ライフサイエンスコーパス: multinucleate cell

1 llular host tissues into a single contiguous multinucleate cell.

2 g to furrow regression and the generation of multinucleate cells.

3 cell cycle progression continues leading to multinucleate cells.

4 gh mitosis was marked by the accumulation of multinucleate cells.

5 s highly clustered in the cytoplasm of large multinucleate cells.

6 ut retract prior to completion, resulting in multinucleate cells.

7 ncomplete cell division and the formation of multinucleate cells.

8 ergillus nidulans, whose mycelium is made of multinucleate cells.

9 RNA interference (RNAi) efficiently induced multinucleate cells.

10 and duplicate their nuclei, generating large multinucleate cells.

11 mitotic spindles, multiple centrosomes, and multinucleate cells.

12 ge furrow invagination and the generation of multinucleate cells.

13 division without cytokinesis, resulting in a multinucleated cell.

14 rporates as many as 200 cells into one large multinucleated cell.

15 accumulation of supernumerary centrosomes in multinucleated cells.

16 s prolonged expression promoted formation of multinucleated cells.

17 hyperproliferation, suprabasal mitoses, and multinucleated cells.

18 tive lymphocytes fuse in lymph nodes to form multinucleated cells.

19 ced from cytokinesis and so produces bi- and multinucleated cells.

20 aa3 expression peaked prior to appearance of multinucleated cells.

21 ormed cell walls, increased DNA content, and multinucleated cells.

22 4 or 21 days to induce formation of OCL-like multinucleated cells.

23 t morphologies including elongated and round multinucleated cells.

24 on were found among the nuclei in individual multinucleated cells.

25 rs abscission and increases the incidence of multinucleated cells.

26 12-Cdc42 lines displayed a high frequency of multinucleated cells.

27 o undergo proper cytokinesis and resulted in multinucleated cells.

28 nd pleiotropic tendencies largely made up of multinucleated cells.

29 mononuclear preosteoclasts fuse to generate multinucleated cells.

30 n of GEFs in the morphological maturation of multinucleated cells.

31 s, resulting in the accumulation of enlarged multinucleated cells.

32 rounds of endoreduplication and resulting in multinucleated cells.

33 ved cell cycle regulators directs mitosis in multinucleated cells.

34 T in HeLa cells resulted in the formation of multinucleated cells.

35 f cell membranes are overcome and cells form multinucleated cells.

36 pensable for psychosine-induced formation of multinucleated cells.

37 and Mat89Bb RNAi in HeLa cells gives rise to multinucleated cells.

38 kinesis failure, and formation of micro- and multinucleated cells.

39 ruiting the fusion of cells with preexisting multinucleated cells.

40 in the heart, resulting in the formation of multinucleated cells.

41 uclei with decondensed DNA, and formation of multinucleated cells.

42 embryo lethality, morphological defects, or multinucleate cells [2, 3].

43 a transdominant-negative TXBP181 results in multinucleated cells, a phenotype consistent with a loss

44 d lysosomes within perivascular macrophages, multinucleated cells, activated microglial cells, and hy

45 ssion of activated Ras does not yield highly multinucleate cells and data on Ras null mutants, sugges

46 AprA may thus decrease the number of multinucleate cells and increase spore production.

47 uble-stranded RNA resulted in a formation of multinucleated cells and also reduced DNA replication.

48 exhibited an increase in both the number of multinucleated cells and cells with swollen flagellar po

49 These abnormalities included both multinucleated cells and enlarged cells with giant nucle

50 this study revealed the presence of abnormal multinucleated cells and increased apoptotic cells withi

51 sion of this mutant induces the formation of multinucleated cells and increases their susceptibility

52 Its failure leads to multinucleated cells and is a possible cause of tumorige

53 tartrate-resistant acid phosphatase-positive multinucleated cells and measuring the expression of ost

54 nhibition of Aurora B by hesperadin produced multinucleated cells and reduced H3S10 phosphorylation.

55 sizes of infected cells were evident: large multinucleated cells and small nondescript (presumptivel

56 Osteoclasts are multinucleated cells and the principal resorptive cells

57 phytic tissue), both TRAP-positive mono- and multinucleated cells and TRAP-negative, NSE-positive mon

58 d size, have increased numbers of nuclei per multinucleated cell, and demonstrate increased resorptio

59 lar spindles, aberrant mitosis, formation of multinucleated cells, and decreased DNA replication.

60 pletion generates supernumerary centrosomes, multinucleated cells, and multipolar spindle formation.

