ライフサイエンスコーパス: multiple gene

1 the other half correlate with expression of multiple genes.

2 -elements or by integrating information from multiple genes.

3 NA potentially regulating the expressions of multiple genes.

4 h integrative model scores were observed for multiple genes.

5 Among the predicted TUs, 44% have multiple genes.

6 all mapped reads, including those mapped to multiple genes.

7 activation, indicating the participation of multiple genes.

8 lineages were significantly decoupled across multiple genes.

9 ed with convergent specialized expression of multiple genes.

10 translocates into the nucleus and regulates multiple genes.

11 tumors in vivo by coordinated regulation of multiple genes.

12 lidation phase and encompass combinations of multiple genes.

13 ast method for estimating species trees from multiple genes.

14 by simultaneously altering the expression of multiple genes.

15 on-dependent regulatory mechanism regulating multiple genes.

16 s often occur over broad domains, and across multiple genes.

17 lators for independent, inducible control of multiple genes.

18 to simultaneously monitor the expression of multiple genes.

19 in 1 Mb of their targets, and often regulate multiple genes.

20 athways requires the concerted expression of multiple genes.

21 naling and regulatory pathways consisting of multiple genes.

22 s with amiRNA candidates targeting single or multiple genes.

23 hat each CNV typically affects the dosage of multiple genes.

24 hancer to produce simultaneous activation at multiple genes.

25 but rather is a variable trait influenced by multiple genes.

26 ptations that require evolutionary change in multiple genes.

27 d DEX up-regulated mRNA expression levels of multiple genes.

28 chanisms between canonical Wnt signaling and multiple genes.

29 combining point mutations and exonic CNVs in multiple genes.

30 isualize and compare expression profiles for multiple genes.

31 ction in situ and is adaptable for targeting multiple genes across model organisms.

32 Here we show that risk alleles spanning multiple genes across the 10q24.32 schizophrenia-related

33 genes for the chromosomal virulence factors multiple-gene activator (mga), M protein (emm23), C5a pe

34 nally, we identified aberrant methylation in multiple genes also targeted by recurring DNA copy numbe

35 generation of animals carrying mutations in multiple genes, an approach that will greatly accelerate

36 limination of Kmo in mice is associated with multiple gene and functional alterations that appear to

37 upon multifactorial processes that regulate multiple gene and protein pathways, including those invo

38 Because cancers are caused by mutations in multiple genes and abnormalities in multiple signaling p

39 There is growing evidence that multiple genes and air pollutants are associated with as

40 This strategy obviates the need to regulate multiple genes and decreases the genetic load required f

41 extensive changes in alternative splicing of multiple genes and in a higher number of enlarged nuclea

42 truction resulting from interactions between multiple genes and multiple environmental exposures.

43 ADHD is highly heritable and multifactorial; multiple genes and non-inherited factors contribute to t

44 ation sequencing facilitates the analysis of multiple genes and now is being used to sequence the cod

45 networks through coordinated changes across multiple genes and pathways.

46 are driven by diverse alterations affecting multiple genes and pathways.

47 Simultaneous delivery of multiple genes and proteins (e.g., transcription factors

48 amma (IFN-gamma) increases the expression of multiple genes and responses; however, the mechanisms by

49 owever, for classification, we must consider multiple genes and their interactions.

50 All of them affect multiple genes (apart from NRXN1) and cause substantial

51 Although multiple genes are likely involved in the genesis of HAP

52 Mice carrying mutations in multiple genes are traditionally generated by sequential

53 el sequencing allows simultaneous testing of multiple genes associated with cancer susceptibility.

