ライフサイエンスコーパス: multipotential

1 al stem cell marker, retinal progenitors are multipotential.

2 Overexpression of Jmjd1a in multipotential 10T1/2 cells decreased global levels of d

3 he potential inductive activity of Pln using multipotential 10T1/2 murine embryonic fibroblast cells.

4 reatment stimulated rapid differentiation of multipotential A404 cells into SMCs that expressed multi

5 othesis that treatment of limb ischemia with multipotential adult progenitor cells (MAPCs) promotes r

6 Here we show that multipotential adult vascular mesenchymal cells self-org

7 Flow cytometry revealed that one subset of multipotential and bipotential intermediate progenitors

8 sor population in the dental pulp, which has multipotential and can regenerate a dentin/pulp-like str

9 splay hematopoietic dysregulation with fewer multipotential and erythroid-committed progenitors.

10 These data indicate that MPs are multipotential and have the capacity to develop into not

11 Although multipotential and responsive to many normal stimuli in

12 kb sox2 core enhancer selectively identified multipotential and self-renewing neural progenitor cells

13 ne marrow progenitors of myeloid, erythroid, multipotential, and megakaryocytic lineages; and the mar

14 regulated in different ways and suggest that multipotential but fate-restricted progenitors contribut

15 ce increased the numbers and cell cycling of multipotential but not other progenitors.

16 e bone marrow cells allowed the expansion of multipotential c-Kit(low)Sca-1(low/-)CD19(-) CD11b/Mac-1

17 timulation of PPARgamma1 and adipogenesis in multipotential C3H10T1/2 cells by the combination of dex

18 Thus, mesenchymal stem cells maintain their multipotential capacity after transplantation, and seem

19 n recently shown to display self-renewal and multipotential capacity, a large body of evidence suppor

20 Mesp1 directs multipotential cardiovascular cell fates, even though it

21 We show that the seeded multipotential cardiovascular progenitor cells migrate,

22 ilament formation from the repopulated human multipotential cardiovascular progenitor cells.

23 human induced pluripotent stem cell-derived multipotential cardiovascular progenitor cells.

24 rdial and myocardial lineages originate from multipotential cardiovascular progenitors.

25 These findings suggest a multipotential cell as the cell of origin of Barrett's e

26 The murine EML cell line is a multipotential cell line that can be used to model some

27 cing a postmitotic neuron and regenerating a multipotential cell.

28 The multipotential cells can be repeatedly isolated from neo

29 Migratory pathways for multipotential cells could be exploited to effect repair

30 In the vertebrate central nervous system, multipotential cells have been identified in vitro and i

31 critical roles of cell-cell interactions of multipotential cells have been shown.

32 the cell fate and cell-cell interactions of multipotential cells in a variety of tissues.

33 Defined mitogens cause the proliferation of multipotential cells in vitro, the magnitude of which is

34 To determine whether Pax5 expression in multipotential cells is sufficient to restrict developme

35 iation into astrocytes, and proliferation of multipotential cells to form spheres.

36 The ability to recruit multipotential cells to the site of injury by in vivo ad

37 Within the bone marrow stroma are multipotential cells which are capable of differentiatio

38 y embryonic stages, the neural tube contains multipotential cells whose identity becomes specified by

39 the ventral gastrula, blood progenitors are multipotential cells with rapid cell cycles; populate th

40 ons and glia have been defined in vitro, and multipotential cells with similar signaling logic can be

41 pl ligand supports the growth of stem cells, multipotential cells, and erythroid precursors.

42 inhibition occurred with Notch activation in multipotential cells, prior to the initiation of endocri

43 al pathways that determine the fate of these multipotential cells.

44 tizing or ordering choices of cell fates for multipotential cells.

45 ained large proportions of highly clonogenic multipotential cells.

46 orticoid action, inhibits erythroid (BFU-E), multipotential (CFU-GEMM), and granulocyte-macrophage (C

47 1a expression was found to contribute to the multipotential character of these progenitors.

48 Multipotential clones contributing to myeloid and lympho

49 not affect the cell cycle progression of the multipotential CNC cells during tooth morphogenesis.

