ライフサイエンスコーパス: multimerize

1 in that it depends on the ability of Gag to multimerize.

2 secreted serum protein with the capacity to multimerize.

3 bunit may bind Abeta and the bound Abeta may multimerize.

4 demonstrated that the proteins did not self-multimerize.

5 nd SH3 domains of CIP4 and on its ability to multimerize.

6 ability of the C-terminal domain of TcpT to multimerize.

7 C was a nonmyristoylated Gag protein able to multimerize.

8 Rev function depends on its ability to multimerize.

9 ndependently in a dose-dependent manner when multimerized.

10 the optimized immunogen, unless it is highly multimerized.

11 ons in these 10 bp abolished activity of the multimerized 18-bp enhancer, and deletion of these 10 bp

12 By multimerizing a conserved Sxl-Pe sequence block, we gene

13 The multimerized Abs target the cell surface receptors HER2,

14 e for certain AML1 target genes that contain multimerized AML1 consensus sites in their regulatory el

15 Upon ligand binding, Toll appears to multimerize and activate the associated kinase, Pelle.

16 CRACM1 proteins multimerize and bind STIM1, and the combined overexpress

17 Homer 1a does not multimerize and blocks the association of mGluRs with CC

18 These C-terminal fragments are able to multimerize and form amyloid-like fibers.

19 in the early endocytic compartment does not multimerize and is promptly degraded by hepcidin (Hepc),

20 active cdk5 reduces the ability of PSD-95 to multimerize and to cluster neuronal ion channels, two fu

21 unction as a monocyte-specific enhancer when multimerized and linked to a heterologous basal promoter

22 When multimerized and placed upstream of the native osteocalc

23 nteraction system, we demonstrated that RhlR multimerized and that the degree of multimerization was

24 FANCG are redox-sensitive proteins that are multimerized and/or form a nuclear complex in response t

25 aturation, the inactive proform dimerizes or multimerizes and autocatalytically removes the prodomain

26 Flower multimerizes and is able to form a channel to control Ca

27 R; pyruvate kinase activity reporter), which multimerizes and is activated upon binding FBP.

28 In this study, we demonstrate that N(ICD) multimerizes and that these multimers function as precur

29 he partner protein can act in a DN manner by multimerizing and binding avidly to gene targets, preven

30 o bind viral single-stranded DNA (ssDNA) and multimerize, and for effects on the accumulation of repl

31 sphate (PIP(2)), the capacity of the tail to multimerize, and its ability to activate protein kinase

32 (FRET) to determine whether IL-17RA subunits multimerize, and, if so, whether they are preassembled i

33 re follicular dendritic cells (FDCs) present multimerized antigens as periodically arranged antigen-a

34 activated transcription from reporters with multimerized AP-1 sites.

35 Prior studies have shown that all of these multimerizing APOBEC3 proteins, but not the monomeric fa

36 Although multimerized binding sites of individual transcription f

37 es and activates heterologous promoters from multimerized binding sites.

38 important hubs for molecular biology, either multimerizing biomolecules, bridging one molecule to ano

39 Reporter genes bearing multimerized bulged C lin-4 binding sites show almost wi

40 N-terminal domains of hA3G were unable to multimerize but remained functional for Gag and viral in

41 ns that had the ability to bind C(4)-HSL and multimerize but were unable to activate lasB expression,

42 All mutants multimerized, but one mutation, C402S, prevented cross-l

43 In phase 2, the binding hits are multimerized by nanoparticle or proteoliposome display,

44 lfide-linked dimers and suggested that MUC5B multimerizes by disulfide linkage between D3-domains to

45 -Fc fusion proteins, which can be clustered (multimerized) by use of antibodies to form DDR2 complexe

46 r-associated factor (TRAF) proteins with the multimerized CD40 cytoplasmic domain.

47 When multimerized, CE1 conferred an osteoblast-specific activ

48 synthetic reporter construct controlled by a multimerized CEH-22 binding site.

49 strate that Ci can bring Su(fu) with it to a multimerized Ci DNA binding site.

50 ead of the conventional bait that contains a multimerized cis element.

51 Using monomers and multimerized complexes labeled with PE, we confirmed the

52 nucleases resulted in the disruption of the multimerized complexes.

53 etween the closed conformation and the open, multimerized conformation of L1.