54 ockdown in RCC cell influenced expression of multiple genes associated with cell adhesion, among whic

55 1 alterations in B-ALL leads to induction of multiple genes associated with proliferation and treatme

56 Similarly, multiple genes associated with rare genetic mutations in

57 ible factor that upregulate transcription of multiple genes associated with the response to hypoxia,

58 Activin A orchestrated the expression of multiple genes associated with the TFH program, independ

59 ependent differences in expression levels of multiple genes associated with the type I IFN pathway we

60 We show that expression of multiple genes becomes dysregulated in a sex-, tissue-,

61 dons under stress conditions, was covered by multiple genes belonging to the Elongator (e.g. ELP3) an

62 Multiple genes (C11orf30/EMSY, SKAP1, and CTNNA3) identi

63 loped to reconstruct organismal history from multiple genes can be divided into supermatrix and super

64 yses of circulating isolates have shown that multiple genes can be recombined from human, avian, and

65 However, as CNVs often include multiple genes, causal genes responsible for CNV-associa

66 ), providing an interface for users to input multiple gene clusters, retrieve promoter sequences, run

67 ommon members but varied connectivity across multiple gene co-expression networks (aka M-modules).

68 processes, however, the expression levels of multiple genes come to be correlated with position, and

69 he species barrier to infect mammals despite multiple genes conferring adaptation and replication of

70 s consistent with a model where imbalance of multiple genes contributes to a disease state.

71 2/Osx1 checkpoint and thus do not upregulate multiple genes controlling mineral metabolism in osteobl

72 bilistic promoter occupancy, the presence of multiple gene copies, and cell-to-cell variability.

73 on over the mRNA lifetime, contribution from multiple gene copies, and mixing of cells from different

74 were compared for parasites with single vs. multiple gene copies, only amodiaquine and piperaquine r

75 A molecular approach using multiple genes, coupled with morphological and chromosom

76 chopulmonary dysplasia disrupt expression of multiple genes critical for development.

77 b is responsive to lipid levels and controls multiple genes critical to dyslipidemia.

78 developmental disorders arise from single or multiple gene defects.

79 vectors to target single (Mecp2) as well as multiple genes (Dnmt1, Dnmt3a and Dnmt3b) in the adult m

80 Loss-of-function (LOF) experiments targeting multiple genes during tumorigenesis can be implemented u

81 In plants, multiple genes encode the three RPA subunits (RPA1, RPA2

82 ion of well-known sugar-responsive genes and multiple genes encoded by the plastid, on the one hand,

83 The organism possesses multiple genes encoding autotransporter proteins, which

84 through NOD2 up-regulated the expression of multiple genes encoding metallothioneins, which bind and

85 ccompanied by the differential expression of multiple genes encoding small molecule-modifying enzymes

86 the green alga Chlamydomonas reinhardtii has multiple genes encoding type 2 DGATs (DGTTs).

87 the generation of mice carrying mutations in multiple genes, endogenous reporters, conditional allele

88 Multiple genes/enzymes that play a role in DNA and histo

89 7 governed the splicing and/or expression of multiple genes essential for hepatocellular differentiat

90 How adaptive traits that are controlled by multiple genes evolve is an intriguing question in evolu

91 of potential significance (P<10(-4)) involve multiple genes expressed in the brain, including GRIN2B,

92 c approach, we compare the cis-regulation of multiple genes expressed in the Drosophila CNS midline p

93 NP-specific enhancer modules associated with multiple genes expressed in this cell type.

94 In conclusion, multiple gene expression associations with MDD were iden

95 and, finally, to perform a meta-analysis of multiple gene expression data sets.

96 rules to facilitate integrative modeling of multiple gene expression data.

97 ethods, this approach focused on integrating multiple gene expression datasets across platforms in or

98 can upload gene or protein lists, single or multiple gene expression datasets to perform comprehensi

99 The capabilities to analyze multiple gene expression experiments are also provided.

100 e number of circuit structures able to drive multiple gene expression patterns decreases rapidly with

101 that transcription rate is tuned to regulate multiple gene expression steps.

