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3 e transport but are consistent with either a multisubunit, allosteric transporter, or a transporter i
5 complex I in mitochondria are membrane-bound multisubunit assemblies of both hydrophilic and hydropho
8 gomeric integral membrane proteins, folding, multisubunit assembly, and recognition of conformational
15 w protein interaction surface that creates a multisubunit-binding site for an S-phase protein kinase
16 esolution will allow the structure of large, multisubunit biological complexes in biologically releva
19 equential rounds of linkage would generate a multisubunit chain that pulls successive subunits into a
21 r single copies of the mammalian double-ring multisubunit chaperonin TRiC/CCT in free solution using
26 for controlling cell cycle transitions, is a multisubunit complex assembled from 13 different protein
29 gether until mitosis by cohesin, a conserved multisubunit complex comprised of Smc1, Smc3, Scc1, and
30 nt-rich conditions, Atg1 is active only in a multisubunit complex comprising constitutive protein agg
32 compartments, and FANCI-D2 interacted with a multisubunit complex containing the virus-encoded single
33 its (CesAs) are the catalytic sites within a multisubunit complex for cellulose biosynthesis in plant
37 ng of ScMcm10 on dsDNA and the assembly of a multisubunit complex on ssDNA suggests that, in addition
38 functional component of Integrator (INT), a multisubunit complex required for 3'-end processing of s
45 The eukaryotic 26S proteasome is a large multisubunit complex that degrades the majority of prote
47 s process also involves the DREAM complex, a multisubunit complex that has recently been identified a
49 omoting complex/cyclosome (APC/C) is a large multisubunit complex that regulates cell cycle progressi
50 the protein-protein interactions within the multisubunit complex were measured by isothermal titrati
57 proteins forms the core structures of three multisubunit complexes as follows: cohesin, condensin, a
58 regulation, and yet it is unclear how these multisubunit complexes coordinate their activities to fa
59 an innovative method to investigate PPIs of multisubunit complexes effectively and to identify new m
61 istone acetyltransferases (HATs) function as multisubunit complexes in which accessory proteins regul
63 velopment incorporate peptides, subunits, or multisubunit complexes representing parts or all of the
66 l insights into the assembly and function of multisubunit complexes that may not be revealed by using
68 s, or remodelers, which are typically large, multisubunit complexes that use an ATPase subunit to tra
69 ATP-dependent motors that often function in multisubunit complexes to regulate chromatin structure.
70 conserved from yeast to humans, assemble in multisubunit complexes, and are needed to regulate gene
71 mTOR functions as part of either of the two multisubunit complexes, mTORC1 and mTORC2, but molecular
72 unction in leukemia occurs in the context of multisubunit complexes, which also protect the LMO2 onco
78 PHB complex participates in the assembly of multisubunit complexes; namely, respiratory complex I an
79 , and the sugar-specific membrane-associated multisubunit components enzymes IIC (EIIC) and IID (EIID
83 Understanding the diverse activities of the multisubunit core promoter recognition complex TFIID in
85 n mammals, is specifically recognized by the multisubunit CPSF (cleavage and polyadenylation specific
87 s its overall architecture is reminiscent of multisubunit cullin-RING ubiquitin ligase complexes.
88 J-NAIP2-NLRC4 inflammasome is assembled into multisubunit disk-like structures through a unidirection
91 ehensive multiple sequence alignments of the multisubunit DNA-dependent RNA polymerase (RNAP) large s
92 tch 3 is a polypeptide loop conserved in all multisubunit DNA-dependent RNA polymerases (RNAPs) that
94 on in all cellular organisms is performed by multisubunit, DNA-dependent RNA polymerases that synthes
100 advance our organizational understanding of multisubunit E3 ligases involved in endoplasmic reticulu
101 complex or cyclosome (APC/C) is a conserved, multisubunit E3 ubiquitin (Ub) ligase that is active bot
102 One such master regulator is the large, multisubunit E3 ubiquitin ligase anaphase-promoting comp
104 phase Promoting Complex/Cyclosome (APC/C), a multisubunit E3 ubiquitin ligase targeting cell-cycle fa
105 se-promoting complex or cyclosome (APC/C), a multisubunit E3 ubiquitin ligase, is regulated by phosph
108 ely 300 human cullin-RING ligases (CRLs) are multisubunit E3s in which a RING protein, either RBX1 or
109 R-Cas systems are divided into Class 1, with multisubunit effector complexes, and Class 2, with singl
112 active site (C-cluster) of the bifunctional multisubunit enzyme complex carbon monoxide dehydrogenas
113 aryotic vacuolar H(+)-ATPase (V-ATPase) is a multisubunit enzyme complex that acidifies subcellular o
115 ulation existing between two subunits of the multisubunit enzyme complex, GPI-N-acetylglucosaminyltra
116 t targeted, signal-dependent dissociation of multisubunit enzyme complexes is an important mechanism
119 proton-translocating ATPase (V-ATPase) is a multisubunit enzyme responsible for organelle acidificat
121 (NADH ubiquinone oxidoreductase) is a large multisubunit enzyme that catalyzes the first step in oxi
124 ating that some basic regulation of the PDE6 multisubunit enzyme was maintained albeit by a unknown m
126 gene expression trends was found for 65% of multisubunit enzymes and 75% of allosteric reactions.
