ライフサイエンスコーパス: multiplicity

1 icant finding just by chance (the problem of multiplicity).

2 d P=0.02, respectively, after adjustment for multiplicity).

3 in terms of mass-productivity and structural multiplicity.

4 ed in PSIP1-/- Jurkat cells infected at high multiplicity.

5 volving two (or potentially more) sources of multiplicity.

6 a single clinical trial without the risk of multiplicity.

7 cited-state species as excitons with triplet multiplicity.

8 identification of the ground state and spin multiplicity.

9 ion in a mouse model of cancer reduces tumor multiplicity.

10 level of alpha = .10 with no adjustments for multiplicity.

11 pproach offers both high throughput and high multiplicity.

12 t to colitis and reduces tumor incidence and multiplicity.

13 ensurate with the rate of primordial stellar multiplicity.

14 6(-/-) mice, had a 10-fold increase in tumor multiplicity.

15 s an excited-state process with triplet spin multiplicity.

16 in the current article were not adjusted for multiplicity.

17 the distribution of nearby reads and mapping multiplicity.

18 ultimately be overcome by infection at high multiplicities.

19 edule was achieved if the lower bound of the multiplicity-adjusted confidence interval (CI) of the ty

20 Multiplicity-adjusted P values for these associations we

21 Diabetes Association, was the prespecified, multiplicity-adjusted secondary outcome.

22 All p values were one-sided and multiplicity-adjusted.

23 The Short Focus Level multiplicity adjustment can perform the full top-down ap

24 (P = 0.06 and P = 0.45, respectively, before multiplicity adjustment).

25 antage of the otherwise powerful Focus Level multiplicity adjustment.

26 : Commonly used multiplicity adjustments fail to control the error rate

27 The colons were analyzed for crypt multiplicity after 12 weeks of treatment.

28 ITAM multiplicity amplifies TCR signals, but the importance o

29 e entropy can be factored into a generalized multiplicity and a constraint term.

30 In cancer, using recurrence, multiplicity and annotation for approximately 10 000 mut

31 has implications for the evolution of origin multiplicity and associated controls, and may explain th

32 exhibited significantly decreased lung tumor multiplicity and attenuated pulmonary inflammation, whic

33 erical insights into critical issues such as multiplicity and binding.

34 We found that the incidence, multiplicity and burden of cSCC that form in Keap1(flox/

35 on of Egfr had significantly decreased tumor multiplicity and burden, protection from high-grade dysp

36 gy has provided greater understanding of the multiplicity and complexity of cellular networks involve

37 out elimination of nitrogen is determined by multiplicity and energy of the excited state, generated

38 ed significant suppression of adenocarcinoma multiplicity and incidence with no toxicity compared to

39 ic island from E. coli NC101 decreased tumor multiplicity and invasion in AOM/Il10(-/-) mice, without

40 /sclerotic or mixed), matrix mineralization, multiplicity and involvement of other sites.

41 Furthermore, tumor multiplicity and malignant progression of papillomas aft

42 The functional multiplicity and mechanistic complexity of defensins und

43 Despite this simplification, the product multiplicity and novelty overwhelmed analytical efforts

44 ific disruption of Vhl increased colon tumor multiplicity and progression from adenomas to carcinomas

45 ividual groups, with the inhibition of tumor multiplicity and reduction of vascular endothelial growt

46 sis, Fusobacterium nucleatum increases tumor multiplicity and selectively recruits tumor-infiltrating

47 PUMA deficiency significantly decreased the multiplicity and size of liver tumors.

48 Because of the differences in the multiplicity and substrate specificity of CYP2D family m

49 s result of concomitant factors, such as the multiplicity and the different concentration of the comp

50 t is difficult to determine the true initial multiplicity and the dominant binary formation mechanism

51 years with regard to whether to correct for multiplicity and, if so, how it should be done.

52 Incidence, multiplicity, and location of tumors were visually count

53 e breast cancer initiation, growth, latency, multiplicity, and lung metastasis.