54 Multimerized copies of either half of the repeat were Ta

55 Moreover, a multimerized copy of either SME-1 or SME-4 subcloned 5'

56 Finally, we have shown that a multimerized copy of SME-4 (bp -190 to -110) when linked

57 In contrast, a multimerized copy of the c-fos SRE is totally inactive i

58 asR demonstrated that the ability of LasR to multimerize correlates with its ability to function as a

59 ening of the skeletal muscle cDNA library by multimerized CSS-DNA as probe.

60 Multimerized de209 enhances transcription similarly to D

61 ycosylphosphatidylinositol (GPI) anchor that multimerizes despite the absence of the TMD.

62 ression and a conserved sequence, which when multimerized directs expression in a broad subset of neu

63 omain is joined to a C-terminal effector and multimerizing domain.

64 an intrinsic ability to dimerize (dsRBM2) or multimerize (dsRBM1).

65 Gag proteins must extensively multimerize during the formation of the spherical immatu

66 Our results indicated that pp28 multimerized during viral infection and that interacting

67 ion of a reporter gene located downstream of multimerized e5, PRS-9, or CD19 DNA-binding sites in thr

68 Here, we demonstrate that multimerized EEs are necessary and sufficient to confer

69 FliM does not multimerize efficiently by itself but does so in the pre

70 the N-terminal cytosolic tail are stable and multimerize efficiently, but are mislocalized to the end

71 or elements (NREs) could not be generated by multimerizing either the palindromic (P) Nru motifs alon

72 on of a reporter gene under the control of a multimerized element fused to an IL-4 minimal promoter.

73 xes, optimal B cell-responses are induced by multimerized FDC-ICs that simultaneously engage multiple

74 e, monodisperse monomer but can be forced to multimerize following lyophilization and resuspension.

75 disease induced by T cell self-epitopes in a multimerized form (oligomers) is mediated by the inducti

76 enhanced if administered to the animal in a multimerized form as a T cell epitope oligomer (i.e., as

77 ted von Willebrand factor, particularly in a multimerized form, which interacts with platelet glycopr

78 cantly influences the anti-viral activity of multimerized forms of SP-D.

79 However, multimerized forms of the combined P plus I elements rec

80 tems largely from ionic interactions between multimerized Gag and negatively charged phospholipids.

81 d transcription of a reporter gene driven by multimerized GATA4-binding DNA elements.

82 ivation of a luciferase reporter driven by a multimerized Gli-responsive element, 3) inhibition of ox

83 in which the zonula occludens (ZO) proteins multimerize has implications for the protein networks th

84 Short forms of Homer, which cannot self-multimerize (Homer 1a and a Homer 2 C-terminal deletion)

85 A multimerized hypoxia-responsive enhancer was constructed

86 hybrid results and suggesting that Pbp1p can multimerize; (iii) DIG1, encoding a mitogen-activated pr

87 CXCR4 was found to multimerize in cell lysates containing the detergents CH

88 ALLINIs multimerize IN protein and concordantly block its assemb

89 sulted in the loss of the ability of pRNA to multimerize in solution, consistent with the hypothesis

90 ts A30P and A53T, show similar tendencies to multimerize in the presence of PUFAs.

91 reas phosphomimicking mutations allow Cnn to multimerize in vitro and to spontaneously form cytoplasm

92 riments demonstrate that Mus81-Mms4 does not multimerize in vivo.

93 pressed with PPCA and beta-galactosidase, it multimerized in a complex of approximately 1350 kDa, tog

94 the RNA-binding domain, which appears to be multimerized in some DAZ proteins.

95 oskeleton-matrix interactions, appears to be multimerized in vivo.

96 Together, our results indicate that APOBEC3G multimerizes in an RNA-dependent fashion and that RNA-AP

97 a Ca(2+)-dependent pore-forming protein that multimerizes in membranes, delivers granzymes into the t

98 In the crystal, the molecule multimerizes in the form of a left-handed superhelix.

99 Our results show that Rev multimerizes in the nucleolus of living cells, suggestin

100 At high concentrations, perforin multimerizes in the plasma membrane to form pores.

101 r glycoprotein of approximately 330 kDa that multimerizes in the presence of calcium.

