ライフサイエンスコーパス: multiple

1 printing technology, we are able to deliver multiple 100pico-liter (pL) volume droplets with pinpoin

2 gene expression in Lsh-/- NSPCs and suggests multiple aberrant pathways.

3 on of many soluble adjuvants, and delivering multiple adjuvants at the same time to mimic the synergi

4 d difficult to define as G6PD deficiency has multiple allelic variants with different effects in male

5 egional differences, high exposure burden to multiple allergens was most consistently associated with

6 itly models gene-centric dependencies across multiple and distinct genomic platforms.

7 r vitreous detachment (PVD) may be unique or multiple, and when multiple they may occur simultaneousl

8 ata emphasize that color perception involves multiple areas across a hierarchy of regions, interactin

9 s identified miR-495 as a novel regulator of multiple ARGs that have a role in modulating motivation

10 lticenter, double-blind, placebo-controlled, multiple-ascending-dose trial of inclisiran administered

11 B cells contribute to multiple aspects of autoimmune disorders and may play a

12 ntial hub of the signaling network affecting multiple aspects of metabolic alterations after burn inj

13 ared due to changes in the coral pathobiome (multiple bacterial species associated with disease) and

14 ions, however, should be taken cautiously as multiple biases affect these trend estimates.

15 In addition, analyses of multiple biochemical biomarkers and metabolomic profiles

16 chers require information synthesized across multiple biological scales, from the patient to the mole

17 Future studies should measure multiple biomarkers in each cancer type to determine whe

18 uracy of d-AQuA enable it to be suitable for multiple biotechnological and medical applications.

19 t complex featuring an unsupported, terminal multiple bond between a Ce(IV) ion and a ligand fragment

20 ed in a widely distributed manner throughout multiple brain areas, but that the striatum may have a p

21 d responses to negative emotional stimuli in multiple brain areas, including amygdala and fronto-limb

22 uptake, and serotonin transporter binding in multiple brain regions were compared by ANCOVA, adjusted

23 Since depression affects multiple brain regions, and the role of p11 has only bee

24 he 4D profiling of chemoconvulsant action in multiple brain regions.

25 roach also performs sequence assembly across multiple breakpoints simultaneously, enabling the recons

26 t-7 levels to suppress let-7 target genes in multiple cancer cell lines such as HMGA2 and MYC.

27 creased MEG3 expression has been reported in multiple cancer tissues.

28 The screen identified multiple candidates in many cell signaling pathways that

29 The strain has multiple carbon fixation routes (Wood-Ljungdahl pathway,

30 reservoirs can be used as smart carriers for multiple cargos, including both naked and nanoparticle-e

31 best performing perovskite materials contain multiple cations and provide power conversion efficienci

32 tor, a marker for ABCs, were generated after multiple cell divisions from C57BL/6 donors but not from

33 framework for the simultaneous formation of multiple cell types by the same transcriptional regulato

34 duce diverse cellular ecosystems composed of multiple cell types, accompanied by genetic diversity in

35 (MCL) may be 1 of the few cancers for which multiple chemotherapy and nonchemotherapy regimens are c

36 um bacteria are remarkably large and contain multiple chromosome copies.

37 Interestingly, we find multiple clusters within individual genes that have diff

38 sed recruitment of prefrontal regions across multiple cognitive tasks.

39 t-episode psychosis had lower regional FA in multiple commissural, corticospinal, and association tra

40 ng a state-of-the-art strategy, we expressed multiple complementary reporter molecules from the murin

41 rable to cascading failures under any out of multiple conditions.

42 Our results also suggest multiple conformations of P450 17A1, as previously propo

43 e variants in families in which a person had multiple congenital malformations.

44 e, an effect that persists over time, across multiple contexts, and depends on actin polymerization.

45 New electronic states emerge as a result of multiple copies of the TOTA(+) making pi-contact with cy

46 "clock" as it integrates information across multiple cortical areas.

