ライフサイエンスコーパス: mural cell

1 itors of endothelial cells, blood cells, and mural cells.

2 endothelial cells as well as of perivascular mural cells.

3 ial cell-mural cell interactions and loss of mural cells.

4 nflammatory and mitogenic status of resident mural cells.

5 expressed by proliferating but not quiescent mural cells.

6 N-cadherin-dependent cell-cell adhesion with mural cells.

7 ial for interactions between endothelial and mural cells.

8 sion were larger and more densely covered by mural cells.

9 in these mice, with abnormal recruitment of mural cells.

10 vascular network concentrically wrapped with mural cells.

11 ly expressing a diphtheria toxin receptor in mural cells.

12 in the retinal venous system and associated mural cells.

13 is and in the recruitment and maintenance of mural cells.

14 he outer vessel layer and differentiate into mural cells.

15 formations involving impaired recruitment of mural cells.

16 n macrophages and endothelial cells, but not mural cells.

17 h factor receptor (PDGFR)-beta in associated mural cells.

18 rocytes, fibroblasts, endothelial cells, and mural cells.

19 te its own expression and that of JAGGED1 in mural cells.

20 Furthermore, in mural cells, a dominant-negative Mastermind-like1 constr

21 We now demonstrate that mural cell accumulation evident at embryonic day (E) 13.

22 Mural cells actively participated during the whole angio

23 b enhanced the proliferation of Wnt7b target mural cells, an effect that associated with decreased ex

24 ressed tip cell migration and recruitment of mural cells and adventitial macrophages.

25 capillaries composed of endothelium lacking mural cells and altered sub-endothelial extracellular ma

26 te chemoattractant protein-1 (MCP-1) in cyst mural cells and increased excretion of this chemokine in

27 at Notch3 is important for the investment of mural cells and is a critical regulator of developmental

28 dhesive interactions between endothelial and mural cells and its impact on vascular barrier function

29 signaling axis disrupted the association of mural cells and lymphatic vessels, improved lymphatic dr

30 he stabilization of nascent blood vessels by mural cells and may be exploited to control angiogenesis

31 e supported by the fibroblasts, which act as mural cells, and their growth is increased by the presen

32 that suggested based on lineage tracing that mural cells are adipogenic, contrasting with the conclus

33 Mural cells are also recruited by endothelial cells to f

34 Mural cells are emerging as multipotent progenitors of p

35 g to show that caSMCs derive from pericytes, mural cells associated with microvessels, and that these

36 tients with glioblastomas developed vigorous mural cell-associated vascular channels but few endothel

37 d GSDCs gave rise to tumors harboring robust mural cell-associated vascular channels.

38 nsity, and normalized vessels with increased mural cell attachment.

39 ated GFP(+) cells were further identified as mural cells based on the presence of the specific XLacZ4

40 that the Arf tumor suppressor gene regulates mural cell biology in the hyaloid vascular system (HVS)

41 gene whose expression is robustly induced in mural cells by coculturing with endothelial cells.

42 DGFR-beta is also involved in recruitment of mural cells by neovessels, regulating maturation of the

43 g glomerular capillary development, arterial mural cell coating, and lymphatic vessel development, re

44 ontributes to the proangiogenic abilities of mural cells cocultured with endothelial cells.

45 These progenitors reside in the mural cell compartment of the adipose vasculature, but n

46 e (NOS) inhibitor, we found that NO mediates mural cell coverage as well as vessel branching and long

47 use of impaired lymphatic drainage, aberrant mural cell coverage fostered the accumulation of fibroge

48 is both necessary and sufficient to support mural cell coverage in arteries using genetic rescue in

49 ll migration, which likely led to stabilized mural cell coverage of mature vessels.

50 NEM inoculation specifically promoted mural cell coverage of tumor vessels and decreased vascu

51 demonstrated RhoA activation induced loss of mural cell coverage on the endothelium and reduced endot

52 lts in severe mucosal hemorrhage, incomplete mural cell coverage on vessel walls, and gastrointestina

53 phatic vessels with reduced and disorganized mural cell coverage.

54 Defective mural-cell coverage is associated with the poorly organi

55 1) with a Cre-loxP approach in mice leads to mural cell defects and postnatal lethality.

56 brain tissues display a marked reduction in mural cell density as well as abnormal vessel wall morph

57 ons synergistically with TGFbeta to regulate mural cell development and vascular wall stability.

58 demonstrate embryonic hemorrhaging, altered mural cell development, or lethality.