102 ay and NGS technology, LA analysis combining multiple gene expression studies can provide more accura

103 However, multiple gene expression studies comparing wild-type and

104 Multiple gene expression-based signatures have been iden

105 e ability to rapidly and accurately genotype multiple gene families in thousands of individuals at lo

106 esis is supported by comparative analysis of multiple gene families, including the apparent absence o

107 s technology for the simultaneous editing of multiple genes (five genes or more) after a single trans

108 werful and highly efficient tool, to deliver multiple genes for a wide range of applications in prima

109 ositive T cells and its capacity to suppress multiple genes from the transforming growth factor-beta

110 In addition, redundancy in which multiple genes fulfill overlapping functions is often ma

111 ent strategies for simultaneous detection of multiple gene fusions are limited by tedious and prolong

112 Multiple genes, gene networks, and variants have been as

113 utations) to include Complex Human Diseases (multiple gene-gene and gene-environment interactions).

114 Serum response factor (SRF) controls multiple genes governing adhesion and migration, mainly

115 Among 21 candidate genes, we identified multiple genes (gp130, CCL4, TNFalpha, SH2D1B, CAV1, aty

116 e variation and that patterns of single- and multiple-gene haplotypes exhibit strong geographical str

117 Exome sequencing studies have identified multiple genes harboring de novo loss-of-function (LoF)

118 Multiple genes have been associated with PD, including P

119 The heritability of autism is high and multiple genes have been implicated as causal.

120 To date, multiple genes have been implicated in single-gene hered

121 els of miR-34a, which is predicted to target multiple genes implicated as genetic risk factors for BD

122 regulatory hub by physical interactions with multiple genes important for prostate carcinogenesis.

123 on of a single promoter for co-regulation of multiple genes in a crop plant.

124 When multiple genes in a pathway were considered together, a

125 sequencing, it is now affordable to examine multiple genes in a single disease-targeted clinical tes

126 Cloning of multiple genes in a single vector has greatly facilitate

127 traits and of an RNA thermometer controlling multiple genes in an operon through a polar effect.

128 ably being associated with the expression of multiple genes in cis.

129 enetic Wnt dysregulation (high tone) express multiple genes in common with colon cancer, including Le

130 However, expression of multiple genes in concert is often needed to ensure surv

131 re the potential to affect the expression of multiple genes in its genomic vicinity.

132 y coordinated posttranscriptional control of multiple genes in lipoprotein and cholesterol metabolism

133 design of synthetic microRNAs able to target multiple genes in multiple sites.

134 eading to altered pathogenic deregulation of multiple genes in muscles.

135 Detailed molecular studies have identified multiple genes in MYXV that are critical for virulence,

136 genes (SpCas9) can be used to edit single or multiple genes in replicating eukaryotic cells, resultin

137 ordinated changes in alternative splicing in multiple genes in response to alterations in cellular st

138 nteractions to the coordinated regulation of multiple genes in response to intracellular and extracel

139 action (qPCR) approaches enable profiling of multiple genes in single cells, bringing new insights to

140 TNBC cells in suspension upregulated multiple genes in the kynurenine pathway of tryptophan c

141 ckdown of NtERF32 reduces the mRNA levels of multiple genes in the nicotine biosynthetic pathway incl

142 of a critical effector gene, is shared with multiple genes in the p53 pathway.

143 We observed that the expression of multiple genes in the vicinity of any single CKD risk al

144 Multiple genes in TP53 pathway were upregulated in HPV+

145 Some of these SNPs affect multiple genes in trans that are known to be altered in

146 ted scratches showed increased expression of multiple genes including the chemokine CXCL2 and its rec

147 Tfap2alpha in turn activates multiple genes including the protocadherin pcdh8l (PCNS)

148 p sequencing identified aberrant splicing of multiple genes including those encoding myofibrillar and

149 sed IL-6- and TGF-beta-induced expression of multiple genes, including HIF-1alpha and PAI-1, in AECs.

150 rrant methylation and expression patterns of multiple genes, including Igf1r and Nr4a2, which are inv

151 typhi A are characterized by inactivation of multiple genes, including in the flagellum-chemotaxis pa

152 ncing analysis, influences the expression of multiple genes, including many involved in cell wall hom

153 erties identified differential expression in multiple genes, including MYC, as potentially affecting

154 CpG sites in multiple genes, including novel findings and results pre

155 CHES1 represses the expression of multiple genes, including the kinases PIM2 and DYRK3, wh

156 lar atrophic processes via the regulation of multiple genes, including the muscle atrophy gene Trim63

157 with reduced damage-responsive expression of multiple genes, including the WNT genes wingless (wg) an

158 sion to the blastema overcomes repression of multiple genes, including wg, and restores cellular resp

159 at differences in severity are the result of multiple gene interactions.