102 nstrate for the first time that human SUMO-1 multimerizes in vitro primarily via three N-terminal lys

103 the SynthOMIC approach (synthesis of ORFs by multimerizing in-frame codons), representative libraries

104 in the human promoter, but that an upstream multimerized insulin response sequence (IRS) motif that

105 study finds that archaeal histone dimers can multimerize into extended superhelical structures that m

106 s, type 1 (HIV-1) assembly, Gag polypeptides multimerize into immature HIV-1 capsids.

107 lical coiled-coil dimers; these subsequently multimerize into thick filaments via electrostatic inter

108 w that SHE complexes have a defined size but multimerize into variable particles upon binding of RNAs

109 PrgH multimerizes into a distinct tetrameric-shaped structure

110 energy transfer (FRET) that alpha-synuclein multimerizes into large homomeric complexes upon membran

111 However, multimerized intronic repeats inhibited calcitonin-speci

112 f additional regions containing low-affinity multimerized IRF sites and composite IRF-AP-1 sites, whi

113 The ability to multimerize is associated with a sequence close to the C

114 e have focused on one such element that when multimerized, is sufficient in mediating both activation

115 ction of the promoter by TGF-beta1 and, when multimerized, is sufficient to transfer TGF-beta1 induci

116 is necessary for enhancer activity and when multimerized it is sufficient to direct a kreisler-like

117 riptional activation of a plasmid containing multimerized kappaB sites by p65 was inhibited by agents

118 Normally, multimerized Labial-PBC binding sites are sufficient to

119 /beta-catenin from a synthetic promoter with multimerized LEF/TCF binding sites and a natural cyclin

120 lf a bona fide transcriptional activator, as multimerized LR1 sites produce an element which can enha

121 and HIV-1 Gag proteins were more similar to multimerized MA than to monomeric MA.

122 The multimerized mammary-specific enhancer of MMTV on its ow

123 a human A-myb expression vector activated a multimerized MBS element-driven reporter construct appro

124 sion vector down-regulated the activity of a multimerized MBS element-driven reporter construct in SM

125 In this study, multimerized MHC-Ig fusion proteins, with a covalently a

126 The specificity and avidity of multimerized MHC-peptide complexes suggests their potent

127 ine zipper sequence from HIV-1 is capable of multimerizing much larger and otherwise monomeric protei

128 Similarly, multimerized NF-kappaB sites enhanced nucleosome binding

129 sactivates a minimal promoter which contains multimerized Nkx-2 DNA-binding sites.

130 oter and a minimal promoter, containing only multimerized Nkx-2.5 DNA binding sites (NKEs), in hetero

131 al gradient formation, whereas those bearing multimerized nonbulged lin-4 binding sites do not form a

132 nstrated that N528S-VWF was neither normally multimerized nor trafficked to storage granules.

133 s thymidine kinase (tk) promoter, or linking multimerized ntcp GLEs either upstream of the ntcp minim

134 reduce the enhancer-blocking activity of the multimerized oligonucleotides.

135 n also confers on it the ability to bind and multimerize on nonspecific double-stranded DNA.

136 ble monomers in the extracellular milieu and multimerize on target cell membranes.

137 GT121 inferred-germline B cells ex vivo when multimerized on liposomes, and primed PGT121-like respon

138 When multimerized on nanoparticles, this immunogen (eOD-GT6)

139 vitro binding studies of ELAV show that ELAV multimerizes on the ewg binding site and forms a defined

140 When multimerized, one of these sites activates the heterolog

141 e RcpA and RcpB abundances, and RcpA did not multimerize or localize to the outer membrane without th

142 edly increased when this oligonucleotide was multimerized or flanking sequences were added.

143 palindromic element or "simple GRE" that is multimerized or linked tightly with an AP1 site.

144 ansfected reporter constructs that contain a multimerized PEPCK IRE or an IGFBP-1 IRE and this stimul

145 Combined with the finding that levels of multimerized PiIQ were greatly reduced in PilP- mutants,

146 Multimerized Pita sites block iab-6<-->iab-7 crosstalk b

147 equired for cooperative binding of PLZF to a multimerized PLZF-RE.

148 the SunTag provides a versatile platform for multimerizing proteins on a target protein scaffold and

149 n PU.1 function is assayed in isolation on a multimerized PU.1 binding site, BSAP targets a portion o

150 in of PU.1 that activates transcription from multimerized PU.1 binding sites is not required to activ

151 nd sufficient to mediate the expression of a multimerized RCSI reporter, a marker of photoreceptor ce

152 cular gammadelta TCR, we demonstrated that a multimerized recombinant form of this gammadelta TCR can

153 NA-LP also stimulates EBNA-2 activation of a multimerized regulatory element from the BamC EBNA promo

154 n protein binding were not detected by using multimerized repeats.

