ライフサイエンスコーパス: multivalent

1 We show that multivalent 6'-sialyllactose-polyamidoamine (6SL-PAMAM)

2 effective VAR2CSA-based vaccine may require multivalent activity.

3 re, we determined the host receptors for the multivalent adhesion molecule (MAM) from the gut commens

4 novel S. sonnei adhesin, SSO1327 which is a multivalent adhesion molecule (MAM) required for invasio

5 We have previously shown that multivalent adhesion molecules (MAMs) are abundant in bo

6 despread group of bacterial adhesins, termed Multivalent Adhesion Molecules (MAMs) that are essential

7 face and that the activity of already active multivalent agonists can be enhanced.

8 inding FcepsilonRI prior to cross-linking by multivalent allergen, receptor aggregation and mast cell

9 -kinase anchoring protein 220 (AKAP220) is a multivalent anchoring protein that can sequester a varie

10 We demonstrate that the multivalent and bispecific format allows the antiCD3/ant

11 ion, driven by collective interactions among multivalent and intrinsically disordered proteins, is th

12 gies exist for their further conversion into multivalent and multispecific formats optimized for the

13 y, we demonstrate a method to build up rigid multivalent and multispecific scaffolds by exploiting th

14 ments, suggesting the these interactions are multivalent and specific.

15 However, the multivalent and unstable nature of Abetao limits molecul

16 nd H5-con HA consensus genes in combination (multivalent) and compared to mice immunized with the tra

17 Although all multivalent anions result in good hydrogel formation, de

18 Yet, transport of therapeutics linked to non-multivalent anti-ICAM ligands has never been shown, sinc

19 pecific conjugation to create multispecific, multivalent antibodies of defined composition with retai

20 could be a feasible platform for generating multivalent antibodies with customizable PCKN profiles.

21 Despite the increasing number of multivalent antibodies, bispecific antibodies, fusion pr

22 cribe a conceptual and mathematical model of multivalent antibody binding to cell surface antigens.

23 BCR-triggering analyses; (ii) generalizable multivalent antigen-display platforms needed for BCR act

24 gE-FcepsilonRI complexes are cross-linked by multivalent antigen.

25 agents of the allergic response, ensues when multivalent antigens bind to and cross-link the cells' r

26 RNA silencing in plants is a multivalent antiviral defense, and viruses respond by el

27 Through application of our multivalent approach to drug discovery we previously rep

28 Our array-based discovery platform for multivalent aptamers (AD-MAP) overcomes this problem to

29 s concentration predominantly depends on its multivalent association constant, which itself exponenti

30 We envisioned that multivalent attachment of nanocarriers incorporating cer

31 that repeat expansions create templates for multivalent base-pairing, which causes purified RNA to u

32 e chemical design of materials for practical multivalent batteries.

33 igorous analysis of the increasing volume of multivalent battery research, focusing on a wide range o

34 idal nanoparticles as substrates to create a multivalent bi-specific nanobioconjugate engager (mBiNE)

35 espite the development of extremely powerful multivalent binders of the Influenza virus and other vir

36 The multivalent binding and single-molecule sensitivity allo

37 Multivalent binding interactions with the human ribosome

38 Multivalent binding keeps the substrate protein in an ex

39 equilibrium (binding affinity) and kinetic (multivalent binding kinetics) aspects of Karyopherinbeta

40 The multivalent binding mode results in proteins wrapping ar

41 ery tightly to chromatin through a concerted multivalent binding mode.

42 understanding of the fundamental aspects of multivalent binding of both artificial and natural ligan

43 Rs (FcgammaRIIa and FcgammaRIIIb) that, upon multivalent binding of IgG in immune complexes or on ops

44 tumor suppressors to DNA damage foci through multivalent binding of Lys-63-linked polyubiquitin chain

45 and interaction kinetics associated with the multivalent binding of NTF2 and karyopherinbeta1 (Kapbet

46 Our data suggest a model in which multivalent binding of trimeric HIV-1 Env proteins to MA

47 Our results suggest that multivalent binding of trimeric HIV-1 Env proteins to MA

48 Multivalent binding proteins can gain biological activit

49 been generated and studied, the mechanism of multivalent binding to cell surface targets is not well

50 Our goal was to explore whether non-multivalent binding to ICAM-1 could drive endocytosis an

51 ling for the first time an importance of the multivalent binding to PG saccharides.