47 transmission of these viruses are ongoing in multiple countries, yet there is a dearth of mass rearin

48 Finally, we found that methylation at multiple CpG sites in the HOXA4 promoter region was asso

49 To pilot a cluster-randomized, multiple-crossover trial using software tools within the

50 Multiple cycles of switching, controllable in real time,

51 ls, including bulls and humans, also contain multiple cysteine residues that form intra- and interpro

52 CGM in adults with type 2 diabetes receiving multiple daily injections of insulin.

53 We conducted a comprehensive search of multiple databases from 1996 to April 25, 2016, for stud

54 Ptrh2 null mice demonstrate multiple degenerating and regenerating muscle fibers, in

55 iants were found in 12 patients (11.9%) with multiple diagnoses.

56 to create multimodal nanomaterials (spanning multiple different physical imaging modalities and thera

57 Multiple different species can exhibit resistance due to

58 mpling and modelling approaches to elucidate multiple dimensions of historical population interaction

59 ons between these regions are complicated by multiple direct and indirect hippocampal-prefrontal conn

60 uding clinicians and researchers from across multiple disciplines.

61 reverse order RR for melanoma in families of multiple discordant cancers.

62 ll create a network effect that will benefit multiple disease programs.

63 g bone length in dogs is a unique example of multiple disease-causing retrocopies of the same parenta

64 nome sequencing make it possible to identify multiple disease-related mutations, but there is current

65 has been proposed as a modifiable factor in multiple disorders, could explain any of these associati

66 evelopment, which invokes homeotic shifts in multiple distinct meristem identities, obscures a recurr

67 These findings suggest that multiple distinct tumor immune microenvironments co-exis

68 ise for predicting population dynamics after multiple disturbance events and for management of river

69 S-based disulfide mapping is challenged when multiple disulfide bonds are present in complicated patt

70 ices, integrated approaches that incorporate multiple drivers of change and account for multiple sour

71 The ability to evaluate and cross-compare multiple drugs and drug combinations simultaneously in l

72 nal tract is a highly complex organ in which multiple dynamic physiological processes are tightly coo

73 study site who had serum samples obtained at multiple early timepoints.

74 CD4 T cells can differentiate into multiple effector subsets, including ThCTL that mediate

75 py reveal that rust fungi might have evolved multiple effectors that target chloroplasts or nuclei.

76 val times for molecules measured by DTIMS at multiple electric fields and compute their associated co

77 The produced multiple emulsion by WPC-pectin-maltodextrin along with

78 correlating with stage-specific activity of multiple enhancer elements.

79 ciation mapping (US-NAM) population grown in multiple environments and genotyped with 2.5 million si

80 nhance the overall activity of a cocktail of multiple enzymes and achieve optimal organ/tissue digest

81 ulates the development of iNKT cells through multiple epigenetic mechanisms.

82 ns from metropolitan Toronto, which revealed multiple episodes of capsular switching.

83 atching is complicated by variants that have multiple equivalent representations.

84 bined into an overall score, the MEESSI-AHF (Multiple Estimation of risk based on the Emergency depar

85 n melanoma correlated with the expression of multiple ETS transcription factors, particularly in SDHD

86 occurrence of long-lasting forms of LTP for multiple experimental protocols.

87 Many participants reported multiple exposures to cold.

88 ein dystroglycan functions as a receptor for multiple extracellular matrix proteins and its dysfuncti

89 Centromeres are also stable in multiple F1 hybrid contexts.

90 TEMENT: Neuroimaging studies have identified multiple face-selective regions in the brain, but the fu

91 We first group multiple features arising from the same analyte, which w

92 ange has been controlled by a combination of multiple forcings, such as tectonics, sea-level fall and

93 eurons can induce inflammation, resulting in multiple forms of brain toxicities.

94 Multiple forms of synaptic inhibition compartmentalized

95 ns were conducted at 10 hospitals, including multiple from the public and social security systems.

96 The binding of multiple fullerenes was observed to increase the electro

97 active intermediates enable the reduction of multiple functional groups.

98 thy who were receiving long-term opioids had multiple functional status markers that were modestly po

99 of specific signals, whereas in plants with multiple Galpha proteins, an even more complex regulatio

100 human craniofacial malformations and involve multiple genetic and environmental factors.

