ライフサイエンスコーパス: multinucleated

1 , whereas 8.7 +/- 1.0% of control cells were multinucleated, 62.4 +/- 8.8% of the NMHC II-B RNAi-trea

2 .8% of the NMHC II-B RNAi-treated cells were multinucleated 72 h after transfection.

3 In both AIA and CIA, multinucleated and cathepsin K-positive osteoclasts firs

4 Skeletal muscle contains long multinucleated and contractile structures known as muscl

5 Multinucleated and enlarged cells were present due to co

6 duction of distal fine processes, and become multinucleated and hypertrophic.

7 tic constructs exhibit aligned architecture, multinucleated and striated myofibers, and a Pax7(+) cel

8 macrophages/monocytes based on the number of multinucleated and tartrate-resistant alkaline phosphata

9 All osteoclasts (cathepsin K-positive, multinucleated, attached to bone) and osteoclast precurs

10 ssed at these sites, where they fuse to form multinucleated bone-resorbing cells.

11 ts directly induced their differentiation to multinucleated, bone-resorbing OCs (P < 0.00002) in a re

12 were enlarged, poikilocytic, and frequently multinucleated, but were able to sustain life despite ex

13 Remarkably, multinucleated cell hybrids gave rise to mononucleated p

14 bone resorption associated with bone-derived multinucleated cell-containing granulomatous lesions.

15 rporates as many as 200 cells into one large multinucleated cell.

16 division without cytokinesis, resulting in a multinucleated cell.

17 als, mandibles and tibiae were isolated, and multinucleated cells (MNCs) were measured.

18 rus-induced cell fusion and the formation of multinucleated cells (syncytia).

19 uble-stranded RNA resulted in a formation of multinucleated cells and also reduced DNA replication.

20 exhibited an increase in both the number of multinucleated cells and cells with swollen flagellar po

21 this study revealed the presence of abnormal multinucleated cells and increased apoptotic cells withi

22 Its failure leads to multinucleated cells and is a possible cause of tumorige

23 tartrate-resistant acid phosphatase-positive multinucleated cells and measuring the expression of ost

24 nhibition of Aurora B by hesperadin produced multinucleated cells and reduced H3S10 phosphorylation.

25 Multinucleated cells are found in diverse contexts and i

26 lonogenic outgrowth, and high percentages of multinucleated cells are found in vivo in remnants of PA

27 Multinucleated cells are important in many organisms, bu

28 Multinucleated cells are relatively resistant to classic

29 lure in mitotic exit, with the appearance of multinucleated cells as a consequence.

30 tartrate-resistant acid phosphatase-positive multinucleated cells at sites of bone erosion.

31 confirmed by immunofluorescence staining on multinucleated cells at the bone surface of inflamed mou

32 indle-shaped cells, as well as flat adherent multinucleated cells capable of spontaneous contractions

33 ure of HPCs manifested by an accumulation of multinucleated cells caused by failed abscission of the

34 Giant multinucleated cells containing nuclei attached by const

35 PARP-inhibitor-induced multinucleated cells fail clonogenic outgrowth, and high

36 eventual degeneration with the formation of multinucleated cells following Cx43 overexpression due t

37 with occasional pseudonuclear inclusion and multinucleated cells in a partly myxoid matrix.

38 tartrate-resistant acid phosphatase-positive multinucleated cells in both cell types.

39 The formation of fused multinucleated cells in ganglia might be associated with

40 nesis was assessed by counting TRAP-positive multinucleated cells in PB CD14+ monocytes cultured with

41 ved in epithelial cells, fibroblasts, and in multinucleated cells in the periodontium.

42 osophila larval skeletal muscles are single, multinucleated cells of different sizes that undergo tre

43 tartrate-resistant acid phosphatase-positive multinucleated cells or resorption pits were observed in

44 Other subcellular effects observed included multinucleated cells seen after RNAi to either pgant2 or

45 are not optimized for capturing very large, multinucleated cells such as myotubes.

46 Some multinucleated cells such as those in muscles arise from

47 Osteoclasts are bone-resorbing multinucleated cells that are derived from the monocyte/

48 Myofibers are multinucleated cells that are formed, repaired and maint

49 leost Sternopygus macrurus, electrocytes are multinucleated cells that do not contract yet retain exp

50 mutant protein resulted in the formation of multinucleated cells that had replicated DNA.

