZ multimerization in chromosome-free regions, consistent w

133 analysis of this tumor-specific HuR protein multimerization in clinical brain tumor samples.

134 , our findings provide new insights into HuR multimerization in glioma and highlight possible pharmac

135 hree) HuR molecules come together during HuR multimerization in glioma cells.

136 sing these data, we developed a model of HuR multimerization in glioma cells.

137 Variants were assessed for multimerization in low ionic strength in vitro and for n

138 ons between protein and membrane, and of Gag multimerization in membrane association in vivo.

139 To directly address the role of multimerization in membrane binding, we fused the MA dom

140 he role of REF binding, RNA interaction, and multimerization in ORF57 function.

141 To assess a role for multimerization in silencing, we conducted structure mod

142 rization of pp28 within the AC and that pp28 multimerization in the AC represented an essential step

143 , we investigated the potential role of pp28 multimerization in the envelopment of the infectious vir

144 study specifically examines the role of HDAg multimerization in the formation of the HDV ribonucleopr

145 dent manner, with dissociation constants for multimerization in the micromolar range.

146 reases the stability of KaiA in vivo, causes multimerization in vitro, and blocks KaiA stimulation of

147 Here, we report HuR aggregation (multimerization) in glioma and the analysis of this tumo

148 ne, Gag association with lipid rafts, or Gag multimerization, indicating that the mechanism of inhibi

149 etal, smooth and nonmuscle myosins, prevents multimerization, inhibition of CBF and inhibition of cel

150 tosolic dopamine caused an increase in DISC1 multimerization, insolubility and complexing with the do

151 her constraints of interaction or additional multimerization interfaces.

152 spindlin at the spindle midzone requires its multimerization into clusters and Aurora B kinase activi

153 A mechanism of multimerization into higher-order asymmetric oligomers v

154 our results further underpin the model that multimerization is critical for PM association of retrov

155 Multimerization is enhanced in the presence of heparin a

156 rotein and suggest that higher-order protein multimerization is essential for E4-ORF3 activity.

157 This multimerization is evolutionarily conserved and independ

158 We conclude that Cox15 multimerization is important for heme a biosynthesis and

159 j3's substrate binding ability, arguing that multimerization is important for substrate binding.

160 ion with Fab1 or Fig4, suggesting that Vac14 multimerization is likely the first molecular event in t

161 ns and support a model in which SAM-mediated multimerization is necessary for TIR-dependent engagemen

162 se interactions promote higher-order protein multimerization is not clear.

163 nction as RRM3 in vivo, which suggested that multimerization is not the only function of RRM3.

164 Dimerization/multimerization is relevant to disease pathogenesis, giv

165 Cox10 multimerization is triggered by progression of Cox1 from

166 in (DIX) domain, but not DIX domain-mediated multimerization, is essential for DVL's centrosomal loca

167 Impairments in adiponectin multimerization lead to defects in adiponectin secretion

168 We engineered alphaS mutants incapable of multimerization, leading to excess monomers at vesicle m

169 ting that important determinants of helicase multimerization lie outside the helicase domain.

170 urface of the CBFbeta-SMMHC ACD that prevent multimerization may be effective as novel therapeutics i

171 novel insights into the interplay among Gag multimerization, membrane binding, virus assembly, CA di

172 This includes actin polymerization, tubulin multimerization, microtubule organizing center formation

173 We explore how substrate multimerization modulates recognition by the ClpX unfold

174 the newly identified compound 5 disrupts HuR multimerization modules and reduces tumor cell survival

175 ion technique, in-source phenomena including multimerization, nonproton cation adduction, and in-sour

176 rly, Sid2 phosphorylation of Cdc12 abrogates multimerization of a previously unrecognized Cdc12 domai

177 Here we demonstrate that multimerization of a soluble single-chain TCR (scTCR), r

178 r-mass (HMM) complexes, suggesting that homo-multimerization of APO3G and assembly into HMM complexes

179 Interestingly, multimerization of APO3G was exquisitely sensitive to RN

180 Overall, our results imply that multimerization of APOBEC3 proteins may be related to th

181 tes that the Bak apoptotic pore forms by the multimerization of BH3:groove homodimers and reveals tha

182 Multimerization of D5 appeared to be a prerequisite for

183 etrin-dependent morphogenesis is preceded by multimerization of DCC, activation of FAK and Src family

184 Potent methylation is dependent on the multimerization of Dnmt3a/Dnmt3L complexes on the DNA.

185 tion, this result suggests that higher-order multimerization of E4-ORF3 may be required for the activ

186 haracterized ligand-induced dimerization and multimerization of EGFR using single-molecule analysis,

187 The multimerization of FliG is promoted by FliF and also by

188 might affect the localization, topology, or multimerization of Fpn.