52 Although multivalent binding to surfaces is an important tool in

53 rions exhibit lateral mobility, although the multivalent binding to the immobilized GAG brushes ensur

54 o target antigens have a strong influence on multivalent binding.

55 These multivalent bonding motifs enable the change of "bond st

56 mposed of repeating structural elements with multivalent carbohydrate-binding function, called ThreeF

57 can affected vesicle aggregation mediated by multivalent carbohydrate-protein interactions.

58 iterature, we provide suggestions for future multivalent cathode studies, including a strong emphasis

59 and challenges of each class of materials as multivalent cathodes.

60 ccumulation processes distinct from those of multivalent cation compounds CeO2 (Ce(3+) and Ce(4+)) an

61 tropical soils is strongly interlinked with multivalent cation interaction and mineral association.

62 ies of MOF membranes and particles, based on multivalent cation substitution.

63 s presented here indicate that the effect of multivalent cations and of spermidine, in particular, on

64 Recombinant NCPs aggregated by multivalent cations form various ordered phases that can

65 ll leachate, indicating that the presence of multivalent cations in leachate could have a negative ef

66 Multivalent cations such as spermidine and magnesium ind

67 Upon addition of multivalent cations, most RNAs are found to be compacted

68 ng-flocculation can occur in the presence of multivalent cations.

69 noids to quantitatively study the potency of multivalent cholera toxin inhibitors.

70 Thus, PWWP2A is a novel H2A.Z-specific multivalent chromatin binder providing a surprising link

71 The multivalent chromatin regulator BRPF1 (bromodomain- and

72 se results identify an essential role of the multivalent chromatin regulator BRPF1 in definitive hema

73 PHD finger-containing protein 1 (BRPF1) is a multivalent chromatin regulator possessing three histone

74 PHD finger-containing protein 1 (BRPF1) is a multivalent chromatin regulator that possesses 4 nucleos

75 re mixed with Nup153 in vitro, higher-order, multivalent complexes form.

76 extent by a corresponding increase in EM in multivalent complexes.

77 alency demonstrate that interactions between multivalent components (TOG and RNA) are modulated by a

78 ve conditions, was displayed in 35 different multivalent configurations, and binding to A2A was deter

79 Here, we report the characterization of a multivalent conjugate presenting two bioactive ethistero

80 The availability of an affordable, multivalent conjugate vaccine may be important in future

81 astly different polymer conformations of the multivalent conjugates.

82 Conversely, the multivalent consensus vaccine (1 x 10(10) virus particle

83 These multivalent constructs, which we termed nanopeptamers, w

84 on of PTs upon AuNP conjugation derives from multivalent contact between the nanoconjugates and metas

85 nd that the BRD and an adjacent AT-hook make multivalent contacts with DNA, leading to robust affinit

86 s) to design small proteins that fold around multivalent cross-linkers.

87 structure can be defined by incorporating a multivalent cross-linking agent, and this approach has b

88 eate a functional scaffold for the design of multivalent disease-targeted complexes.

89 d over the monomeric apo-protein through its multivalent display of ClpX recognition tags.

90 d platform, called nanoallergens that enable multivalent display of potential allergy epitopes for de

91 d to increase apoptotic peptide activity via multivalent display.

92 or, and its impact is only noticeable if the multivalent dissociation constant is far below the virus

93 the efficacy of combinational treatments of multivalent DLL-1 with oncoprotein targeting drugs in pr

94 l mechanistic support for the development of multivalent DLL1 to stimulate antitumor immunity.

95 matin fiber interacting with an ensemble of (multivalent) DNA-binding proteins able to switch between

96 s employed for the synthesis of a Janus-type multivalent donor-acceptor system.

97 ess of ionic cross-linking of peptides using multivalent drugs to create hydrogels for sustained long

98 The structures can also produce strong multivalent effects, where the nanomaterial scaffold gre

99 inding affinity than is observed by standard multivalent effects.