51 cell fusion to form the fully differentiated multinucleated cells that mediate bone resorption.

52 a 40% growth decrease and the appearance of multinucleated cells that result from defective cytokine

53 ty of the population emerges from mitosis as multinucleated cells that subsequently undergo cell deat

54 sis and remarkably, elicits the formation of multinucleated cells that then arrest or die by mitotic

55 ell death was the appearance of enlarged and multinucleated cells that was related to the inhibition

56 Multinucleated cells were characterized as striated musc

57 RANKL immunolabeling and fewer TRAP-positive multinucleated cells were observed in the EA-treated gro

58 matrix are all promoted by myosin-II, and so multinucleated cells with distended membranes--typical o

59 reased Nek2 protein leads to accumulation of multinucleated cells with supernumerary centrosomes.

60 pletion generates supernumerary centrosomes, multinucleated cells, and multipolar spindle formation.

61 l-cell fusion that resulted in generation of multinucleated cells, centrosome amplification, multipol

62 c phenotype, which includes the formation of multinucleated cells, centrosome and mitotic spindle abn

63 g, resulting in cell flattening, senescence, multinucleated cells, decreased S-phase progression, dim

64 dges, micronuclei, centrosome amplification, multinucleated cells, gradual accumulation of DNA damage

65 mitotic phase with the formation of abnormal multinucleated cells, indicating that this compound affe

66 sion led to a highly significant increase of multinucleated cells, nuclear volume, and 3D telomeric a

67 ates that included death, fusion that formed multinucleated cells, or another round of mitosis with n

68 -zoster virus (VZV) characteristically forms multinucleated cells, or syncytia, during the infection

69 re characterized by an increased presence of multinucleated cells, osteoclasts, and cementicles.

70 The presence of binucleated and multinucleated cells, reminiscent of large lymphocytes w

71 Cs to overexpress NS decreases senescent and multinucleated cells, restores morphology, and antagoniz

72 pX-1 cells exhibit pX-dependent formation of multinucleated cells, similar to human T-cell lymphotrop

73 nockdown of I-2 by RNA interference produced multinucleated cells, with supernumerary centrosomes, mu

74 mononuclear preosteoclasts fuse to generate multinucleated cells.

75 n of GEFs in the morphological maturation of multinucleated cells.

76 f cell membranes are overcome and cells form multinucleated cells.

77 s, resulting in the accumulation of enlarged multinucleated cells.

78 rounds of endoreduplication and resulting in multinucleated cells.

79 ved cell cycle regulators directs mitosis in multinucleated cells.

80 T in HeLa cells resulted in the formation of multinucleated cells.

81 pensable for psychosine-induced formation of multinucleated cells.

82 and Mat89Bb RNAi in HeLa cells gives rise to multinucleated cells.

83 kinesis failure, and formation of micro- and multinucleated cells.

84 ruiting the fusion of cells with preexisting multinucleated cells.

85 in the heart, resulting in the formation of multinucleated cells.

86 uclei with decondensed DNA, and formation of multinucleated cells.

87 accumulation of supernumerary centrosomes in multinucleated cells.

88 aa3 expression peaked prior to appearance of multinucleated cells.

89 rs abscission and increases the incidence of multinucleated cells.

90 o undergo proper cytokinesis and resulted in multinucleated cells.

91 nd pleiotropic tendencies largely made up of multinucleated cells.

92 However, only 32% of these cells were multinucleated compared with 57% in wild-type littermate

93 an enzymatic electrode, due to the use of a multinucleated complex of manganese with mu-oxo units, w

94 ny formation, invasion, and development of a multinucleated dendritic-like phenotype.

95 Syncytiotrophoblast is the multinucleated epithelium of the placenta.

96 a cells, consistent with appearance of large multinucleated erythroblasts in CDA III patients.

97 erythropoiesis characterized by increased bi/multinucleated erythroid precursors in the bone marrow.

98 erodera glycines) induces the formation of a multinucleated feeding site, or syncytium, whose etiolog

99 y endoparasites that induce the formation of multinucleated feeding structures termed syncytia in the

100 bundant in muscles undergoing fusion to form multinucleated fibers and that enforced expression of GR

101 myogenic progenitors were specified to form multinucleated fibers that enabled development of quiesc

102 We propose that the multinucleated filament creates an environmental niche w

103 Moreover, in multinucleated fission yeast cells, Neumann and Nurse (s

104 l/substrate adhesive mechanisms that support multinucleated foreign body giant cell (FBGC) formation.