54 rexpression increases tumor incidence, tumor multiplicity, and malignant progression in the chemicall

55 n existing familywise error rate controlling multiplicity approach (the Focus Level method) for gene

56 es the following different contexts in which multiplicity arises: testing for baseline differences in

57 The multiplicity associated with the nature of the neural co

58 on ovarian follicle counts and ovarian tumor multiplicity at 7.5 months of age, with Gclm(-/-) female

59 These cores have the same multiplicity but different conformations.

60 in plus DFMO suppressed colon adenocarcinoma multiplicity by 76% compared to low-dose Rosuvastatin (2

61 However, infection at high multiplicity can saturate TRIM21 and overcome neutraliza

62 atistically significant after correction for multiplicity, clear trends were observed.

63 e a twofold increase in tumour incidence and multiplicity compared to controls.

64 te regressions, with those significant after multiplicity control by the Hochberg method reported.

65 e tested simultaneously require some sort of multiplicity correction to account for the multiplicity

66 Transcriptomic subtype multiplicity correlated with increased intratumoral hete

67 ations (4.4, 2.3-8.6), but age, sex, and CCM multiplicity did not add independent prognostic informat

68 f exclusive stem cell markers, the location, multiplicity, dynamics and fate of mammary stem cells (M

69 NMR via C-H coupled and decoupled (1)H-(13)C multiplicity edited gHSQC, (1)H-(31)P HMBC, and dqfCOSY

70 f multiplicity correction to account for the multiplicity effect.

71 that E/Z photoswitching of 4TCE operates by multiplicity-exclusive pathways, enabling additional mea

72 ection in Bdellovibrio, documents protection-multiplicity for products of two different genomic loci,

73 ain-sequence multiplicity is higher than the multiplicity found in field stars, which suggests that d

74 The newfound multiplicity, functional redundancy and conservation of

75 This multiplicity has confounded efforts to simultaneously me

76 ay) significantly enhanced tumor penetrance, multiplicity, histologic dysplasia scores, and adenocarc

77 acrophages (MDM) efficiently transmit a high-multiplicity HIV-1 infection to autologous CD4(+) T cell

78 tes Apc, to have an increased polyp size and multiplicity if they also carry the Apc(mNLS) allele.

79 riation in three areas: (i) intestinal polyp multiplicity, (ii) intestinal polyp distribution, and (i

80 The functional roles of the MBD multiplicity in Cu(+) trafficking are not well understoo

81 esigned promoters, we find that binding-site multiplicity in native promoters is associated with high

82 n contrast, deletion of Akt3 increased tumor multiplicity in the carcinogen model and increased tumor

83 luded skin tumors, which displayed increased multiplicity in wild-type animals, and leukemias, which

84 ne-based activation motifs (ITAMs; high ITAM multiplicity) in the complex of the T cell antigen recep

85 of hard to soft currencies as an instance of multiplicity, including discussion of different combinat

86 s that have been proposed for correcting for multiplicity, including single-step procedures (e.g., Bo

87 deletion of Ccn1 suffer increased HCC tumor multiplicity induced by the hepatocarcinogen diethylnitr

88 sequence lineages could be explained by high multiplicity infection from a donor whose viral sequence

89 cant reductions in VACV growth following low-multiplicity infection.

90 permissive murine fibroblasts following low-multiplicity infection.

91 ve fibroblasts was partially rescued by high-multiplicity infection.

92 mplex model, with broad implications for the multiplicity inherent in signaling networks.

93 Although heterogeneity and multiplicity is a fundamental characteristic of biologic

94 nalysis to Broad and E74 and found that EcRE multiplicity is a general feature of the early genes.

95 Hemoglobin (Hb) multiplicity is common in fish, yet despite its ubiquito

96 show that protostellar and pre-main-sequence multiplicity is higher than the multiplicity found in fi

97 Here we demonstrate that ITAM multiplicity is important for the development of innate-

98 Interestingly, we observe that motif pairing multiplicity is linked to several characteristics such a

99 ivo, but the functional significance of this multiplicity is unknown.

100 Raman scattering offers high sensitivity and multiplicity, it cannot be readily used to image specifi

101 is not effective and tumor localization and multiplicity make surgery and radiosurgery challenging a

102 -type mice, but was sufficient to reduce HCC multiplicity, maximal size, and burden in GSNOR(-/-) mic

103 MDP treatment following infection at low multiplicity (MOI = 0.1 PFU/cell) inhibited HCMV in a do

104 the results indicate that in infections at a multiplicity near 1, HIV-1 reverse transcription is comp

105 GHOST-R5X4 cells, followed by infection at a multiplicity near unity with HIV-1 or an HIV-1-derived v

106 At multiplicities of genome equivalents (mge) >8,000, almos

107 oltzmann-Gibbs-Shannon entropy is related to multiplicities of independent random processes.