160 ix analysis consists of the concatenation of multiple genes into a single, possibly partitioned align

161 methodology would enable the transfection of multiple genes into the same cell or different genes int

162 ey B cell transcription factors and affected multiple genes involved in B cell biology.

163 tion factor that regulates the expression of multiple genes involved in cell growth, viability and ti

164 isms have been identified, notably including multiple genes involved in epithelial function/secretion

165 Mutations in multiple genes involved in homology-directed repair (HDR

166 RAMP) mice resulted in a strong induction of multiple genes involved in inflammatory responses and mo

167 Additionally, multiple genes involved in maintaining the mitotic cell

168 Axud1 loss leads to downregulation of multiple genes involved in neural crest specification, s

169 evealed that HuR regulates the expression of multiple genes involved in nuclear pore formation and is

170 arvation responses, such as up-regulation of multiple genes involved in Pi uptake and solubilization,

171 In Arabidopsis thaliana, multiple genes involved in shoot apical meristem (SAM) t

172 ed that the circadian protein Per1 regulates multiple genes involved in sodium transport in the colle

173 sion levels and/or gene number expansion for multiple genes involved in stress responses and the bios

174 Multiple genes involved in TCA cycle metabolism were als

175 demonstrated that SRSF2 governs splicing of multiple genes involved in the stress-induced cell death

176 llagen synthesis and increased expression of multiple genes involved in tissue remodeling and extrace

177 RNA sequencing and microarrays, we show that multiple genes involved in various steps of mRNA process

178 othelial cells (BMECs) changes expression of multiple genes involved in vascular development.

179 Multiple genes involved with tissue repair/regeneration

180 e one element controls allelic expression of multiple genes, is not fully understood.

181 ors are optimized to create either single or multiple gene knockouts and large chromosomal deletions.

182 omitant with a decrease in the expression of multiple genes known to be important for HSPCs survival,

183 We uncovered multiple genes known to be involved in p53 and Rb regula

184 of gene-level influences, and we identified multiple gene level variables associated with splicing r

185 f statistical procedures via combinations of multiple gene-level and gene set-level statistics, each

186 ing variants may increase risk for COPD, but multiple genes likely contribute to COPD susceptibility.

187 number of populations is small and there are multiple gene lineages from each population.

188 Transcription factor MEF2C regulates multiple genes linked to autism spectrum disorder (ASD),

189 Multiple gene loci are associated with inflammatory bowe

190 rade myopia is highly heritable, and to date multiple gene loci have been reported.

191 een implicated in the coordinated control of multiple gene loci in Epstein-Barr virus (EBV) latency.

192 ecific single-base mutations are achieved in multiple gene loci.

193 We hypothesize that the combination of multiple genes may generate biomarkers with prognostic p

194 entified three genetic components comprising multiple genes mediating ERP subcomponent abnormalities

195 ary being related to secretory function, and multiple genes more highly expressed in the female pitui

196 uitary as compared to the hypothalamus, with multiple genes more highly expressed in the male pituita

197 ajority of existing mouse SCC models involve multiple gene mutations.

198 We show that KLF6 transactivates multiple genes negatively controlling the NF-kappaB path

199 omputational methods that enable analysis of multiple gene networks, each of which exhibits different

200 nal analysis of GM corn containing traits of multiple genes (NK603, MON88017xMON810 and MON89034xMON8

201 rophic forms downregulated the expression of multiple genes normally associated with the response to

202 lycistronic system to simultaneously express multiple genes of interest.