155 We show that, whereas a multimerized response element from the germline IgE prom

156 ously, but in transient-transfection assays, multimerized RFX binding sites in front of a basal promo

157 A multimerized SBE promoter responsive to TGF-beta1 signal

158 Because soluble Env trimers or multimerized scaffolded epitopes are best at activating

159 , in particular, soluble gp140 trimers and a multimerized, scaffolded epitope protein.

160 ivation was not modulated by the presence of multimerized SCIP binding sites, and squelching was not

161 that neutrophils presented with immobilized multimerized Siaalpha2-3Galbeta1-4GlcNAc units engage th

162 as well as MRF-directed transcription from a multimerized skeletal muscle E-box reporter gene (4Rtk-l

163 transcription of a reporter gene containing multimerized Smad binding sites These cofactors interact

164 h the VIP CyRE and more specifically through multimerized STAT-binding sites.

165 erleukin-8 promoter or a promoter containing multimerized synthetic estrogen response elements were u

166 These multimerized tags, with translational enhancers, display

167 lt transgenic reporter constructs containing multimerized TCF binding sites.

168 ally, three caveats to the interpretation of multimerized TCF reporter expression patterns will be pr

169 However, multimerized TCF reporters should not be assumed to give

170 riments suggest that Mto1/2 multimers act to multimerize the fission yeast gamma-tubulin small comple

171 oplasmic accumulation of intronless mRNA, we multimerized the most conserved CAR-E and inserted it up

172 ly boundary activity can be reconstituted by multimerizing the Elba recognition site.

173 By multimerizing the MDB domain of Mbd1, we engineered a po

174 egarding the propensity of these proteins to multimerize, their subcellular distribution and mechanis

175 Moreover, if Fgd1 is multimerized, then cortactin's activity should be enhanc

176 AFAP-110 binds actin filaments directly and multimerizes through a leucine zipper motif.

177 During HIV-1 assembly, Gag polypeptides multimerize to form an immature capsid and also package

178 CpG-A, but not CpG-B, can multimerize to form exceedingly large lattices.

179 es target to the plasma membrane, where they multimerize to form immature capsids that undergo buddin

180 Once activated, how BAK homodimers multimerize to form the putative apoptotic pore is unkno

181 These dimers multimerize to higher-order oligomers via a labile inter

182 bine into a soluble, 7 S heterodimer that is multimerized to form the microtubule filament.

183 ligand for a given population of T cells was multimerized to make soluble peptide-MHC tetramers.

184 Although TRIM5alpha multimerizes to form cytoplasmic bodies, which are thoug

185 ate protein dimerization, and the CA protein multimerizes to form the core retroviral and retrotransp

186 A multimerized TR as found in the viral genome results in

187 CD40 cross-linking probably multimerizes TRAF proteins which may act as direct trans

188 ion tagging using T-DNA vectors that contain multimerized transcriptional enhancers from the cauliflo

189 ctivator, suggesting that dimers of TraM can multimerize TraR.

190 A minimal multimerizing Tsg101 domain is a dominant negative inhib

191 rse in structure, share a common property of multimerizing tubulin, thus acting as polymerization cha

192 stimulation of a minimal promoter containing multimerized VCAM-1 NF-kappaB sites was inhibited by DN-

193 ral murine alpha2(I) collagen promoter and a multimerized version of the proximal NF-Y(CBF) CCAAT box

194 The ability of MD-2 to multimerize was confirmed, and MD-1 was also shown to po

195 responses and protein binding properties of multimerized wild-type and mutant elements added upstrea

196 Based on the ability of DeltaBAFF to multimerize with full-length BAFF and to limit BAFF prot

197 ion of the nuclease domain and sufficient to multimerize with full-length WRN in human cells.

198 Unexpectedly, we find that endogenous EJCs multimerize with one another and with numerous SR protei

199 ragment of HeT-A and/or TART Gags, TAHRE Gag multimerizes with either protein.

200 ominant negative effect on NAB repression by multimerizing with native NAB proteins and preventing bi