105 Multinucleated foreign body giant cells (FBGCs) form by

106 acrophages from Xid mice also failed to form multinucleated foreign body giant cells.

107 al demonstrated an intimate association with multinucleated foreign body-type giant cells.

108 ro to certain phthalate plasticizers exhibit multinucleated germ cell (MNG) induction and suppressed

109 ine), maternal hepatotoxicity, and increased multinucleated germ cells (MNGs) in fetal testes without

110 e-resistant acid phosphatase (TRAP)-negative multinucleated giant (MNG) cells.

111 ated implants contained significantly higher multinucleated giant cell (MNGC) density compared to NT,

112 nt did not exhibit signs of cytopathology or multinucleated giant cell (MNGC) formation, which were o

113 ically, I-PGCG was associated with: 1) lower multinucleated giant cell count (P = 0.04); 2) lower den

114 ntercellular signaling mechanisms modulating multinucleated giant cell formation and function are nec

115 targets for the modulation and inhibition of multinucleated giant cell formation and function.

116 g HIV-1 replication, macrophage biology, and multinucleated giant cell formation are incompletely und

117 173Q mutation enhanced viral replication and multinucleated giant cell formation upon infection of rh

118 inding, evidence of actin-based motility and multinucleated giant cell formation were observed betwee

119 miR-7a-1 functions to regulate IL-4-directed multinucleated giant cell formation.

120 he tssE mutants lacked the ability to induce multinucleated giant cell formation.

121 precursors, other cell types can generate a multinucleated giant cell phenotype with bone resorbing

122 The function of osteoclasts (OCs), multinucleated giant cells (MGCs) of the monocytic linea

123 ental macrophages spontaneously matured into multinucleated giant cells (MGCs), a property not exhibi

124 xtensive emperipolesis of lymphocytes within multinucleated giant cells (MGCs), MGC death, and fibrin

125 ame time promoting macrophage fusion to form multinucleated giant cells (MNG).

126 is is the formation of granulomas containing multinucleated giant cells (MNGCs) and cell death.

127 host cell and to stimulate the formation of multinucleated giant cells (MNGCs).

128 cell division, resulting in the formation of multinucleated giant cells and cells with decondensed, h

129 stimulated to limitless differentiation into multinucleated giant cells and provide useful suggestion

130 parenchymal, noncaseating granulomas lacking multinucleated giant cells and, in 1 patient, CD68-posit

131 okine expression along with the formation of multinucleated giant cells appeared consistent with in v

132 We found that multinucleated giant cells are formed in the inflamed mo

133 Abnormal multinucleated giant cells are present in the bone marro

134 r macrophages that comprise SIVE lesions and multinucleated giant cells are present in the CNS early,

135 ons with numerous SIV-p28(+) macrophages and multinucleated giant cells had fewer MAC387(+) monocytes

136 Spl574 produces large syncytia of multinucleated giant cells in M. dunni cells, but its re

137 accumulation of eosinophilic macrophages and multinucleated giant cells in the lung.

138 RAW 264.7 macrophages and was unable to form multinucleated giant cells in this cell line.

139 Cellular fusion of macrophages into multinucleated giant cells is a distinguishing feature o

140 acrophage fusion leading to the formation of multinucleated giant cells remains unclear.

141 fficiently degrade mineralized tissue, these multinucleated giant cells secrete acid into a resorptio

142 Mature osteoclasts are multinucleated giant cells that are generated from the f

143 BI2536-treated LNCaP-AI cells formed multinucleated giant cells that contain clusters of nucl

144 from the seminiferous tubules, forming large multinucleated giant cells that underwent apoptosis.

145 The percentage of multinucleated giant cells was lower in brain-injured pa

146 ed microglia in SIV encephalitis lesions and multinucleated giant cells were also CD163 positive.

147 s, parenchymal microglia are infected as are multinucleated giant cells when present.

148 On the remaining surface, multinucleated giant cells with varying intensity of tar

149 by brightly autofluorescent macrophages and multinucleated giant cells, but interestingly, the macro

150 indle cells in the ABC and were not found in multinucleated giant cells, inflammatory cells, endothel

151 granulomatous inflammation characterized by multinucleated giant cells, some of which displayed elas

152 s, confer hyperfusogenicity on HSV and cause multinucleated giant cells, termed syncytia.