128 n order to operate in a coordinated fashion, multisubunit enzymes use cooperative interactions intrin
134 and its binding partner, FAAP24, anchor the multisubunit FA core complex to chromatin after DNA dama
135 duced by uropathogenic Escherichia coli, are multisubunit fibres crucial in recognition of and adhesi
137 the presumptive catalytic components of the multisubunit gamma-secretase complex, which proteolyzes
140 ion of three tubulin cofactors and Arl2 as a multisubunit GTP-hydrolyzing catalytic chaperone that cy
141 tion of a DNA double-strand break (DSB) by a multisubunit helicase-nuclease machine (e.g. RecBCD, Add
144 SAGA (Spt-Ada-Gcn5) complex, a well-studied multisubunit histone modifier, regulates gene expression
146 l stress response that antagonizes mTORC1, a multisubunit host kinase that controls protein synthesis
147 iated by single-subunit T7 RNA polymerase or multisubunit human RNA polymerase II in vitro and in hum
148 iated by single-subunit T7 RNA polymerase or multisubunit human RNA polymerase II in vitro and in hum
149 tations onto a model of the structure of the multisubunit IN-viral DNA complex, we found the lethal m
150 g to eIF4G, thereby reducing assembly of the multisubunit initiation factor eIF4F, viral protein prod
154 rases METTL3 and METTL14 are components of a multisubunit m(6)A writer complex whose enzymatic activi
155 vacuolar H(+) ATPase (V-ATPase) is a complex multisubunit machine that regulates important cellular p
157 any cyanobacteria use brilliantly pigmented, multisubunit macromolecular structures known as phycobil
158 hanism involving recruitment to ERSEs of the multisubunit Mediator and several histone acetyltransfer
159 Molecular Cell provide insights into how the multisubunit Mediator coactivator complex dynamically li
162 that activate cells of the immune system are multisubunit membrane protein complexes in which ligand
163 rgy into chemical energy is catalyzed by two multisubunit membrane protein complexes, photosystem I (
167 of yeast oligosaccharyl transferase (OT), a multisubunit membrane-associated enzyme complex catalyzi
169 plex I (NADH:ubiquinone oxidoreductase) is a multisubunit, membrane-bound enzyme of the respiratory c
170 of chlorophyllide a by the nitrogenase-like multisubunit metalloenzyme, chlorophyllide a oxidoreduct
172 They are synthesized by a multistep and multisubunit mitochondrial machinery that includes the s
174 reconstitution and characterization of this multisubunit monoubiquitin E3 ligase, providing key insi
180 The transcriptional regulation of such a multisubunit, multichromosomal, and bigenomic enzyme is
183 by coexpressing large transgenes encoding a multisubunit neuronal voltage-gated sodium channel (SCN1
184 damage responses through the formation of a multisubunit nuclear complex that facilitates the E3 ubi
188 The IFT machinery is composed of motors and multisubunit particles, termed IFT-A and IFT-B, that car
191 conservation of initiation mechanisms among multisubunit Pols and reveal a key function of yeast cor
193 apsid, containing scaffolding proteins and a multisubunit portal but lacking DNA, which matures into
194 we identified a role for the proteasome, the multisubunit protease that degrades proteins in the nucl
198 densin is a large, evolutionarily conserved, multisubunit protein assembly composed of dimers of the
200 Escherichia coli RNA polymerase (RNAP) is a multisubunit protein complex containing the smallest sub
201 cle targeting and fusion require a conserved multisubunit protein complex termed the exocyst, which h
203 terations in the function of the retromer, a multisubunit protein complex that plays a specialized ro
204 Mediator, an evolutionary conserved large multisubunit protein complex with a central role in regu
205 ullin4A-RING E3 ubiquitin ligase (CRL4) is a multisubunit protein complex, comprising cullin4A (CUL4)
214 lated through the assembly onto chromatin of multisubunit protein complexes that license DNA for a fu
219 used to target the subunit interfaces of any multisubunit protein having a similar mechanism of actio