59 To explore the cues that regulate mural cell differentiation and homeostasis, we have gene

60 Our findings emphasize that the level of mural cell differentiation and stabilization of the vasc

61 l cells, Cx43-/- progenitors did not undergo mural cell differentiation as did Cx43+/+ cells.

62 ells did produce latent TGF-beta and undergo mural cell differentiation in response to exogenous TGF-

63 own a role for TGF-beta in coculture-induced mural cell differentiation, growth inhibition resulting

64 OTCH3 is necessary for endothelial-dependent mural cell differentiation, whereas overexpression of NO

65 helial cells and undergo endothelial-induced mural cell differentiation.

66 f later stages of vessel assembly, including mural cell differentiation.

67 mediates TGF-beta activation and subsequent mural cell differentiation.

68 ication is necessary for endothelial-induced mural cell differentiation.

69 ent required for survival of endothelial and mural cells during vascularization.

70 Pericytes are vascular mural cells embedded in the basement membrane of blood m

71 Pericytes are vascular mural cells embedded within the basal lamina of blood mi

72 stead, we identify a stromal source of SLIT, mural cells encircling blood vessels, and show that loss

73 pericytes and vascular smooth muscle cells (mural cells) ensures the formation of a mature and stabl

74 hrough VEGFA-laden microparticles and act as mural cells for newly formed vessels, driving scar progr

75 , we observed a rapid physical withdrawal of mural cells from the endothelium that was accompanied by

76 PDGFRbeta-dependent signal transduction and mural cell function.

77 sis or angiogenesis, requires recruitment of mural cells, generation of an extracellular matrix and s

78 nt investment of the vascular endothelium by mural cells (i.e., pericytes and vascular smooth muscle

79 t in vivo evidence for a functional role for mural cells in patterning and stabilization of the early

80 bility of a broad range of investigations of mural cells in vascular development, neurovascular coupl

81 increased the proliferation and migration of mural cells in vitro and improved perivascular cell cove

82 ecise tracing of the lineage contribution of mural cells in vivo than previous versions.

83 The number of endothelial and mural cells increased significantly, and the local tissu

84 th muscle cell-specific alpha-actin-positive mural cells, indicative of maturation.

85 model revealed that NO mediates endothelial-mural cell interaction prior to vessel perfusion and als

86 athway causes disruption of endothelial cell-mural cell interactions and loss of mural cells.

87 also a key mediator of endothelial-vascular mural cell interactions, a role that may contribute to t

88 deficient mice and led to a higher number of mural cell-invested vessels than control transfection.

89 xamined the emergence and functional role of mural cells investing the dorsal aorta during early deve

90 ll remodelling in association with losses in mural cell investment and disruptions in arterial-venous

91 Angiogenesis, mural cell investment, leukocyte recruitment, vascular p

92 Moreover, Notch3 deletion impairs mural cell investment, resulting in progressive loss of

93 nication between endothelial cells (ECs) and mural cells is critical in vascular maturation.

94 s by which nascent vessels are invested with mural cells, is important in angiogenesis.

95 mediates coating of developing vessels with mural cells, leading to the formation of a mature vascul

96 RISPR-mediated knockout of N-cadherin in the mural cells led to loss of barrier function, and overexp

97 man bone marrow stromal cells, which adopt a mural cell-like phenotype that recapitulates barrier fun

98 ation of an agonist Notch3 antibody prevents mural cell loss and modifies plasma proteins associated

99 ndothelial precursor cell marker (CD133) and mural cell markers (calponin, desmin, and smooth muscle

100 ndent enlargement, ii) altered expression of mural cell markers (eg, down-regulation of NG2 and up-re

101 od-perfused vascular channels that coexpress mural cell markers smooth muscle alpha-actin and platele

102 proliferation, expression of mesenchymal and mural cell markers, and coronary blood vessel formation.

103 ed cardiomyocytes, endothelial, and vascular mural cells matured in vitro for 14 days.

104 Mural cells (MCs) consisting of vascular smooth muscle c

105 (CMs), endothelial cells (ECs), and vascular mural cells (MCs) differentiated from hiPSCs.

106 uration and stability require recruitment of mural cells (MCs) to the nascent vessel.

107 Recruitment of mural cells (MCs), namely pericytes and smooth muscle ce

108 found a higher number and magnitude of NG2+ mural-cell mediated capillary constrictions in the hippo

109 indicated that Notch3, which is expressed in mural cells, mediates these cell-cell interactions.