153 ogy, with disrupted seminiferous epithelium, multinucleated giant cells, uncleared apoptotic germ cel

154 onocytes that transform into macrophages and multinucleated giant cells.

155 d, to a lesser extent, epithelioid cells and multinucleated giant cells.

156 e formation and function of various types of multinucleated giant cells.

157 d fusion of macrophages and the formation of multinucleated giant cells.

158 ted the cells ability to form TRAP positive, multinucleated giant cells.

159 s), ie, the formation of single nucleated or multinucleated giant cells.

160 read dissemination of SIV in macrophages and multinucleated giant cells.

161 d clearance of amyloid by macrophage-derived multinucleated giant cells.

162 Endothelial syncytia, comprised of multinucleated giant-endothelial cells, are frequently f

163 Osteoclasts are multinucleated, giant cells of hematopoietic origin form

164 redominantly undifferentiated), induction of multinucleated gonocytes (MNGs), and aggregation of diff

165 organs showed congestions, aggregations and multinucleated hepatocytes in the liver, infiltration of

166 tion and failure of cytokinesis resulting in multinucleated "large" cells.

167 Cpd A prevents cytokinesis, resulting in multinucleated, multiflagellated cells that eventually l

168 f proliferating progeny from differentiated, multinucleated muscle cells by first inducing and subseq

169 essary at multiple steps in the formation of multinucleated muscle cells.

170 growth requires multiple steps to form large multinucleated muscle cells.

171 es apoptosis of a subset of myonuclei within multinucleated muscle fibers.

172 ation and fusion ability and ultimately form multinucleated "myoballs" rather than maintain elongated

173 toplasmic puncta at the nuclear periphery in multinucleated myoblasts, and that this change in locali

174 le gene transcription and differentiation in multinucleated myocytes.

175 ealed an identical phenotype: replacement of multinucleated myofibers by groups of single, myosin-exp

176 Fusion of individual myoblasts to form multinucleated myofibers constitutes a widely conserved

177 The formation of multinucleated myofibers is essential for the growth of

178 owth require the fusion of myoblasts to form multinucleated myofibers or myotubes, but few molecules

179 erved process that leads to the formation of multinucleated myofibers, syncytiotrophoblasts and osteo

180 ell as their differentiation and fusion into multinucleated myofibers, which are greatly reduced in m

181 n occurs through fusion of myoblasts to form multinucleated myofibers.

182 es fusion of mononucleated myoblasts to form multinucleated myofibers.

183 traction of highly specialized, postmitotic, multinucleated myofibers.

184 l muscle development, myoblasts fuse to form multinucleated myofibers.

185 from the fusion of precursor myoblasts into multinucleated myofibres.

186 Multinucleated myotube differentiation was inhibited by

187 also found in the cytoplasm of post-mitotic multinucleated myotubes and adult human skeletal myofibe

188 on of caveolin-3 inhibits myoblast fusion to multinucleated myotubes and lack of caveolin-3 enhances

189 s stimulated fusion into post-differentiated multinucleated myotubes and the appearance of skeletal a

190 Multinucleated myotubes develop by the sequential fusion

191 hich arise from the fusion of myoblasts into multinucleated myotubes during myogenesis.

192 protein required for myoblast fusion to form multinucleated myotubes in mouse, chick, and zebrafish.

193 fferentiated myotubes, it induced fission of multinucleated myotubes into mononucleated fragments.

194 Myoblast fusion into multinucleated myotubes is a crucial step in skeletal mu

195 Differentiation of skeletal myoblasts into multinucleated myotubes is a multistep process orchestra

196 Fusion of undifferentiated myoblasts into multinucleated myotubes is a prerequisite for developmen

197 r deprivation either by differentiating into multinucleated myotubes or by undergoing apoptosis; henc

198 to differentiate either form differentiated multinucleated myotubes or give rise to quiescent, undif

199 S proteinases contribute to the formation of multinucleated myotubes such as is necessary for both sk

200 During myogenesis, myoblasts fuse into multinucleated myotubes that acquire the contractile fib

201 Here we used primary chicken and duck multinucleated myotubes to examine their susceptibility

202 Conversely, myogenic differentiation into multinucleated myotubes was decreased when Pitx2 or Pitx

203 es fusion of mononuclear progenitors to form multinucleated myotubes, a critical but poorly understoo

204 is in C2 myoblasts upon differentiation into multinucleated myotubes, a well established model system

205 d that their steady-state levels increase in multinucleated myotubes, suggesting a global increase in

206 the time when myoblasts were fusing to form multinucleated myotubes.