220 alpha interacts with IkappaB kinase (IKK), a multisubunit protein kinase that consists of two catalyt
223 the importance of including all subunits of multisubunit proteins to map realistic kinetically acces
224 n, and Changeux (MWC) explained allostery in multisubunit proteins with a widely applied theoretical
225 e 26S proteasome is a 2.5-MDa, ATP-dependent multisubunit proteolytic complex that processively destr
227 hemoglobins of gnathostomes and cyclostomes, multisubunit quaternary structures provide the basis for
231 protein complexes consisting of two stacked multisubunit rings, which open and close in an ATP-depen
234 a complete transcription system, including a multisubunit RNA polymerase, stage-specific transcriptio
235 xviruses are large DNA viruses that encode a multisubunit RNA polymerase, stage-specific transcriptio
245 ntified the subunits of Arabidopsis thaliana multisubunit RNA polymerases I and III (abbreviated as P
249 All eukaryotes have three essential nuclear multisubunit RNA polymerases, abbreviated as Pol I, Pol
250 ants are remarkable in having two additional multisubunit RNA polymerases, Pol IV and Pol V, which sy
254 e thought to assemble into two non-canonical multisubunit RNAPs - a virion RNAP (vRNAP) that is injec
255 rity with the largest, catalytic subunits of multisubunit RNAPs and contains the conserved metal-bind
257 action of two varphiKZ-encoded, noncanonical multisubunit RNAPs, one of which is packed within the vi
258 nalogous to the transcription factors of the multisubunit RNAPs, which provides an intriguing link be
262 oup of E3 ubiquitin ligases is formed by the multisubunit SCF complex, whose core complex (Rbx1/Cul1-
263 TCR is noncovalently coupled to a conserved multisubunit signaling apparatus, the CD3 complex, that
264 al component of the evolutionarily conserved multisubunit SIN3 complex that has roles in regulating g
267 chemical complementation assay to discover a multisubunit stem cell coactivator complex (SCC) that is
268 cterized terms identified by NeXO, including multisubunit structures related to protein trafficking o
270 erichia coli, crRNAs are incorporated into a multisubunit surveillance complex called Cascade (CRISPR
271 RNAs (crRNAs) assemble into a 405-kilodalton multisubunit surveillance complex called Cascade (CRISPR
272 ipt by the Cas6 endonuclease and loaded into multisubunit surveillance/effector complexes, allowing h
276 I (transport protein particle II) complex, a multisubunit tethering complex that is a GEF for the Rab
277 y which the exocyst, the exocytosis-specific multisubunit tethering complex, interacts with the exocy
278 ic fusion and vacuole protein-sorting (HOPS) multisubunit tethering complex, which is involved in the
280 7 shares structural similarity with cellular multisubunit tethering complexes (MTCs), which control v
282 ition of Rab GTPase on transport vesicles by multisubunit tethering complexes and subsequent coupling
283 erly localized vesicle fusion, including the multisubunit tethering complexes and the SNARE complexes
284 s between MUN domain-containing proteins and multisubunit tethering complexes such as exocyst, conser
285 uctural similarity to components of cellular multisubunit tethering complexes, which control vesicula
291 bosomes are loaded onto capped mRNAs via the multisubunit translation initiation factors eIF3 and eIF
292 Type IV secretion systems (T4SSs) are large multisubunit translocons, found in both gram-negative an
294 of cellulose synthase proteins in this large multisubunit transmembrane protein complex and the numbe
296 assembly is driven by crRNA and suggest that multisubunit type I CRISPR effectors may have evolved fr
297 phase-promoting complex/cyclosome (APC/C), a multisubunit ubiquitin E3 ligase that regulates the prog
299 ination is carried out by the Gid complex, a multisubunit ubiquitin ligase that consists of seven dif
300 s damage caused by interstrand crosslinks, a multisubunit ubiquitin ligase that monoubiquitinates two
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