50 Consequently, human fetal brain-derived multipotential CNS progenitor cells (NPCs) that can be d

51 h known pathways initiates fate decisions by multipotential CNS stem cells.

52 ise to endothelium and blood precursors with multipotential colony-forming capacity.

53 potential colony-forming cells (HPP-CFC) and multipotential (colony-forming unit granulocyte, erythro

54 These cells were CD271-, multipotential, considerably more clonogenic, and less a

55 TGFbeta/BMP signaling regulates the fate of multipotential cranial neural crest (CNC) cells during t

56 Interleukin-6 (IL-6) is a multipotential cytokine detected in the serum of patient

57 The multipotential cytokine transforming growth factor-beta

58 forming growth factor-beta1 (TGF-beta1) is a multipotential cytokine, which regulates remodeling of t

59 ly committed B lineage progenitors and their multipotential descendants.

60 ossessed self-renewal, spheroid-forming, and multipotential differentiation activities in tissue cult

61 the small cells had a greater potential for multipotential differentiation than samples enriched for

62 of human HSCs and maintains self-renewal and multipotential differentiation will allow us to better u

63 ule STRO-1, single-colony-strain generation, multipotential differentiation, cementum/periodontal-lig

64 significantly greater lineage-committed and multipotential donor progenitors in recipient spleens 1

65 nants that segregate neural crest cells from multipotential dorsal progenitors within the neural tube

66 ch directly regulates cell fate decisions in multipotential early endocrine precursor cells.

67 tic agents that have antimicrobial and other multipotential effects.

68 h prior infarction was performed to evaluate multipotential electrograms at sites where pacing entrai

69 the early stages of development of SMC from multipotential embryonic cells but did not elucidate the

70 rvival, proliferation and differentiation of multipotential ENS progenitors present in the gut of E12

71 SF MPCs are clonogenic and multipotential fibroblasts that, despite the pathologic

72 The MSC isolated from circulation exhibited multipotential for differentiation in culture, developin

73 These neural stem cells are multipotential for neurons, astrocytes, and oligodendroc

74 ed by apoptosis, exclusively neurogenic, and multipotential, generating up to five types of LRPs.

75 erve in part by targeting Schwann cells, the multipotential glial cells that synthesize multilamellar

76 ndispensable for imposing the T-cell fate on multipotential haematopoietic progenitors, but the downs

77 neage-committed cells able to be produced by multipotential hematopoietic blast colony-forming cells

78 h H4K8ac in megakaryocyte or H3K27me3 in the multipotential hematopoietic cell line HPC7.

79 an embryonic rho-globin gene expression, the multipotential hematopoietic cell line K562 was transien

80 early expression, already in evidence within multipotential hematopoietic cell lines, has made it dif

81 evel of mRNA expression in undifferentiated, multipotential hematopoietic cells (FDCP-Mix) and that d

82 The process through which multipotential hematopoietic cells commit to distinct li

83 e2 and H3K4me3 are concordant at most genes, multipotential hematopoietic cells have a subset of gene

84 PU.1-induced macrophage differentiation of a multipotential hematopoietic progenitor cell line.

85 e the levels of GATA-2 in the IL-3-dependent multipotential hematopoietic progenitor cell model FDCP

86 Expression-based studies of multipotential hematopoietic progenitor cells has shown

87 y-forming cell (HPP-CFC), which represents a multipotential hematopoietic progenitor.

88 associations during the differentiation of a multipotential hematopoietic progenitor.

89 Mast cells are derived from multipotential hematopoietic progenitors and are clonall

90 in megakaryocytes, mast cells, eosinophils, multipotential hematopoietic progenitors and Sertoli cel

91 that GATA-2 is required for the expansion of multipotential hematopoietic progenitors and the formati

92 was apparent for granulocyte-macrophage and multipotential hematopoietic progenitors, although some

93 isms are important during differentiation of multipotential hematopoietic progenitors, where they are

94 uct the generation of B cell precursors from multipotential hematopoietic progenitors.

95 ression program during lineage commitment of multipotential hematopoietic progenitors.

96 h well-described inhibitors of committed and multipotential hematopoietic progenitors.

97 yclonal repopulation and the transduction of multipotential hematopoietic repopulating cells.