189 SMA-causing missense mutations that block multimerization of full-length SMN are also stabilized i

190 multimers and TSPAN12 cooperatively promote multimerization of FZD4 and its associated proteins to e

191 lasma membrane association and capsid-driven multimerization of Gag are sufficient to drive MLV Gag t

192 dent on plasma membrane (PM) association and multimerization of Gag but independent of the viral glyc

193 an approach for probing the galectin-induced multimerization of glycoconjugates on cultured cells.

194 cysteine in the GPIHBP1 Ly6 motif results in multimerization of GPIHBP1, defective LPL binding, and s

195 residues, hydrophobicity at residue 29, and multimerization of HD5, which increases initial binding

196 recombinant proteins show that RelA enhances multimerization of Hfq monomers and stimulates Hfq bindi

197 reas the intermolecular interaction leads to multimerization of HTLV-1 NC on the NA.

198 investigated the functional determinants for multimerization of human APO3G and studied the role of A

199 irus viability, strongly suggesting that the multimerization of I3 is biologically significant.

200 We conclude that cooperative multimerization of IN by ALLINIs together with the inabi

201 Instead, ALLINIs markedly altered the multimerization of IN by promoting aberrant higher order

202 intermediates and suggest that differential multimerization of IN in the presence of various ligands

203 infected cells is through inducing aberrant multimerization of IN.

204 and it remains to be determined whether the multimerization of M1 is affected by its binding to the

205 of MASC target Mto1 to different MTOCs, and multimerization of MASC is important for efficient targe

206 ga4 is still able to bind DNA in vitro, homo-multimerization of Mga is disrupted and the protein is u

207 g a Homo-FRET assay shows that the inducible multimerization of mGBP2 is dependent on a functional GT

208 n yeast gamma-tubulin small complex and that multimerization of Mto2 in particular may underlie assem

209 constitutive dimer of MYO6+, indicating that multimerization of MYO6 on endosomes through binding to

210 report, we investigated the requirements for multimerization of ORF50/Rta in transactivation and vira

211 Here, we show that multimerization of PAX5 DNA-binding domain (DBD) is nece

212 Interestingly, multimerization of PGLYRP1 bypassed the need for peptido

213 accumulation of pp28 was a prerequisite for multimerization of pp28 within the AC and that pp28 mult

214 studies with a mutant pRNA, it appears that multimerization of pRNA is not essential for connector b

215 e CE- and D-loops believed to be involved in multimerization of pRNA, 35- and 19-nt RNA molecules con

216 chain) is a small polypeptide that regulates multimerization of secretory IgM and IgA, the only two m

217 nce of more than one structural conformer or multimerization of some of the molecules.

218 ce the compound reversed the store-dependent multimerization of STIM1.

219 minal phosphorylation sites neither affected multimerization of the channels nor the electrophysiolog

220 active site, as important for the obligatory multimerization of the enzyme and viral replication as a

221 avidity-enhanced interactions resulting from multimerization of the ISPs.

222 es promoting stability and another promoting multimerization of the membrane-targeted assembling Gag

223 e for Holliday junctions and does not induce multimerization of the Mus81-Mms4 heterodimer.

224 ovel WRN coiled coil domain is necessary for multimerization of the nuclease domain and sufficient to

225 Multimerization of the peptides results in cell binding

226 rtant role in the inhibitor induced aberrant multimerization of the WT protein.

227 Multimerization of this NFAT/Egr sequence in the context

228 important role for C97 in the RNA-dependent multimerization of this protein.

229 sion of TRPC6, whereas protein stability and multimerization of TRPC6 are not altered, making serine

230 re a major motif in proteins and orchestrate multimerization of various complexes important for biolo

231 clease and helicase domains that facilitates multimerization of WRN.

232 The differential multimerization of WT and A128T INs induced by ALLINIs c

233 itor binding site and which lead to aberrant multimerization of WT but not A128T IN.

234 We analyzed multimerization of WT, mutant, and chimeric ORF50 protei

235 as the C-terminus is known to stimulate PABP multimerization on poly(A).

236 ults revealed that INI1 residues involved in multimerization overlap with IN-binding and nuclear expo

237 EC3G mutants, which are each compromised for multimerization, packaging and HIV-1 restriction.

238 at nanoparticles (NPs) can be used as ligand-multimerization platforms to activate specific cellular

239 In this study, we found that Gag multimerization prior to budding but beyond dimerization

240 ther, our results revealed that NC-dependent multimerization promotes VCC targeting.