207 atic myoblasts prior to their fusion to form multinucleated myotubes.

208 dysferlin expression is increased in mature, multinucleated myotubes.

209 myogenesis as individual myoblasts fuse into multinucleated myotubes.

210 he fusion of mononucleated myoblasts to form multinucleated myotubes.

211 ficant differentiation of C2C12 myoblasts to multinucleated myotubes.

212 -fast twitch, myogenin, and the formation of multinucleated myotubes.

213 taining and differentiated successfully into multinucleated myotubes.

214 ructural proteins and myocyte fusion to form multinucleated myotubes.

215 e late steps of differentiation that lead to multinucleated myotubes.

216 as myogenin, and began to differentiate into multinucleated myotubes.

217 ry for the proper repair and regeneration of multinucleated myotubes.

218 muscle cells that differentiate into fused, multinucleated myotubes.

219 oles of Notch1 in mononucleated myocytes and multinucleated myotubes.

220 and 66+/-2% MD2 expression in differentiated multinucleated myotubes.

221 ciently drives myogenic differentiation into multinucleated myotubes.

222 ration requires the fusion of myoblasts into multinucleated myotubes.

223 with cytokinesis defects attributed to CIT, multinucleated neurons were observed throughout the cere

224 uber-like lesions containing cytomegalic and multinucleated neurons with abnormal dendritic trees res

225 The microcapsules were multinucleated, not very water-soluble or hygroscopic an

226 arrow monocytes (BMMs) to differentiate into multinucleated OCLs in response to exogenously supplied

227 the fusion of OC precursors and formation of multinucleated OCs and decreases bone matrix resorption.

228 equired for RANKL-induced formation of giant multinucleated OCs by up-regulating the expression of nu

229 nonuclear myeloid precursors into functional multinucleated OCs.

230 ved macrophages (BMM), the formation of both multinucleated osteoclast and MNG induced by RANKL or IL

231 BMMs from MCP-1(-/-) mice showed decreased multinucleated osteoclast formation compared with WT mic

232 rived conditioned medium stimulated in vitro multinucleated osteoclast formation.

233 This correlated with fewer multinucleated osteoclast-like cells and more trabecular

234 factor-kappaB ligand, and the appearance of multinucleated osteoclast-like cells in the MPS bone mar

235 id phosphatase staining was used to identify multinucleated osteoclast-like cells.

236 , which increased their differentiation into multinucleated osteoclast-like cells.

237 Fusion is required for the formation of multinucleated osteoclasts and giant cells, although the

238 orm sphingosine 1-phosphate (S1P), in mature multinucleated osteoclasts as compared with preosteoclas

239 differentiate into morphologically distinct, multinucleated osteoclasts capable of inducing the resor

240 of mononucleated osteoclast precursors into multinucleated osteoclasts in an ERK1/2-dependent manner

241 ntaining mature osteoblasts and formation of multinucleated osteoclasts in response to BMP-2.

242 ings that Darc-antibody blocked formation of multinucleated osteoclasts in vitro and that Darc from C

243 lls substantially inhibited the formation of multinucleated osteoclasts in vitro.

244 was correlated to the increased activity of multinucleated osteoclasts on the distal side of the mol

245 bone marrow cells fail to differentiate into multinucleated osteoclasts or resorb bone in vitro and s

246 IL1 showed significantly fewer TRAP-positive multinucleated osteoclasts than EP and EP-Saline (P <0.0

247 gand (RANKL), these precursors formed large, multinucleated osteoclasts that expressed tartrate-resis

248 Bone-resorbing multinucleated osteoclasts that play a central role in t

249 KL) resulted in a robust formation of large, multinucleated osteoclasts which generated sealing zones

250 artrate-resistant acid phosphatase-positive) multinucleated osteoclasts, and the osteoclasts were sma

251 NAs and proteins and impaired fusion to form multinucleated osteoclasts, defects secondary to diminis

252 ow that, while homozygous c-Fos mice have no multinucleated osteoclasts, heterozygous mice have a red

253 nsition from mononucleated preosteoclasts to multinucleated osteoclasts.

