ライフサイエンスコーパス: mumps virus

1 al myocarditis, in particular of that due to mumps virus.

2 measuring serological responses to wild-type mumps virus.

3 d have reduced efficacy against heterologous mumps viruses.

4 copy of the genome of a Jeryl Lynn strain of mumps virus (15,384 nucleotides) was assembled from cDNA

5 proteins of Nipah virus, measles virus, and mumps virus also abolishes MDA5 interaction.

6 We demonstrate that mumps virus also eliminates cellular STAT3, a protein th

7 Like MV, mumps virus and dsRNA failed to induce I kappa B alpha d

8 nist activity exhibited by the V proteins of mumps virus and human parainfluenza virus type 2.

9 mber of cellular genes compared to wild-type mumps virus and increases cell death in infected cells,

10 metric mean titers of antibody to measles or mumps viruses and low seroconversion rates.

11 to affect attenuation were detected in OPV, mumps virus, and varicella-zoster virus.

12 Wild type mumps viruses are highly neurotropic and a frequent caus

13 also infected with a related paramyxovirus, mumps virus, as a specificity control.

14 Mumps virus-associated CNS complications in vaccinees co

15 luate the antigenic relationship between bat mumps virus (BMV) and the JL5 vaccine strain of mumps vi

16 l culture, or by detection of the RNA of the mumps virus by reverse transcription (RT)-PCR.

17 A recombinant mumps virus carrying the E95D mutation in its P and V pr

18 er paramyxoviruses in the genus Rubulavirus, mumps virus catalyzes the proteasomal degradation of cel

19 nesis of the disease, with enteroviruses and mumps virus considered potential causes.

20 associated with the presence of antibody to mumps virus, data from the 1999-2004 National Health and

21 e-adjusted seroprevalence of IgG antibody to mumps virus during 1999-2004 was 90.0% (95% CI, 88.8%-91

22 Mumps virus, enteroviruses (including human parechovirus

23 of the L protein, did not prevent rescue of mumps virus, even though an amino acid alignment for the

24 pressing the canine distemper virus (CDV) or mumps virus F protein.

25 on of three animal models with an isolate of mumps virus from a recent outbreak (MuV-IA).

26 me cDNA was demonstrated by amplification of mumps virus from transfected-cell cultures and by subseq

27 Vaccination against mumps virus has been effective in reducing mumps cases.

28 , parainfluenza virus type 5, measles virus, mumps virus, Hendra virus, and Nipah virus.

29 ramyxovirus pathogens include measles virus, mumps virus, human respiratory syncytial virus, and the

30 Anti-mumps virus immunoglobulin M (IgM) antibodies were detec

31 n of immunoglobulin M-specific antibodies to mumps virus in acute-phase serum samples, the isolation

32 no evidence of resistance to infection with mumps virus in any cell line.

33 acute-phase serum samples, the isolation of mumps virus in cell culture, or by detection of the RNA

34 developed to allow rapid characterization of mumps virus in clinical samples.

35 primers, indicating that the persistence of mumps virus in the myocardium may be related to the sele

36 tly assesses the neurovirulence potential of mumps viruses in humans and is robust and reproducible.

37 indered analysis of the neuropathogenesis of mumps virus infection and the identification of molecula

38 al fibroelastosis associated with persistent mumps virus infection by vaccination supports the notion

39 r neuropathological and clinical outcomes of mumps virus infection of the neonatal rat brain demonstr

40 his report we show, for the first time, that mumps virus infection of the neonatal rat leads to devel

41 Mumps virus is a common infectious agent of humans, caus

42 The mumps virus is a negative-strand RNA virus in the family

43 Mumps virus is highly neurotropic and, prior to widespre

44 pinal fluid (CSF) samples and in extracts of mumps virus isolates from patients with various clinical

45 Furthermore, we generated recombinant mumps viruses lacking expression of both the V protein a

46 hown that clinical isolate-based recombinant mumps viruses lacking expression of either the V protein

47 Mumps virus, like other paramyxoviruses in the Rubulavir

48 uently, PIV5 NP protein is incompatible with mumps virus M protein.