98 t-AML), a neoplastic disorder arising from a multipotential hematopoietic stem cell.

99 the reliability of limit-dilution assays of multipotential hematopoietic stem cells that use stromal

100 an obligate intermediate step for transit of multipotential hematopoietic stem cells to natural kille

101 ells can support the stable proliferation of multipotential hematopoietic stem cells, thus generating

102 TLRs and their coreceptors were expressed by multipotential hematopoietic stem cells, whose cell cycl

103 ests activation of lineage-specific genes in multipotential hemopoietic cells before their unilineage

104 signals that can support the self-renewal of multipotential hemopoietic progenitor cells (MHPCs) is p

105 induced signals generate unique responses in multipotential hemopoietic progenitor cells, the signali

106 We have tested the hypothesis that multipotential hemopoietic stem and progenitor cells pri

107 Intimate interactions between multipotential hemopoietic stem cells and their microenv

108 marrow cells that had phenotypic markers of multipotential HSC.

109 -)) did not depend on p53, the percentage of multipotential HSCs and committed progenitors (Lin- Sca-

110 HSC pool, (2) stimulating the production of multipotential HSCs, (3) increasing the sensitivity of h

111 present study, we examined whether immature, multipotential human brain-derived progenitor cells (nes

112 Using this cell culture system of multipotential human brain-derived progenitor cells, we

113 Multipotential human central nervous system progenitor c

114 s the observed T21-driven hyperproduction of multipotential immature precursors precedes the bifurcat

115 Mesenchymal stem cells (MSCs) are multipotential in vitro, but their endogenous properties

116 share common mechanisms that guarantee their multipotentials in development.

117 ed tracheal epithelium demonstrated that two multipotential keratin 14-expressing cells (K14ECs) func

118 en very late sclerotome tissue fragments are multipotential, lead to the conclusion that sclerotome t

119 cycle status and for in vitro stem-cell-like multipotential long-term culture capability.

120 ily of DNA-binding proteins, is expressed in multipotential lymphoid progenitors and throughout the T

121 Multipotential lymphoid-myeloid progenitors (AA4.1+, Lin

122 Thus, transplantation of multipotential marrow cells containing the osteocalcin p

123 Multipotential mesenchymal cells (C3H10T1/2) transfected

124 During bone formation, multipotential mesenchymal cells proliferate and differe

125 cle of neonatal mice and asked whether these multipotential mesenchymal progenitors from bone marrow

126 ondrogenesis is a multistep pathway in which multipotential mesenchymal stem cells (MSC) differentiat

127 Multipotential mesenchymal stem cells (MSCs) are found i

128 he induction of PPARgamma gene expression in multipotential mesenchymal stem cells (NIH 3T3 fibroblas

129 serve as an accessible source of autogenous multipotential mesenchymal stem cells.

130 nce that QCE-6 cells are representative of a multipotential mesodermal stem cell and that they posses

131 These findings indicate that multipotential MPCs are present in adult human articular

132 been shown to have the potential to generate multipotential myelo-lymphoid hematopoietic stem/progeni

133 stinfection, revealed a striking decrease in multipotential myeloid and erythroid progenitors.

134 As a result, multipotential myeloid progenitors from the mutant fetal

135 Multipotential naive CD4(+) T cells differentiate into d

136 emonstrated by Northern blot analysis in the multipotential neoplastic K-562 cell line, the high grad

137 a direct lineal relationship exists between multipotential NEP cells and more restricted neuronal pr

138 sults we propose that differentiation of the multipotential NEP cells to terminally differentiated gl

139 Formation of pigment cells from multipotential neural crest cells involves a number of c

140 lfatides) on the regulation of PDGFRalpha in multipotential neural precursors (NPs) that are deficien

141 oligodendrocyte precursor cells to revert to multipotential neural stem cells, which can self-renew a

142 cent-activated cell sorting and can generate multipotential neurospheres.