101 Using multiple genetic strategies, we demonstrated that E prot

102 In multiple glioma cell lines and patient-derived glioma st

103 has been shown to be required for binding of multiple glycan receptors.

104 es treated with insulin pump therapy or with multiple (>/=4) daily insulin injections.

105 erature (Tmix) and reappear below Tmix, over multiple heating and cooling cycles.

106 ging because of its complex architecture and multiple highly flexible regions.

107 In addition to HIFs, multiple histone demethylases are altered in their expre

108 plete glycosylation profile at every site in multiple HIV-1 Env trimers, accomplishing two goals.

109 Multiple hospital sites of the Aravind Eye Care System,

110 ributes significantly to GAS pathogenesis at multiple host anatomic sites.

111 tunately, both of these approaches can match multiple identities with a single feature.

112 tissue microstructure, integrating data from multiple imaging modalities, strategic longitudinal obse

113 echanistic insights into this association in multiple immunocompetent orthotopic models of lung cance

114 d on a Cox proportional hazards model, using multiple imputation for missing data.

115 based measurements of membrane coverage with multiple, independent measurements of membrane vesiculat

116 netic elements, bona fide viruses evolved on multiple, independent occasions throughout the course of

117 Multiple inflammatory pathways showed stronger enrichmen

118 pair reveals a hierarchy of regulation among multiple inputs-sex, age, nutritional status, and microb

119 harge, not steric properties, resulting from multiple interdependent phosphorylation sites is require

120 Signals arising from measurement using multiple ion channels are more complicated to interpret.

121 Multiple isomiRs and tRFs arising from specific miRNA lo

122 We then constructed two RBDs mutated in multiple key residues in the receptor-binding motif (RBM

123 Using multiple labeling approaches to identify pathways and th

124 This study used multiple labeling immunohistochemistry, confocal maging

125 d EGFR were determined in blinded fashion in multiple laboratories.

126 on in additional mouse and human neurons and multiple learning tests from 1486 rats identified BRaf a

127 systematically annotate chromatin states at multiple length scales.

128 mulating evidence points to the existence of multiple, less well-defined layers of regulation.

129 Multiple linear and logistic regression models were used

130 We used multiple linear regression analysis to compare SMC with

131 ce analysis and residual analysis based on a multiple linear regression model.

132 Multiple lines of evidence implicate chromatin in the re

133 Multiple lines of evidence show that cold stadials in th

134 el-based RL remain largely unknown; however, multiple lines of evidence suggest that neural circuits

135 trated that LAIT provides convenience to run multiple local ancestry inference software.

136 cording from large numbers of neurons across multiple local circuits and, importantly, allow stable t

137 Using multiple logistic regression, we identified significant

138 GMSCs were adoptively transferred to multiple low-dose streptozotocin (STZ)-induced T1DM.

139 tes the master female determinant Sxl, since multiple m(6)A components enhance female lethality in Sx

140 nal enhancement was observed in the DN after multiple macrocyclic GBCA injections.

141 Purpose To investigate whether combining multiple magnetic resonance (MR) imaging modalities such

142 ASPD patients showed decreased FA in multiple major white matter fiber bundles, which connect

143 yandrous populations where females mate with multiple males.

144 s to interrogate the human immune system for multiple markers of inflammation at a scale that was not

145 We then analyze multiple markers of neurodegeneration and neurotoxicity

146 able accuracy and without the need for using multiple markers.

147 come apparent that the immune system evolved multiple mechanisms for controlling self-reactivity, and

148 nd non-reward modulated STDP and implemented multiple mechanisms for homeostatic regulation of synapt

149 tion, a transcription factor can act through multiple mechanisms to generate a common behavioral outp

150 late that resistance to T-DM1 occurs through multiple mechanisms, one of which is impaired lysosomal

151 relatives diagnosed with melanoma, including multiple melanoma, and in reverse order RR for melanoma

152 and are well documented in families in which multiple members have had pancreatic cancer.