49 myxoviruses parainfluenza virus 5 (PIV5) and mumps virus, M-NP interaction also contributes to effici

50 virus, Nipah virus, varicella-zoster virus, mumps virus, measles virus, lyssavirus, herpes simplex v

51 However, results with several mumps virus MNVTs have raised questions as to whether th

52 ic and neurovirulent properties of wild-type mumps viruses, most national regulatory organizations re

53 Here we demonstrate that mumps virus (MuV) and vesicular stomatitis virus (VSV) a

54 Here we report that while PIV2, PIV5, and mumps virus (MuV) are sensitive to IFIT1, nonrubulavirus

55 Mumps virus (MuV) causes an acute infection in humans ch

56 The mumps virus (MuV) genome encodes a phosphoprotein (P) th

57 otype F has been the predominant genotype of mumps virus (MuV) in the last 20 years in mainland China

58 Mumps virus (MuV) infection may cause serious diseases i

59 Mumps virus (MuV) is a highly contagious pathogen, and d

60 Mumps virus (MuV) is a reemerging paramyxovirus that cau

61 Mumps virus (MuV) is highly neurotropic and was the lead

62 We systematically mapped the domains in mumps virus (MuV) P and investigated their interactions

63 iral proteins play in the phosphorylation of mumps virus (MuV) P.

64 To define mumps virus (MuV) proteins important for this process, v

65 To investigate the role of the mumps virus (MuV) SH protein in virulence, multiple stop

66 Three hundred nine mumps virus (MuV) strains detected in the United Kingdom

67 with high phylogenetic relatedness to human mumps virus (MuV) was identified recently at the nucleic

68 Mumps virus (MuV), a paramyxovirus containing a negative

69 The nucleocapsid protein (NP) of mumps virus (MuV), a paramyxovirus, was coexpressed with

70 Mumps virus (MuV), a rubulavirus of the paramyxovirus fa

71 luenza virus 3 (HPIV3), measles virus (MeV), mumps virus (MuV), and respiratory syncytial virus (RSV)

72 esults were obtained for the closely related mumps virus (MuV), except that MuV particles derived fro

73 RNA-mediated signaling; these are encoded by mumps virus (MuV), human parainfluenza virus 2 (hPIV2),

74 to detect the small hydrophobic (SH) gene of mumps virus (MuV).

75 breaks and to understand the pathogenesis of mumps virus (MuV).

76 ps virus (BMV) and the JL5 vaccine strain of mumps virus (MuVJL5), we rescued a chimeric virus bearin

77 For mumps virus N, a binding site for the P protein maps to

78 For both measles and mumps virus N, truncated proteins encompassing amino aci

79 Nonetheless, the genetic basis of mumps virus neurotropism and neurovirulence was until re

80 effective safety test with which to measure mumps virus neurovirulence has also hindered analysis of

81 the United States, to test a novel rat-based mumps virus neurovirulence safety test.

82 value in elucidating the molecular basis of mumps virus neurovirulence.

83 Mumps virus-neutralizing antibodies are believed to be t

84 oteins of the paramyxoviruses measles virus, mumps virus, Newcastle disease virus, human parainfluenz

85 shown systemic efficacy: vaccinia, measles, mumps, viruses, Newcastle disease virus, and reovirus.

86 that interactions between this region of the mumps virus NP and its polymerase leads to exposure of t

87 Mumps virus NP protein harbors DWD in place of the DLD s

88 together with support plasmids which express mumps virus NP, P, and L proteins under control of the T

89 The structure of an empty mumps virus nucleocapsid-like particle is determined to

90 samples were seropositive for measles virus, mumps virus, or rubella virus antibodies, and there were

91 ast 50 amino acids of both measles virus and mumps virus P (measles virus P, 457 to 507; mumps virus

92 mumps virus P (measles virus P, 457 to 507; mumps virus P, 343 to 391) by themselves constitute the

93 a lesser degree of tertiary organization in mumps virus P.