143 cytes and biliary epithelial cells) and (ii) multipotential nonparenchymal progenitor cells (oval cel

144 tside the OB, demonstrating the existence of multipotential OB progenitors, likely at a stage before

145 This could be due to the presence of multipotential or several types of adult stem cells in d

146 r SOX9 to be required for the maintenance of multipotential pancreatic progenitor cells in the early

147 e demonstrate here that SOX9 marks a pool of multipotential pancreatic progenitors throughout the win

148 on was restored when Nkx6.1 was expressed in multipotential Pdx1(+) pancreatic progenitors, whereas n

149 We discovered that multipotential precursor cells from E13 ganglionic emine

150 death is the primary mode of death in tissue multipotential precursor cells, or "clonogens," the targ

151 nificantly greater in striatal than cortical multipotential precursor cells.

152 gammadelta T cells originate from a common, multipotential precursor population in the thymus, but t

153 haematopoietic lineages arise from a common multipotential precursor that develops within embryoid b

154 The naive CD4 T cell is a multipotential precursor with defined antigen recognitio

155 ensable for T-cell fate specification from a multipotential precursor.

156 sis, RGCs are specified from a population of multipotential precursors capable of generating RGC, ama

157 ggest that Brn3b specifies the RGC fate from multipotential precursors not only by promoting RGC diff

158 on factors can direct the differentiation of multipotential precursors through activation of expressi

159 Thus, Math1 is a key effector directing multipotential precursors to adopt secretory and not abs

160 The second transition from multipotential precursors to oligodendrocyte progenitors

161 C/EBPalpha initiates with the commitment of multipotential precursors to the myeloid lineage, is spe

162 lineage hematopoietic progenitors arise from multipotential precursors, we investigated the kinetics

163 ; third, generation of neurons and glia from multipotential precursors; fourth, apoptotic cell death;

164 were EML, which is representative of normal multipotential primitive progenitors (Sca-1(+), CD34(+),

165 The optic vesicle is a multipotential primordium of the retina, which becomes s

166 the vertebrate retina, progenitor cells are multipotential, producing a variety of distinctive cell

167 sis helps to maintain hematopoietic stem and multipotential progenitor cell (HSPC) quiescence.

168 through regulation of hematopoietic stem and multipotential progenitor cell maintenance and myelomono

169 n the bone marrow and hematopoietic stem and multipotential progenitor cell mobilization and extramed

170 lts in suppression of hematopoietic stem and multipotential progenitor cell mobilization and extramed

171 phagocytes regulates hematopoietic stem and multipotential progenitor cell mobilization from the bon

172 control the transition between expansion of multipotential progenitor cell populations and final sta

173 ion factors implicated in the maintenance of multipotential progenitor cell populations, suggesting t

174 cy reversed ApoE(-/-) hematopoietic stem and multipotential progenitor cell proliferation and expansi

175 the proliferation of hematopoietic stem and multipotential progenitor cells (HSPCs) in mice with def

176 rate of formation of short-term repopulating multipotential progenitor cells (MPPs) as well as long-t

177 the proliferation of hematopoietic stem and multipotential progenitor cells and connect expansion of

178 metabolic activity of hematopoietic stem and multipotential progenitor cells and higher Glut1 express

179 that the self-renewal and differentiation of multipotential progenitor cells can be influenced throug

180 se nominally glial progenitors might include multipotential progenitor cells capable of neurogenesis.

181 Conversely, ectopic expression of EBF in multipotential progenitor cells directed B cell generati

182 te that FOG-1 antagonizes the fate choice of multipotential progenitor cells for the mast cell lineag

183 on of granulocyte-macrophage, erythroid, and multipotential progenitor cells in both bone marrow and

184 the proliferation of hematopoietic stem and multipotential progenitor cells in the bone marrow and h

185 er sequences can predict lineage pathways of multipotential progenitor cells in the human central ner

186 o-bright and Rho-dull cells are enriched for multipotential progenitor cells or for HSC, respectively

187 lia in the absence of hematopoietic stem and multipotential progenitor cells proliferation.

188 human granulocyte-macrophage, erythroid, and multipotential progenitor cells stimulated by combinatio

189 rrow, granulocyte-macrophage, erythroid, and multipotential progenitor cells stimulated by combinatio

190 lf-renewing neural stem cells (NSCs) or from multipotential progenitor cells that cannot self-renew i

191 of Glut1 in ApoE(-/-) hematopoietic stem and multipotential progenitor cells was not because of alter

192 Haematopoietic multipotential progenitor cells, as well as bipotential

193 to normal mice significantly increased only multipotential progenitor cells, demonstrating that IL-2

194 hways in macrophages, hematopoietic stem and multipotential progenitor cells, or platelet progenitors

195 ble expansion of megakaryocyte-committed and multipotential progenitor cells, the latter displaying b

196 line, most likely from one or more types of multipotential progenitor cells.