100 with multiple TLR9 like a zipper, leading to multivalent electrostatic interactions that drastically

101 ins associate with membranes through similar multivalent electrostatic interactions, without specific

102 PLEKHM1 is thus a multivalent endocytic adaptor involved in the lysosome f

103 The multivalent engagement with DNA and HP1 results in a nuc

104 represents a promising strategy for creating multivalent enzyme inhibitors for selectively imaging ex

105 In summary, we describe features of the multivalent ETV4- and AP1-MED25 interactions, thereby im

106 ctional interactions with the ubiquitous and multivalent factors Ctcf and cohesin.

107 f which are located at sites occupied by the multivalent factors Ctcf and cohesin.

108 that trans-presenting IL-15:IL-15Ralpha in a multivalent fashion on the surface of antigen-encapsulat

109 demonstrate that PHF13 binds chromatin in a multivalent fashion via direct interactions with H3K4me2

110 Based on multivalent fluorescence amplification of the nascent po

111 its oligomerization domains, rendering SPOP multivalent for its substrates.

112 r presenting receptor-binding biologics in a multivalent format that facilitates receptor clustering

113 tic of the Ph1 gene mutants, including HECP, multivalent formation, and disrupted chromosome alignmen

114 reversed by treating tumor-bearing mice with multivalent forms of the Notch receptor ligand DLL-1, bu

115 rently available to study how monovalent and multivalent GAG.protein bonds respond to directed mechan

116 After vaccination with a multivalent GI.1 and GII.4c norovirus virus-like particl

117 Many multivalent glycoconjugates have therefore been synthesi

118 Here we employed the use of multivalent glycopolymers to enable the first proteome-w

119 controls the formation of tyrosine-dependent multivalent hnRNP assemblies that, in turn, function to

120 Multivalent host-guest interactions between beta-cyclode

121 e use of superparamagnetic nanoparticles and multivalent host-guest interactions has a promising pote

122 type 1 is unique and important for designing multivalent hosts capable of effectively sequestering ta

123 Therefore, non-multivalent ICAM-1 targeting also provides transport of

124 ated a 1:2 antibody:enzyme conjugate for non-multivalent ICAM-1 targeting.

125 Localization of multivalent IL-15:IL-15Ralpha and encapsulated antigen t

126 controlled size that were used to synthesize multivalent iminosugars.

127 ysiological high-affinity conditions using a multivalent immunogen, rare VRC01-class B cells successf

128 Together, our study provides an arsenal of multivalent immunogens for HIV-1 vaccine development.

129 Annual review of multivalent influenza vaccines targets strains of influe

130 cal systems makes the design of an efficient multivalent inhibitor a toilsome task.

131 pendent on the nature and properties of both multivalent inhibitors and pathogens, such as viruses an

132 with different cores or carrier scaffolds of multivalent inhibitors are concisely discussed with sele

133 ved design of GM1 mimics, either alone or as multivalent inhibitors connecting multiple GM1-binding s

134 targeting multiple adjacent sites to create multivalent inhibitors may be effective for some protein

135 -particle cryo-electron microscopy reveals a multivalent intasome-nucleosome interface involving both

136 rter-staggered collagen fibril, suggesting a multivalent interaction between fibromodulin and several

137 Our findings support a multivalent interaction mechanism, by which an activatin

138 s relatively modest affinity for F-actin but multivalent interactions allow a marked increase in bind

139 r to be phase-separated liquids organized by multivalent interactions among proteins and RNA molecule

140 continuous open space to bind DNA chains via multivalent interactions and protect the gene molecules

141 hat are highly infectious toward host cells, multivalent interactions are formed taking advantage of

142 Interfacial multivalent interactions at pathogen-cell interfaces can

143 r importance for material and life sciences, multivalent interactions between polymers and surfaces r

144 output signal can be regulated by tuning the multivalent interactions between the complex and the NP.

145 e Influenza A virus onto host cells involves multivalent interactions between virus surface hemagglut

146 Finally, it is shown that multivalent interactions drive the self-selection of a h

147 s mechanistic insight into the regulation of multivalent interactions in biology.