61 In cells lacking Swe1, multinucleate cells are formed in response to delays in

62 These multinucleate cells are remarkable in that nuclei cycle

63 Multinucleate cells are widespread in nature, yet the me

64 Multinucleated cells are found in diverse contexts and i

65 lonogenic outgrowth, and high percentages of multinucleated cells are found in vivo in remnants of PA

66 Multinucleated cells are important in many organisms, bu

67 Multinucleated cells are relatively resistant to classic

68 Multinucleate cells arose through aberrant division of b

69 lure in mitotic exit, with the appearance of multinucleated cells as a consequence.

70 tartrate-resistant acid phosphatase-positive multinucleated cells at sites of bone erosion.

71 confirmed by immunofluorescence staining on multinucleated cells at the bone surface of inflamed mou

72 in deposition, and a significant fraction of multinucleate cell bodies, confirming the presence of a

73 Wee1 homolog Swe1 prevents the formation of multinucleate cells by restraining M phase CDK activity

74 gillus nidulans grows by apical extension of multinucleate cells called hyphae that are subdivided by

75 osteoclasts and suggest that osteoclast-like multinucleated cells can arise in synovial soft tissues

76 indle-shaped cells, as well as flat adherent multinucleated cells capable of spontaneous contractions

77 ure of HPCs manifested by an accumulation of multinucleated cells caused by failed abscission of the

78 l-cell fusion that resulted in generation of multinucleated cells, centrosome amplification, multipol

79 c phenotype, which includes the formation of multinucleated cells, centrosome and mitotic spindle abn

80 it had no effect on the formation of giant, multinucleated cells characteristic of mitotic catastrop

81 Giant multinucleated cells containing nuclei attached by const

82 bone resorption associated with bone-derived multinucleated cell-containing granulomatous lesions.

83 ell cycle, whereas other nuclei, in the same multinucleate cell, cycle normally, accumulating and deg

84 g, resulting in cell flattening, senescence, multinucleated cells, decreased S-phase progression, dim

85 increased resorption capacity compared with multinucleated cells derived from empty vector-transduce

86 Multinucleated cells expressing both TRAP and cathepsin

87 PARP-inhibitor-induced multinucleated cells fail clonogenic outgrowth, and high

88 fects, including the formation of elongated, multinucleate cells, failure to maintain the cytokinetic

89 eventual degeneration with the formation of multinucleated cells following Cx43 overexpression due t

90 s activation of apoptosis was independent of multinucleate cell formation.

91 bited the differentiation of osteoclast-like multinucleated cell formation in the presence of several

92 Legumain significantly inhibited OCL-like multinucleated cell formation induced by 1,25-dihydroxyv

93 ion of AXII significantly increased OCL-like multinucleated cell formation.

94 dges, micronuclei, centrosome amplification, multinucleated cells, gradual accumulation of DNA damage

95 Remarkably, multinucleated cell hybrids gave rise to mononucleated p

96 y inactive form resulted in the formation of multinucleate cells in budding yeast.

97 diploid, and form clones that can fuse into multinucleate cells in culture or into myofibers after i

98 h wild type, there is a higher percentage of multinucleate cells in the aprA- population, and when st

99 and uterus, and mitotic chromosome loss and multinucleate cells in the germline.

100 with occasional pseudonuclear inclusion and multinucleated cells in a partly myxoid matrix.

101 tartrate-resistant acid phosphatase-positive multinucleated cells in both cell types.

102 The formation of fused multinucleated cells in ganglia might be associated with

103 nesis was assessed by counting TRAP-positive multinucleated cells in PB CD14+ monocytes cultured with

104 428 and KM-H2 as well as on the formation of multinucleated cells in the mononuclear human embryonic

105 ved in epithelial cells, fibroblasts, and in multinucleated cells in the periodontium.

106 mitotic phase with the formation of abnormal multinucleated cells, indicating that this compound affe

107 rant cell plates, incomplete cell walls, and multinucleated cells, leading to severely abnormal seedl

108 dsSIN:C3 infection led to the formation of multinucleate cells, likely by inhibiting the actin micr

109 opic expression of the Tg737 gene results in multinucleated cells, loss of Tg737 gene expression resu

110 ed and isolated from a human osteoclast-like multinucleated cell (MNC) cDNA library, named osteoclast

111 als, mandibles and tibiae were isolated, and multinucleated cells (MNCs) were measured.

112 Multinucleated cells (MNCs) were present in resorption l

113 cell types: mononuclear polyhedral cells and multinucleated cells (MNCs).