203 The T2D enrichment signal was largely due to multiple genes of modest effects (P = 4 x 10(-4), after

204 d that VO2 max trainability is influenced by multiple genes of small effects, but these findings stil

205 n-containing proteins regulate expression of multiple genes of therapeutic relevance, including those

206 This study shows that multiple genes, often within pathways involving DNA repl

207 MicroRNAs (miRNAs) regulate multiple genes, often within the same pathway, fine-tuni

208 By providing one or multiple genes or gene sets as input and specifying a ge

209 nsdifferentiation requires the modulation of multiple genes or pathways at one time in a single cell.

210 y controlled, and cell-specific silencing of multiple genes or pathways.

211 h as the ability to coordinate expression of multiple genes or to implement threshold crossing mechan

212 ied in this study shows the value of using a multiple-gene panel in pancreatic cancer.

213 by next-generation sequencing using a custom multiple-gene panel.

214 isk is evolving rapidly, with growing use of multiple-gene panels that can yield uncertain results.

215 design and construct viable genomes lacking multiple genes, paving the way toward genome minimizatio

216 ated with schizophrenia and autism, spanning multiple genes possibly involved in synaptic neurotransm

217 high-quality gene models, this program runs multiple gene predictors, evaluates all predicted genes,

218 lex traits arise from the interactions among multiple gene products.

219 ypes is the ability to simultaneously modify multiple genes rapidly and selectively.

220 ession, potentially driven by interaction of multiple genes rather than a dominant role of the major

221 ypoxia in animals involves the expression of multiple genes regulated by the alphabeta-hypoxia-induci

222 type C57BL/6 donors normalized expression of multiple genes regulating immune function and epithelial

223 The discovery of multiple genes regulating vesicular trafficking, cell su

224 three distinct temporal peaks demonstrating multiple gene regulation waves in LTAM.

225 rtionate number of SNPs in the gene encoding multiple gene regulator of group A Streptococcus (mga).

226 al (3D) organization of DNA is implicated in multiple gene regulatory mechanisms, but understanding t

227 might have evolved via concerted changes in multiple gene regulatory networks.

228 astasis, as well as suppressed expression of multiple genes related to cell migration and microenviro

229 that does not change in number and expresses multiple genes related to lipid metabolism and lipid sig

230 ped the "NanoScript" platform by integrating multiple gene repression molecules with a nanoparticle.

231 the combination or synthesis of mutations in multiple genes results in cell death, provides a framewo

232 Multiple gene segment exchanges among and within subtype

233 genetically and functionally compatible with multiple gene segments from the 2009 pandemic influenza

234 ent eukaryotic genome projects have reported multiple gene sequences that were much more similar to h

235 omen testing negative for BRCA1/2 mutations, multiple-gene sequencing identified 16 potentially patho

236 Multiple-gene sequencing is entering practice, but its c

237 However, these results suggest that multiple-gene sequencing may benefit appropriately selec

238 adult mice, allowing simultaneous editing of multiple gene sets in individual cells.

239 te that by identifying genes associated with multiple gene-sets, FCM clustering algorithm significant

240 ector options, particularly when delivery of multiple gene/shRNA combinations is required.

241 Results from the analysis of multiple gene signatures, which would previously have ta

242 Combinatorial RNAi technology and concurrent multiple gene silencing are expected to provide advanced

243 dothelial cells in vivo by durably silencing multiple genes simultaneously, but efficient siRNA deliv

244 ctively used to induce targeted mutations in multiple genes simultaneously, create conditional allele

245 iautomatic imaging analysis, and it can test multiple genes simultaneously, gene-dosing effects and a

246 To target multiple genes simultaneously, we established simple one

247 visualize and compare expression profiles of multiple genes simultaneously.