148 by phase separations caused by low-affinity, multivalent interactions involving proteins and nucleic

149 ing QDs have been successfully used to probe multivalent interactions of HIV/Ebola receptors DC-SIGN

150 Analysis of multiple equilibria showed that multivalent interactions of Kapbeta1 with the disordered

151 Selective multivalent interactions of the CPs with mammalian cell

152 -cell maps indicate that NL contacts involve multivalent interactions over hundreds of kilobases.

153 machinery consists of lower affinity, highly multivalent interactions that are metastable, but easily

154 nt here a structural model for how Set8 uses multivalent interactions to bind and methylate the nucle

155 We report on exploring multivalent interactions to CNC surface and show that de

156 define the chemical determinants controlling multivalent interactions we designed glycopeptide HMTG m

157 leolus via a multi-modal mechanism involving multivalent interactions with proteins containing argini

158 In multivalent interactions, such weak linear motifs can co

159 ellular bodies assembled through heterotypic multivalent interactions.

160 tion to silica nanoparticles via dynamic and multivalent interactions.

161 tant hubs in signaling networks, scaffolding multivalent interactions.

162 aling complex is assembled and functions via multivalent interactions.

163 precise molecular assemblies to investigate multivalent interactions.

164 cription due to complexities associated with multivalent interactions.

165 carbohydrate binding sites, thus diminishing multivalent interactions.

166 ough a signal transduction pathway involving multivalent interactions.

167 The rapidly expanding field of nonaqueous multivalent intercalation batteries offers a promising w

168 ring beyond the traditional understanding of multivalent ion dependent DNAzyme catalysis.

169 tion cathode materials and the mechanisms of multivalent ion insertion and migration within those fra

170 The membrane exhibited excellent multivalent ion rejection (e.g., 86.3% for Ca(2+), 98.0%

171 variety of effective intercalation hosts for multivalent-ion batteries.Magnesium rechargeable batteri

172 ients for two of the most prevalent cases of multivalent ions (zi = 2, zj = 1 and zi = 1, zj = 2) was

173 e stream and a retentate stream in which the multivalent ions accumulate, offering opportunities for

174 ations that show a preferential insertion of multivalent ions into titanium vacancies, allowing a muc

175 or sodium ions, the reversible insertion of multivalent ions such as Mg(2+) and Al(3+) into electrod

176 tractive for the ultrasensitive detection of multivalent ions with environmental and biomedical impor

177 Thus, while multivalent KLA polymers are more potent than KLA peptid

178 ides, known binding partners for a family of multivalent lectins called galectins.

179 les (NPs) whose surface is functionalized by multivalent ligand molecules that specifically bind to t

180 omerization of FtsZ converting the CCTP to a multivalent ligand that binds multiple ZipAs bound to a

181 molecules could be transformed into potent, multivalent ligands by a reaction that is catalyzed by b

182 Together, our data demonstrate that several multivalent ligands for ApoER2 induce clustering in tran

183 Conjugates of these multivalent ligands with auristatin and saporin toxins a

184 unctionalized scaffolds for the synthesis of multivalent ligands.

185 a separate mode of signaling that relied on multivalent ligation of BCR sialyl-oligosaccharide.

186 (proline-rich motif) interactions involving multivalent linker proteins play central roles in concen

187 Finally, we evaluated all multivalent M2pep and M2pepKLA analogs using a syngeneic

188 absorbance measurements of the experimental multivalent malaria system.

189 ogy for quantitatively characterizing large, multivalent membrane proteins.

190 We have thus successfully developed a novel multivalent METH-binding nanomedicine by conjugating mul

191 neutralizing antibodies (NAbs) is to utilize multivalent mixtures of HIV-1 envelope (Env) immunogens.

192 tic model, we propose that dockerins utilize multivalent modes of cohesin recognition to recruit cell

193 models developed for the related problem of multivalent molecular binding.