153 plays an important role in the formation of multiple membrane-less organelles involved in RNA metabo

154 d phase stability to simultaneously activate multiple micromechanisms that resist crack propagation i

155 Multiple micronutrient supplements did not significantly

156 -objects, and cooperative manipulation using multiple microrobots.

157 lipid bilayer and cytoskeleton as modeled by multiple millions of mesoscopic particles-using a single

158 itin chains are particularly challenging, as multiple modifications on a single ubiquitin preclude th

159 e expression profiles (GEP) from a cohort of multiple myeloma (MM) patients and normal individuals us

160 ded for patients with relapsed or refractory multiple myeloma (MM).

161 orubicin were observed in vitro against both multiple myeloma and ovarian cancer cells.

162 ssess the ex vivo drug sensitivity of single multiple myeloma cells based on measuring their mass acc

163 s associated with increased recirculation of multiple myeloma PCs.

164 tors in patients with relapsed or refractory multiple myeloma.

165 Moreover, we identify multiple neurite-targeted non-coding RNAs and RNA-bindin

166 We used simultaneous recordings from multiple neurons in the hippocampus and neocortex of rat

167 reclinical studies showing the importance of multiple neuropeptides in reinstatement of drug use, we

168 suppress the synapse organizing function of multiple NLs.

169 They have been associated with multiple non-motor symptoms in PD and have important cli

170 tion of this fingerprint that is mirrored in multiple observational surface temperature datasets.

171 of complex new molecular materials in which multiple optoelectronically active components are arrang

172 ent; p = 0.004), especially in patients with multiple organ failure (acute-on-chronic liver failure g

173 m ulti- oc alization of cellular proteins in multiple organisms.

174 tion between different endocrine systems and multiple organs.

175 ution and many producer strains resistant to multiple other antibiotics.

176 Species that have HP1 proteins possess multiple paralogs that perform non-overlapping roles in

177 Large investments made by multiple partner organizations and the federal Ministry

178 Evolution of a nano-machine consisting of multiple parts, each with a specific function, is a comp

179 on in conjunction with CRIMP compression and multiple passes through the serpentine path provides the

180 Analysis of simultaneous multiple patch-clamp recordings from 6068 pairs of rat n

181 iption co-factors and integrate signals from multiple pathways to control metabolism, oxidative stres

182 HBV uses multiple pathways to harness host innate immunity to enh

183 differential expression of 412 genes and of multiple pathways, including CADM1, SPHK1, and YAP/TAZ,

184 A combination of multiple patient-reported outcomes measurement (PROM) to

185 knockdown of KPNA4 reduces cell migration in multiple PCa cell lines, suggesting a role of KPNA4 in P

186 Culture of multiple periprosthetic tissue samples is the current go

187 software enable discovery and dissection of multiple phenotype association signals through implement

188 sults of genome-wide association analyses of multiple phenotypes and two measures of phenotypic plast

189 ta from genome-wide association studies from multiple phenotypes using conditional false discovery ra

190 t sporadic FTD is a polygenic disorder where multiple pleiotropic loci with small effects contribute

191 While multiple post-translational modifications have been repo

192 regation has proven a challenge owing to the multiple potential phosphorylation sites and their clust

193 rom progression of MCC clinically resembling multiple primaries, allowing appropriate staging of the

194 Patients with clinically designated multiple primary MCC were identified from the multidisci

195 es and mutations is useful in distinguishing multiple primary MCCs from progression of MCC clinically

196 portantly, GRHL2 maintained AR expression in multiple prostate cancer model systems, was required for

197 an yield time-resolved information and probe multiple protein binding partners simultaneously, using

198 Multiple protein complexes regulate the Rag GTPases in r

199 rker for cancer diagnosis because they carry multiple proteins that reflect the origins of parent cel

200 eted entities and processes to interact with multiple proteins, can have profound biological impacts

201 ver, we numerically studied both single- and multiple-pulse AOS under different coupling strength bet

202 tion, functionalization of nanocapsules with multiple pyridine molecules at the capsule surface preve

203 n and MIC ranges for cefepime-tazobactam for multiple QC reference strains.