241 bers of the APOBEC3 family, we show that the multimerization propensities of APOBEC3B, APOBEC3D, APOB

242 urine GBPs (mGBP1/2/3/5/6), homo- and hetero-multimerization properties of mGBP2 and its function in

243 mo-multimeric protein whose conformation and multimerization properties respond to allosteric activat

244 We provide evidence that multimerization provides a mechanism by which Rev transi

245 Mechanistically, XBP1s promotes adiponectin multimerization rather than activating its transcription

246 We conclude that ALLINIs primarily target IN multimerization rather than IN-LEDGF/p75 binding.

247 ase phosphorylation site proximal to the WRN multimerization region.

248 phaS amphipathic helix formation and dynamic multimerization regulate a normal function of alphaS at

249 assessed secretion/intracellular retention, multimerization, regulated storage, and ADAMTS13 proteol

250 timers, but the mechanism and consequence of multimerization remain incompletely defined.

251 owever, the properties and function of Vac14 multimerization remain mostly uncharacterized.

252 However, the nature of Gag multimerization required for this movement, the composit

253 ring PB1 mutations in Arabidopsis suggests a multimerization requirement for ARF protein repression,

254 This multimerization requirement was evaluated in mice using

255 cytoplasmic trafficking, oligomerization and multimerization requirements for signaling, and for expa

256 t to begin with Gag dimerization followed by multimerization, resulting in a hexameric lattice.

257 residue substitutions negatively impacted IN multimerization, resulting in an inactive viral enzyme a

258 of biological solutions was increased using multimerization, resulting in the detection of lower con

259 The pyridine-based multimerization selective HIV-1 integrase (IN) inhibitor

260 DBD of the transcription factor (TF) and the multimerization sequence of the partner protein can act

261 to the discovery of a minimal 7-amino acid "multimerization sequence" (SLLISWD), which induces polym

262 with the unfolding of 10FNIII to expose the multimerization sequence, which interacts with strand B

263 In addition, WRN nuclease multimerization significantly increased nuclease process

264 te selection mechanisms coupled to different multimerization states.

265 itory and activating responses relies on the multimerization status of IgA and interaction with their

266 Furthermore, APP multimerization stimulated increased protein levels of t

267 tients' phenotype is the result of defective multimerization, storage, and secretion.

268 support a three-component model for Gag-Gag multimerization that includes membrane interactions medi

269 cluding a head and tail domain organization, multimerization that may regulate ligand binding, and pH

270 s two roles: (1) APC promotes efficient Axin multimerization through one known and one novel APC:Axin

271 We propose a structural model for EGFR multimerization through self-association of ligand-bound

272 (318) switch, creating a nucleation site for multimerization through the C-terminal domain for tetram

273 The precise requirements for Gag-Gag multimerization under conditions present in mammalian ce

274 ess (N&B) microscopy to characterize protein multimerization upon interaction with the PM of living c

275 e E345R mutation, which can promote antibody multimerization upon receptor binding, facilitated anti-

276 lated mutants of INI1 that are defective for multimerization using a reverse yeast two-hybrid system.

277 s were also shown to have differences in Rev multimerization using gel shift binding assays.

278 This report demonstrates that antigen multimerization using IMX313 is a simple and effective c

279 These results demonstrate that antigen multimerization using IMX313 is a very promising strateg

280 amino acid residues, mediating front-to-back multimerization via electrostatic interactions.

281 hat the level of binding enhancement through multimerization was not equivalent across patient sample

282 ndency to form RNA-dependent homo-multimers, multimerization was not essential for encapsidation into

283 GPIHBP1 dimerization/multimerization was not unique to cysteine mutations; mu

284 entary DNA depressed VWF secretion, although multimerization was only mildly affected.

285 The requirement of myristic acid for multimerization was reproduced using the heterologous my

286 CA multimerization was triggered by multivalent anions prov

287 e ability of FN2 to drive ligand-independent multimerization was verified by coimmunoprecipitation an

288 utation, L30M, potentially affecting insulin multimerization, was identified in five diabetic individ

289 dent of its role in membrane localization or multimerization, we examined the effect of the PBR in th

290 d coils can mediate protein interactions and multimerization, we studied their possible involvement i

291 Reducible fibulin-4 dimerization and multimerization were consistently observed by SDS-PAGE,

292 These in vivo effects of multimerization were reproduced in vitro.

293 proteins or purified Bsp22 showed extensive multimerization which was shown by transmission electron

294 residue cryptic peptide 1 (CP1) initiates FN multimerization, which is mediated by interactions with

295 Thus, multimerization, which is mediated by the N-peptide, is

296 P1s is an important regulator of adiponectin multimerization, which may lead to a new therapeutic app

297 promotes and regulates the extent of Bright multimerization, which occurs in the absence or presence

298 verexpression of DsbA-L promoted adiponectin multimerization while suppressing DsbA-L expression by R

299 APP multimerization with an anti-N-terminal APP antibody, 22

300 Mutation of individual helices C-H reduced multimerization, with alteration of the outer surface of