194 asured binding interactions among three core multivalent molecular components necessary for such asse

195 at granule assembly is tightly controlled by multivalent molecular interactions among RNA molecules,

196 Modeling multivalent molecular interactions in granules is challe

197 Here we report a new multivalent molecular motif, the polyethylenimine-perphe

198 5pM (0.82ng/mL) for the detection of a model multivalent molecule, biotinylated anti-streptavidin, in

199 Collective interactions of multivalent molecules mediated by modular binding domain

200 ve attenuated bacteria hold great promise as multivalent mucosal vaccines against a variety of pathog

201 ngle binding site) Pproxy and monovalent and multivalent (multiple equivalent and independent binding

202 The structure-based design of multivalent nanomaterials, involving modulation of nanos

203 Our results demonstrate that multivalent nanoparticles based on the T6SS sheath repre

204 Competitive binding inhibitors based on multivalent nanoparticles have shown great potential for

205 Dendrimers are branched, multivalent nanoparticles with a well-defined structure

206 The resulting multivalent nanotoxoids are capable of delivering virule

207 Therefore, considering the multivalent nature of the MAG-IgM interaction, polylysin

208 The multivalent nature of the SynGAP/PSD-95 complex is criti

209 This initial attachment is of a multivalent nature, i.e., it requires the establishment

210 rin is imparted by the avidity gained from a multivalent network of context-specific individually wea

211 ate that the GII.2-protective component of a multivalent norovirus vaccine may not require frequent r

212 ential cross-strain protection provided by a multivalent NoV virus-like particle (VLP) candidate vacc

213 a from ten human volunteers immunized with a multivalent NoV VLP vaccine (genotypes GI.1/GII.4) were

214 the potential feasibility of an efficacious multivalent NoV VLP vaccine for future use in human popu

215 Vaccination with a multivalent NoV VLP vaccine induces a broadly blocking A

216 The assembly of E4-ORF3 into a multivalent nuclear matrix is required to target PIAS3.

217 ioconjugation technology it is expected that multivalent O antigen conjugate vaccines can be produced

218 Multivalent oligonucleotide-based bonding elements have

219 between thiol-terminated tetravalent PEG and multivalent ONDs yielded self-supporting hydrogels withi

220 l molecular complexes and interactions among multivalent or multistate molecules.

221 c strain associated with the binding of one (multivalent) or two (monovalent) target molecules to the

222 different generations and oppositely charged multivalent organic dyes relying on the combination of e

223 wth approach, which can be extended to other multivalent oxide systems.

224 sheath was exploited to generate immunogenic multivalent particles for vaccine delivery.

225 Multivalent peptide materials were prepared with comb-li

226 Binding of multivalent peptide-MHC to the TCR stabilizes the active

227 The conjugate, named Multivalent Peptoid Conjugate 6 (MPC6), suppressed the p

228 The new multivalent-permeable Fuji T1 is able to transport dival

229 re, we quantitatively analyze the effects of multivalent phosphorylation of LAT by reconstituting the

230 s molecular switches in highly demanding and multivalent photoresponsive systems.

231 granule protein FUS (fused in sarcoma) to a multivalent poly-Src homology 3 (SH3) domain protein tha

232 mbinatorial strategy for the optimization of multivalent polyamine scaffolds as DNA/RNA ligands.

233 peptide as the model system, here we report multivalent polymer-peptide conjugates (mPPCs) that disa

234 upramolecular polymerization, here we report multivalent polymer-peptide conjugates (mPPCs) that redi

235 ombination of experiments and simulations on multivalent polymers, that such "superselective" binding

236 uilding blocks via linker sequences into one multivalent polypeptide chain is an elegant alternative

237 re-as biocompatible carbon platforms for the multivalent presentation of carbohydrates.

238 The multivalent presentation of specific carbohydrates by us

239 be transformed into potent agonists through multivalent presentation on a micelle surface and that t

240 those elicited by the ST-5 CPS component in multivalent Prevnar13.

241 nding can be tuned through the design of the multivalent probe, to target a desired density of bindin

242 It was recently demonstrated that multivalent probes can selectively target surfaces with

243 ens up a route toward the rational design of multivalent probes with defined superselective targeting

244 hindrance and no crosslinking compared with multivalent probes.

245 has led to development of three FDA-approved multivalent prophylactic HPV vaccines composed of virus-

246 for probing structure and thermodynamics of multivalent protein-ligand interactions.

247 nucleoprotein (RNP) granules and concentrate multivalent proteins and mRNA.

248 led cellular bodies using several engineered multivalent proteins and RNA.