108 ells infected with poliovirus at low or high multiplicities of infection (MOI) and measured viral gen

109 with HRV or UV-irradiated HRV at increasing multiplicities of infection (MOI) without or with IFN-be

110 s and perfused human anterior segments using multiplicities of infection (MOIs) 25 or 50.

111 were passaged in Vero cells at high and low multiplicities of infection (MOIs) for 11 generations an

112 control neutrophils (without antibiotic) at multiplicities of infection (MOIs) of 30 and 90 bacteria

113 ood allelic discrimination and detected high multiplicities of infection in 63 P. vivax infections in

114 Infection of HPMECs with increasing multiplicities of infection of an adenovirus encoding fo

115 lated neutrophils were infected with varying multiplicities of infection of both viruses, and opsonop

116 High fungal:epithelial cell multiplicities of infection were able to rescue the cell

117 In head-to-head infections at fixed multiplicities of infection, one SA13/JFH1orig mutant te

118 g-passaged populations was reduced at higher multiplicities of infection, suggesting the presence of

119 At low multiplicities of infection, wild-type virus yields are

120 uired for efficient viral replication at low multiplicities of infection.

121 d in PML(-/-) infected at low, but not high, multiplicities of infection.

122 roduct required for viral replication at low multiplicities of infection.

123 of MDP were observed following infection at multiplicity of 1.

124 One of the conclusions is that, despite the multiplicity of acceptable models, an overall structure

125 The multiplicity of beta:gamma combinations that can partici

126 transactions, nucleic acid synthesis, and a multiplicity of biochemical reactions.

127 egory IV lesion and/or solid renal mass, and multiplicity of Bosniak III lesions were each associated

128 The multiplicity of candidate mechanisms underscores a major

129 wever, the landscape analysis also reveals a multiplicity of case definitions, levels of clinician in

130 lex system of health-care production, with a multiplicity of causes.

131 What emerges is a surprising multiplicity of CD4(+) T-cell functions that indicate a

132 ces in chromatin organization are key to the multiplicity of cell states that arise from a single gen

133 gic heterogeneity of CAVD, but also from the multiplicity of cell types that can participate in valve

134 s a complex inflammatory response in which a multiplicity of cell types, cytokines, and growth factor

135 e less curation time, are generalizable to a multiplicity of cell types, from bacteria to mammalian c

136 Here, the multiplicity of cellular infection (MOI) and population

137 However, the multiplicity of chemokines within tumours has obscured t

138 Collectively, our data demonstrate the multiplicity of clathrin functions in cortical pattern f

139 d multivariate data analysis, correction for multiplicity of comparisons with correlated data, and fi

140 btained using flow-based techniques, but the multiplicity of conventional IF is limited.

141 , a problem typically intractable due to the multiplicity of coordination environments found in many

142 The multiplicity of critical points in our model allows it t

143 Topics covered include: multiplicity of data, interpreting secondary endpoints a

144 he various size parameters obtained from the multiplicity of detectors employed shows that the string

145 different sodium channel isoforms produce a multiplicity of distinct sodium currents with different

146 s, which serve a dual role by coordinating a multiplicity of enzymes as well as anchoring the microbe

147 asing binding affinity between partners, the multiplicity of evolutionary pathways between selectivel

148 p2c gene cluster varies significantly in the multiplicity of functional genes and in the substrate sp

149 The multiplicity of gastric tumor in carcinogen-treated mice

150 The multiplicity of gene mutations derived from clonal heter

151 ction of U(VI), this tool is applicable to a multiplicity of geological epochs and terrestrial enviro

152 tal structure can be obtained because of the multiplicity of geometrical isomers present.

153 It is the culmination of a multiplicity of heterogeneous disease states and their v

154 ce (P = 0.1) if Bonferroni corrected for the multiplicity of hypotheses tested (n = 8).