254 tment with CID755673 and restore fusion into multinucleated osteoclasts.

255 did not completely differentiate into mature multinucleated osteoclasts.

256 at Nf1(+/-) mice contain elevated numbers of multinucleated osteoclasts.

257 (RANKL), as the cells failed to form large, multinucleated osteoclasts.

258 .7 monocyte/macrophage cell line into mature multinucleated osteoclasts.

259 nificantly increased during the formation of multinucleated osteoclasts.

260 tro was inhibited and also resulted in large multinucleated parasites.

261 Overexpression of p190 resulted in a multinucleated phenotype that was dependent on the GTPas

262 letion of the NF90/NF45 complex results in a multinucleated phenotype.

263 nable to bind filamin-A failed to induce the multinucleated phenotype.

264 in the absence of cytokinesis, resulting in multinucleated, polyploidy cells.

265 Muscle fibres are multinucleated post-mitotic cells that can change dramat

266 ble cross-over homologous recombination, but multinucleated R. oryzae could not be forced to segregat

267 rvived longer after mitotic arrest, becoming multinucleated rather than dying directly from mitotic a

268 Multinucleated Reed-Sternberg (RS) cells are pathognomon

269 enlarged cardiac myocytes, some of which are multinucleated, reflecting a defect in cytokinesis.

270 ased cell shedding and the presence of large multinucleated RPE cells, suggesting defects in intercel

271 pletion of CPG-1/CEJ-1 and CPG-2 resulted in multinucleated single-cell embryos.

272 Multinucleated skeletal muscle fibers form through the f

273 Myoblast fusion to form multinucleated skeletal muscle myotubes is a well studie

274 ene silencing is possible in differentiated, multinucleated skeletal muscle myotubes.

275 otic null germ cells with many misshapen and multinucleated spermatids, and no spermatozoa are detect

276 immature germ cells, and formation of giant multinucleated spermatids, are commonly detected in test

277 nuclei and reproduce clonally through large multinucleated spores.

278 s capable of inducing the formation of large multinucleated syncytia in Mus dunni cells.

279 A subset of infected cells formed multinucleated syncytia through HIV envelope-dependent c

280 n immunodeficiency virus-1 receptors, formed multinucleated syncytia with cells expressing S protein.

281 neous fusion of infected cells to form large multinucleated syncytia.

282 ng individual CMV glycoproteins did not form multinucleated syncytia.

283 py in which tumor cells are fused into large multinucleated syncytia.

284 gh the formation, and degeneration, of large multinucleated syncytia.

285 ell interstitial pneumonitis, accompanied by multinucleated syncytial cells, edema, and bronchiolitis

286 totrophoblasts (CT) ends in formation of the multinucleated syncytiotrophoblast representing the feta

287 subsequently fuse, and differentiate to form multinucleated syncytiotrophoblast with induction of aro

288 hoblasts, including the transcriptome of the multinucleated syncytiotrophoblast.

289 their differentiation potential from TGCs to multinucleated syncytiotropholasts (SynTs) and blocks ox

290 ial layer (YSL) in the zebrafish embryo is a multinucleated syncytium essential for embryo developmen

291 Skeletal muscle is a multinucleated syncytium that develops and is maintained

292 r activator of NF-kappaB ligand formation of multinucleated tartrate-resistant acid phosphatase (TRAP

293 y promote preosteoclast cell fusion, forming multinucleated tartrate-resistant acid phosphatase-posit

294 The number of multinucleated tartrate-resistant acid phosphatase-posit

295 s and an increase in the formation of giant, multinucleated TRAP(+) cells capable of F-actin ring for

296 ar bone loss and reduced the total number of multinucleated TRAP+ cells in mice that received ligatur

297 expressing osteoblasts and reduced number of multinucleated TRAP-expressing osteoclasts.

298 e-marrow precursors that differentiated into multinucleated TRAP-positive cells in the presence of EP

299 MW-E-overexpressing cells are binucleated or multinucleated with amplified centrosomes, whereas EL-ov

300 sors (cathepsin K-positive, mononucleated or multinucleated, within synovial tissue) were also positi