249 In gelation driven by phase separation multivalent proteins and their ligands condense into den

250 Phase transitions of linear multivalent proteins control the reversible formation of

251 luorescence detection of both monovalent and multivalent proteins has been developed.

252 rmine the extent to which gelation of linear multivalent proteins is driven by phase separation.

253 ta indicate that granule formation driven by multivalent proteins modulates tau isoform expression an

254 Binding kinetics of the multivalent proteins peanut agglutinin (PnA) and cholera

255 sequences that direct enzyme encapsulation, multivalent proteins that organize the lumen enzymes, th

256 es for self-assembly and phase separation of multivalent proteins.

257 ered linkers influences phase transitions of multivalent proteins.

258 nism in which sequential binding events on a multivalent receptor are coupled such that the first enh

259 TatB and TatC form an oligomeric, multivalent receptor complex that binds Tat substrates,

260 etic nanoparticles with prey proteins allows multivalent receptor interactions with sensor-immobilize

261 l surfaces or artificial surfaces displaying multivalent recognition motifs-within a layer of polymer

262 p a fitting-free, minimal model: bivalent or multivalent red and green 'transcription factors' bind t

263 pproach to improve molecular buffering using multivalent ring-chain systems.

264 the components, timing, and kinetics of the multivalent role of ubiquitin signals in control of ampl

265 a promising strategy for the development of multivalent Salmonella vaccines.

266 ion presents simple cationic self-assembling multivalent (SAMul) first generation dendrons based on L

267 We then investigated a "multivalent scaffolding" approach by displaying 24 copie

268 interfaces can be competitively inhibited by multivalent scaffolds that prevent pathogen adhesion to

269 sponges is mediated by the calcium-dependent multivalent self-interactions of sulfated polysaccharide

270 y central roles in establishment of a robust multivalent SH3 domain-PRM network in vivo, giving actin

271 of chromatin marks at pluripotency loci, and multivalent states (comprising previously undetermined c

272 support the use of Wolbachia biocontrol as a multivalent strategy against Ae. aegypti-transmitted vir

273 In the next section, multivalent structures such as glycoclusters and glycode

274 This review is focused on smaller multivalent structures such as glycoclusters emphasizing

275 ding to and lower enzymatic activity against multivalent substrates, resulting from mutation of the 2

276 t discoveries point to an important role for multivalent SUMO binding through multiple SIMs in the bi

277 other types of protein are recruited through multivalent SUMO interactions.

278 Aided by a delivery technology capable of multivalent surface display, which can be adapted easily

279 ugar units was used as a template to prepare multivalent systems displaying a protected d-mannose der

280 Weak motifs may generally be employed in multivalent systems to act as gatekeepers regulating pos

281 heng-Prusoff equation for its application to multivalent systems.

282 a rotating magnetic field and stabilized by multivalent target molecules.

283 a homogeneous biosensor for the detection of multivalent targets by combination of magnetic nanoparti

284 ns are reciprocal: relaxed Fn fibrils act as multivalent templates for collagen assembly, but once as

285 In combination, our data demonstrate that a multivalent tethering complex uses its two Rab bindings

286 e A antitoxins, including those contained in multivalent therapeutic antitoxin products that are the

287 of the plant-derived recombinant enzyme as a multivalent therapeutic.

288 a binding that we simulate to be strong and multivalent to the VAL repeating units, generating force

289 ral and functional properties for a range of multivalent transition metal oxides.

290 f competition in a ring-chain equilibrium of multivalent ureidopyrimidinone monomers and a monovalent

291 easibility of producing a safe, efficacious, multivalent vaccine against the encephalitic alphaviruse

292 We developed a multivalent vaccine construct based on VD4s and their su

293 hallenges, demonstrating the potential for a multivalent vaccine formulation.

294 and a foundation for design of an effective multivalent vaccine.

295 The development of multivalent vaccines is an attractive methodology for th

296 be of less concern with the introduction of multivalent vaccines that include most of the carcinogen

297 lusters, raising new opportunities to design multivalent vaccines with broad coverage.

298 Integrating a multivalent VD4 construct into the sequence of the major

299 provides a rationale for the development of multivalent VHHs that target both toxins and are broadly

300 This highlights the complexity of multivalent virus-GAG interactions and suggests that the