94 ative responses to measles virus (P=.01) and mumps virus (P=.006).

95 important viruses, including measles virus, mumps virus, parainfluenza viruses, respiratory syncytia

96 esent the best animal model for the study of mumps virus pathogenesis.

97 STAT3 are independently targeted by a single mumps virus protein, called V, that assembles STAT-direc

98 mon respiratory viruses (HPIV-2, -3, and -4, mumps virus, respiratory syncytial virus, and influenza

99 scribe the generation of a novel recombinant mumps virus (rMuV) expressing HIV-1 Gag (rMuVgag) and me

100 The duration of mumps virus RNA detection was studied during a mumps out

101 Mumps virus RNA was characterized directly from cerebros

102 predict genes for 12 viruses: measles virus, mumps virus, rubella virus, respiratory syncytial virus,

103 ype 6, varicellazoster virus, measles virus, mumps virus, rubella virus, the picornavirus group, infl

104 ble EIA kits were used to evaluate wild-type mumps virus serological responses in human serum samples

105 of sequence relationships, with examples for mumps virus SH gene cDNA and prion protein sequences.

106 Moreover, since mumps virus-specific antibody titers are generally low i

107 A mumps virus-specific enzyme immunoassay was used to meas

108 A*26-Cw*12-B*38 was associated with both mumps virus-specific humoral (P=.007) and cell-mediated

109 The study also allowed characterization of mumps virus strains from Argentina as part of a new subg

110 accine viruses, raising concern that certain mumps virus strains may escape vaccine-induced immunity.

111 Here, various mumps virus strains representing a wide range of neuropa

112 Neurovirulence of several mumps virus strains was assessed in a prototype rat neur

113 and highly neurovirulent (88-1961 wild type) mumps virus strains were passaged in human neural cells

114 riminate neurovirulent from nonneurovirulent mumps virus strains.

115 (Kilham) from nonneurovirulent (Jeryl Lynn) mumps virus strains.

116 efully selected group of genetically diverse mumps virus strains.

117 te among the relative neurovirulent risks of mumps virus strains.

118 man parainfluenza virus 2 targets STAT2, and mumps virus targets both STAT1 and STAT3.

119 ue cytokine and oncogene evasion property of mumps virus that provides a molecular basis for its obse

120 To test whether attenuated mumps viruses used in the manufacture of mumps vaccines

121 interferon-activated STAT1 or STAT2 protein, mumps virus V protein is unique in its ability to also t

122 Consequently, mumps virus V protein prevents responses to interleukin-

123 that a single amino acid substitution in the mumps virus V protein, E95D, results in defective STAT3

124 stigate genetic variation in live attenuated mumps virus vaccine by using both MAPREC and a platform

125 t can reliably predict the neurovirulence of mumps virus vaccine candidates in humans.

126 ples to neutralize the genotype A Jeryl Lynn mumps virus vaccine strain and a genotype G wild-type vi

127 potentially neurovirulent, live, attenuated mumps virus vaccines stems largely from the lack of an a

128 bserved in monkeys inoculated with wild type mumps virus versus vaccine strains, although differences

129 In contrast, mumps virus was not inhibited by the expression of flavi

130 adoption of widespread vaccination programs, mumps virus was the leading cause of virus-induced centr

131 Two regions of mumps virus were amplified: the nucleocapsid gene and th

132 erologous, nonubiquitous viruses such as the mumps virus were low or absent in the HIV+ group.

133 iated N protein (N-RNA) for both measles and mumps viruses with proteins produced in a bacterial expr

134 lent cellular immune responses to measles or mumps viruses, with or without passive antibodies when i