248 een developed to estimate species trees from multiple genes, some which have statistical guarantees u

249 ic-5 is a versatile coregulator that acts by multiple gene-specific mechanisms that influence genomic

250 es differentially expressed), transcripts of multiple genes specifically associated with the transpor

251 he virus genome and phylogenetic analysis of multiple genes strongly suggested that this virus is a b

252 Brpf1 loss led to decreased transcription of multiple genes, such as Robo3 and Otx1, important for ne

253 l tissue and observe that in this condition, multiple genes switch their APA patterns, demonstrating

254 romising and versatile tool for knockdown of multiple gene targets and could greatly facilitate disse

255 Stable and efficient knockdown of multiple gene targets is highly desirable for dissection

256 ation of high-dimensional sequencing data of multiple gene targets.

257 on vector platform that enables knockdown of multiple gene targets.

258 overexpression, knock-down, and knock-out of multiple gene targets.

259 46-gene hotspot cancer panel assay allowing multiple gene testing from small diagnostic biopsies.

260 High-altitude adaptation may be due to multiple genes that act in concert with one another.

261 l walls, and genetic studies have identified multiple genes that affect xylan formation.

262 This network includes multiple genes that are activated by different nuclear c

263 hronically exposed skin contain mutations in multiple genes that are mutated in cutaneous squamous ce

264 Multiple genes that contribute to ExPEC fitness in mucus

265 revealed that ModM2 regulates expression of multiple genes that have potential roles in colonization

266 tic choriomeningitis virus (LCMV) identified multiple genes that regulated development of follicular

267 entiation by orchestrating the expression of multiple genes that show diversified expression profiles

268 Transcriptome analysis identified multiple genes that were deregulated by Trex2 loss after

269 Multiple genes, therefore, participate in the specificat

270 r developmental stage-specific expression of multiple genes through chromatin compaction at its targe

271 generate rat strains that carry mutations in multiple genes through direct injection of RNAs into one

272 -wide association studies (GWAS) have linked multiple genes to ARDS.

273 ocations of autosomal genome regions causing multiple genes to become partially sex-linked.

274 Overall, our data annotated multiple genes to previously reported CKD-associated sin

275 Multiple gene transfections are often required to contro

276 ong the VacA-resistant clones, we identified multiple gene trap library clones and an shRNA library c

277 this approach by deleting single (Ptch1) or multiple genes (Trp53, Pten, Nf1) in the mouse brain, re

278 Remarkably, 219 (14%) genes possessed multiple gene TSSs (gTSSs), and 84 genes exhibited tempe

279 ate gene testing or a very limited screen of multiple genes using Sanger sequencing.

280 ar fragment and by controlling expression of multiple genes via its cytoplasmic domain.

281 h PML-II contributes to the transcription of multiple genes via the association of its C-terminal dom

282 Despite the generation of scaffolds spanning multiple genes, we find no evidence of clustering of Syc

283 an NK cell developmental subsets showed that multiple genes were dysregulated by IRF8 mutation.

284 Each time, multiple genes were recruited into C4 metabolism.

285 lants involves the coordinated expression of multiple genes, which leads to nodule formation and nitr

286 y number variation (CNV) affecting a gene or multiple genes will manifest as disease.

287 embers of the Homeobox family, we identified multiple genes with ability to repress p16(INK4a).

288 identified genetic mutations, ASD stems from multiple genes with complex interactions.

289 recombineering technology to serially label multiple genes with different reporters in a single bact

290 hown that, "modular markers," that integrate multiple genes with potential interactions can improve d

291 NA microarray analysis, and found to include multiple genes with putative association to the cell env

292 on allergen sensitization, when it occurs in multiple genes with the pre-existing epigenetic alterati

293 atory modules that coordinate the control of multiple genes with the same regulatory logic.

294 However, most TFs are shared between multiple genes with varying binding affinities.

295 The simultaneous targeting of multiple genes within a pathway may enable miRNAs to mor

296 c miRNA (miR-10b), and preferentially target multiple genes within regulatory networks, suggesting 3'

297 ella enterica pathogenicity and dependent on multiple genes within Salmonella pathogenicity island 1

298 in which concomitant dosage perturbation of multiple genes within the CNV drive the microcephaly and

299 y module initiated via transient activity of multiple genes within the HoxA and HoxC clusters.

300 sms occur through concerted relationships of multiple genes working in networks that are often repres