110 Impaired mural cell migration, differentiation, partial embryonic

111 ARCL1 secretion from quiescent ECs inhibited mural cell migration, which likely led to stabilized mur

112 epatocyte growth factor (HGF), a mediator of mural cell motility, was up-regulated by Ang1 stimulatio

113 hich line the vascular lumen, and associated mural cells, namely vascular smooth muscle cells and per

114 defects with lack of proper investment with mural cells of both large and small vessels.

115 Pericytes are perivascular mural cells of brain capillaries.

116 the potential targets is the pericytes, the mural cells of microvessels, which regulate microvascula

117 l cells of Wnt7b/canonical Wnt signaling are mural cells of periureteric bud capillaries in the nasce

118 0-V5-His were localized to vessel walls in a mural cell (pericyte) position indicating a possible dir

119 of carcinoma cells and in vessel walls in a mural cell (pericyte) position.

120 by loss of alpha5 from Pdgfrb-Cre expressing mural cells (pericytes and vascular smooth muscle cells)

121 Mural cells (pericytes and vascular smooth muscle cells)

122 s may be related to the presence of vascular mural cells (pericytes or smooth muscle cells).

123 Mesenchymal cells including microvascular mural cells (pericytes) are major progenitors of scar-fo

124 ed here are the myofibroblasts, fibroblasts, mural cells (pericytes) of the vasculature, bone marrow-

125 BM-derived periendothelial vascular mural cells (pericytes) were detected at sites of neovas

126 alphaSMA), and iii) dramatic alterations in mural cell phenotype near the optic nerve head.

127 n of mesodermal progenitor cells to a mature mural cell phenotype through activation of the transform

128 atrix adhesion is a major determinant of the mural cell phenotype.

129 further showed that N-cadherin expression in mural cells plays a key role in barrier function, as CRI

130 -derived NO induces directional migration of mural cell precursors toward endothelial cells.

131 irect the recruitment and differentiation of mural cell precursors.

132 ryonic 10T1/2 cells were used as presumptive mural cell precursors.

133 ells to areas of hypoxia, where perivascular mural cells present stromal-derived factor 1 (CXCL-12) a

134 To further dissect the role of NO in mural cell recruitment and vascular morphogenesis, we pe

135 ate that endothelial cell-derived NO induces mural cell recruitment as well as subsequent morphogenes

136 In the developing vasculature, mural cell recruitment is associated with the functional

137 derived growth factor B (PDGF-B), leading to mural cell recruitment thereby contributing to vascular

138 promoting arteriogenesis, angiogenesis, and mural cell recruitment to immature angiogenic sprouts.

139 Our results implicate aberrant mural cell recruitment to lymphatic vessels in the patho

140 Inhibition of mural cell recruitment to the dorsal aorta through disru

141 Mural cell recruitment to the growing endothelial tube i

142 gnaling pathways, which are both crucial for mural cell recruitment, via its intracellular domain.

143 Here we report that mural cells require ephrin-B2, a ligand for Eph receptor

144 otypic interactions of endothelial cells and mural cells (smooth muscle cells or pericytes) are cruci

145 Endothelial cells and mural cells (smooth muscle cells, pericytes, or fibrobla

146 However, the mechanistic details of how mural cells stabilize vessels are not fully understood.

147 ctivity and increase in RhoA activity in the mural cells themselves upon inflammation.

148 o suppress cell proliferation and to recruit mural cells, thereby establishing endothelial quiescence

149 othelial cells induce the differentiation of mural cells through activation and induction of NOTCH3.

150 el perfusion and also induces recruitment of mural cells to angiogenic vessels, vessel branching, and

151 r maturation characterized by the failure of mural cells to migrate around endothelial cells.

152 s integrin-ligand pair block the adhesion of mural cells to proliferating endothelia in vitro and in

153 asculature relies on active participation of mural cells to stabilize endothelium and a basal level o

154 strains, only those that marked perivascular mural cells tracked the cold-induced beige lineage.

155 Mural cells (vascular smooth muscle cells and pericytes)

156 nitors and induce their differentiation into mural cells via contact-dependent transforming growth fa

157 ney is dependent on the kinetics of vascular mural cell (VMC) differentiation.

158 othelial trafficking with pericytes/vascular mural cells (VMC), an interaction crucial to vessel stab

159 eural crest migration and the recruitment of mural cells, which are essential for vascular stability.

160 atial coordination of endothelial cells with mural cells, which delivers oxygen and nutrients.

161 Loss of mural cells, which encompass pericytes and vascular smoo

162 that capillary pericytes are a population of mural cells with distinct morphological, molecular and f

163 mechanistic insights into the cooperation of mural cells with endothelial cells induced by YKL-40 dur