197 to specify the B cell fate from uncommitted, multipotential progenitor cells.

198 n identified in mouse adult bone marrow as a multipotential progenitor population specified toward in

199 CD27(+)Flk-2(+)IL-7R alpha(-) subset of this multipotential progenitor population.

200 cal cell lineage is proposed that involves a multipotential progenitor that gives rise to potentially

201 (FL) have reduced numbers of lymphoid-primed multipotential progenitors (LMPP), common lymphoid proge

202 er, we unequivocally show here that HSCs and multipotential progenitors (MPPs) have higher mitochondr

203 wing hematopoietic stem cells and downstream multipotential progenitors (MPPs) that possess very limi

204 Gfi1(-/-) multipotential progenitors (MPPs) were unable to constra

205 ca or Fancc gene enhances Notch signaling in multipotential progenitors (MPPs), which is correlated w

206 In lymphopoiesis, T21 FL lymphoid-primed multipotential progenitors and early lymphoid progenitor

207 d marrow cells, with a dramatic expansion of multipotential progenitors and megakaryocytes.

208 The role of multipotential progenitors and neural stem cells in the

209 cy diminished after H-I, whereas that of two multipotential progenitors and three unique glial-restri

210 b region of anagen pelage follicles contains multipotential progenitors and whether their individual

211 l progenitors in C/EBPalpha(-/-) FL, whereas multipotential progenitors are unaffected.

212 d megakaryocytic programs are specified from multipotential progenitors by the transcription factor G

213 f fetal gut in mammalian embryos consists of multipotential progenitors capable of colonising efficie

214 st specific marker and maintenance factor of multipotential progenitors during pancreas organogenesis

215 This has led to the identification of new multipotential progenitors for the hematopoietic, neural

216 ved in the commitment and differentiation of multipotential progenitors have been well documented, li

217 es in the vertebrate retina are generated by multipotential progenitors in response to interactions b

218 t cell progenitors are derived directly from multipotential progenitors instead of, as previously pro

219 xistence of either restricted precursors, or multipotential progenitors instructed by a restricted ce

220 Differentiation of hematopoietic cells from multipotential progenitors is regulated by multiple grow

221 k or inhibition of p53 was observed in Sox2+ multipotential progenitors of the subventricular zone th

222 tive zone of the developing cerebral cortex, multipotential progenitors predominate early in developm

223 s process involves a selection among several multipotential progenitors so that ultimately only one s

224 (mapping studies) of colony development from multipotential progenitors suggested that ML triggers th

225 ssion, have dramatically fewer erythroid and multipotential progenitors than normal controls.

226 Neural crest cells are multipotential progenitors that contribute to various ce

227 ells perform diverse roles in CNS repair, as multipotential progenitors that generate both classes of

228 to induce dedifferentiation into stem and/or multipotential progenitors that populate the mucosa with

229 The rare GATA-2-/- multipotential progenitors that survive proliferate poor

230 ration of HPCs and a block in the ability of multipotential progenitors to differentiate into bipoten

231 at overexpression of Sox17 can convert adult multipotential progenitors to self-renewing HSCs that po

232 6 signals are required for the commitment of multipotential progenitors to the myeloid lineage or for

233 Effects of the combination of ML and SF on multipotential progenitors were not mediated through oth

234 Multipotential progenitors were present in G0 or early G

235 ies have shown that retinal cells arise from multipotential progenitors whose fates are regulated by

236 ressed in several hematopoietic lineages and multipotential progenitors, is required for the developm

237 f the thrombopoietin (TPO) effects on murine multipotential progenitors, we tested the effects of sol

238 roid and inducing myeloid gene expression in multipotential progenitors.

239 ammalian cardiovascular system develops from multipotential progenitors.

240 0 (IL-20) enhanced colony formation by CD34+ multipotential progenitors.