155 draw process, we produce fibers containing a multiplicity of identical cylindrical cores made of the

156 But how the unique L protein carries out the multiplicity of individual steps in these two distinct p

157 ecificity likely compensates for the lack of multiplicity of individual subunits, and helps to fine t

158 is within 48 h after exposure to low titers (multiplicity of infection > 0.07) of an African lineage

159 versity (pi = 2.4 x 10(-4)), moderately high multiplicity of infection (2.7), and low linkage disequi

160 ations, along with estimates of the cellular multiplicity of infection (MOI) and MOI model selection,

161 has not been previously shown how the viral multiplicity of infection (MOI) can affect IFN induction

162 Multiplicity of infection (MOI) can be an indicator of i

163 t diversity has been defined in terms of the multiplicity of infection (MOI) derived by PCR-based gen

164 However, infection at a low multiplicity of infection (MOI) in the presence of acycl

165 ned from healthy individuals and primed at a multiplicity of infection (MOI) of 10(2) with different

166 evident only at ~72 hpi at the corresponding multiplicity of infection (MOI) of 10.

167 that viruses can be transmitted at a higher multiplicity of infection (MOI) that, in vitro, results

168 phage-adapted chlamydiae correlates with the multiplicity of infection (MOI), and optimal chlamydial

169 f blood-stage parasites affects the observed multiplicity of infection (MOI), as well as the relation

170 efficiency than the wild-type virus at a low multiplicity of infection (MOI), but it grew similarly w

171 ate in noncomplementing cells, even at a low multiplicity of infection (MOI), though a reduction in t

172 tomas, we screened 12 parvoviruses at a high multiplicity of infection (MOI).

173 seasonal influenza A (H1N1) viruses at a low multiplicity of infection (MOI; 0.0001 PFU/cell) or with

174 ng strain), or RSV (A/2001/2-20 strain) with multiplicity of infection 0.01 to 1.

175 -to-cell contact and increased together with multiplicity of infection and HCV protein levels.

176 required a threshold level of SipA linked to multiplicity of infection and may be a limiting factor c

177 on severely attenuated viral growth at a low multiplicity of infection by modestly reducing viral DNA

178 o with varicella-zoster virus (VZV) at a low multiplicity of infection does not result in a cytopathi

179 ses to better immune control if a sufficient multiplicity of infection is attained in vivo, but this

180 The multiplicity of infection is determined by the rate of n

181 ffective concentration (EC50) ranging from a multiplicity of infection of 0.01 to 0.1.

182 miRNAs was modulated 3 h postinfection (at a multiplicity of infection of 25).

183 bone marrow-derived in vitro cultures, high multiplicity of infection or the use of opsonized bacter

184 d normalized by the PreS1*-MOI, which is the multiplicity of infection that reflects the number of Pr

185 12 months and at sick visits were assessed; multiplicity of infection was evaluated by PCR that targ

186 assortants, suggesting that a uniformly high multiplicity of infection was not achieved in vivo.

187 yping demonstrated a significant decrease in multiplicity of infection within the first 2 days in bot

188 After enrollment, mixed infections (multiplicity of infection, >1) were only present in the

189 (10 ng/muL), and heat-killed whole bacteria (multiplicity of infection, 1:100) for 16 hours with or w

190 the effect of different aspects: perfusion, multiplicity of infection, and temporal patterns of infe

191 caused apoptosis of MPhis at a wide range of multiplicity of infection, but smaller inocula resulted

192 Finally, we show that at a low multiplicity of infection, either UL97 or UL21a can part

193 At a low multiplicity of infection, induction of autophagy by RNa

194 ild-type infections generally occur at a low multiplicity of infection, it is unlikely that these del

195 e of one strain (W3) in Vero cells at a high multiplicity of infection, under conditions of competiti

196 At a low multiplicity of infection, we observed only a small perc

197 F and exhibits a replication defect at a low multiplicity of infection.

198 were added to RPE and THP-1 cells with a 5:1 multiplicity of infection.

199 sages in cell culture of the virus at a high multiplicity of infection.

200 with CJ2-gD2 and wild-type HSV-2 at the same multiplicity of infection.

201 the findings of a virus yield assay at a low multiplicity of infection.