114 sion led to a highly significant increase of multinucleated cells, nuclear volume, and 3D telomeric a

115 he nucleus, p53 localization was analyzed in multinucleated cells obtained by polyethylene glycol-med

116 osophila larval skeletal muscles are single, multinucleated cells of different sizes that undergo tre

117 Osteoclasts are multinucleated cells of hemopoietic origin that are resp

118 tartrate-resistant acid phosphatase-positive multinucleated cells or resorption pits were observed in

119 ates that included death, fusion that formed multinucleated cells, or another round of mitosis with n

120 -zoster virus (VZV) characteristically forms multinucleated cells, or syncytia, during the infection

121 re characterized by an increased presence of multinucleated cells, osteoclasts, and cementicles.

122 was equally distributed among the nuclei of multinucleated cells regardless of the stage of the cell

123 The presence of binucleated and multinucleated cells, reminiscent of large lymphocytes w

124 The multinucleate cells resembled the syncytia caused by phy

125 Cs to overexpress NS decreases senescent and multinucleated cells, restores morphology, and antagoniz

126 induced a dramatic increase in the number of multinucleate cells, rounded cells with condensed ball-l

127 Other subcellular effects observed included multinucleated cells seen after RNAi to either pgant2 or

128 pX-1 cells exhibit pX-dependent formation of multinucleated cells, similar to human T-cell lymphotrop

129 are not optimized for capturing very large, multinucleated cells such as myotubes.

130 Some multinucleated cells such as those in muscles arise from

131 causes an increased number of binucleate and multinucleate cells, suggesting that the kinase activity

132 tions also exhibit an increased frequency of multinucleated cells, suggesting an impairment in cytoki

133 overexpression resulted in the production of multinucleated cells, suggesting the failure of proper c

134 y, SIRC cells expressing CD4 and CCR5 formed multinucleated cells (syncytia) upon exposure to BaL, a

135 rus-induced cell fusion and the formation of multinucleated cells (syncytia).

136 , which produces bone, and the osteoclast, a multinucleate cell that 'eats' bone.

137 Osteoclasts are bone-resorbing multinucleated cells that are derived from the monocyte/

138 Myofibers are multinucleated cells that are formed, repaired and maint

139 leost Sternopygus macrurus, electrocytes are multinucleated cells that do not contract yet retain exp

140 mutant protein resulted in the formation of multinucleated cells that had replicated DNA.

141 cell fusion to form the fully differentiated multinucleated cells that mediate bone resorption.

142 pression are placental syncytiotrophoblasts, multinucleated cells that originate from fetal trophobla

143 Osteoclasts (OCs) are multinucleated cells that resorb bone and are essential

144 a 40% growth decrease and the appearance of multinucleated cells that result from defective cytokine

145 c clusters of adherent mononuclear and giant multinucleated cells that stained positive for tartrate-

146 ty of the population emerges from mitosis as multinucleated cells that subsequently undergo cell deat

147 sis and remarkably, elicits the formation of multinucleated cells that then arrest or die by mitotic

148 ell death was the appearance of enlarged and multinucleated cells that was related to the inhibition

149 ated with 5-FUra were prevented from forming multinucleate cells upon infection with dsSIN:C3.

150 To discern whether the formation of multinucleate cells was responsible for the activation o

151 Using a cell fusion approach to generate multinucleate cells, we investigate the effects of check

152 Multinucleated cells were characterized as striated musc

153 RANKL immunolabeling and fewer TRAP-positive multinucleated cells were observed in the EA-treated gro

154 rasgap1 null cells are very large and highly multinucleate cells when grown in suspension, indicating

155 , which results in an increased frequency of multinucleate cells when grown in suspension.

156 transduced cells formed increased numbers of multinucleated cells, which contained many more nuclei a

157 uce mitotic block and apoptosis and increase multinucleated cells with 8 N DNA content.

158 ression of mutated Nek8 results in enlarged, multinucleated cells with an abnormal actin cytoskeleton

159 matrix are all promoted by myosin-II, and so multinucleated cells with distended membranes--typical o

160 mRNA 5' untranslated region (5' UTR) led to multinucleated cells with striking morphological alterat

161 reased Nek2 protein leads to accumulation of multinucleated cells with supernumerary centrosomes.

162 ls of inflammatory arthritis have identified multinucleated cells with the phenotype of osteoclasts i

163 nockdown of I-2 by RNA interference produced multinucleated cells, with supernumerary centrosomes, mu