241 ences hematopoiesis, with specificity toward multipotential progenitors.

242 mixed lineage colonies normally generated by multipotential progenitors.

243 -associated cis-regulatory modules (CRMs) in multipotential progenitors.

244 olony formation, especially by erythroid and multipotential progenitors.

245 ntal pathway and commitment of NK cells from multipotential progenitors.

246 nd differentiation of specific lineages from multipotential progenitors.

247 ination of ML and SF increased the number of multipotential progenitors.

248 it participates in regulating the numbers of multipotential progenitors.

249 at least in part, from the transformation of multipotential progenitors.

250 rogenitor cells be constantly generated from multipotential progenitors.

251 response has remained ambiguous owing to the multipotential properties of this T-cell subpopulation.

252 (p2l-activated protein kinase), a ubiquitous multipotential protein kinase of 58-60 kDa, has been sho

253 horylated in vitro by the insulin-stimulated multipotential protein kinase, the maps of the beta and

254 esoderm, implicating the cell of origin as a multipotential renal progenitor.

255 he second is necessary for the generation of multipotential reserve cells in the cervix and may be op

256 the amacrine and horizontal cell fates from multipotential retinal progenitors.

257 reticulocytes was examined as substrate for multipotential S6 kinase, up to 1 mol/mol of phosphate w

258 insulin appears to be mediated primarily by multipotential S6 kinase.

259 via phosphorylation of initiation factors by multipotential S6 kinase.

260 al protein S6 and is due at least in part to multipotential S6 kinase.

261 with 80 S ribosomes phosphorylated on S6 by multipotential S6 kinase.

262 F-1 and ribosomes through phosphorylation by multipotential S6 kinase.

263 hosts, indicating efficient transduction of multipotential self-renewing HSC.

264 TNFalpha promotes multipotential signal transduction cascades, including t

265 The steps that commit multipotential somite cells to muscle differentiation ar

266 se specialized interneuronal cell types from multipotential spinal progenitors are not known.

267 f definitive progenitors blocked at an early multipotential stage.

268 Furthermore, the multipotential state is characterized by the coexpressio

269 ssion correlated with a shift of NSCs into a multipotential state or apoptosis.

270 uction requires preservation of a quiescent, multipotential stem cell pool that intermittently gives

271 enewed throughout life by proliferation of a multipotential stem cell population and terminal differe

272 he human Lin(-) UCB SP contains both CD34(+) multipotential stem cells and a novel CD7(+)CD34(-)Lin(-

273 ly located cells appears to be distinct from multipotential stem cells and myofibroblasts.

274 tual regeneration, fueled by a population of multipotential stem cells and oligopotential daughters l

275 that the adult nervous system develops from multipotential stem cells and that cells with stem-like

276 In a variety of tissues in eukaryotes, multipotential stem cells are responsible for maintainin

277 ive fashion to direct the differentiation of multipotential stem cells derived from the embryonic cen

278 During fracture healing, multipotential stem cells differentiate into specialized

279 we show that enforced expression of IL-7R on multipotential stem cells does not influence lymphoid ve

280 Here, we have reported the isolation of multipotential stem cells from hemangioma tissue that gi

281 In vertebrates, multipotential stem cells have been demonstrated in the

282 artery wall is evidence for the presence of multipotential stem cells in the vasculature.

283 e central nervous system (CNS), for example, multipotential stem cells produce various kinds of speci

284 Neural crest cells are multipotential stem cells that contribute extensively to

285 Multipotential stem cells throughout the developing cent

286 Here we identify multipotential stem cells within human colorectal adenom

287 tric body units are clonal, contain multiple multipotential stem cells, and provide definitive eviden

288 The later developing lineages arise from multipotential stem cells, but the relationship of primi

289 g whether MPIN can restore PIG-A function in multipotential stem cells, thereby providing a potential

290 ge animals is polyclonal and that individual multipotential stem or progenitor cells can contribute t

291 n of adipogenic transcription factors in the multipotential stromal cell line ST2.

292 nd functionality of rare bone marrow-derived multipotential stromal cells (BM-MSCs), including their

293 B lymphoid lineages, implicating a primitive multipotential target cell.

294 increase cardiac progenitor density within a multipotential zone.