202 number detected in Huh-7.5/JFH-1 coculture (multiplicity of infection: 0.01) at an effector:target r

203 ll parasitemic individuals were assessed for multiplicity of infections by nPCR and gametocyte carria

204 These data strengthen the idea that a multiplicity of interactions is needed to assemble a hig

205 The multiplicity of markers, limited information on their in

206 Given the inherent multiplicity of MDS's, our findings offer tools to explo

207 so drives dysregulated cell growth through a multiplicity of mechanisms that include altering the act

208 Physically, it quantifies the multiplicity of metastable states in which an amorphous

209 Aging and longevity are controlled by a multiplicity of molecular and cellular signaling events

210 wever, cellular activities usually involve a multiplicity of molecules; thus, tracking the motion of

211 Using a multiplicity of morphological, biochemical, functional,

212 This multiplicity of morphologies in the crimped scaffold wor

213 Recognizing that there is a multiplicity of motives - and that the accessibility and

214 d charitable acts are over-determined, and a multiplicity of motives should be considered in explaini

215 instability is essential to account for the multiplicity of mutations often seen in malignancies.

216 s with dysplasia and neoplasia and increased multiplicity of neoplasia, relative to similarly treated

217 l to NXF family function; however, given the multiplicity of NXF/NXT complexes, the specificity and m

218 e and interdomain interactions, leading to a multiplicity of packing symmetries.

219 epends on both the inter-DNA spacing and the multiplicity of parallel DNA ligands in the self-assembl

220 unity that enables host protection against a multiplicity of pathogens and a weakness that gives rise

221 n accumulation in brain tissue may reflect a multiplicity of pathological processes.

222 ndirect action of selection on GS, through a multiplicity of phenotypes and life-history traits.

223 ion are separable and are coordinated by the multiplicity of phosphorylated ITAMs in TCR-CD3.

224 Malate is a central metabolite involved in a multiplicity of plant metabolic pathways, being associat

225 The multiplicity of pockets within the ensembles adds an ext

226 have had limited success, likely due to the multiplicity of potential sources for recolonization.

227 may be a critical predictor of the size and multiplicity of precancerous lesions.

228 hanisms and neural substrates underlying the multiplicity of processes involved in motor learning.

229 o be trapped in local conformations, and the multiplicity of protomer interfaces, makes the AXH domai

230 s comprise pore-forming alpha subunits and a multiplicity of regulatory proteins, including the cardi

231 tudy of these protein tethers has revealed a multiplicity of roles in cell physiology, including regu

232 In this study, we used a model of low multiplicity of S. pneumoniae infection with HL-1 mouse

233 The LCA classified predominantly by type and multiplicity of sensitization (food vs inhalant), allerg

234 SeqGL successfully scales to the large multiplicity of sequence signals in DNase- or ATAC-seq m

235 s frequently up-regulated in human HCCs; the multiplicity of SETDB1 activating mechanisms at the chro

236 family of scaffolding proteins coordinates a multiplicity of signaling pathways to maintain and regul

237 lecular mechanics simulations elucidates the multiplicity of signals observed in the NMR spectra of t

238 d potassium channels (BK) are regulated by a multiplicity of signals.

239 being required from several individuals, the multiplicity of sites at which donation may occur, its u

240 eased latency and about a fivefold increased multiplicity of skin cancer (invasive squamous cell carc

241 cal science that is informed and tested by a multiplicity of sociopolitical paradigms.

242 ergence to a unique fixed point, (ii) a huge multiplicity of stable fixed points, and (iii) chaotic b

243 aracterization is not trivial because of the multiplicity of states in the ensemble and rapid (micros

244 The initial multiplicity of stellar systems is highly uncertain.

245 en an E3 and its cognate E2 in governing the multiplicity of substrate ubiquitination.

246 pection because the scattered signals from a multiplicity of such elements would end up interfering w

247 We developed methods to synthesise the multiplicity of surveillance datasets in order to evalua

248 Schizophrenia is characterized by a multiplicity of symptoms arising from almost all domains

249 In view of the multiplicity of target citrullinated autoantigens descri

250 vents that led to cytokine secretion, a high multiplicity of TCR-CD3 ITAMs was required for TCR-drive

251 Here we found that whereas a low multiplicity of TCR-CD3 ITAMs was sufficient to engage c

252 utic nanocarriers, where the combination and multiplicity of the affinity moieties utilized allow mod

253 eral previous motor learning studies and the multiplicity of the neural coding underlying visually gu

254 Our findings reveal the inherent multiplicity of the process of protein misfolding and th

255 of long-chain fatty acyl-CoAs because of the multiplicity of their cellular functions.