204 pendencies in the collision probabilities of multiple random walks.

205 We sought to re-examine the significance of multiple rare variants in patients with hypertrophic car

206 iquid-chromatography-stable-isotope dilution-multiple-reaction monitoring-mass spectrometry.

207 Mut has already been successfully applied in multiple recent studies to find unique, treatment induce

208 PI3K/Akt/mTOR pathway mediates signals from multiple receptors including insulin receptors, pathogen

209 -methylimidazolate ligand is responsible for multiple redox transformations.

210 the reflection loss of p-polarized light and multiple reflections within the wafer-based IRE.

211 erful synthetic transformations used to make multiple regioselective and stereoselective carbon-carbo

212 The use of multiple regression analysis demonstrates that FAEE cont

213 Multiple regression models were fitted to estimate genet

214 e a foundation for understanding the role of multiple regulatory factors in modulating Fshb gene acti

215 cob, and kernel attributes is being used by multiple research groups as an automated Web service run

216 The multiple response issue was also carefully addressed.

217 rial response to antimicrobials that involve multiple riboregulators.

218 e initiation codon, which cannot accommodate multiple ribosomes, are not subject to NGD.

219 opriate times during the life course, target multiple risks, and build on existing delivery platforms

220 h gene is Wilms' tumour 1 (WT1), which plays multiple roles in development, tissue homeostasis and di

221 -interacting protein (HHIP) and subjected to multiple rounds of affinity maturation through the scree

222 Our approach utilizes multiple rounds of targeted imaging at different scales

223 composed of hundreds of unique genes, during multiple rounds of vegetative growth when sporulation is

224 reveal its efficiency to invade the CNS via multiple routes of peripheral administration.

225 Multiple RPE fates in AMD, including intraretinal cells

226 vation of MeCP2 T158M expression ameliorated multiple RTT-like features, including motor dysfunction

227 st, we theoretically model the importance of multiple scattering effects and computationally predict

228 ect and quantify peripheral nerve lesions in multiple sclerosis (MS) by magnetic resonance neurograph

229 , which occurs in the demyelinating disorder multiple sclerosis (MS), contributes to axonal dysfuncti

230 st function of CLEC12A in an animal model of multiple sclerosis (MS), we administered blocking antibo

231 Multiple sclerosis is a degenerative inflammatory diseas

232 We examined multiple sclerosis lesions and other central nervous sys

233 easures of subsequent disease progression in multiple sclerosis patients.

234 g understanding of the immunopathogenesis of multiple sclerosis suggests that depleting B cells could

235 assigned 821 and 835 patients with relapsing multiple sclerosis to receive intravenous ocrelizumab at

236 Secondary outcomes included conversion to multiple sclerosis within 24 months after randomization

237 erative conditions affecting humans, such as multiple sclerosis, neuromyelitis optica spectrum disord

238 s, which is the most-studied animal model of multiple sclerosis.

239 odels of acute graft-versus-host disease and multiple sclerosis.

240 n's syndrome, inflammatory bowel disease and multiple sclerosis.

241 B cells influence the pathogenesis of multiple sclerosis.

242 ology Program's (NTP's) effectiveness across multiple sectors and demonstrate the utility of the appr

243 siblast PSSMs are built from the query-based multiple sequence alignment (MSA) implied by the pairwis

244 ng Analysis (DCA) of correlated mutations in multiple sequence alignments (MSAs).

245 s generally done by random priming, creating multiple sequencing fragments along each transcript.

246 SiNVICT has the capability to handle multiple sequencing platforms with different error prope

247 related 'necklace' dislocation consisting of multiple short component dislocations in adjacent twins,

248 pathologic progression of HCC by integrating multiple signaling pathways and suggest that Gab2 might

249 ene set enrichment analysis (GSEA) indicated multiple signaling pathways are involved DKD pathogenesi

250 xpression of a variety of genes and identify multiple signaling pathways underlying taste cell differ

251 amily, and that they play important roles in multiple signalling pathways in vivo.