256 GE) is a powerful approach for revealing the multiplicity of transcription start site (TSS) events ac

257 ved type 1 membrane proteins that initiate a multiplicity of transient gene transcriptions, resulting

258 technique revealed an unanticipated kinetic multiplicity of transitions: from microseconds-lasting f

259 r patient survival and accelerated onset and multiplicity of urethane-induced lung tumors in mice.

260 latency and decreased both the incidence and multiplicity of UVR-induced SCC.

261 cated by the broad range of variables (e.g., multiplicity of varieties, pedo-climatic aspects, produc

262 We show that by continuously monitoring a multiplicity of vibrational modes, the spatial moments o

263 Understanding the multiplicity of ways in which sex can alter the brain is

264 Inductive affects and the effect of CH donor multiplicity on the core proline-pi interaction also dem

265 RE (P = .03 unadjusted; P = .06 adjusted for multiplicity) or time to first-and-subsequent (multiple)

266 (P = .001), cirrhosis (P = .007), and tumor multiplicity (P = .001).

267 cantly increased tumour size (P = 0.025) and multiplicity (P = 0.025), compared with control Apc (Min

268 FN) induction cascade were generated by high-multiplicity passage in order to accumulate defective in

269 clusters peak around 500 keV/mum, while DSB multiplicities per cluster steadily increase with LET.

270 ict the effects of knob density and receptor multiplicity per knob on rolling adhesion of schizonts.

271 Here we explore the hypothesis that Hb multiplicity plays a role in hypoxia tolerance using the

272 propagation of the viral population through multiplicity reactivation under conditions of widespread

273 tal conditions, inoculation at low infection multiplicities resulted in either robust spread, or in l

274 rt a public-domain method for achieving high multiplicity single-cell IF using cyclic immunofluoresce

275 uces tumor lag time and increases incidence, multiplicity, size and progression to malignant squamous

276 ted mice exhibited a large increase in tumor multiplicity, size, and incidence compared with control

277 DSS-induced weight loss and increased tumor multiplicity, size, and invasiveness.

278 vity resulting in a dramatic change in tumor multiplicity, size, morphology and invasiveness.

279 provide the first detailed insight into the multiplicity, structure, and membrane organization of K-

280 versus D75 (30.9%; nominal P = .037, without multiplicity test adjustment).

281 In addition, the collision of end-point multiplicity (the drive to measure multiple end points)

282 uction is higher in cells infected at a high multiplicity, the production of infectious particles is

283 While still limited by conformational multiplicity, this resolution is some 4 times greater th

284 rotein-water fluctuations with quantum-state multiplicity to allow low activation barriers and robust

285 est that bacterial sRNAs may use target-site multiplicity to enhance the efficiency and stringency of

286 rough electronic manifolds of different spin multiplicity: trans-to-cis isomerization only occurs via

287 was increased 32% in Ahr null mice and tumor multiplicity was approximately increased 3-fold compared

288 rated in three isomers and the basis of this multiplicity was explored by 2D NMR spectroscopy.

289 Increased tumor multiplicity was not a consequence of CX3CL1-induced met

290 Furthermore, tumor multiplicity was reduced 92% by treatment of I3C in wild

291 mammary tumorigenesis was delayed and tumor multiplicity was reduced by genetic deletion of CX3CL1 i

292 Tumor incidence and multiplicity were dramatically smaller in the R group re

293 No adjustments for multiplicity were performed for the prespecified explora

294 Tumor latency and multiplicity were remarkably similar in both immune coho

295 uce a novel measurement called motif pairing multiplicity which is defined as the number of motifs th

296 tively predict the number of droplet layers (multiplicity), which we used to devise self-assembly rou

297 aches presupposes that we should correct for multiplicity, which is not universally accepted, and the

298 e (TPA) exhibited higher tumor incidence and multiplicity with a significant thickening of skin after

299 ral proteins in MDCK cells infected at a low multiplicity with IAV, we observe that the majority of i

300 After infection at a low multiplicity with wild-type FIX virus, neutralizing anti