252 phages are sufficiently plastic to integrate multiple signals, such as those from microbes, damaged t

253 re than half the identified proteins possess multiple sites of phosphorylation that are often cluster

254 found that, compared to stepwise conditional multiple-SNP analysis, SOJO provided better sensitivity

255 e multiple drivers of change and account for multiple sources of uncertainty are needed.

256 r systems that need to integrate inputs from multiple sources to generate normal neuronal functions.S

257 esulting from random sensorimotor noise from multiple sources, and non-linear input transformations,

258 ns.On the basis of nutrition label data from multiple sources, we used a stepwise approach to derive

259 species abundance and community dynamics at multiple spatial scales.

260 role during spontaneous cardiac fibrosis in multiple species, we hypothesized that PAI-1 also regula

261 ion of a standardized assay for HIV-1 RNA in multiple specimen types.

262 ockdown line and NF54 wild-type parasites at multiple stages of development, we show that sexually co

263 The possibility of having multiple states in a single nanomagnet with vertical cou

264 here is no standardized method for analyzing multiple-stressor data using dose-response regression.

265 rvation was further investigated through the multiple structural analyses including HPLC, IR and NMR.

266 mal RNA gene sequences to be followed across multiple studies and allow us to explore patterns of div

267 From the biological standpoint, multiple studies have correlated individual biomarkers w

268 ed by AURKB-catalyzed autophosphorylation on multiple subunits, but how this regulates CPC interactio

269 Can the lessons learned from multiple successes within the PSMA experience be transfe

270 a with Lewy bodies, Parkinson's disease, and Multiple System Atrophy are age-related neurodegenerativ

271 We here tested the hypothesis that multiple system atrophy is associated with brain insulin

272 odendrocytes in the putamen of patients with multiple system atrophy.

273 on's disease, dementia with Lewy bodies, and multiple systems atrophy.

274 NIFICANCE STATEMENT Neurons communicate with multiple targets by forming axonal branches.

275 Meta-analyses were performed and multiple testing corrections were carried out using the

276 After correction for multiple testing, three of the 78 microRNAs remained sig

277 dependent SNPs was calculated to correct for multiple testing.

278 We have identified and validated multiple TFs influencing asthma treatment response.

279 nt (PVD) may be unique or multiple, and when multiple they may occur simultaneously or subsequently a

280 To study its dynamics at multiple time scales in response to inputs approximating

281 kernel learning, complementary features from multiple time-varying FC networks constructed at differe

282 genomic position being mutationally affected multiple times in individual tumors for 11 of 12 single-

283 promoters able to drive strong expression in multiple tissue/organs.

284 Thus, Rab8a and PI3Kgamma are positioned in multiple TLR pathways, and this signaling axis may serve

285 tobacco users, adults and youths alike, used multiple tobacco products; cigarettes plus e-cigarettes

286 Therapies based on activation of multiple Toll-like receptors (TLRs) may offer superior t

287 effective vaccine formulation would deliver multiple tumor antigens in a fashion that potently stimu

288 ion images yields high resolution 3D maps of multiple tumor microenvironment components and biomarker

289 Analyses of multiple ultrastructural variables revealed four organiz

290 ripheral tissue dynamics in single, dual and multiple unit microfluidic platforms (Solo-MFP, Duet-MFP

291 populations, whereas few strains occurred in multiple unrelated cohorts.

292 able human-wildlife coexistence across large multiple-use landscapes.

293 ep understanding of neutralizing mechanisms, multiple vaccine strategies have advanced to the stage o

294 ighly similar scenes, faces, or objects from multiple viewpoints, and has revealed selective impairme

295 asis of this defect, we tracked the fates of multiple viral components in infected cells.

296 Risk factors for detection of multiple viruses included cord blood or HLA-mismatched H

297 itical for autophagy-mediated restriction of multiple viruses, and this activity was dependent on bot

298 further developed a method, iMAAPs, to infer multiple-wave admixture by fitting ALD using a p-spectru

299 Results were compared in multiple ways to determine whether statistically signifi

300 Ampharetidae) individuals that had colonized multiple wood falls in the deep ( 1600 m) NE Pacific Oce